LOCUS       NM_001107379            3803 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus synuclein, alpha interacting protein (Sncaip),
            mRNA.
ACCESSION   NM_001107379 XM_001055030 XM_225768
VERSION     NM_001107379.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3803)
  AUTHORS   Xie,Y.Y., Zhou,C.J., Zhou,Z.R., Hong,J., Che,M.X., Fu,Q.S.,
            Song,A.X., Lin,D.H. and Hu,H.Y.
  TITLE     Interaction with synphilin-1 promotes inclusion formation of
            alpha-synuclein: mechanistic insights and pathological implication
  JOURNAL   FASEB J 24 (1), 196-205 (2010)
   PUBMED   19762560
REFERENCE   2  (bases 1 to 3803)
  AUTHORS   Szargel,R., Rott,R., Eyal,A., Haskin,J., Shani,V., Balan,L.,
            Wolosker,H. and Engelender,S.
  TITLE     Synphilin-1A inhibits seven in absentia homolog (SIAH) and
            modulates alpha-synuclein monoubiquitylation and inclusion
            formation
  JOURNAL   J Biol Chem 284 (17), 11706-11716 (2009)
   PUBMED   19224863
  REMARK    GeneRIF: synphilin-1A has a novel role as a regulator of SIAH
            activity, modulating alpha-synuclein, and formation of Lewy
            body-like inclusions
REFERENCE   3  (bases 1 to 3803)
  AUTHORS   Eyal,A., Szargel,R., Avraham,E., Liani,E., Haskin,J., Rott,R. and
            Engelender,S.
  TITLE     Synphilin-1A: an aggregation-prone isoform of synphilin-1 that
            causes neuronal death and is present in aggregates from
            alpha-synucleinopathy patients
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5917-5922 (2006)
   PUBMED   16595633
REFERENCE   4  (bases 1 to 3803)
  AUTHORS   Lim,K.L., Chew,K.C., Tan,J.M., Wang,C., Chung,K.K., Zhang,Y.,
            Tanaka,Y., Smith,W., Engelender,S., Ross,C.A., Dawson,V.L. and
            Dawson,T.M.
  TITLE     Parkin mediates nonclassical, proteasomal-independent
            ubiquitination of synphilin-1: implications for Lewy body formation
  JOURNAL   J Neurosci 25 (8), 2002-2009 (2005)
   PUBMED   15728840
REFERENCE   5  (bases 1 to 3803)
  AUTHORS   Kalia,S.K., Lee,S., Smith,P.D., Liu,L., Crocker,S.J.,
            Thorarinsdottir,T.E., Glover,J.R., Fon,E.A., Park,D.S. and
            Lozano,A.M.
  TITLE     BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
  JOURNAL   Neuron 44 (6), 931-945 (2004)
   PUBMED   15603737
REFERENCE   6  (bases 1 to 3803)
  AUTHORS   Liani,E., Eyal,A., Avraham,E., Shemer,R., Szargel,R., Berg,D.,
            Bornemann,A., Riess,O., Ross,C.A., Rott,R. and Engelender,S.
  TITLE     Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its
            presence in cellular inclusions and Lewy bodies imply a role in
            Parkinson's disease
  JOURNAL   Proc Natl Acad Sci U S A 101 (15), 5500-5505 (2004)
   PUBMED   15064394
REFERENCE   7  (bases 1 to 3803)
  AUTHORS   Nagano,Y., Yamashita,H., Takahashi,T., Kishida,S., Nakamura,T.,
            Iseki,E., Hattori,N., Mizuno,Y., Kikuchi,A. and Matsumoto,M.
  TITLE     Siah-1 facilitates ubiquitination and degradation of synphilin-1
  JOURNAL   J Biol Chem 278 (51), 51504-51514 (2003)
   PUBMED   14506261
REFERENCE   8  (bases 1 to 3803)
  AUTHORS   Ribeiro,C.S., Carneiro,K., Ross,C.A., Menezes,J.R. and
            Engelender,S.
  TITLE     Synphilin-1 is developmentally localized to synaptic terminals, and
            its association with synaptic vesicles is modulated by
            alpha-synuclein
  JOURNAL   J Biol Chem 277 (26), 23927-23933 (2002)
   PUBMED   11956199
  REMARK    GeneRIF: Our data indicated that synphilin-1 is a synaptic partner
            of alpha-synuclein, and it may mediate synaptic roles attributed to
            alpha-synuclein.
            Erratum:[J Biol Chem 2002 Sep 13;277(37):34651-4]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225768.4, XM_001055030.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3803
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
     exon            1..326
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..429
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..3264
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /note="synuclein, alpha interacting protein (synphilin)"
                     /codon_start=1
                     /product="synphilin-1"
                     /protein_id="NP_001100849.1"
                     /db_xref="GeneID:307309"
                     /db_xref="RGD:1309283"
                     /translation="MEAPEYLDLDEIDFSDDISYSVTSLKTIPALCRRCDSQNEDRPV
                     SSSSWNCGVSTLITNPQKPTGIADVYSKFRPVKRVSPLKHQPETLESNESDDQKNNTV
                     EYQKGGETDQGPQPEELSPEDGVGGLPGKGSEPSQALGELEHYDLDMDEILDVPYIKS
                     SQQLAPLTKVTSEKRILGLCTTVNGLSAKTCPIVSAETSTPNMAPLCVLSPVKSPHLR
                     KVPSVLRDQHKLPAEESENSPAPGKCGPAFESENHSKDFLNKVFSDPHSRKAEKSGPD
                     CKLRPFRLQTSAAGAKPEEQVNGVSWASAQGAEERTEYLQKVRSILNIVNEGQISLLP
                     HLAADNLDKIHDENGNNLLHVAASKGHAECLQHLTSLMGEDCLNERNAEQLTPAGLAI
                     KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD
                     EVDQEGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL
                     VVVETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGKSLPSSPSSPSSP
                     ASRKSQWKILDADDESTGKSKLGTQEGIQVLGNLSSRARTKGKDEDSDKILRQLLGKE
                     ISENVCTQEKLSLEFQDAQVSSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNS
                     EDPKNTPVKRVDRPRPQPIVESVENMDSAESLHLMIKKHSVASGRRFPFGMKASKSLD
                     GHSPSPTSESSEPDLDSHCPSLGMTPPTQPSTEATQCSPDSATAQKVATSPKSALKSP
                     SSKRRTSQNSKLRVTFEEPVVQMEQTSLELNGEKDKERGRAPQRTSESGEQMKRPFGT
                     FRSIMESLSGNQNNNNNYQPASQLKTCTLPLTSLGRKTADAKGNPVSPASKGKNKAAM
                     YSSCIHLPSNALVEEHLRDYARLNDIKRNTKKTYNVKHIAEPEPKELFL"
     exon            430..502
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..1371
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1551
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1665
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1791
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1961
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2054
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..3108
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3179
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3803
                     /gene="Sncaip"
                     /gene_synonym="Syph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctagctgg cgttctgctt gctgctacct cggatcgtcc cggaggcggg gatgggctgt
       61 gccgaggctc ctaagagctc ccagggaggg gcaaaggctt ggtgatagct acactagtaa
      121 ccagaacaat aacaaacgtg aaggggatgc cgggtggtgt cgctacccga agggagcccc
      181 tggcccatca gccccgcggc gcctaggctg ccccgtccag cttcagctcc tcctcccggc
      241 gctgtccggc gtcccgggat tatccacgtc ctggggaagg cttctttcct gaccctctca
      301 gtggcggtga ctttcctttg caggtggata ttataaatat tcgaccttac tcaaaatgta
      361 caaagaagaa taatggaagc ccctgaatat cttgatctgg atgaaatcga ctttagtgat
      421 gacatttctt attcagtcac atctctcaag accatcccag cactgtgcag aagatgtgac
      481 tcacagaacg aagacagacc agtttctagc tctagctgga attgtggtgt ctcaactctc
      541 attacaaacc cgcaaaagcc cactggaatc gctgatgtat acagtaagtt ccgcccggtg
      601 aagcgagttt ctccactgaa acatcagcca gagactctgg agagcaatga aagtgacgac
      661 cagaagaaca atacagtgga ataccagaaa gggggggaga ctgaccaggg cccccagcct
      721 gaggagctca gccctgaaga tggagtcgga ggcttgccag gcaagggctc agagcccagc
      781 caggcactgg gtgagctgga gcactatgac ctcgacatgg atgagattct ggatgtgcct
      841 tacattaaat ccagtcaaca gctggccccg ctcaccaagg tgacttcaga aaaaaggatt
      901 ttgggtttat gcacaactgt caatggcctc tctgccaaaa cctgccctat tgtaagcgct
      961 gagacctcca cacccaacat ggctccattg tgtgttcttt ctcctgtgaa aagccctcac
     1021 ttacggaaag tacccagtgt cctccgggac cagcacaagc tccctgcgga agaatcggag
     1081 aactcacccg ctcctggtaa atgcggccct gcatttgaat cagaaaacca cagtaaggac
     1141 ttcttaaaca aggtctttag tgatccccat agtcggaaag ctgagaagtc tgggccagac
     1201 tgcaagctca ggcccttccg cctgcagacc tcggcagcag gagccaaacc agaggagcag
     1261 gtcaacggcg tgagctgggc cagtgcccaa ggcgcagaag aaaggactga gtacctgcag
     1321 aaagtaagaa gcatactgaa cattgtgaac gaagggcaga tatcgctctt gccacaccta
     1381 gctgcagata atctggacaa aattcacgac gagaacggaa acaatctgtt acacgttgct
     1441 gcatcaaagg gccatgcgga atgtctgcag cacctcacgt cgctgatggg cgaagactgt
     1501 ctgaatgaac ggaacgcaga gcaactgact ccagcgggcc tggccatcaa gaatggtcag
     1561 ctggagtgtg tacgctggat ggtgagtgag acggaagcca ttgcggaact gagttgttcc
     1621 aaggatttcc caagcctaat tcattacgca ggctgctatg ggcaggaaaa gattcttctg
     1681 tggcttcttc agttcatgca agaacaaggc atctcattgg atgaagtaga tcaggaaggc
     1741 aacagtgctg ttcatgtcgc ttcacaacat ggctaccttg gatgcataca gaccctggtg
     1801 gagtatggag caaatgttac gatgcagaac cacgctgggg aaaagccctc ccagagtgcc
     1861 gagcggcacg gccacaccct atgttcccgg tacctcgtgg tggtagagac ctgtatgtca
     1921 ctggcctcac aagtggtaaa gttgaccaag cagctaaagg agcagacagt ggagcgcgtc
     1981 acactgcaga gtcaactcca acaacttctg gaagcccaga aatcagaggg caagtccctc
     2041 ccatcttcac ccagttcacc ctcctcacca gcttctagaa agtcccagtg gaaaattcta
     2101 gatgcagatg acgagtctac aggcaaaagc aaactgggaa cccaggaggg aatacaagtc
     2161 cttggaaact tatccagcag ggctaggacc aaaggaaaag acgaagactc tgataaaatc
     2221 ctacgtcagt tattggggaa agaaatatca gagaatgtct gcacccagga aaagctgtca
     2281 ttggaattcc aggatgctca ggtatcctct aggaattcga aaaaaatacc tctagagaag
     2341 agggaactga agctagctag actgcggcag ctgatgcaga gatctttgag tgaatctgac
     2401 acggattcaa acaactctga ggaccccaaa aatactcctg tgaaaagagt ggacagacct
     2461 agaccacagc ccattgtgga aagtgtggag aatatggaca gtgcagaaag cttacacctg
     2521 atgataaaga aacactctgt ggcatcagga cgcaggtttc cttttggtat gaaggcctcc
     2581 aaatccctgg atgggcacag cccatctccc acttcagaga gcagtgaacc agatttggac
     2641 tcccattgcc cgagcctggg aatgactcct ccaacccaac cttctacaga agccactcag
     2701 tgcagtcctg acagtgccac tgcccagaaa gttgctacaa gccccaagag tgccctcaag
     2761 tctccatcat ccaagcgccg gacatcccaa aactcaaaac tgagagtgac ctttgaggag
     2821 cctgttgtgc aaatggagca aactagcctt gaactaaatg gagaaaaaga caaagagagg
     2881 ggcagggccc cccagaggac tagtgagtca ggagaacaaa tgaaaaggcc ttttggaacc
     2941 ttccgatcca tcatggagag tttaagtggt aatcagaaca acaataataa ctaccagcca
     3001 gccagccagc tgaagacctg cacactaccc ttgacgtcac ttggaaggaa gacagcagat
     3061 gccaagggaa accctgtgag ccctgctagc aaaggaaaga ataaggcagc gatgtacagc
     3121 agctgcattc atcttccctc taatgcgctg gtcgaagagc atctgcgtga ttatgcacgg
     3181 cttaatgaca tcaaaagaaa cacgaagaaa acttacaacg taaagcacat tgctgaacca
     3241 gagccaaagg aactcttctt ataaattact cttagtatga gtctcacaca tgccctctgg
     3301 ccaccattgg gagttaatgg actgtggcaa tcagaccatg agaacaacac ctcaccagcg
     3361 agcagaatat ctggatgcct taaatttata atatgagact tgttataaga tacattttgg
     3421 accatatctg tacatagaac ttgtttgatt tcttttttaa tatgctgttt gaaaacatga
     3481 tcgggcaatg tatgcattga cacattggac atttgattga gtcgaccttc ttgaagcaca
     3541 tccaccagca cctgacacga ctagtgtttt tgtgaattgc atgaggattt gctgatgttg
     3601 attagatgtt caccttcttt gtaacaaggg cagctgtggc tcagctcagt gaggccaggt
     3661 cactggtttt attttctgtc cagtgtgttt ttctgtcatt tctacttttt taataaagaa
     3721 aattaaacat ttgtaacagc agactctggg cgtggggggc agggcatcta ctttctaata
     3781 aatctgtgaa gctctgattt cta
//
