LOCUS       NM_019169               1150 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus synuclein alpha (Snca), mRNA.
ACCESSION   NM_019169
VERSION     NM_019169.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Hui,S., George,J., Kapadia,M., Chau,H., Bariring,Z., Earnshaw,R.,
            Shafiq,K., Kalia,L.V. and Kalia,S.K.
  TITLE     Mitophagy Upregulation Occurs Early in the Neurodegenerative
            Process Mediated by alpha-Synuclein
  JOURNAL   Mol Neurobiol 61 (11), 9032-9042 (2024)
   PUBMED   38581539
  REMARK    GeneRIF: Mitophagy Upregulation Occurs Early in the
            Neurodegenerative Process Mediated by alpha-Synuclein.
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   De Barros Oliveira,R., Anselmi,M., Marchette,R.C.N., Roversi,K.,
            Fadanni,G.P., De Carvalho,L.M., Damasceno,S., Heinrich,I.A.,
            Leal,R.B., Cavalli,J., Moreira-Junior,R.E., Godard,A.L.B. and
            Izidio,G.S.
  TITLE     Differential expression of alpha-synuclein in the hippocampus of
            SHR and SLA16 isogenic rat strains
  JOURNAL   Behav Brain Res 461, 114835 (2024)
   PUBMED   38151185
  REMARK    GeneRIF: Differential expression of alpha-synuclein in the
            hippocampus of SHR and SLA16 isogenic rat strains.
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Ali,A., Zhaliazka,K., Dou,T., Holman,A.P. and Kurouski,D.
  TITLE     The toxicities of A30P and A53T alpha-synuclein fibrils can be
            uniquely altered by the length and saturation of fatty acids in
            phosphatidylserine
  JOURNAL   J Biol Chem 299 (12), 105383 (2023)
   PUBMED   37890776
  REMARK    GeneRIF: The toxicities of A30P and A53T alpha-synuclein fibrils
            can be uniquely altered by the length and saturation of fatty acids
            in phosphatidylserine.
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Chen,X., Tsika,E., Levine,N. and Moore,D.J.
  TITLE     VPS35 and alpha-Synuclein fail to interact to modulate
            neurodegeneration in rodent models of Parkinson's disease
  JOURNAL   Mol Neurodegener 18 (1), 51 (2023)
   PUBMED   37542299
  REMARK    GeneRIF: VPS35 and alpha-Synuclein fail to interact to modulate
            neurodegeneration in rodent models of Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1150)
  AUTHORS   Yang,H.M., Cheng,Y.Z., Hou,T.Z., Fan,J.K., Gu,L., Zhang,J.N. and
            Zhang,H.
  TITLE     Upregulation of Parkinson's disease-associated protein
            alpha-synuclein suppresses tumorigenesis via interaction with
            mGluR5 and gamma-synuclein in liver cancer
  JOURNAL   Arch Biochem Biophys 744, 109698 (2023)
   PUBMED   37487948
  REMARK    GeneRIF: Upregulation of Parkinson's disease-associated protein
            alpha-synuclein suppresses tumorigenesis via interaction with
            mGluR5 and gamma-synuclein in liver cancer.
REFERENCE   6  (bases 1 to 1150)
  AUTHORS   Kruger,R., Kuhn,W., Muller,T., Woitalla,D., Graeber,M., Kosel,S.,
            Przuntek,H., Epplen,J.T., Schols,L. and Riess,O.
  TITLE     Ala30Pro mutation in the gene encoding alpha-synuclein in
            Parkinson's disease
  JOURNAL   Nat Genet 18 (2), 106-108 (1998)
   PUBMED   9462735
REFERENCE   7  (bases 1 to 1150)
  AUTHORS   Polymeropoulos,M.H., Lavedan,C., Leroy,E., Ide,S.E., Dehejia,A.,
            Dutra,A., Pike,B., Root,H., Rubenstein,J., Boyer,R., Stenroos,E.S.,
            Chandrasekharappa,S., Athanassiadou,A., Papapetropoulos,T.,
            Johnson,W.G., Lazzarini,A.M., Duvoisin,R.C., Di Iorio,G.,
            Golbe,L.I. and Nussbaum,R.L.
  TITLE     Mutation in the alpha-synuclein gene identified in families with
            Parkinson's disease
  JOURNAL   Science 276 (5321), 2045-2047 (1997)
   PUBMED   9197268
REFERENCE   8  (bases 1 to 1150)
  AUTHORS   Ueda,K., Fukushima,H., Masliah,E., Xia,Y., Iwai,A., Yoshimoto,M.,
            Otero,D.A., Kondo,J., Ihara,Y. and Saitoh,T.
  TITLE     Molecular cloning of cDNA encoding an unrecognized component of
            amyloid in Alzheimer disease
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11282-11286 (1993)
   PUBMED   8248242
REFERENCE   9  (bases 1 to 1150)
  AUTHORS   Maroteaux,L. and Scheller,R.H.
  TITLE     The rat brain synucleins; family of proteins transiently associated
            with neuronal membrane
  JOURNAL   Brain Res Mol Brain Res 11 (3-4), 335-343 (1991)
   PUBMED   1661825
REFERENCE   10 (bases 1 to 1150)
  AUTHORS   Maroteaux,L., Campanelli,J.T. and Scheller,R.H.
  TITLE     Synuclein: a neuron-specific protein localized to the nucleus and
            presynaptic nerve terminal
  JOURNAL   J Neurosci 8 (8), 2804-2815 (1988)
   PUBMED   3411354
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 25, 2021 this sequence version replaced NM_019169.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087682.1, CF975989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000004.1  91126178-91126315   c
            139-285             JAXUCZ010000004.1  91124914-91125060   c
            286-327             JAXUCZ010000004.1  91114139-91114180   c
            328-470             JAXUCZ010000004.1  91108590-91108732   c
            471-554             JAXUCZ010000004.1  91028003-91028086   c
            555-1150            JAXUCZ010000004.1  91026474-91027069   c
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1150
                     /gene="Snca"
                     /note="synuclein alpha"
                     /db_xref="GeneID:29219"
                     /db_xref="RGD:3729"
     exon            1..138
                     /gene="Snca"
                     /inference="alignment:Splign:2.1.0"
     exon            139..285
                     /gene="Snca"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..587
                     /gene="Snca"
                     /note="synuclein, alpha (non A4 component of amyloid
                     precursor)"
                     /codon_start=1
                     /product="alpha-synuclein"
                     /protein_id="NP_062042.1"
                     /db_xref="GeneID:29219"
                     /db_xref="RGD:3729"
                     /translation="MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKT
                     KEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGK
                     GEEGYPQEGILEDMPVDPSSEAYEMPSEEGYQDYEPEA"
     exon            286..327
                     /gene="Snca"
                     /inference="alignment:Splign:2.1.0"
     exon            328..470
                     /gene="Snca"
                     /inference="alignment:Splign:2.1.0"
     exon            471..554
                     /gene="Snca"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1150
                     /gene="Snca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcagcag acggcaggag accagcaggt gctccccctg cccttgcccc tcagcccaga
       61 gcctttcacc cctcttgcat tgaaattaga ttggggaaaa caggaggaat cagagttctg
      121 cggaagccta gagagccgtg tggagcaaag atacatcttt agccatggat gtgttcatga
      181 aaggactttc aaaggccaag gagggagttg tggctgctgc tgagaaaacc aagcagggtg
      241 tggcagaggc agctgggaag acaaaagagg gcgtcctcta tgtaggttcc aaaactaagg
      301 agggagtcgt tcatggagtg acaacagtgg ctgagaagac caaagaacaa gtgacaaatg
      361 ttggaggggc agtggtgact ggtgtgacag cagtcgctca gaagacagtg gagggagctg
      421 ggaacattgc tgctgccact ggttttgtca agaaggacca gatgggcaag ggtgaagaag
      481 ggtacccaca agagggaatc ctggaagaca tgcctgtgga ccctagcagt gaggcttatg
      541 aaatgccttc agaggaaggc taccaagact atgagcctga agcctaagaa tgtcgttgta
      601 cccactgtcc taagatctgc ccaggtgttc ttccatggcg tacaagtgct cagttccaac
      661 gtgcccagtc atgacctttt ctcaaagctg tacagtgtat ttcaaagtct tccatcagca
      721 gtgatcggag tcctgtacct gcccctcagc atcccggtgc tcccctctca ctacagtgaa
      781 tacatggtag caggctcttg tgtgctgtgg atattgttgt ggcttcaaac ctaaaatgtt
      841 agaagaaact taaaacacct aagtgactac cacttatttc taactcttca ccgttttttg
      901 ttgctgttct caagaagttg tgatttgcta taagactttt agatgtcctt aatgattctt
      961 tctgtctaag aagaatgatg tgctgtgaaa tttgttaata tatattttaa aatatgtgag
     1021 catgagacta tgcacctata aatattaatt tatgaatttt acagttttgt gacgtgtttt
     1081 attaacttgt gtttgtatat aaatggtgga aattaaaata aaataaaaca ttatctcatt
     1141 gcaaaacctt
//
