LOCUS       NM_001170576            1539 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus SNAP-associated protein (Snapin), transcript
            variant 1, mRNA.
ACCESSION   NM_001170576
VERSION     NM_001170576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Somanath,S., Partridge,C.J., Marshall,C., Rowe,T. and Turner,M.D.
  TITLE     Snapin mediates insulin secretory granule docking, but not
            trans-SNARE complex formation
  JOURNAL   Biochem Biophys Res Commun 473 (2), 403-407 (2016)
   PUBMED   26946359
  REMARK    GeneRIF: In pancreatic beta-cells the SNAP-25 accessory protein,
            snapin, C-terminal H2 domain binds SNAP-25 through its N-terminal
            Sn-1 domain.
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Pu,J., Schindler,C., Jia,R., Jarnik,M., Backlund,P. and
            Bonifacino,J.S.
  TITLE     BORC, a multisubunit complex that regulates lysosome positioning
  JOURNAL   Dev Cell 33 (2), 176-188 (2015)
   PUBMED   25898167
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Yun,H.J., Park,J., Ho,D.H., Kim,H., Kim,C.H., Oh,H., Ga,I., Seo,H.,
            Chang,S., Son,I. and Seol,W.
  TITLE     LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with
            SNAP-25
  JOURNAL   Exp Mol Med 45 (8), e36 (2013)
   PUBMED   23949442
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Kim,H.J., Zhong,Q., Sheng,Z.H., Yoshimori,T., Liang,C. and
            Jung,J.U.
  TITLE     Beclin-1-interacting autophagy protein Atg14L targets the
            SNARE-associated protein Snapin to coordinate endocytic trafficking
  JOURNAL   J Cell Sci 125 (Pt 20), 4740-4750 (2012)
   PUBMED   22797916
REFERENCE   5  (bases 1 to 1539)
  AUTHORS   Lee,H.H., Nemecek,D., Schindler,C., Smith,W.J., Ghirlando,R.,
            Steven,A.C., Bonifacino,J.S. and Hurley,J.H.
  TITLE     Assembly and architecture of biogenesis of lysosome-related
            organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 287 (8), 5882-5890 (2012)
   PUBMED   22203680
REFERENCE   6  (bases 1 to 1539)
  AUTHORS   Starcevic,M. and Dell'Angelica,E.C.
  TITLE     Identification of snapin and three novel proteins (BLOS1, BLOS2,
            and BLOS3/reduced pigmentation) as subunits of biogenesis of
            lysosome-related organelles complex-1 (BLOC-1)
  JOURNAL   J Biol Chem 279 (27), 28393-28401 (2004)
   PUBMED   15102850
REFERENCE   7  (bases 1 to 1539)
  AUTHORS   Vites,O., Rhee,J.S., Schwarz,M., Rosenmund,C. and Jahn,R.
  TITLE     Reinvestigation of the role of snapin in neurotransmitter release
  JOURNAL   J Biol Chem 279 (25), 26251-26256 (2004)
   PUBMED   15084593
  REMARK    GeneRIF: snapin may not have a role as a SNARE regulator in
            neurotransmitter release, as had been previously thought [SNAPIN]
REFERENCE   8  (bases 1 to 1539)
  AUTHORS   Buxton,P., Zhang,X.M., Walsh,B., Sriratana,A., Schenberg,I.,
            Manickam,E. and Rowe,T.
  TITLE     Identification and characterization of Snapin as a ubiquitously
            expressed SNARE-binding protein that interacts with SNAP23 in
            non-neuronal cells
  JOURNAL   Biochem J 375 (Pt 2), 433-440 (2003)
   PUBMED   12877659
REFERENCE   9  (bases 1 to 1539)
  AUTHORS   Chheda,M.G., Ashery,U., Thakur,P., Rettig,J. and Sheng,Z.H.
  TITLE     Phosphorylation of Snapin by PKA modulates its interaction with the
            SNARE complex
  JOURNAL   Nat Cell Biol 3 (4), 331-338 (2001)
   PUBMED   11283605
REFERENCE   10 (bases 1 to 1539)
  AUTHORS   Ilardi,J.M., Mochida,S. and Sheng,Z.H.
  TITLE     Snapin: a SNARE-associated protein implicated in synaptic
            transmission
  JOURNAL   Nat Neurosci 2 (2), 119-124 (1999)
   PUBMED   10195194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY315040.1 and BC098864.1.
            
            On Jan 18, 2018 this sequence version replaced NM_001170576.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY315040.1, CO401616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               DY315040.1         1-730
            731-1539            BC098864.1         809-1617
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1539
                     /gene="Snapin"
                     /gene_synonym="Snapap"
                     /note="SNAP-associated protein"
                     /db_xref="GeneID:295217"
                     /db_xref="RGD:1560377"
     exon            1..174
                     /gene="Snapin"
                     /gene_synonym="Snapap"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..442
                     /gene="Snapin"
                     /gene_synonym="Snapap"
                     /note="isoform 1 is encoded by transcript variant 1; SNARE
                     associated protein snapin; synaptosomal-associated protein
                     25-binding protein; BLOC-1 subunit 7; biogenesis of
                     lysosome-related organelles complex 1 subunit 7"
                     /codon_start=1
                     /product="SNARE-associated protein Snapin isoform 1"
                     /protein_id="NP_001164047.1"
                     /db_xref="GeneID:295217"
                     /db_xref="RGD:1560377"
                     /translation="MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHV
                     HAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNA
                     QERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK"
     exon            175..221
                     /gene="Snapin"
                     /gene_synonym="Snapap"
                     /inference="alignment:Splign:2.1.0"
     exon            222..340
                     /gene="Snapin"
                     /gene_synonym="Snapap"
                     /inference="alignment:Splign:2.1.0"
     exon            341..1539
                     /gene="Snapin"
                     /gene_synonym="Snapap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcaggctg agggcgtcag ggcagttcgc gatggccgcg gctggttccg ctgccgtgtc
       61 tggggccggg accccagtgg cggggcccac aggccgcgac ctctttgccg aggggctcct
      121 ggagttcctg cgacctgctg tgcagcaact cgactctcac gtgcacgcgg tcagagaaag
      181 ccaagtagag ctccgggaac aaattgacaa cctagctaca gaactgtgcc ggatcaatga
      241 ggatcagaag gtggccctgg atctggaccc ctatgttaag aagctgctta atgccaggcg
      301 gcgagttgtc ttggtcaaca atattttaca gaatgcacag gaacgactaa ggcggttaaa
      361 ccacagtgtg gccaaggaaa cagcccgcag gagagccatg ctggattcag gagtttaccc
      421 tcctggttct ccaagcaaat aagcctggac ctatgaccag agtatacagt actattctcc
      481 aacagctttg tcttggtaga cagaagattc cagcaaagtc tccgtagacc tttgatttgt
      541 ttgcactatg tactcattca tgtagcagcc tcaagaaata tgcatacagc aggactattc
      601 ctaaagaacc tccattacag tgtccttcca agaatgagcc tctacctttt gttttgtttc
      661 ttgagacaag gtctcaatat gtaaggcagg ctggcctcaa acatattttc ttgccttagc
      721 ctcctgaatg ctgggatcat aataggcatg tgtcagggtg cctggctcaa gcctttgtac
      781 attttctccc aaagaatgtt aagtaaatta ggcatcatgt gctagaaaat ctgggaagac
      841 accagagatt tattgcagaa agtacactac ttctccctct ctgcctcacc acagttcctc
      901 tcagaaggta ataaccttcc cagaatcatc ttacacattt ttagtgttta ggttagttcc
      961 tattaacaag tatcacaact attgccttca ttcctgccca aggagagcat gacaaataac
     1021 atgagaatcc aaggtcaagg gcagagcctt gatagctgag agcccctaag cttttgtgat
     1081 tgtgtttagg ctactacatg ttttaagggc tagagggata gctcaatggt taagagcact
     1141 ggtggttctt ccagatggag ttcagttcct agcacccaca tggtgattcc aggtgaatcc
     1201 aatgcccttg tctggccttt ctaggtgtag cacacataca cacacgttgc agacatacat
     1261 gcaggtaaaa catccattct cataaaataa aaaattaaaa gttacatatt taagtgctac
     1321 catttcgagg cctagttagc cagtgttaac catactgtta ctcttattac ttgggcctgg
     1381 gcaaagttta cctgtaactt aattttgttt acaattacag acctaggtaa agtcaagata
     1441 aataatttat cctcttgacc accctggctt gactatgtta atattaagta ttactcagca
     1501 ttattaataa atccttgcaa tggttatttt aacaaaaaa
//
