LOCUS       NM_031728               4376 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Rattus norvegicus synaptosome associated protein 91 (Snap91), mRNA.
ACCESSION   NM_031728
VERSION     NM_031728.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4376)
  AUTHORS   Koo,S.J., Kochlamazashvili,G., Rost,B., Puchkov,D., Gimber,N.,
            Lehmann,M., Tadeus,G., Schmoranzer,J., Rosenmund,C., Haucke,V. and
            Maritzen,T.
  TITLE     Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control
            Efficient Neurotransmission
  JOURNAL   Neuron 88 (2), 330-344 (2015)
   PUBMED   26412491
REFERENCE   2  (bases 1 to 4376)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   3  (bases 1 to 4376)
  AUTHORS   Abid,S.N., Richardson,T.E., Powell,H.M., Jaichander,P.,
            Chaudhary,J., Chapman,K.M. and Hamra,F.K.
  TITLE     A-single spermatogonia heterogeneity and cell cycles synchronize
            with rat seminiferous epithelium stages VIII-IX
  JOURNAL   Biol Reprod 90 (2), 32 (2014)
   PUBMED   24389876
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4376)
  AUTHORS   Petralia,R.S., Wang,Y.X., Indig,F.E., Bushlin,I., Wu,F.,
            Mattson,M.P. and Yao,P.J.
  TITLE     Reduction of AP180 and CALM produces defects in synaptic vesicle
            size and density
  JOURNAL   Neuromolecular Med 15 (1), 49-60 (2013)
   PUBMED   22851330
  REMARK    GeneRIF: Neurons with reduced AP180 had smaller
            Synaptophysin::EGFP-illuminated puncta. Synaptic vesicles were
            enlarged & their density and size were reduced.
REFERENCE   5  (bases 1 to 4376)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4376)
  AUTHORS   Lee,J.H., Daud,A.N., Cribbs,L.L., Lacerda,A.E., Pereverzev,A.,
            Klockner,U., Schneider,T. and Perez-Reyes,E.
  TITLE     Cloning and expression of a novel member of the low
            voltage-activated T-type calcium channel family
  JOURNAL   J Neurosci 19 (6), 1912-1921 (1999)
   PUBMED   10066244
REFERENCE   7  (bases 1 to 4376)
  AUTHORS   Lee,C., Kang,H.S., Chung,J.K., Sekiya,F., Kim,J.R., Han,J.S.,
            Kim,S.R., Bae,Y.S., Morris,A.J. and Rhee,S.G.
  TITLE     Inhibition of phospholipase D by clathrin assembly protein 3 (AP3)
  JOURNAL   J Biol Chem 272 (25), 15986-15992 (1997)
   PUBMED   9188501
REFERENCE   8  (bases 1 to 4376)
  AUTHORS   Hao,W., Tan,Z., Prasad,K., Reddy,K.K., Chen,J., Prestwich,G.D.,
            Falck,J.R., Shears,S.B. and Lafer,E.M.
  TITLE     Regulation of AP-3 function by inositides. Identification of
            phosphatidylinositol 3,4,5-trisphosphate as a potent ligand
  JOURNAL   J Biol Chem 272 (10), 6393-6398 (1997)
   PUBMED   9045662
REFERENCE   9  (bases 1 to 4376)
  AUTHORS   Norris,F.A., Ungewickell,E. and Majerus,P.W.
  TITLE     Inositol hexakisphosphate binds to clathrin assembly protein 3
            (AP-3/AP180) and inhibits clathrin cage assembly in vitro
  JOURNAL   J Biol Chem 270 (1), 214-217 (1995)
   PUBMED   7814377
REFERENCE   10 (bases 1 to 4376)
  AUTHORS   Morris,S.A., Schroder,S., Plessmann,U., Weber,K. and Ungewickell,E.
  TITLE     Clathrin assembly protein AP180: primary structure, domain
            organization and identification of a clathrin binding site
  JOURNAL   EMBO J 12 (2), 667-675 (1993)
   PUBMED   8440257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 8, 2020 this sequence version replaced NM_031728.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68878.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000008.1  96732317-96732507   c
            192-351             JAXUCZ010000008.1  96731476-96731635   c
            352-494             JAXUCZ010000008.1  96698204-96698346   c
            495-570             JAXUCZ010000008.1  96697490-96697565   c
            571-673             JAXUCZ010000008.1  96696326-96696428   c
            674-767             JAXUCZ010000008.1  96695203-96695296   c
            768-879             JAXUCZ010000008.1  96693624-96693735   c
            880-986             JAXUCZ010000008.1  96677562-96677668   c
            987-1028            JAXUCZ010000008.1  96674370-96674411   c
            1029-1099           JAXUCZ010000008.1  96668477-96668547   c
            1100-1105           JAXUCZ010000008.1  96665933-96665938   c
            1106-1133           JAXUCZ010000008.1  96662082-96662109   c
            1134-1243           JAXUCZ010000008.1  96657219-96657328   c
            1244-1356           JAXUCZ010000008.1  96655235-96655347   c
            1357-1371           JAXUCZ010000008.1  96649558-96649572   c
            1372-1533           JAXUCZ010000008.1  96649266-96649427   c
            1534-1641           JAXUCZ010000008.1  96644333-96644440   c
            1642-1920           JAXUCZ010000008.1  96643441-96643719   c
            1921-1998           JAXUCZ010000008.1  96643140-96643217   c
            1999-2070           JAXUCZ010000008.1  96642904-96642975   c
            2071-2211           JAXUCZ010000008.1  96642465-96642605   c
            2212-2295           JAXUCZ010000008.1  96641046-96641129   c
            2296-2430           JAXUCZ010000008.1  96634522-96634656   c
            2431-2565           JAXUCZ010000008.1  96632787-96632921   c
            2566-2596           JAXUCZ010000008.1  96628913-96628943   c
            2597-2696           JAXUCZ010000008.1  96627452-96627551   c
            2697-2780           JAXUCZ010000008.1  96626043-96626126   c
            2781-2885           JAXUCZ010000008.1  96625332-96625436   c
            2886-2988           JAXUCZ010000008.1  96621291-96621393   c
            2989-4376           JAXUCZ010000008.1  96618041-96619428   c
FEATURES             Location/Qualifiers
     source          1..4376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4376
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /note="synaptosome associated protein 91"
                     /db_xref="GeneID:65178"
                     /db_xref="RGD:69276"
     exon            1..191
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..351
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2978
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /note="91 kDa synaptosomal-associated protein; clathrin
                     coat-associated protein AP180; synaptosomal-associated
                     protein, 91kDa homolog; synaptosomal-associated protein,
                     91 kDa; assembly protein 180 (AP180);
                     synaptosomal-associated protein 91; clathrin assembly
                     protein 3"
                     /codon_start=1
                     /product="clathrin coat assembly protein AP180"
                     /protein_id="NP_113916.2"
                     /db_xref="GeneID:65178"
                     /db_xref="RGD:69276"
                     /translation="MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDY
                     LIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNT
                     LFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMV
                     PEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINL
                     LEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLME
                     TLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDIFATA
                     SAAAPVSSAKPSSDLLDLQPDFSGAAAGAAAPVPPPTGGATAWGDLLGEDSLAALSSV
                     PSEAPISDPFAPEPSPPTTTTEPASASASATTAVTAATTEVDLFGDAFAASPGEAPAA
                     SEGATAPATPAPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSAPVVTPTA
                     STAPPVPATAPSPAPTAVAATAAATTTTTAAAAATTTATTSAAAAATAAAPPALDIFG
                     DLFDSAPEVAAASKPDVAPSIDLFGTDAFSSPPRGASPVPESSLTADLLSGSGFHCAE
                     DDRHVPLFFTAVDAFAAPSPASTASPAKAESSGVIDLFGDAFGSSASETQPAPQAVSS
                     SSASADLLAGFGGSFMAPSTTPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSGDLL
                     MPTMAPSGQPAPVSMVPPSPAMSASKGLGSDLDSSLASLVGNLGISGTTSKKGDLQWN
                     AGEKKLTGGANWQPKVTPATWSAGVPPQGTVPPTSSVPPGAGAPSVGQPGAGYGMPPA
                     GTGMTMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPATQSPKKPPAKDPLADLNI
                     KDFL"
     exon            352..494
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            495..570
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..673
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            674..767
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..879
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..986
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1028
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1099
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1105
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1133
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1243
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1356
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1371
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1533
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1641
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1920
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1998
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2070
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2211
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2295
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2430
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2565
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2596
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2696
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2780
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2885
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2988
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..4376
                     /gene="Snap91"
                     /gene_synonym="Ap180; AP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgccga gcgctagaga gacgcggcgg cgctggcgga ggcggcggcg ggcggggacc
       61 gcggggaccg cggagctgag acaggggccg ggccggagct gtaggcatcg cggcccgggg
      121 actccagggc ggcgcgcgcc ttcacccagc taccccgcgc ggcgtccggg ctgcggtgct
      181 cctggggcgg gaagaggagg cggtagacgc gaccggtgaa gatgtcgggc caaacgctca
      241 cggatcggat cgctgccgct cagtacagcg tgactggctc tgctgtagca agagccgtct
      301 gcaaagccac cactcatgag gtgatgggcc ccaagaagaa gcacctggac tatttgatcc
      361 aggctaccaa cgagaccaat gtcaatattc ctcagatggc ggataccctc tttgagcggg
      421 cgacaaacag cagctgggtg gtggtattta aagctttagt gaccacacac cacctcatgg
      481 tgcacggaaa tgagagattt attcagtatt tggcctctag aaatacgctg ttcaacctga
      541 gcaactttct agataagagt ggatcccacg gttatgatat gtccacgttc atacgacgtt
      601 atagtagata cttgaatgag aaggctttct cctacagaca gatggcattc gactttgcca
      661 gagtgaagaa aggggccgac ggtgtaatga ggacaatggt tcctgaaaag ttgctgaaga
      721 gcatgccaat cctgcagggg cagatcgacg cgctgctgga gttcgatgtg catccaaatg
      781 agctaacaaa tggtgtcata aatgctgcat ttatgcttct tttcaaagat cttatcaaac
      841 tgtttgcttg ctacaatgac ggcgtcatta acttacttga aaaatttttt gagatgaaga
      901 aaggtcaatg caaagacgca ctagaaattt acaaacgatt tctaactaga atgactcgag
      961 tctccgaatt cctcaaggtc gcggagcaag ttggtattga taaaggtgac attcccgacc
     1021 tcacacaggc tcccagcagt cttatggaga cccttgaaca acatctaaat accttagaag
     1081 gaaagaaacc tggaaacaat gaaggatctg gtgctccctc tccattaagt aagtcttctc
     1141 cagccacaac tgttacatct cctaattcta caccagctaa aactatcgac acgtccccac
     1201 cagtcgacat ctttgcaaca gcatccgcgg ctgccccagt cagctctgct aagccatcaa
     1261 gcgatctcct tgatcttcag ccagacttct ccggagcagc tgcgggggca gcagcgcctg
     1321 taccaccacc tactggggga gccactgcgt ggggagacct tttgggagag gattccttgg
     1381 ctgcactttc ctctgttccc tctgaagcac cgatttctga cccatttgca ccagaacctt
     1441 cccctcctac tacaaccact gaacctgctt cagcttctgc ctcagccacc acagctgtga
     1501 cagctgccac tacagaagtg gatctctttg gagatgcctt tgcagcttct cctggggagg
     1561 cccctgcagc atccgaaggg gccacggcac cagctacccc ggccccggtg gctgcagctc
     1621 ttgatgcatg ctcaggaaat gacccttttg ccccatctga aggtagcgca gaggctgcac
     1681 ctgagctcga cctctttgca atgaagccac ctgagaccag cgctcctgta gttaccccta
     1741 cagctagcac agcccctcca gttcccgcaa ctgctccttc tcctgctccc acggctgtgg
     1801 cagccactgc tgccgccacc accaccacca ccgccgccgc tgcagctacg accactgcca
     1861 ccacctctgc tgctgctgct gccaccgctg ctgctcctcc tgctctagat atctttggtg
     1921 atttgtttga ttctgctcct gaagttgctg cggcatctaa gccggacgtg gctcctagca
     1981 tagacctgtt tggcacagac gctttctcct ccccaccacg aggggcctct ccggtgcctg
     2041 agagttctct cactgctgac ctcttatccg ggtctgggtt tcactgtgct gaggatgacc
     2101 gtcatgttcc cctgttcttc actgcagtgg acgcgtttgc agcgccgtcg cctgcatcca
     2161 ctgcctctcc tgcaaaggcg gagtcctcgg gtgtcataga cctttttggg gatgcgtttg
     2221 gaagtagtgc ttctgaaacc cagccagcac cacaggctgt ttctagttca tcagcatcgg
     2281 cagatctact ggctggattt gggggttctt tcatggcccc ttctacaaca cctgtgactc
     2341 cagctcagaa taacctgctg caacccaatt ttgaggcagc ttttggaaca acgccttcga
     2401 cttcaagcag cagctccttc gacccatcag gcgatcttct gatgccaacc atggcaccgt
     2461 ccgggcagcc tgcccctgtc tcaatggtcc cacccagtcc tgcaatgtca gccagcaaag
     2521 gccttggaag tgaccttgac tcgtctctgg ccagcttagt aggcaatctt gggatttctg
     2581 gtaccacatc aaaaaaggga gatctccagt ggaatgctgg ggagaagaag ttgaccggtg
     2641 gagccaactg gcaaccaaaa gtcactccgg ccacatggtc agcaggcgtt ccaccgcaag
     2701 gcactgttcc tccaaccagc tcagtccctc cgggtgccgg cgccccgtct gttgggcaac
     2761 ctggagcagg atatggaatg cctcctgcgg ggacaggcat gaccatgatg cctcagcagc
     2821 cagtcatgtt tgcacagccc atgatgaggc caccctttgg agctgcagct gtgcccggca
     2881 cacagctttc tccaagccct acacctgcca ctcagagtcc caagaaacct ccagccaagg
     2941 acccattagc ggatcttaac atcaaggatt tcttgtaaac aatttaagct gcaatttttg
     3001 tgactgaata ggaaaactaa gctgagtttg gaaacgtcag tttcaaagtg agccaccagt
     3061 accaaaccca gtgctgactc gtaacttcct ctcccaaacg cacagcccag ctgtgactgt
     3121 gaacattagg aatgtgtact ttagctgtta accctactct ccagctcata gcgtattggg
     3181 ttctttgtgt gttgtacgac gtaaacaatg agtgaatggt tccaatgcct ttagtgcttt
     3241 tctggacgtt gcctgtggac ggatgatgac gcagctgtca tgtggtgagc catttggaaa
     3301 gatgtgtctg tgttttcgaa ggtttcaatg tatatataac ttggacgacc gctcaagtcc
     3361 tcccatgaac tctcttctct tctgtacctc tgttccaagc gtaacgtgat actatcagct
     3421 agtgaggaaa acacccttaa ctatacagaa actttttccg tgtggagtac atttttccaa
     3481 tcacagaaac ttcaacttgt cgtgggaaat gtttattttt gtgcgctgta tatgttaaga
     3541 aattttattt taaaaaaaaa tgaagtttaa tgtccataat aaaacttctc cttatgaagc
     3601 taccttatca agagtgagaa aaaccgtatg agaagtccat atttatcact gctatattaa
     3661 gatatatatt ttaattatat ttgcagggtt tgcatctaaa ttgacctatt tattcattct
     3721 tgatcaaagg cactgaaaag tggagcctgt ttctattgtg tctgtgaaaa atgcaattag
     3781 agatgtgctg tttattgtga ctatgaacgt gccccaagag acatctgtaa cttaaagaga
     3841 actgcaaata ttttttattt cagtgtggat ttacgtacat ctgttcagtt agtatttctt
     3901 tgtgtattct ataaactagc gttcctccct ccttcgactg aactcaaagt gacttctatt
     3961 gtaccttgtg ataggattgc aaccaatcca gcgaattgta tcttttaatg tacatactgg
     4021 attctttgat ttttagtttg ttgtcatact gtctgtgccg atggcttggc tgaagatttt
     4081 gatgcgtaca caaggtcact gttgatcagt gttgtttagt ggcttggcag ctctttgtaa
     4141 aagcatattg ggttggaaag gcatttgcct atttttcaaa ttatttaata gatgtatggt
     4201 accctttaaa gtggttgtat ctgaacttat tgtggggata aacatacact gtaacggggg
     4261 aaaattacct aaaaccaatt tcaaaatggc ttttctttgt attttggttt aaaaacccag
     4321 tgcatgtctg ccctctgaga tgcaataaac accttgaaca aagaaaatgc aaacaa
//
