LOCUS       NM_022689               2549 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus synaptosome associated protein 23 (Snap23),
            transcript variant 1, mRNA.
ACCESSION   NM_022689
VERSION     NM_022689.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Chen,J., Wang,Z., Wang,T., Cheng,J., Zhuang,R. and Wang,W.
  TITLE     SNAP23 decreases insulin secretion by competitively inhibiting the
            interaction between SNAP25 and STX1A
  JOURNAL   Biosci Rep 43 (5) (2023)
   PUBMED   37057886
  REMARK    GeneRIF: SNAP23 decreases insulin secretion by competitively
            inhibiting the interaction between SNAP25 and STX1A.
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Dolai,S., Takahashi,T., Qin,T., Liang,T., Xie,L., Kang,F.,
            Miao,Y.F., Xie,H., Kang,Y., Manuel,J., Winter,E., Roche,P.A.,
            Cattral,M.S. and Gaisano,H.Y.
  TITLE     Pancreas-specific SNAP23 depletion prevents pancreatitis by
            attenuating pathological basolateral exocytosis and formation of
            trypsin-activating autolysosomes
  JOURNAL   Autophagy 17 (10), 3068-3081 (2021)
   PUBMED   33213278
  REMARK    GeneRIF: Pancreas-specific SNAP23 depletion prevents pancreatitis
            by attenuating pathological basolateral exocytosis and formation of
            trypsin-activating autolysosomes.
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Serrano-Lopez,E.M., Lopez-Martinez,D., Gomez-Fernandez,J.C.,
            Egea-Jimenez,A.L. and Corbalan-Garcia,S.
  TITLE     PKCepsilon controls the fusion of secretory vesicles in mast cells
            in a phosphatidic acid-dependent mode
  JOURNAL   Int J Biol Macromol 185, 377-389 (2021)
   PUBMED   34147527
  REMARK    GeneRIF: PKCepsilon controls the fusion of secretory vesicles in
            mast cells in a phosphatidic acid-dependent mode.
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Naskar,P., Naqvi,N. and Puri,N.
  TITLE     Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23
            leads to massive inhibition in exocytosis from mast cells
  JOURNAL   J Biosci 43 (1), 127-138 (2018)
   PUBMED   29485121
  REMARK    GeneRIF: Blocking dephosphorylation at serine 120 residue in
            SNAP-23 leads to massive inhibition in exocytosis from mast cells.
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Weber,P., Batoulis,H., Rink,K.M., Dahlhoff,S., Pinkwart,K.,
            Sollner,T.H. and Lang,T.
  TITLE     Electrostatic anchoring precedes stable membrane attachment of
            SNAP25/SNAP23 to the plasma membrane
  JOURNAL   Elife 6, e19394 (2017)
   PUBMED   28240595
  REMARK    GeneRIF: Electrostatic anchoring precedes stable membrane
            attachment of SNAP25 and SNAP23 to the plasma membrane.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Rao,S.K., Huynh,C., Proux-Gillardeaux,V., Galli,T. and Andrews,N.W.
  TITLE     Identification of SNAREs involved in synaptotagmin VII-regulated
            lysosomal exocytosis
  JOURNAL   J Biol Chem 279 (19), 20471-20479 (2004)
   PUBMED   14993220
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Abonyo,B.O., Gou,D., Wang,P., Narasaraju,T., Wang,Z. and Liu,L.
  TITLE     Syntaxin 2 and SNAP-23 are required for regulated surfactant
            secretion
  JOURNAL   Biochemistry 43 (12), 3499-3506 (2004)
   PUBMED   15035620
  REMARK    GeneRIF: SNAP-23 is expressed in alveolar type II cells of the
            lung; evidence supports its functional role in exocytosis of lung
            surfactant by alveolar type II cells.
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Banerjee,A., Li,G., Alexander,E.A. and Schwartz,J.H.
  TITLE     Role of SNAP-23 in trafficking of H+-ATPase in cultured inner
            medullary collecting duct cells
  JOURNAL   Am J Physiol Cell Physiol 280 (4), C775-C781 (2001)
   PUBMED   11245593
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Okamoto,M., Schoch,S. and Sudhof,T.C.
  TITLE     EHSH1/intersectin, a protein that contains EH and SH3 domains and
            binds to dynamin and SNAP-25. A protein connection between
            exocytosis and endocytosis?
  JOURNAL   J Biol Chem 274 (26), 18446-18454 (1999)
   PUBMED   10373452
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   St-Denis,J.F., Cabaniols,J.P., Cushman,S.W. and Roche,P.A.
  TITLE     SNAP-23 participates in SNARE complex assembly in rat adipose cells
  JOURNAL   Biochem J 338 (Pt 3) (Pt 3), 709-715 (1999)
   PUBMED   10051443
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127494.1.
            
            On Nov 13, 2006 this sequence version replaced NM_022689.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127494.1, DY319893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2549
                     /gene="Snap23"
                     /note="synaptosome associated protein 23"
                     /db_xref="GeneID:64630"
                     /db_xref="RGD:620221"
     exon            1..104
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     exon            105..205
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..781
                     /gene="Snap23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SNAP-23; vesicle-membrane fusion protein SNAP-23;
                     synaptosomal-associated protein, 23 kD;
                     synaptosomal-associated protein 23"
                     /codon_start=1
                     /product="synaptosomal-associated protein 23 isoform 1"
                     /protein_id="NP_073180.1"
                     /db_xref="GeneID:64630"
                     /db_xref="RGD:620221"
                     /translation="MDDLSPEEIQLRAHQVTDESLESTRRILGLAIESQDAGIKTITM
                     LDEQGEQLNRIEEGMDQINKDMREAEKTLTELNKCCGLCVCPCNRTKNFESGKNYKAT
                     WGDGGDSSPSNVVSKQPSRITNGQPQQTTGAASGGYIKRITNDAREDEMEENLTQVGS
                     ILGNLKNMALDMGNEIDAQNQQIQKITEKADTNKNRIDIANTRAKKLIDS"
     exon            206..247
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     exon            248..296
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     exon            297..414
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     exon            415..570
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     exon            571..715
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
     exon            716..2525
                     /gene="Snap23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggatcttaa gagagtccaa gagcagcggg gcccggagag gagtggctgg agcagccggg
       61 tgagccttct gaaaagtagc tgagtgagct ggtcagcggg acagagtatc catatttccg
      121 tttctgtgtc caatagtttt gactcatcat ggatgatcta tcaccagaag aaattcagct
      181 tcgggctcac caagttactg atgagtctct ggaaagcaca aggagaatcc tgggtttagc
      241 cattgagtct caggatgcag gaatcaagac tatcactatg ctggatgagc aaggggaaca
      301 actaaatcgc atagaagaag gcatggacca aataaataaa gacatgagag aggcagagaa
      361 gactttaaca gaactcaaca agtgttgtgg cctctgcgtc tgcccttgta ataggaccaa
      421 gaactttgag tctggaaaga actataaggc aacatggggt gatggtggag acagctcacc
      481 tagcaatgtg gtatctaagc aaccaagccg gataacaaat ggtcagcctc agcagactac
      541 aggagcggcc agcggtggat acattaaacg cataactaat gatgccagag aagatgagat
      601 ggaagagaac ctgactcaag tgggcagcat cctagggaac ctaaagaaca tggctctgga
      661 tatgggcaat gaaattgatg ctcaaaacca gcaaatacag aagatcacag aaaaggctga
      721 caccaacaag aatcgcattg acattgccaa tacaagagca aagaaactca ttgacagcta
      781 aaaccctgct gtacttcttt acctgttaac tcagtctcgg gctcctgctg agtcttttct
      841 tactcagttt gaaagactgt gcgagaaggg cgggaggagg atccctcctc cttccttcct
      901 ttctgtcttt tggggtaggt tcttgctcag gcgttcttac agtctttctc agtttactct
      961 tgtaggctgc tttctgtaca tcacttagtc tctccatctc gtcatttagc ttttgtgttc
     1021 aagacttgga agcattgcca aagagccatg aagggaggca gctggataag tagcttttgc
     1081 cattattggt tggttggctt ggttttggtt tggttttggt tttatggtaa agagcaagag
     1141 gaaggaagaa gaaatgaagt gactcattaa agaaactaca ggtcacaaaa aaccctcagt
     1201 gcttggggta ggagctttca cacgtgtttt gttctacact gtttttcagc ttctgctcca
     1261 aagagagtac agtgagtttt ccagaagtga gcttcactcc taaatcctta gtgatttggg
     1321 tataaacgta ggctcttggg tcccgtttca tattgcacat gcaggaacac tatataaacg
     1381 agtgcctttt attctcatac agtaagtcat agcatggtcc cattgcaggc ctgttaactt
     1441 catggagttg tcagtagcct tgaaaagatg tacatatata tgtgaaatcg gagacttcct
     1501 cactaaagca gggtgtatca tgtgaattca gatttacctc ataagaatta tgtttagata
     1561 tgaaaaagac ttgttttgat ctcaggtaga aaaatagatt gctttgagtt ttgtatagtt
     1621 ttagacattt aaaaagttat aatctgttac taaaagttgt ttggaaaatt atgcctttga
     1681 ttaattattg atgaccacac tgccattctc tctgccttac acacagaatc aagtttgtgt
     1741 agaccctgaa gtgttaggaa agctgaactg gtatttgtca cctttgttta aaaatcagca
     1801 tgtacaattg ctgattgtag atcgcaatta gcgcaaagta gatcggtttg accagtaacc
     1861 attgcttgat tcttacaatt aaattttgta attaatggta ttgttcttca aataggtgat
     1921 gtttctatga cttatttgta ggggcaatca ttttaccagc ttttgttaac attagataaa
     1981 gcaaatgtcc atacgtcatg cactccaata gaaagttgca ttagctcttc tctaattttc
     2041 accagaagtg tgtacaggac ttcctacggt ttgctttgag ttcattctag acattacttg
     2101 tcttagtcgt ttgaacttaa atacactact gagtatttct gagtgagaat tcaagtcatg
     2161 tattgaagaa gatgcatcta gcatagcaac attcagaggg tgaagaggac agtgtgcaaa
     2221 acaaagcagt gttccatgcc agagtgaaga gcttattggg tacagatacc taatgtatga
     2281 agtatggctg agtgtaaaac actggactgt gctgtgccca aaagtgcttc ccttagtcat
     2341 ttaaaaacaa catgctgatt tgtccaaagg aacagtacca aaaggtagta tccaaggtat
     2401 atttggctag aatatgcact aaagcaaccc tttgctcttg ctggctggtg tgaatgcatg
     2461 cttatttctt gccttaattt ctatatctgt aaatgggaat taataaatcc tgttttataa
     2521 actaaaaaaa aaaaaaaaaa aaaaaaaaa
//
