LOCUS       NM_013035               1913 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Rattus norvegicus snail family transcriptional repressor 2 (Snai2),
            mRNA.
ACCESSION   NM_013035
VERSION     NM_013035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Wang,L., Jia,Y., Jiang,Z., Gao,W. and Wang,B.
  TITLE     FSCN1 is upregulated by SNAI2 and promotes epithelial to
            mesenchymal transition in head and neck squamous cell carcinoma
  JOURNAL   Cell Biol Int 41 (8), 833-841 (2017)
   PUBMED   28488774
  REMARK    GeneRIF: SNAI2 overexpression significantly increased FSCN1
            expression at both mRNA and protein level. FSCN1 overexpression
            reduced the expression of E-cadherin and Claudin 1, but increased
            the expression of Vimentin and N-cadherin in SCC9 and SCC-15 cells.
            It is inferred that FSCN1 is a downstream effector of SNAI2 in
            promoting EMT in HNSC cells.
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Horiguchi,K., Fujiwara,K., Tsukada,T., Yako,H., Tateno,K.,
            Hasegawa,R., Takigami,S., Ohsako,S., Yashiro,T., Kato,T. and
            Kato,Y.
  TITLE     Expression of Slug in S100beta-protein-positive cells of postnatal
            developing rat anterior pituitary gland
  JOURNAL   Cell Tissue Res 363 (2), 513-524 (2016)
   PUBMED   26246400
  REMARK    GeneRIF: S100beta-positive cells express Slug and that its
            expression is important for subsequent migration and proliferation.
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Hwangbo,C., Tae,N., Lee,S., Kim,O., Park,O.K., Kim,J., Kwon,S.H.
            and Lee,J.H.
  TITLE     Syntenin regulates TGF-beta1-induced Smad activation and the
            epithelial-to-mesenchymal transition by inhibiting
            caveolin-mediated TGF-beta type I receptor internalization
  JOURNAL   Oncogene 35 (3), 389-401 (2016)
   PUBMED   25893292
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Piva,R., Manferdini,C., Lambertini,E., Torreggiani,E.,
            Penolazzi,L., Gambari,R., Pastore,A., Pelucchi,S., Gabusi,E.,
            Piacentini,A., Filardo,G., Facchini,A. and Lisignoli,G.
  TITLE     Slug contributes to the regulation of CXCL12 expression in human
            osteoblasts
  JOURNAL   Exp Cell Res 317 (8), 1159-1168 (2011)
   PUBMED   21182836
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Onodera,T., Sakai,T., Hsu,J.C., Matsumoto,K., Chiorini,J.A. and
            Yamada,K.M.
  TITLE     Btbd7 regulates epithelial cell dynamics and branching
            morphogenesis
  JOURNAL   Science 329 (5991), 562-565 (2010)
   PUBMED   20671187
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Sanchez-Martin,M., Rodriguez-Garcia,A., Perez-Losada,J.,
            Sagrera,A., Read,A.P. and Sanchez-Garcia,I.
  TITLE     SLUG (SNAI2) deletions in patients with Waardenburg disease
  JOURNAL   Hum Mol Genet 11 (25), 3231-3236 (2002)
   PUBMED   12444107
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Hajra,K.M., Chen,D.Y. and Fearon,E.R.
  TITLE     The SLUG zinc-finger protein represses E-cadherin in breast cancer
  JOURNAL   Cancer Res 62 (6), 1613-1618 (2002)
   PUBMED   11912130
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Hemavathy,K., Guru,S.C., Harris,J., Chen,J.D. and Ip,Y.T.
  TITLE     Human Slug is a repressor that localizes to sites of active
            transcription
  JOURNAL   Mol Cell Biol 20 (14), 5087-5095 (2000)
   PUBMED   10866665
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Inukai,T., Inoue,A., Kurosawa,H., Goi,K., Shinjyo,T., Ozawa,K.,
            Mao,M., Inaba,T. and Look,A.T.
  TITLE     SLUG, a ces-1-related zinc finger transcription factor gene with
            antiapoptotic activity, is a downstream target of the E2A-HLF
            oncoprotein
  JOURNAL   Mol Cell 4 (3), 343-352 (1999)
   PUBMED   10518215
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Savagner,P., Yamada,K.M. and Thiery,J.P.
  TITLE     The zinc-finger protein slug causes desmosome dissociation, an
            initial and necessary step for growth factor-induced
            epithelial-mesenchymal transition
  JOURNAL   J Cell Biol 137 (6), 1403-1419 (1997)
   PUBMED   9182671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Oct 4, 2022 this sequence version replaced NM_013035.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.49223.1,
                                           SRR26643294.45300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000011.1  99690177-99690349   c
            174-719             JAXUCZ010000011.1  99688963-99689508   c
            720-1913            JAXUCZ010000011.1  99686934-99688127   c
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1913
                     /gene="Snai2"
                     /gene_synonym="Slug"
                     /note="snail family transcriptional repressor 2"
                     /db_xref="GeneID:25554"
                     /db_xref="RGD:3722"
     exon            1..173
                     /gene="Snai2"
                     /gene_synonym="Slug"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..901
                     /gene="Snai2"
                     /gene_synonym="Slug"
                     /note="protein snail homolog 2; neural crest transcription
                     factor Slug; Slug, chicken homolog; snail family zinc
                     finger 2"
                     /codon_start=1
                     /product="zinc finger protein SNAI2"
                     /protein_id="NP_037167.1"
                     /db_xref="GeneID:25554"
                     /db_xref="RGD:3722"
                     /translation="MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLCESYPMPVIPK
                     PEILTSGAYSPITVWTSAVPFHSPLPSGLSPLTGYSSSLGRVSPLPSSDTSSKDHSGS
                     ESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQARKSFS
                     CKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHC
                     NRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH"
     exon            174..719
                     /gene="Snai2"
                     /gene_synonym="Slug"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1913
                     /gene="Snai2"
                     /gene_synonym="Slug"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcgtct gcctgtcccc gccgcacctg agccaccgcg atgcgatagg accgccgccg
       61 ggaccgttat ccgccgtgcc cgcccgccgc caccatgccg cgctccttcc tcgtcaagaa
      121 acatttcaac gcctccaaga agcccaacta cagcgaactg gacacacaca cagtgatcat
      181 ttctccatac ctctgtgaga gctaccccat gcctgtcata ccaaaaccag agatcctcac
      241 ctcaggagcg tacagcccta taactgtatg gacatcagca gttccattcc actcccctct
      301 gcccagcggc ctttctcctc ttactggata ctcctcatct ttggggcgtg taagccccct
      361 gccttcatct gacacttcat ccaaggatca cagtggttca gaaagtccca ttagtgacga
      421 agaggagaga ctccagccca agctttcaga cccccatgcc attgaagctg agaagtttca
      481 gtgcaattta tgcaataaga cctattctac tttctctggt ctggccaaac ataagcagct
      541 gcactgtgat gcccaggcta ggaaatcgtt cagctgcaaa tactgtgaca aggaatatgt
      601 gagcctgggt gccctgaaga tgcacattcg gacccacacg ttgccttgtg tctgcaagat
      661 ctgtggcaag gctttctcca gaccctggct gcttcaagga cacattagaa cacacactgg
      721 ggaaaagcct ttctcttgcc ctcactgcaa tagagctttt gcagacagat caaacctgag
      781 ggcacatctg cagacccact ctgatgtaaa gaaataccag tgcaaaaact gctccaaaac
      841 cttctccaga atgtcgcttc tgcataaaca tgaggaatct ggctgctgtg tggcacactg
      901 agtggcgcaa ccagtgttta ctcaaacaga atgcatttct tcactccaat gacaaatgac
      961 aaatgaaagt ccaaagacat tttctcatgt gctcaccaac caaataatat acataaaaac
     1021 acaaaagaca cacacacaca cacacacaca cacacacaca ccctacagaa cagaatctat
     1081 gtacttaaag ttaatctatt ctatgtgaag tttaaaattt atttactgac agctaaattg
     1141 aaacataaga atctttcttt ttaaagatga agtgaaaagc acatcacatc ttttcttact
     1201 aagaaagaat acagaggttt acactgctgc caaaccattt caaccaaaag gaacagtatt
     1261 acttcttaat agaattgtaa tagtgtttcc aagagtaaga gaatctgcca gacactatct
     1321 caggtgcctt acaaagtact ccaagtttac ttccttactt gtctgatgcc tggttgtcac
     1381 cggtgaatga aagccttttc tggattacct acaatgcttt aaaactatat tataaagagg
     1441 aaaaaagcag gaaaaagaac agaacacaag agaatgtatt aaagtattct tattttgttt
     1501 catttttgcc atgtgtgcct tggaagagga gggaaggaca aacttcaaac attcctggtg
     1561 cgtgtcccat gtctttcttt aaaaaaaaga atcttagtgt tttataagac aaagtaatga
     1621 aaatgttcaa aagagtttct tagacattca gtaatgtact cagacttttg aaacttcata
     1681 tgacggatgc aataacaatg cccctccaag tgcctgtttt aatgaattct gtagttgatg
     1741 aattgatgta aatttgtgtt tatttttata tgactgaatg aactctgtat aaaagtgagg
     1801 tgtggtttat agccatgcct atattcaacc agaatacttt tgaaatcaat gtccttttta
     1861 aaaaaaaaac tttcgaggtc tcttttttta caataaacat ttttgactta aaa
//
