LOCUS       NM_053805               1623 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus snail family transcriptional repressor 1 (Snai1),
            mRNA.
ACCESSION   NM_053805 XM_342587
VERSION     NM_053805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Xian S, Chen A, Wu X, Lu C, Wu Y, Huang F and Zeng Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Qian W, Cai X, Qian Q, Zhang W and Tian L.
  TITLE     Metastasis-associated protein 1 promotes epithelial-mesenchymal
            transition in idiopathic pulmonary fibrosis by up-regulating Snail
            expression
  JOURNAL   J Cell Mol Med 24 (11), 5998-6007 (2020)
   PUBMED   32187849
  REMARK    GeneRIF: Metastasis-associated protein 1 promotes
            epithelial-mesenchymal transition in idiopathic pulmonary fibrosis
            by up-regulating Snail expression.
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Kostic S, Williams B, Ksouri S, Hardung L, Filipovic N, Hamzic LF,
            Puljak L, Ghahramani N and Vukojevic K.
  TITLE     Changes in snail and SRF expression in the kidneys of diabetic rats
            during ageing
  JOURNAL   Acta Histochem 122 (1), 151460 (2020)
   PUBMED   31668740
  REMARK    GeneRIF: Changes in snail and SRF expression in the kidneys of
            diabetic rats during ageing.
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Yi XM, Chen Y and Tu GJ.
  TITLE     Neuregulin-1 impacting bone marrow mesenchymal stem cell migration
            is conducive to functional recovery following spinal cord injury
  JOURNAL   Mol Med Rep 20 (1), 41-48 (2019)
   PUBMED   31115509
  REMARK    GeneRIF: The NRG1modified bone marrow mesenchymal stem cells
            (BMSCs) promoted the functional recovery of spinal cord injury
            (SCI). These results suggested that NRG1 significantly promoted the
            expression of MMP2 by upregulating the expression of Snail, and
            enhanced cell migration of the BMSCs conducive to the functional
            recovery of SCI
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Zhang X, Kim KY, Zheng Z, Kim HS, Cha IH and Yook JI.
  TITLE     Snail and Axin2 expression predict the malignant transformation of
            oral leukoplakia
  JOURNAL   Oral Oncol 73, 48-55 (2017)
   PUBMED   28939076
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Hajra KM, Chen DY and Fearon ER.
  TITLE     The SLUG zinc-finger protein represses E-cadherin in breast cancer
  JOURNAL   Cancer Res 62 (6), 1613-1618 (2002)
   PUBMED   11912130
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Carver EA, Jiang R, Lan Y, Oram KF and Gridley T.
  TITLE     The mouse snail gene encodes a key regulator of the
            epithelial-mesenchymal transition
  JOURNAL   Mol Cell Biol 21 (23), 8184-8188 (2001)
   PUBMED   11689706
REFERENCE   8  (bases 1 to 1623)
  AUTHORS   Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del
            Barrio MG, Portillo F and Nieto MA.
  TITLE     The transcription factor snail controls epithelial-mesenchymal
            transitions by repressing E-cadherin expression
  JOURNAL   Nat Cell Biol 2 (2), 76-83 (2000)
   PUBMED   10655586
REFERENCE   9  (bases 1 to 1623)
  AUTHORS   Nakayama H, Scott IC and Cross JC.
  TITLE     The transition to endoreduplication in trophoblast giant cells is
            regulated by the mSNA zinc finger transcription factor
  JOURNAL   Dev Biol 199 (1), 150-163 (1998)
   PUBMED   9676199
REFERENCE   10 (bases 1 to 1623)
  AUTHORS   Nelson TM, Evelyn B and Taylor R.
  TITLE     Experimental intercomparisons of younger and older driver
            perceptions
  JOURNAL   Int J Aging Hum Dev 36 (3), 239-253 (1992)
   PUBMED   1302246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079210.1.
            
            On Apr 19, 2005 this sequence version replaced XM_342587.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079210.1, EV777950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132275, SAMD00132302
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1623
                     /gene="Snai1"
                     /gene_synonym="Sna"
                     /note="snail family transcriptional repressor 1"
                     /db_xref="GeneID:116490"
                     /db_xref="RGD:620758"
     exon            1..162
                     /gene="Snai1"
                     /gene_synonym="Sna"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..875
                     /gene="Snai1"
                     /gene_synonym="Sna"
                     /note="snail homolog 1; snail family zinc finger 1"
                     /codon_start=1
                     /product="zinc finger protein SNAI1"
                     /protein_id="NP_446257.1"
                     /db_xref="GeneID:116490"
                     /db_xref="RGD:620758"
                     /translation="MPRSFLVRKPSDPRRKPNYSELQDACVEFTFQQPYDQAHLLAAI
                     PPPEVLNPAASLPTLIWDSLLVPQVQPVAWATLPLRESPRAAELTSLSDEDSGKSSQP
                     PSPPSPAPSSFSSTSASSLEAEAFIAFPGLGQLPKQLARLSVAKDPQSRKAFNCKYCN
                     KEYLSLGALKMHIRSHTLPCVCTTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFA
                     DRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQESGCSGGPR"
     exon            163..690
                     /gene="Snai1"
                     /gene_synonym="Sna"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1599
                     /gene="Snai1"
                     /gene_synonym="Sna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgggcc tcgcgagcag agttgtctac cgaccttgcg cgacccggtg accccgacta
       61 cctaggtcgc tccggccacc atgccgcgct ccttcctggt caggaagccg tccgaccccc
      121 gccggaagcc caactatagc gagctgcagg acgcgtgtgt ggagttcacc ttccagcagc
      181 cctacgacca ggcccacctg ctggcggcca tccctccgcc cgaggtcctc aaccccgccg
      241 cttcgctgcc caccctcatc tgggactctc tcctggtgcc ccaagtacag ccggtggcct
      301 gggccaccct cccgctgcgg gagagcccca gggccgcaga gctgacttct ctgtccgatg
      361 aggacagtgg caaaagctcc cagccgccca gcccgccctc gccggcgccg tcgtccttct
      421 cttccacctc ggcctcatcc ctggaagccg aggccttcat tgccttcccg ggcttgggcc
      481 aacttcccaa gcagctggcc aggctctcgg tggccaagga cccccagtcc cggaaggcct
      541 tcaactgcaa atattgtaat aaggagtacc tcagcctggg cgctctgaag atgcacatcc
      601 gaagccacac gctgccttgc gtctgcacga cctgcggaaa ggccttctcc aggccctggc
      661 tgctccaggg ccacgtccgc acccacactg gtgagaagcc tttctcctgc tcccactgca
      721 accgtgcctt tgccgaccgc tccaacctac gtgcccacct ccagacccac tcggatgtga
      781 agagatacca gtgtcaggcc tgcgcccgaa ccttctcccg aatgtccttg ctccacaaac
      841 accaagagtc tggctgctcc ggaggccctc gctgaccctg ctacctcccc atcctcactg
      901 gcatctccct ggtgccctgg agctcctcac tgccaggatt ccttccagct taagtccagg
      961 gacctgtgga gtccatgtct ggccctggtt cctgcttggc tctcttggtg gcctttgctg
     1021 cagatggctg atggaaggca gagtgccttt gtaccctccc agagcctcct gcccctcagt
     1081 attcatgagg tgtagcctct ggacacagct gcttcgagcc atagaactaa agccaaccca
     1141 ctggctggga agcttgaacc ccactcaggg gaccccactt ccctacctcc cccaaggacc
     1201 ctttcaggcc accttcctcg aggtacaaca gactatgcaa tagtcccatc cctcctgcgt
     1261 ccatgcctcg gcagggtggt tactggacac atgtccaggt gcccctgggc ctgagcagct
     1321 gtttcagccc ccgccccatt tgtcctgggg acacctgtct cacagcagtt taactgtctc
     1381 agaagggacc atgaataatg gccgtcactt gttaggggcc aagtggggtg cttcagcctg
     1441 gccaacgtgt ctcccagaac tattttgggg cccaacaggt gtccccgggg agaaagatgt
     1501 ttacatttta aaggtattta tattgtaagc agcattttgt atagttgata tgtacagttt
     1561 attgatattc aataaagtgg ttaatttata tactaaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaa
//
