LOCUS       NM_001025762            1585 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SET and MYND domain containing 3 (Smyd3), mRNA.
ACCESSION   NM_001025762 XM_573523
VERSION     NM_001025762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Yang D, Wang Q, Wei G, Wu J, Zhu YC, Zhu Q, Ni T, Liu X and Zhu YZ.
  TITLE     Smyd3-PARP16 axis accelerates unfolded protein response and
            vascular aging
  JOURNAL   Aging (Albany NY) 12 (21), 21423-21445 (2020)
   PUBMED   33144524
  REMARK    GeneRIF: Smyd3-PARP16 axis accelerates unfolded protein response
            and vascular aging.
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Brown MA, Foreman K, Harriss J, Das C, Zhu L, Edwards M, Shaaban S
            and Tucker H.
  TITLE     C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif
            in oncogenesis
  JOURNAL   Oncotarget 6 (6), 4005-4019 (2015)
   PUBMED   25738358
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Proserpio V, Fittipaldi R, Ryall JG, Sartorelli V and Caretti G.
  TITLE     The methyltransferase SMYD3 mediates the recruitment of
            transcriptional cofactors at the myostatin and c-Met genes and
            regulates skeletal muscle atrophy
  JOURNAL   Genes Dev 27 (11), 1299-1312 (2013)
   PUBMED   23752591
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Black JC, Van Rechem C and Whetstine JR.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Brown MA, Sims RJ 3rd, Gottlieb PD and Tucker PW.
  TITLE     Identification and characterization of Smyd2: a split SET/MYND
            domain-containing histone H3 lysine 36-specific methyltransferase
            that interacts with the Sin3 histone deacetylase complex
  JOURNAL   Mol Cancer 5, 26 (2006)
   PUBMED   16805913
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097455.1.
            
            On Jul 22, 2005 this sequence version replaced XM_573523.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097455.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1585
                     /gene="Smyd3"
                     /note="SET and MYND domain containing 3"
                     /db_xref="GeneID:498295"
                     /db_xref="RGD:1562635"
     exon            1..218
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1341
                     /gene="Smyd3"
                     /EC_number="2.1.1.354"
                     /note="SET and MYND domain-containing protein 3"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SMYD3"
                     /protein_id="NP_001020933.1"
                     /db_xref="GeneID:498295"
                     /db_xref="RGD:1562635"
                     /translation="MEVLKVEKFTTADRGNGLRAVAPLRPGELLFRSDPLAYTVSKGS
                     RGVVCDRCLLGKEKLMRCSQCRIAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSV
                     RLLGRVVVKLMDGKPSESEKLYSFYDLESNISKLTEDKKEGLRQLAMTFQHFMREEIQ
                     DASQLPPSFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNG
                     PHLLLRAVREIEAGEELTICYLDMLMTSEERRKQLRDQYCFECDCIRCQTQDKDADML
                     TGDEQIWKEVQESLKKIEELKAHWKWEQVLALCQAIINSNSERLPDINIYQLKVLDCA
                     MDACINLGMLEEALFYAMRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKN
                     LRLAFDIMKVTHGREHSLIEDLILLLEECDANIRAS"
     exon            219..282
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            283..390
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..448
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..585
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            586..653
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..756
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..867
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            868..955
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1130
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1239
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1556
                     /gene="Smyd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagactcaa gccgagggac cccgctcgag tctgaggtgt ggagctgaga aaggatggag
       61 gttctgaagg tggaaaagtt cacgactgcc gaccggggaa acgggctgcg cgctgtggcc
      121 ccactgcgcc ccggggagct gctcttccgc tccgacccct tggcttacac tgtgagcaag
      181 gggagtcgtg gcgtcgtttg cgatcgctgc ctcctgggga aggaaaagct gatgcggtgt
      241 tctcaatgcc ggattgccaa atactgcagc gccaagtgtc agaaaaaagc ctggccggac
      301 cacaagcggg aatgcaaatg cctcaaaagc tgcaaaccca ggtatccgcc cgactccgtg
      361 agacttctgg gcagggtagt cgtcaaactg atggatggca agccgtcaga gtcagagaaa
      421 ctttattcct tttatgatct ggagtccaat attagcaaac tcactgaaga taagaaagag
      481 ggcctgaggc aactcgcaat gacatttcaa catttcatga gagaagaaat acaggacgct
      541 tctcagctgc cgccttcttt tgaccttttt gaagccttcg caaaagtgat ctgcaactca
      601 ttcaccatct gcaatgcgga gatgcaggag gtcggcgttg gcctgtaccc cagtatgtct
      661 ttgctgaatc acagctgtga ccccaactgc tccattgtgt tcaacgggcc ccacctctta
      721 cttcgtgccg tgcgagaaat tgaggcagga gaggagctca ctatctgcta cctggacatg
      781 ctgatgacca gcgaggaacg ccggaagcag ctgagggatc agtactgctt tgagtgtgac
      841 tgcatccgat gccaaacaca ggacaaggat gctgatatgc tgacgggtga cgagcaaata
      901 tggaaggagg ttcaagaatc actgaaaaag atcgaagagc tgaaggcgca ctggaagtgg
      961 gaacaggttc tggccctgtg ccaggcgatc ataaacagca actcggaacg tcttcccgac
     1021 atcaacatct accagctgaa ggtgctcgac tgtgccatgg acgcctgcat caacctgggg
     1081 atgctggagg aggcgctgtt ctatgccatg cgcaccatgg agccgtaccg gatttttttc
     1141 cctggaagcc atcctgtcag aggtgtgcaa gtgatgaaag ttggcaagct gcagctccat
     1201 caaggcatgt ttccccaagc catgaagaat ctgcggctgg cctttgacat tatgaaagtg
     1261 acccacggcc gcgagcacag cttgattgaa gatttgattc ttctcctgga agaatgtgat
     1321 gccaacatca gagcttccta agacacccag gaggagggga gggcggcgca cccttcatcg
     1381 aaggccttac cgaggtcaca cacgctgtga tgtttgtcgt gcggacctcc tgtagaagtc
     1441 accgatgtgt ttatgtggga aaatgtgttt ctgtagcatg tcgtgagacg tctcattcgt
     1501 ggtagagcag aaccacgtgc taacatcata ataaatacaa aagatgagtc caaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaa
//
