LOCUS       NM_206851               1592 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus SET and MYND domain containing 2 (Smyd2), mRNA.
ACCESSION   NM_206851 XM_001066311 XM_213972
VERSION     NM_206851.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Li,Y., Wei,X., Xiao,R., Chen,Y., Xiong,T., Fang,Z.M., Huo,B.,
            Guo,X., Luo,H., Wu,X., Liu,L., Zhu,X.H., Hu,Q., Jiang,D.S. and
            Yi,X.
  TITLE     SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced Pulmonary
            Hypertension by Activating Mitophagy
  JOURNAL   Circ Res 135 (1), 93-109 (2024)
   PUBMED   38770649
  REMARK    GeneRIF: SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced
            Pulmonary Hypertension by Activating Mitophagy.
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Sun,X.L., Lv,J.L., Dou,L., Chen,D., Zhu,Y.C. and Hu,X.
  TITLE     LncRNA NEAT1 promotes cardiac hypertrophy through
            microRNA-19a-3p/SMYD2 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (3), 1367-1377 (2020)
   PUBMED   32096186
  REMARK    GeneRIF: LncRNA NEAT1 promotes cardiac hypertrophy through
            microRNA-19a-3p/SMYD2 axis.
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Munkanatta Godage,D.N.P., VanHecke,G.C., Samarasinghe,K.T.G.,
            Feng,H.Z., Hiske,M., Holcomb,J., Yang,Z., Jin,J.P., Chung,C.S. and
            Ahn,Y.H.
  TITLE     SMYD2 glutathionylation contributes to degradation of sarcomeric
            proteins
  JOURNAL   Nat Commun 9 (1), 4341 (2018)
   PUBMED   30337525
  REMARK    GeneRIF: SMYD2 glutathionylation is a novel molecular mechanism by
            which reactive oxygen species contribute to sarcomere
            destabilization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Hamamoto,R., Toyokawa,G., Nakakido,M., Ueda,K. and Nakamura,Y.
  TITLE     SMYD2-dependent HSP90 methylation promotes cancer cell
            proliferation by regulating the chaperone complex formation
  JOURNAL   Cancer Lett 351 (1), 126-133 (2014)
   PUBMED   24880080
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Kruse,J.P. and Gu,W.
  TITLE     Modes of p53 regulation
  JOURNAL   Cell 137 (4), 609-622 (2009)
   PUBMED   19450511
  REMARK    Review article
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Chen,J., Jiang,H., Xu,L., Zhu,L.H., Wang,L., Wen,H.Z. and Hu,X.R.
  TITLE     Dysregulation of CREB binding protein triggers thrombin-induced
            proliferation of vascular smooth muscle cells
  JOURNAL   Mol Cell Biochem 315 (1-2), 123-130 (2008)
   PUBMED   18496732
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Huang,J., Perez-Burgos,L., Placek,B.J., Sengupta,R., Richter,M.,
            Dorsey,J.A., Kubicek,S., Opravil,S., Jenuwein,T. and Berger,S.L.
  TITLE     Repression of p53 activity by Smyd2-mediated methylation
  JOURNAL   Nature 444 (7119), 629-632 (2006)
   PUBMED   17108971
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Brown,M.A., Sims,R.J. 3rd, Gottlieb,P.D. and Tucker,P.W.
  TITLE     Identification and characterization of Smyd2: a split SET/MYND
            domain-containing histone H3 lysine 36-specific methyltransferase
            that interacts with the Sin3 histone deacetylase complex
  JOURNAL   Mol Cancer 5, 26 (2006)
   PUBMED   16805913
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Oduru,S., Campbell,J.L., Karri,S., Hendry,W.J., Khan,S.A. and
            Williams,S.C.
  TITLE     Gene discovery in the hamster: a comparative genomics approach for
            gene annotation by sequencing of hamster testis cDNAs
  JOURNAL   BMC Genomics 4 (1), 22 (2003)
   PUBMED   12783626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB726546.1, BK001057.1 and AW433707.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_001066311.1, XM_213972.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CB726546.1         12-21
            11-1366             BK001057.1         1-1356
            1367-1592           AW433707.1         1-226               c
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..1592
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /note="SET and MYND domain containing 2"
                     /db_xref="GeneID:289372"
                     /db_xref="RGD:727785"
     exon            1..207
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1336
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /EC_number="2.1.1.354"
                     /note="SET and MYND domain-containing protein 2; histone
                     methyltransferase SMYD2"
                     /codon_start=1
                     /product="N-lysine methyltransferase SMYD2"
                     /protein_id="NP_996733.1"
                     /db_xref="GeneID:289372"
                     /db_xref="RGD:727785"
                     /translation="MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLT
                     VGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVFGENWNP
                     SETVRLTARILAKQKMHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFY
                     SKHLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYK
                     GTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAK
                     VEIRKLSNPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFED
                     SNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLY
                     MGLENKAAGEKALKKAIAIMEIAHGKDHPYISEIKQEIESH"
     exon            208..271
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            272..382
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            383..443
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            444..568
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            569..636
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            637..739
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            740..850
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            851..971
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1146
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1255
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1578
                     /gene="Smyd2"
                     /gene_synonym="HSKM-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccccgca gcgcgcagcc gcagcgctgc cagcatgcgc gccgaggccc gcggcggcct
       61 ggagcgcttc tgcagcgcgg gcaagggccg ggggctccgt gcgctgcggc ccttccacgt
      121 gggcgacctc ctcttctcct gcccggccta cgcctgcgtg ctcaccgtgg gcgagcgggg
      181 ccaccactgc gagtgctgct tcgccaggaa agaaggattg tcgaaatgtg gacgatgcaa
      241 gcaagccttc tactgcgatg tggagtgtca gaaagaagac tggcccctgc acaagctgga
      301 gtgctcctcc atggttgttt tcggggagaa ctggaatccc tcggagactg tgcggctcac
      361 agcaaggatc ctggccaagc agaaaatgca cccagagagg acaccttcag agaaactgtt
      421 ggccgtgagg gagtttgagt cacatctgga caagctagac aacgagaaga aggatctcat
      481 ccagagcgac atcgcggcgc tccatcagtt ctactccaag cacctggagt tccctgacca
      541 cagcagcctt gtggtgctct ttgcccaggt gaactgtaat ggcttcacta ttgaagatga
      601 ggagctctct cacttgggat cggcgatatt tcctgatgtt gcgctgatga atcacagctg
      661 ctgcccgaat gtcattgtga cctacaaagg taccctggca gaagtcagag ctgtgcagga
      721 gatccaccca ggagatgagg tgttcaccag ctatatcgac ctgctgtatc caacagaaga
      781 caggaacgac cggttaagag actcctactt ctttacctgt gagtgccggg agtgtacgac
      841 caaggacaag gacaaggcca aggtggaaat ccggaagctc agcaacccac ctcaggcaga
      901 agccatccga gacatggtca gatacgcacg caatgtcatc gaggagttcc ggagggccaa
      961 gcactacaaa tcccctagtg agctgttgga aatctgtgag ctcagccagg agaagatgag
     1021 ctctgtgttt gaggacagca atgtgtacat gctacacatg atgtaccagg ccatgggcgt
     1081 ctgcctgtac atgcaggact gggaaggagc cctgaaatat ggccagaaga tcatcaaacc
     1141 ctacagtaag cactaccccg tgtactccct caacgtggcc tccatgtggc tgaagttggg
     1201 aagactgtac atgggcctgg agaacaaagc tgccggggag aaggccctga agaaggccat
     1261 cgccatcatg gaaatagctc atggcaagga ccacccgtac atctccgaga tcaagcagga
     1321 aattgagagc cactgaccat gcgtcccagc tttccgtcag aaacctcaca gtcaccccag
     1381 ccttctgcaa gcctcgccat gctgtgttcc agttcgcatt tccagtgctt gcctgtgctc
     1441 taagggccgt ggcatgattt cacataatac atattttggg cagattgagc tttaaaaaat
     1501 gcaaccattt tccctctgtg cctgtcggaa tgctctgcag agctgaccga ggagagaata
     1561 aaagcgccag tccttaaaaa aaaaaaaaaa aa
//
