LOCUS       NM_001106595            2146 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus SET and MYND domain containing 1 (Smyd1), mRNA.
ACCESSION   NM_001106595 XM_001062526 XM_216172
VERSION     NM_001106595.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Liang Q, Cai M, Zhang J, Song W, Zhu W, Xi L and Tian Z.
  TITLE     Role of Muscle-Specific Histone Methyltransferase (Smyd1) in
            Exercise-Induced Cardioprotection against Pathological Remodeling
            after Myocardial Infarction
  JOURNAL   Int J Mol Sci 21 (19), 7010 (2020)
   PUBMED   32977624
  REMARK    GeneRIF: Role of Muscle-Specific Histone Methyltransferase (Smyd1)
            in Exercise-Induced Cardioprotection against Pathological
            Remodeling after Myocardial Infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran
            T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO and
            Vondriska TM.
  TITLE     The chromatin-binding protein Smyd1 restricts adult mammalian heart
            growth
  JOURNAL   Am J Physiol Heart Circ Physiol 311 (5), H1234-H1247 (2016)
   PUBMED   27663768
  REMARK    GeneRIF: Smyd1 is responsible for restricting growth in the adult
            heart, with its absence leading to cellular hypertrophy, organ
            remodeling, and fulminate heart failure. Molecular studies reveal
            Smyd1 to be a muscle-specific regulator of gene expression and
            indicate that Smyd1 modulates expression of gene isoforms whose
            expression is associated with cardiac pathology. Activation of
            Smyd1 can prevent pathological cell growth.
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Black JC, Van Rechem C and Whetstine JR.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela
            T, Moffat J, Hudson TJ and Sladek R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Li D, Niu Z, Yu W, Qian Y, Wang Q, Li Q, Yi Z, Luo J, Wu X, Wang Y,
            Schwartz RJ and Liu M.
  TITLE     SMYD1, the myogenic activator, is a direct target of serum response
            factor and myogenin
  JOURNAL   Nucleic Acids Res 37 (21), 7059-7071 (2009)
   PUBMED   19783823
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV,
            Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O and Srivastava
            D.
  TITLE     Bop encodes a muscle-restricted protein containing MYND and SET
            domains and is essential for cardiac differentiation and
            morphogenesis
  JOURNAL   Nat Genet 31 (1), 25-32 (2002)
   PUBMED   11923873
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Srivastava D, Gottlieb PD and Olson EN.
  TITLE     Molecular mechanisms of ventricular hypoplasia
  JOURNAL   Cold Spring Harb Symp Quant Biol 67, 121-125 (2002)
   PUBMED   12858532
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062526.1, XM_216172.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..2146
                     /gene="Smyd1"
                     /note="SET and MYND domain containing 1"
                     /db_xref="GeneID:297333"
                     /db_xref="RGD:1305105"
     exon            1..186
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1522
                     /gene="Smyd1"
                     /EC_number="2.1.1.354"
                     /note="SET and MYND domain-containing protein 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SMYD1"
                     /protein_id="NP_001100065.1"
                     /db_xref="GeneID:297333"
                     /db_xref="RGD:1305105"
                     /translation="MTVGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVF
                     DSLINFVCHTCFKRQERLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNE
                     NIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPP
                     QSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNN
                     GNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLHLSEERRQQLKKQYYFDCSC
                     EHCQKGLKDDLFLAVKEDPKPSQEVVKEMTQFSKDTLEKIDKARSEGLYHEVVKLCRE
                     CLEKQEPVFADTNLYVLRLLSIVSEVLSYLQAFEEASHYARRMVDGYMKLYHHNNAQL
                     GMAVMRAGLTNWHAGHIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRMQTEMELRM
                     FRQNEFMYHKMREAALNNQPMQVMAEPSNEPAPALFHKKQ"
     exon            187..363
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..577
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..708
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..747
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..937
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1030
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1194
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1363
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..2146
                     /gene="Smyd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttggctca gtgtgagcga accaccctgg gggcctgaca gactctgaga tgacagtagg
       61 cagcatggag aatgtggagg tctttacttc cgagggcaaa ggcagaggac tgaaggccac
      121 gaaggagttc tgggctgcgg atgtcatctt tgctgagagg gcttattcgg cagtggtttt
      181 tgacagcctc attaacttcg tgtgccacac ctgcttcaag aggcaggaga ggctccatcg
      241 ctgcgggcaa tgcaagttcg cccattactg cgaccgcaca tgccagaagg atgcctggct
      301 gaaccacaag aacgagtgct ctgccatcaa gagatacggg aaggtgccca acgaaaatat
      361 caggctggca gcccgcatca tgtggcgggt ggagagagag ggcactggac tcacagaggg
      421 ctgcctggtg tcagtggatg acttacagaa ccatgtggag cactttgggg aggaggagca
      481 gaaggaacta cgagtagacg tggatacatt cttgcagtac tggccaccac agagccagca
      541 gttcagcatg cagtacatct cacacatctt tggcgtgatc aactgcaatg gtttcacact
      601 cagtgaccag agagggctac aggcagtggg cgtgggcatc ttccccaacc tgggcctggt
      661 gaaccatgac tgctggccaa actgcactgt catattcaac aatggcaatc atgaggcggt
      721 gaaatccatg tttcacacgc agatgaggat tgagctccgg gccctgggca agatctcaga
      781 aggtgaggag ctgacggtgt cctacataga cttcctccac ctcagcgagg agcgcaggca
      841 gcagctgaag aagcagtact actttgactg ctcctgtgaa cactgccaga aggggctgaa
      901 ggacgacctc ttcctggcag tgaaggaaga ccccaagccc tcccaggagg tggtgaagga
      961 gatgacacaa ttctcaaagg atacactgga aaaaatagac aaggctcgct ctgagggttt
     1021 gtatcacgag gttgtgaagc tgtgtcggga gtgcctggag aagcaggaac cagtgtttgc
     1081 tgacaccaac ctctacgtgc ttcggttgct aagcattgtg tcagaagtcc tctcctacct
     1141 ccaggccttt gaagaggcct cccattatgc caggaggatg gtggatggct acatgaaact
     1201 ctaccaccat aacaatgccc aactgggcat ggctgtgatg cgggcagggc tgaccaactg
     1261 gcatgctggt cacattgaag tagggcacgg gatgatctgc aaagcctatg ctattctcct
     1321 ggtgacccat ggaccctccc accctatcac caaagactta gaggccatgc ggatgcagac
     1381 agagatggag ctgcgtatgt tccgccaaaa tgaattcatg taccacaaaa tgcgagaggc
     1441 tgccctgaac aaccagccca tgcaggtcat ggctgagccc agcaacgagc cagccccagc
     1501 tctgttccat aagaagcaat gaggaccttg ttggagggtg ggggcattgt ggctgcggag
     1561 ctgaggaaat tactactctg tgtcccccac cgccattttg gttcaattca actcagctta
     1621 gttctctctc atttcagacc aactctttct ctatgtgtcg ggtgctagat tccaccgtct
     1681 atttaacaag gaagccccaa atatacttcg gctagaaaga aaaatgtaaa caaacaaggt
     1741 acagcataat agtaaatgcc acggtgcact ctatggagag gggttcagag gaggtgagtg
     1801 tgtgtgagtg agtgagtgtg tgtgagtgag tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1861 tgtgtgtgta aaacacctga gctaagagtg gcaggtacct agaatctcag gtggctgctt
     1921 gtttctttgt gcaggggtct ctggggctgc tggtttcatc tacagttacg aacatttagg
     1981 gttctgcaga ctgggatggg tgatgatgac ctgtatcctg aggctgggac tgttcttggc
     2041 cctttgagat ctactcaatg gtgcctagaa agaggtaggg atcttgggat cctgtggtct
     2101 taatttccta atccaagttg aagcatactt ttagaataac tctaga
//
