LOCUS       NM_001107061            4972 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SMAD specific E3 ubiquitin protein ligase 2
            (Smurf2), mRNA.
ACCESSION   NM_001107061 XM_001081579 XM_221048
VERSION     NM_001107061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4972)
  AUTHORS   Zhang Q, Yin J and Zou Y.
  TITLE     MiR-568 mitigated cardiomyocytes apoptosis, oxidative stress
            response and cardiac dysfunction via targeting SMURF2 in heart
            failure rats
  JOURNAL   Heart Vessels 38 (6), 857-868 (2023)
   PUBMED   36717388
  REMARK    GeneRIF: MiR-568 mitigated cardiomyocytes apoptosis, oxidative
            stress response and cardiac dysfunction via targeting SMURF2 in
            heart failure rats.
REFERENCE   2  (bases 1 to 4972)
  AUTHORS   Liu Y, Guo W, Guo Y, Chen X and Liu W.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes improve renal
            fibrosis via regulating Smurf 2/Smad 7
  JOURNAL   Front Biosci (Landmark Ed) 27 (1), 17 (2022)
   PUBMED   35090322
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes improve
            renal fibrosis via regulating Smurf 2/Smad 7.
REFERENCE   3  (bases 1 to 4972)
  AUTHORS   Zhang J, Zhang J and Zhang Q.
  TITLE     The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced
            pulmonary fibrosis in rats
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 66 (3), 79-84 (2020)
   PUBMED   32538751
  REMARK    GeneRIF: The effects of miR-27a-3p-mediated Smurf2 on bleomycin
            A5-induced pulmonary fibrosis in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4972)
  AUTHORS   Gao X, Xu H, Xu D, Li S, Wei Z, Li S, Cai W, Mao N, Jin F, Li Y, Li
            T, Yi X, Liu H and Yang F.
  TITLE     MiR-411-3p alleviates Silica-induced pulmonary fibrosis by
            regulating Smurf2/TGF-beta signaling
  JOURNAL   Exp Cell Res 388 (2), 111878 (2020)
   PUBMED   32004504
  REMARK    GeneRIF: MiR-411-3p alleviates Silica-induced pulmonary fibrosis by
            regulating Smurf2/TGF-beta signaling.
REFERENCE   5  (bases 1 to 4972)
  AUTHORS   Dong W, Xie F, Chen XY, Huang WL, Zhang YZ, Luo WB, Chen J, Xie MT
            and Peng XP.
  TITLE     Inhibition of Smurf2 translation by miR-322/503 protects from
            ischemia-reperfusion injury by modulating EZH2/Akt/GSK3beta
            signaling
  JOURNAL   Am J Physiol Cell Physiol 317 (2), C253-C261 (2019)
   PUBMED   30649914
  REMARK    GeneRIF: By inhibition of Smurf2 translation, miR-322/503 induces
            EZH2 expression and activates Akt/GSK3beta pathway, thereby
            protecting cardiac myocytes from ischemia reperfusion injury.
REFERENCE   6  (bases 1 to 4972)
  AUTHORS   Liu FY, Li XZ, Peng YM, Liu H and Liu YH.
  TITLE     Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in
            a rat model of tubulointerstitial fibrosis
  JOURNAL   Am J Nephrol 27 (2), 176-183 (2007)
   PUBMED   17347560
REFERENCE   7  (bases 1 to 4972)
  AUTHORS   Cai Y, Shen XZ, Zhou CH and Wang JY.
  TITLE     Abnormal expression of Smurf2 during the process of rat liver
            fibrosis
  JOURNAL   Chin J Dig Dis 7 (4), 237-245 (2006)
   PUBMED   17054587
  REMARK    GeneRIF: This study demonstrated changes of Smurf2 in the process
            of liver fibrosis.
REFERENCE   8  (bases 1 to 4972)
  AUTHORS   Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A,
            Meil A, Wojcik J, Legrain P and Gauthier JM.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 4972)
  AUTHORS   Li H and Seth A.
  TITLE     An RNF11: Smurf2 complex mediates ubiquitination of the AMSH
            protein
  JOURNAL   Oncogene 23 (10), 1801-1808 (2004)
   PUBMED   14755250
REFERENCE   10 (bases 1 to 4972)
  AUTHORS   Shi Y and Massague J.
  TITLE     Mechanisms of TGF-beta signaling from cell membrane to the nucleus
  JOURNAL   Cell 113 (6), 685-700 (2003)
   PUBMED   12809600
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001107061.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JACYVU010000220.1  48686779-48686932   c
            155-193             JACYVU010000220.1  48643265-48643303   c
            194-302             JACYVU010000220.1  48638886-48638994   c
            303-436             JACYVU010000220.1  48636053-48636186   c
            437-502             JACYVU010000220.1  48632316-48632381   c
            503-587             JACYVU010000220.1  48627828-48627912   c
            588-671             JACYVU010000220.1  48624167-48624250   c
            672-874             JACYVU010000220.1  48620961-48621163   c
            875-959             JACYVU010000220.1  48618515-48618599   c
            960-1118            JACYVU010000220.1  48613592-48613750   c
            1119-1314           JACYVU010000220.1  48610679-48610874   c
            1315-1418           JACYVU010000220.1  48608082-48608185   c
            1419-1533           JACYVU010000220.1  48603227-48603341   c
            1534-1712           JACYVU010000220.1  48601206-48601384   c
            1713-1850           JACYVU010000220.1  48598386-48598523   c
            1851-1971           JACYVU010000220.1  48595122-48595242   c
            1972-2173           JACYVU010000220.1  48591073-48591274   c
            2174-2249           JACYVU010000220.1  48589627-48589702   c
            2250-4972           JACYVU010000220.1  48586656-48589378   c
FEATURES             Location/Qualifiers
     source          1..4972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4972
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /note="SMAD specific E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:303614"
                     /db_xref="RGD:1310067"
     exon            1..154
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2349
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /EC_number="2.3.2.26"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SMURF2"
                     /protein_id="NP_001100531.1"
                     /db_xref="GeneID:303614"
                     /db_xref="RGD:1310067"
                     /translation="MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGS
                     GQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSN
                     AINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLP
                     DGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGA
                     TCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGV
                     STWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANL
                     HLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGH
                     CRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEML
                     NPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPF
                     YKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKP
                     NGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELEL
                     IICGLGKIDVSDWKANTRLKHCTPDSNVVKWFWKAVELFDEERRARLLQFVTGSSRVP
                     LQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE
                     ETCGFAVE"
     exon            155..193
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            194..302
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            303..436
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            437..502
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            503..587
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            588..671
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            672..874
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            875..959
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1118
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1314
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1418
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1533
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1712
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1850
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1971
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2173
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2249
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..4972
                     /gene="Smurf2"
                     /gene_synonym="RGD1310067"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgactcct ccgcgcctcg ccgtcgtccc agcccagccc agcccgcccg cccgcgggcc
       61 gcgagcgccg ccgccgccgc cgcctccccc gccgctgggg acatgtctaa ccccggaggc
      121 cggaggaacg ggcccgtcaa gctgcgcctg acagtactct gtgcaaaaaa cttggtgaaa
      181 aaggattttt tccgactccc tgatccgttt gctaaggtgg tagttgatgg ttctgggcaa
      241 tgccattcta cagatactgt gaagaacaca cttgatccaa agtggaatca gcattatgac
      301 ctgtatattg ggaagtctga ttccgtcacg atcagcgtgt ggaatcataa gaagatccat
      361 aagaagcaag gtgctggatt tcttggttgt gttcgtcttc tttccaatgc catcaatcgc
      421 ctcaaagaca ctggctatca gaggttggat ttatgcaaac tggggccaaa tgacaatgat
      481 acagttcgag gacaaattgt agtaagtctt caatccagag accgaatagg cacgggagga
      541 caagttgtgg actgcagtcg tttgtttgat aatgatttac cagacggttg ggaagaaagg
      601 cgaactgcct ctggaagaat ccagtatcta aaccacatca caagaactac acagtgggaa
      661 cgcccaacaa gaccggcgtc agaatattct agtcctggca ggcctcttag ctgctttgtg
      721 gatgagaata ctccaattac tggaacaaat ggtgcaacat gtggacagtc ttcagatccc
      781 agactagcag agaggagagt ccggtctcag cgacatagaa attacatgag caggacacac
      841 ttacacactc ctccagacct acccgaaggc tatgaacaga ggacaacaca acagggtcag
      901 gtatatttct tacatactca gactggcgtg agcacgtggc atgatccacg agtgcctagg
      961 gatcttagca acatcaattg tgaagagctc ggtcctctgc ctcctgggtg ggagatccgc
     1021 aataccgcga caggcagagt ttatttcgtg gaccataaca acagaacaac acagtttaca
     1081 gatcctcgtc tctctgctaa cttgcattta gttttaaatc gtcagaacca gttgaaagac
     1141 caacagcaac agcaagtggt gtcgttgtgt cccgatgaca ctgagtgtct gacagtgcca
     1201 aggtacaagc gagacttggt tcaaaaacta aagatcttgc ggcaagaact ttcccaacag
     1261 cagcctcaag ctggccactg ccgcattgag gtgtcaaggg aagagatttt tgaggaatca
     1321 tatcgacaag tcatgaaaat gagaccaaag gatctatgga agcgattaat gataaaattt
     1381 cgaggagaag aaggccttga ctatggagga gttgccaggg aatggttgta tctcctgtcg
     1441 catgaaatgt tgaatcctta ctacggtctc ttccagtatt caagagatga tatctacacg
     1501 ttacagatca atcccgattc tgcagttaat ccggagcatt tgtcctattt ccactttgtt
     1561 ggacgaataa tgggaatggc tgtattccat ggacattata ttgatggtgg tttcacatta
     1621 cctttttata aacagttgct tgggaagtca attactttgg acgacatgga gctagttgat
     1681 ccagaccttc ataatagttt ggtgtggata cttgaaaatg atatcacagg tgttctggac
     1741 cataccttct gtgttgaaca taacgcatat ggtgaaatta ttcagcatga actcaaacca
     1801 aatggcaaaa gtattcctgt tactgaagaa aataaaaaag aatatgtcag gctttacgta
     1861 aactggagat tcctccgagg cattgaagct cagttcctgg cactacagaa gggatttaat
     1921 gaagtcattc cacagcatct gctgaagaca tttgatgaga aggagctgga gctcattatc
     1981 tgtgggcttg gcaaaattga cgtgagcgac tggaaggcca acacccggtt aaagcactgc
     2041 accccagaca gcaacgtcgt caagtggttt tggaaagctg tggagctttt tgatgaggag
     2101 agacgagcac ggctgctcca gtttgtgaca gggtcctctc gagtgcctct gcagggcttc
     2161 aaagcactcc aaggtgccgc gggcccacgg ctctttacca tacaccagat tgatgcctgc
     2221 acgaacaacc tgccaaaagc ccacacttgt ttcaatcgaa tagacattcc gccctatgag
     2281 agctatgaga agctctacga aaagctgcta acagccatcg aggagacctg tggctttgct
     2341 gtggagtgat gagcgccgag gactcaccca cagctcttac tgacccctgg ccaacagcct
     2401 ccttcagcag cgcttcagag aacgctggag tacaggacaa cagcccctcc cctgctcctt
     2461 agattctagg acactgtgag gggaagggac aattttgaaa ttccttttca aggaaaaata
     2521 aaggtcttta tgctttgcca tgaggacaca ctcagctgct atttaaaaat taataccttg
     2581 aacctaaaga atgctgaccc ctgcatctcc agagttaggc agtattctac acttaaaaga
     2641 ctactactat ttttatacaa ggttatctat ccaaactgct tctcagactc gcgtctctca
     2701 cactcaagac agctccccag tcggtacaag ccacatttca gttggattga acacgtggtt
     2761 ttgaacagct cctgtccctg ctctttgtaa gaaactaaag ttattttgga ttgttcacct
     2821 ttgtaaacag ttggctaaag ggattgtcac ctttatgaaa ctaagccatt tacatgtttt
     2881 tagttgtgct tttctatagc agagggttct attttgcatt atgtgggtca ccgtagctta
     2941 agtggggttt tatatttttc aagtgtgact ttcttggaaa ttcctaatgc aaccatttaa
     3001 attgagttta tttgctgccc ttcctgtttt taagatgact taaaaaaaac caaaaaacaa
     3061 aaaaacaaaa aaaacctcat gttcttgaat caagaagatg aggtattgtg gatttatttc
     3121 atcttaaact gaaatactgc gattttatag cttctcagtc tgtgatgggg tgggattttc
     3181 attctctgct gggtcagttt gtcttttata tgctatttct ataaaccaaa gtctctaata
     3241 agtacatcta acttatattt taattaagtt tctaaaaggc aagcttgtgc tctaaagatc
     3301 gtttggcaag cttagagcgc cctgctttta caaactcatt ggatgaactg gaggtggtag
     3361 tgggcgtggt gggccaggaa agtcatacgt gagtgaggcc agctgtgctg accacctctg
     3421 ctccccattc ctgggaggct aaggcggggg cgcaattcag gtttaaggcc agcctgagct
     3481 acatagcaga tcttgcctca agaaagagtg actctaagtc aatcacacaa tttactctga
     3541 aactgaggag ttcgtgagaa gtaagggagg aggccaggct gccacactgc tgacttcaag
     3601 tgtcgaggtt aagctttcaa ggtatgtggc tcatcctgtg atctagaagg taacaaaaat
     3661 tctggggtga agggttgcag ccattaaaaa agtcacattg gattttaaaa ttgcaccatc
     3721 agaacaatgc actgttgttt ttaaacactg atgagaaata agaacagcaa atctggctga
     3781 gcttggcaca aggttgtgag gaacagttta cagaaaatgt gattcagcct ggtggctgac
     3841 acccgtaatc ccatcaccgt ggaggcagag gcagaaggat cagcaagtca aggccagcct
     3901 cacctacgca gtgggttaga ggctgcttga gaccctgtct cagaggggca aggaccataa
     3961 ctgacaggga tgcagtggta tcgagatgct gcttgcagtg gttttccgtg cagtgtaacg
     4021 caggcaaatc ccaccgcttt ttgagtgcct tttaactatt atagtgactt gacagagctt
     4081 taaagaaaat cgccctctgt aacagtctac aatagcacat gacatctgaa aacatgattt
     4141 agattgcaat ttcaaaatta cattacctga ttacttccaa ataggtgcta agcaaacaaa
     4201 aatccccggt gtcacagaac ctggacttgc cttgtgttta atgtgaatat ttatctgttt
     4261 ccaggcatcc ttcctccagt cgctctgttc catcaggaaa ggctaattct gaccaatggt
     4321 taccttgtgc tcatgtgcag taagaggcca ctatttcctg gcacacagtt ttaaagtaat
     4381 gctgtttcct gtgcattttg ttttgcagtt tgttgctctg tattctacag tgctgcccca
     4441 cccacccaca tttacaggcc agagcacaat gtgtcttctc ctaaatccac tgtaatttgc
     4501 ttcctttgac aacactaaat ctgctctgaa cttgcagtgc attggacaga tggcactgat
     4561 gggtgttaga ggcttccagt gcctgcaggg gggggggggg gcagcacagc gccttgccct
     4621 ttggctgcag gcttctgtcg gggccactgc tctcacacta ggatgatgat tgtaccaaat
     4681 gccgagtcgc tttctctagg tgtaattagt tcactgtatg taatattcct ccttttcctc
     4741 taaactgact ttaaaaacaa agttttatca tttccattgt atttattaca gaatgtttta
     4801 gccttgatat tctttgtaat ttcactcatt tgttacatga gctttatcaa taacatctgt
     4861 ataaatggtt tttaaaaatt aactatgtac gtatgtatgt gcccatgccg aagttgagca
     4921 ataaaatgaa tgctgtttgc actgtcacaa cagcgaggtt tttaaaaatg tc
//
