LOCUS       NM_057195               1728 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus SMU1, DNA replication regulator and spliceosomal
            factor (Smu1), mRNA.
ACCESSION   NM_057195
VERSION     NM_057195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Di Benedetto,A.J., Klick Stoddard,J. and Glavan,B.J.
  TITLE     Cloning and molecular characterization of a novel gene encoding a
            WD-repeat protein expressed in restricted areas of adult rat brain
  JOURNAL   Gene 271 (1), 21-31 (2001)
   PUBMED   11410362
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY029526.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029526.1, SRR8487227.285930.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1728
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /note="SMU1, DNA replication regulator and spliceosomal
                     factor"
                     /db_xref="GeneID:117541"
                     /db_xref="RGD:620694"
     exon            1..51
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1567
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /note="brain-enriched WD repeat-containing protein; smu-1
                     suppressor of mec-8 and unc-52 protein homolog; suppressor
                     of Mec and Unc defects 1 homolog; brain-enriched WD-repeat
                     protein; homolog of C. elegans smu-1; smu-1 suppressor of
                     mec-8 and unc-52 homolog; DNA replication regulator and
                     spliceosomal factor"
                     /codon_start=1
                     /product="WD40 repeat-containing protein SMU1"
                     /protein_id="NP_476543.1"
                     /db_xref="GeneID:117541"
                     /db_xref="RGD:620694"
                     /translation="MSIEIESSDVIRLIMQYLKENSLHRALATFTEETTVSLNTVDSI
                     ESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDP
                     MIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSR
                     LMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVE
                     CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT
                     EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH
                     GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGS
                     TAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCAL
                     SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLL
                     KLWKP"
     exon            52..262
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..415
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..526
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..655
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..775
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..892
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1020
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1147
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1315
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1468
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1728
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctagacc cggagcgtta ccgctatgtc gatcgaaatc gagtcttccg atgtgattcg
       61 tctaatcatg cagtacttga aggagaacag tttacatcgg gcattggcca ccttcacgga
      121 ggaaaccact gtctctctga atactgtgga tagcattgaa agttttgtgg ctgatattaa
      181 tagtggccac tgggacactg ttttacaggc tatccagtct ctgaaattgc cagacaaaac
      241 ccttattgat ctctatgaac aggttgtttt ggaattgata gagcttcgtg aactgggtgc
      301 tgccaggtca cttctgagac agactgaccc catgattatg ttaaagcaaa cacaaccaga
      361 gcgatatatt catctggaaa acctgctagc cagatcttac tttgaccctc gggaggcgta
      421 tccagatgga agcagcaaag agaaaaggag agcggcgatt gcccaggctt tggctgggga
      481 ggtcagcgtg gtgccgcctt cccgtctcat ggcgttgctg ggacaggcac tgaagtggca
      541 gcagcaccag ggattgcttc ctcctggtat gaccatagat ttgtttcgag gcaaggcagc
      601 tgtcaaagat gtggaagaag agaagtttcc cacacagctg agcagacata ttaagtttgg
      661 gcagaaatcc cacgtggagt gcgctcggtt ctctccagac ggtcagtatc tggtcaccgg
      721 ctctgttgac ggatttattg aggtgtggaa cttcactact gggaaaatca ggaaggatct
      781 taagtaccag gcccaggata acttcatgat gatggatgat gctgtcctct gcatgtgttt
      841 cagcagagac actgaaatgt tagcaactgg ggcccaagac ggaaagatca aggtttggaa
      901 gattcagagt ggacagtgtt tgagaagatt tgaaagggca catagtaaag gtgtcacctg
      961 tctaagcttt tccaaggaca gcagtcagat cctcagtgct tcttttgacc agacaataag
     1021 aattcatggt ttaaaatctg gaaaaacact taaggaattt cgaggccatt cctcctttgt
     1081 caatgaggca acatttacac aagatgggca ttacattatc agtgcatcct ctgatggcac
     1141 tgtgaagatc tggaatatga agaccaccga atgttcaaat acctttaaat ccctgggcag
     1201 tactgcaggg acagatatta cagtcaatag tgtaattctg cttcctaaaa acccagagca
     1261 ttttgttgtg tgcaaccgat cgaacacagt ggtcatcatg aacatgcagg ggcagattgt
     1321 cagaagcttc agctctggta aaagagaggg tggtgacttt gtctgctgtg ccctctcccc
     1381 tcgtggcgag tggatctact gtgttgggga ggactttgtg ctctactgct tcagcacagt
     1441 cactggcaag ctggagagaa ctctgacggt tcatgaaaag gatgtgatcg gaattgcaca
     1501 ccacccgcac cagaacttga ttgccaccta cagtgaagat ggactcctga agctctggaa
     1561 accctaagtc agcctttaca gtgcagccaa ggagcgtgta cttaagtgga gggcatggtc
     1621 atgtattatt tttacttttt catgtctgcg tcctagcata aaacttgtaa ataagtcagt
     1681 agctacgggt tcttttaaaa aagattttaa taaacctctc tttaccat
//
