LOCUS       NP_476543                513 aa            linear   ROD 02-JUN-2024
DEFINITION  WD40 repeat-containing protein SMU1 [Rattus norvegicus].
ACCESSION   NP_476543
VERSION     NP_476543.1
DBSOURCE    REFSEQ: accession NM_057195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 513)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (residues 1 to 513)
  AUTHORS   Di Benedetto,A.J., Klick Stoddard,J. and Glavan,B.J.
  TITLE     Cloning and molecular characterization of a novel gene encoding a
            WD-repeat protein expressed in restricted areas of adult rat brain
  JOURNAL   Gene 271 (1), 21-31 (2001)
   PUBMED   11410362
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY029526.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029526.1, SRR8487227.285930.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..513
                     /product="WD40 repeat-containing protein SMU1"
                     /note="brain-enriched WD repeat-containing protein; smu-1
                     suppressor of mec-8 and unc-52 protein homolog; suppressor
                     of Mec and Unc defects 1 homolog; brain-enriched WD-repeat
                     protein; homolog of C. elegans smu-1; smu-1 suppressor of
                     mec-8 and unc-52 homolog; DNA replication regulator and
                     spliceosomal factor"
                     /calculated_mol_wt=57420
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q2TAY7; propagated from
                     UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          2..315
                     /region_name="Required for interaction with IK.
                     /evidence=ECO:0000250|UniProtKB:Q2TAY7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M63.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine, in WD40 repeat-containing protein
                     SMU1, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:Q2TAY7; propagated from
                     UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          7..36
                     /region_name="LisH_TPL"
                     /note="LisH-like dimerization domain; pfam17814"
                     /db_xref="CDD:375350"
     Region          40..90
                     /region_name="CTLH"
                     /note="C-terminal to LisH motif; smart00668"
                     /db_xref="CDD:128914"
     Region          141..513
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          219..262
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          268..305
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          305..346
                     /region_name="WD 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          310..346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          347..386
                     /region_name="WD 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          353..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          395..436
                     /region_name="WD 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          400..436
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          440..479
                     /region_name="WD 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          444..481
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          482..513
                     /region_name="WD 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99M63.1)"
     Region          487..511
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..513
                     /gene="Smu1"
                     /gene_synonym="Bwd; Smu-1"
                     /coded_by="NM_057195.1:26..1567"
                     /db_xref="GeneID:117541"
                     /db_xref="RGD:620694"
ORIGIN      
        1 msieiessdv irlimqylke nslhralatf teettvslnt vdsiesfvad insghwdtvl
       61 qaiqslklpd ktlidlyeqv vlelielrel gaarsllrqt dpmimlkqtq peryihlenl
      121 larsyfdpre aypdgsskek rraaiaqala gevsvvppsr lmallgqalk wqqhqgllpp
      181 gmtidlfrgk aavkdveeek fptqlsrhik fgqkshveca rfspdgqylv tgsvdgfiev
      241 wnfttgkirk dlkyqaqdnf mmmddavlcm cfsrdtemla tgaqdgkikv wkiqsgqclr
      301 rferahskgv tclsfskdss qilsasfdqt irihglksgk tlkefrghss fvneatftqd
      361 ghyiisassd gtvkiwnmkt tecsntfksl gstagtditv nsvillpknp ehfvvcnrsn
      421 tvvimnmqgq ivrsfssgkr eggdfvccal sprgewiycv gedfvlycfs tvtgklertl
      481 tvhekdvigi ahhphqnlia tysedgllkl wkp
//
