LOCUS       NM_001191739            1636 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus smoothelin-like 1 (Smtnl1), mRNA.
ACCESSION   NM_001191739 XM_230278
VERSION     NM_001191739.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Ulke-Lemee,A., Turner,S.R. and MacDonald,J.A.
  TITLE     In situ analysis of smoothelin-like 1 and calmodulin interactions
            in smooth muscle cells by proximity ligation
  JOURNAL   J Cell Biochem 116 (11), 2667-2675 (2015)
   PUBMED   25923522
  REMARK    GeneRIF: Results suggest that CBD1 of SMTNL1 contributes to
            proximity to calmodulin within A7r5 smooth muscle cells, whereas
            CBD2 does not play a role.
REFERENCE   2  (bases 1 to 1636)
  AUTHORS   MacDonald,J.A., Ishida,H., Butler,E.I., Ulke-Lemee,A.,
            Chappellaz,M., Tulk,S.E., Chik,J.K. and Vogel,H.J.
  TITLE     Intrinsically disordered N-terminus of calponin homology-associated
            smooth muscle protein (CHASM) interacts with the calponin homology
            domain to enable tropomyosin binding
  JOURNAL   Biochemistry 51 (13), 2694-2705 (2012)
   PUBMED   22424482
REFERENCE   3  (bases 1 to 1636)
  AUTHORS   Bodoor,K., Lontay,B., Safi,R., Weitzel,D.H., Loiselle,D., Wei,Z.,
            Lengyel,S., McDonnell,D.P. and Haystead,T.A.
  TITLE     Smoothelin-like 1 protein is a bifunctional regulator of the
            progesterone receptor during pregnancy
  JOURNAL   J Biol Chem 286 (36), 31839-31851 (2011)
   PUBMED   21771785
REFERENCE   4  (bases 1 to 1636)
  AUTHORS   Lontay,B., Bodoor,K., Weitzel,D.H., Loiselle,D., Fortner,C.,
            Lengyel,S., Zheng,D., Devente,J., Hickner,R. and Haystead,T.A.
  TITLE     Smoothelin-like 1 protein regulates myosin phosphatase-targeting
            subunit 1 expression during sexual development and pregnancy
  JOURNAL   J Biol Chem 285 (38), 29357-29366 (2010)
   PUBMED   20634291
REFERENCE   5  (bases 1 to 1636)
  AUTHORS   Ishida,H., Borman,M.A., Ostrander,J., Vogel,H.J. and MacDonald,J.A.
  TITLE     Solution structure of the calponin homology (CH) domain from the
            smoothelin-like 1 protein: a unique apocalmodulin-binding mode and
            the possible role of the C-terminal type-2 CH-domain in smooth
            muscle relaxation
  JOURNAL   J Biol Chem 283 (29), 20569-20578 (2008)
   PUBMED   18477568
REFERENCE   6  (bases 1 to 1636)
  AUTHORS   Wooldridge,A.A., Fortner,C.N., Lontay,B., Akimoto,T., Neppl,R.L.,
            Facemire,C., Datto,M.B., Kwon,A., McCook,E., Li,P., Wang,S.,
            Thresher,R.J., Miller,S.E., Perriard,J.C., Gavin,T.P.,
            Hickner,R.C., Coffman,T.M., Somlyo,A.V., Yan,Z. and Haystead,T.A.
  TITLE     Deletion of the protein kinase A/protein kinase G target SMTNL1
            promotes an exercise-adapted phenotype in vascular smooth muscle
  JOURNAL   J Biol Chem 283 (17), 11850-11859 (2008)
   PUBMED   18310078
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_001191739.2.
            
            On Jul 17, 2010 this sequence version replaced XM_230278.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.10714.1,
                                           SRR26643295.14056.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               JAXUCZ010000003.1  90303080-90303736   c
            658-793             JAXUCZ010000003.1  90301810-90301945   c
            794-845             JAXUCZ010000003.1  90301653-90301704   c
            846-1001            JAXUCZ010000003.1  90300442-90300597   c
            1002-1116           JAXUCZ010000003.1  90300153-90300267   c
            1117-1268           JAXUCZ010000003.1  90299837-90299988   c
            1269-1636           JAXUCZ010000003.1  90295682-90296049   c
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1636
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /note="smoothelin-like 1"
                     /db_xref="GeneID:311167"
                     /db_xref="RGD:1311701"
     CDS             1..1413
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /codon_start=1
                     /product="smoothelin-like protein 1"
                     /protein_id="NP_001178668.1"
                     /db_xref="GeneID:311167"
                     /db_xref="RGD:1311701"
                     /translation="MEQTEGNPSEDGTTVSPTAGNLATPGSQGTAEEVAEGTAEEVAE
                     GTVGTNDKEEPPDGAEHLCKAASEGGISGGCQVEASILEELKTDSQGEARGKEEAKAD
                     LAEEKGGKEDTTVSSQEDTGKKEETKPEPSEVTEKEEAVLPLEKQKVDEKETNLESKE
                     KSDVNDKAEPESKEDAGAEVTVKEAETESQKKADVKDQAEPQLQEVDGKEARSDTKEL
                     VEPGSPTEEQEEQGKENESEERAAVIPSSPEDWPESPTDEGTSLSPDGLGPESTASGE
                     TSASASESSPSEVPESPTEPLPSEKKKERAPERRVSAPTRPRGPRAQNRKAIMDKFGG
                     AASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCAL
                     IHKFFPDAFDYAELDPTKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYT
                     YIQELYRSLVQKGLVKTKKK"
     exon            1..657
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
     exon            658..793
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
     exon            794..845
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1001
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1116
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1268
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1636
                     /gene="Smtnl1"
                     /gene_synonym="RGD1311701"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaacaga cagaagggaa cccctctgag gatgggacca ctgtctcccc aactgcaggg
       61 aatcttgcaa caccaggaag tcaaggcact gcagaagagg tggccgaagg cactgcagaa
      121 gaggtggccg aaggcacagt tgggacaaat gacaaagaag agcctccaga tggggcagaa
      181 catttgtgta aagcagcatc tgagggtggt atatcagggg gatgccaggt ggaagcaagt
      241 atattagagg agctcaagac agactcgcaa ggggaggcca gagggaagga ggaagccaag
      301 gctgaccttg ccgaggagaa aggtgggaag gaagacacca cagtgtcttc tcaggaagac
      361 actggtaaga aagaagagac aaaacctgaa cccagtgagg ttacggagaa agaggaagcc
      421 gtgctgccct tggagaagca gaaggttgat gagaaagaga ccaatctaga atctaaggag
      481 aaatcagatg tgaatgataa ggctgagcct gaatccaagg aggatgctgg agcagaggtt
      541 actgtcaaag aggctgagac tgaatctcaa aagaaggctg atgtgaaaga ccaggccgag
      601 cctcagcttc aggaagttga tgggaaagag gccagaagtg acacaaagga gttggtggag
      661 ccagggagtc ccactgaaga gcaggaggaa caaggtaagg aaaatgaatc agaagaaagg
      721 gcagcggtga ttcccagctc ccccgaggac tggcccgaga gccccacaga tgaggggacc
      781 agcctcagcc cagatgggtt gggtccagag tctacagcat ctggagagac cagtgcttca
      841 gccagtgaat cttcgcccag tgaggtgcca gagagcccca cagagcccct tccctcggag
      901 aaaaagaagg aacgggcacc agaacgcagg gtgtcggccc ccacccggcc ccgagggcca
      961 cgtgcacaga atcggaaggc catcatggac aaatttggcg gggcagcctc tggccccact
     1021 gcactgttcc ggaacacaaa ggcagccggg gcagccattg gtggtgttaa gaacatgctt
     1081 ttggagtggt gccgggccat gacgagaaac tacgagcacg tggacatcca aaacttctcc
     1141 tccagctgga gcagcggcat ggccttctgt gccctcatcc acaagttttt tccagacgcc
     1201 tttgactatg cagagctgga cccaacaaag cgccggcaca acttcacgct agctttctct
     1261 actgcagaga aactagccga ctgcgcccag ctgctggagg tggatgacat ggtgcggctg
     1321 gcagtgcccg attccaagtg tgtctacact tacatccagg agctataccg tagccttgta
     1381 cagaaagggc tggtgaagac gaaaaagaaa tgaatggcaa agccgtgcgg gaggaggaag
     1441 cggggactgc tgccaaccat ggcctcgagg tgctcttata ccaccaggca taaaacgggt
     1501 ggcaccggcc tcaacgacat taaaagtact tctgcaaaat tcctctcatt ccttgctgct
     1561 ccccaaacgc atcccaacca gacacacata cgtactaggc gatggccaaa aataaaagaa
     1621 acctgcattc gcagcc
//
