LOCUS       NM_001013049            3307 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus smoothelin (Smtn), mRNA.
ACCESSION   NM_001013049 XM_001061663 XM_001066720 XM_214078
VERSION     NM_001013049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Rensen,S.S., Niessen,P.M., van Deursen,J.M., Janssen,B.J.,
            Heijman,E., Hermeling,E., Meens,M., Lie,N., Gijbels,M.J.,
            Strijkers,G.J., Doevendans,P.A., Hofker,M.H., De Mey,J.G. and van
            Eys,G.J.
  TITLE     Smoothelin-B deficiency results in reduced arterial contractility,
            hypertension, and cardiac hypertrophy in mice
  JOURNAL   Circulation 118 (8), 828-836 (2008)
   PUBMED   18678771
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Bar,H., Wende,P., Watson,L., Denger,S., van Eys,G., Kreuzer,J. and
            Jahn,L.
  TITLE     Smoothelin is an indicator of reversible phenotype modulation of
            smooth muscle cells in balloon-injured rat carotid arteries
  JOURNAL   Basic Res Cardiol 97 (1), 9-16 (2002)
   PUBMED   11998981
  REMARK    GeneRIF: Smoothelin is an indicator of reversible phenotype
            modulation of smooth muscle cells in balloon-injured rat carotid
            arteries.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Aug 29, 2008 this sequence version replaced
            XM_214078.4, XM_001061663.1, XM_001066720.1, NM_001013049.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.114170.1,
                                           SRR21887620.1377835.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000014.1  82644362-82644514   c
            154-268             JAXUCZ010000014.1  82642504-82642618   c
            269-417             JAXUCZ010000014.1  82637940-82638088   c
            418-511             JAXUCZ010000014.1  82637358-82637451   c
            512-590             JAXUCZ010000014.1  82637183-82637261   c
            591-688             JAXUCZ010000014.1  82637004-82637101   c
            689-1009            JAXUCZ010000014.1  82635843-82636163   c
            1010-1082           JAXUCZ010000014.1  82635686-82635758   c
            1083-1154           JAXUCZ010000014.1  82635013-82635084   c
            1155-1673           JAXUCZ010000014.1  82634400-82634918   c
            1674-1846           JAXUCZ010000014.1  82634075-82634247   c
            1847-2005           JAXUCZ010000014.1  82630977-82631135   c
            2006-2081           JAXUCZ010000014.1  82630813-82630888   c
            2082-2249           JAXUCZ010000014.1  82629770-82629937   c
            2250-2312           JAXUCZ010000014.1  82629613-82629675   c
            2313-2394           JAXUCZ010000014.1  82629375-82629456   c
            2395-2568           JAXUCZ010000014.1  82627585-82627758   c
            2569-2686           JAXUCZ010000014.1  82627268-82627385   c
            2687-2838           JAXUCZ010000014.1  82626612-82626763   c
            2839-3003           JAXUCZ010000014.1  82625535-82625699   c
            3004-3307           JAXUCZ010000014.1  82622223-82622526   c
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3307
                     /gene="Smtn"
                     /note="smoothelin"
                     /db_xref="GeneID:289734"
                     /db_xref="RGD:1310216"
     exon            1..153
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            154..268
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2983
                     /gene="Smtn"
                     /codon_start=1
                     /product="smoothelin"
                     /protein_id="NP_001013067.2"
                     /db_xref="GeneID:289734"
                     /db_xref="RGD:1310216"
                     /translation="MADEALAGLDEGALRKLLEVTADLAERRRIRSAIRELQRQELER
                     EEGALASKRFRAERQDNKENWLHSQQREAEQQAALARLAGRLESMNDVEELTTLLRSA
                     GEYEERKLIRAAIRRVRAQEIEAATLAGRLCSRLPSSGSREDSRRQAAHTLDPGKVPE
                     EEKQGQQTEVREPTPTPEDTSQDVTTVTLLLRAPPGGTPSSPASPDSSPTTASPEPLL
                     EPAGAQCPAAEAPVSSEPLPHPSEAPSPEPPMSPAPPSSQGRVISKPLLGSTEPSDTV
                     DSTRGSSNTKRADLAEPKPCQRSLSVLSPRQPTQNQEPTPLAGSSQFRRAGSVRDRVR
                     KFTSDSPVVARLQDGPPRTALASPTPTRLPGPSLMSTTLASSSSSSNSSSPSPSDTSS
                     HKKQRELAHSLAQLQSCPQEEGPGGRSLAPRSLENRAGGPRPCSEEPSTPPPVAVGTG
                     EPGGSMKTTFTIEIKDGRGQASTGRVVLPTGNQRAELTLGLRAPPTLLSTSSGGKNTI
                     THVSSPGTVTRLGSVTHVTTFSHASPGNRGGCNFKMEPDPAEPPSATVEAANGTEQTL
                     DKVNKGPEGRSPLSAEELMAIEDEGILDKMLDQATNFEERKLIRAALRELRQRKRDQR
                     DKERERRLREARARPGESRSNMATTETTTRHSQRAADGSAVSTVTKTERLVHSNDGTQ
                     TARTTTVESSFVRRSENGSSSSSSTTVQTKTFSSSSSSSKKMGSIFDREDQTSSRSGS
                     LAALEKRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGSSGSPGTPRTAVQRSTS
                     FGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQ
                     LSPQNRRQNFEMAFSSAETHADCPQLLDTEDMVRLREPDWKCVYTYIQEFYRCLVQKG
                     LVKTKKS"
     exon            269..417
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            418..511
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            512..590
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            591..688
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1009
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1082
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1154
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1673
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1846
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2005
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2081
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2249
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2312
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2394
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2568
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2686
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2838
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3003
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3307
                     /gene="Smtn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgtctga agcagagtcc aggagacgtt gctgaaccgg ccggggctcc cgggctgcgg
       61 tgcctcccgc ccgtctgccg gtctctactg catctgcccg gtcccgagca aactaacacg
      121 aaatcgcgcc ggaacggcgg gccggattga gagaattctg agtgccaccg ggaccttggt
      181 gggagctgac acacttaaag aactaggagc cagcaagatg gcagatgagg ccttggctgg
      241 gctggatgaa ggagccctcc gaaaactgct ggaggtcaca gcagatctgg cagaacggcg
      301 gcggatccgt tcagccatcc gggagctgca gcggcaggag ctagaacgag aagagggggc
      361 tctggcatcc aaacgtttcc gtgctgagcg gcaagacaac aaggagaact ggctacactc
      421 tcaacagcga gaagccgagc aacaggccgc cctcgcacgg ttggcaggga gactggagtc
      481 catgaacgat gtagaggagt tgaccacact gcttcggagt gctggtgaat acgaggaacg
      541 caagttgatc cgagccgcca tccgccgtgt gcgagctcag gagatcgaag ctgccacctt
      601 ggctgggaga ctatgcagta gacttcccag tagtgggtcc cgagaagaca gcaggaggca
      661 ggcagcacac acattggacc ctggtaaggt gccagaggaa gagaaacagg gacagcagac
      721 agaagtacga gagccaactc cgacaccaga ggacaccagc caggatgtga ccacagtgac
      781 actcctgctg agggccccgc ctgggggcac gcccagctca cctgcctccc ctgacagttc
      841 gcccaccacg gcctctccag agcctctgct ggagcctgct ggggcccagt gtcctgctgc
      901 tgaggctcca gtcagctctg aaccacttcc tcacccttca gaagctccca gccctgagcc
      961 tcccatgtcg ccggcacccc caagctctca ggggcgggtc atcagcaagc ccctgcttgg
     1021 ctccacagag ccctctgata ccgtggactc caccagaggc tcctctaaca ctaagagagc
     1081 agacctggct gaaccgaaac cctgccaacg ctccctgtct gtgctcagtc cccgacagcc
     1141 aacccaaaat caagagccaa cccctcttgc aggatcatcc cagttccgtc gagctggctc
     1201 tgtgagagac cgagtgcgca agttcacatc tgactctcct gtggttgcca ggctccagga
     1261 tggcccaccc cgaacagccc tcgcttcacc gacccccaca aggctcccgg gcccttccct
     1321 catgagcacc acccttgcct cctcctcctc ctccagcaac tcctcctctc caagtcccag
     1381 tgacacttcc tcccacaaga agcaaagaga acttgctcat tccctggccc agcttcagag
     1441 ttgccctcaa gaggagggcc ctggggggcg gagcttggct cccaggtccc ttgaaaacag
     1501 agcagggggg cccaggccct gctcagaaga gcccagtacc ccaccacccg tggccgtcgg
     1561 cactggggag ccagggggca gtatgaagac tacatttacc attgagatca aggatggccg
     1621 tggtcaggcc tccacaggcc gggtggtgct gcctacaggc aaccagagag cagaactgac
     1681 tctgggactg cgggcacccc ctacccttct cagcaccagc agtgggggca agaacaccat
     1741 cacccacgtc agcagccctg ggactgtgac ccgactgggc agtgtcactc atgtcactac
     1801 cttcagccat gcctcccctg gtaaccgagg aggctgcaac tttaagatgg agcccgatcc
     1861 agcagagccc ccctctgcca cagtggaagc agctaatgga acagagcaga ctctggacaa
     1921 agtgaacaaa ggcccagagg ggcggagccc cctgagtgca gaggagctga tggccattga
     1981 ggacgaagga atcctggaca agatgctgga ccaggctacg aactttgaag agcggaagct
     2041 catccgggct gcgctccgtg agctccgaca aagaaagaga gaccagaggg acaaggaacg
     2101 agaacggcgg ctacgagagg cacgggcccg gccaggcgag agccgaagca atatggctac
     2161 tacagagacc accaccaggc acagccagag ggcggctgat ggctcggcgg tcagcacagt
     2221 taccaaaact gagcggctcg tccactccaa tgacggcacg cagactgcgc gcaccaccac
     2281 agtggagtcg agtttcgtga ggcgctcgga gaatggcagc agcagcagca gcagcaccac
     2341 ggtccaaacc aagacctttt cctcttcctc ttcctcatcc aaaaaaatgg gcagtatctt
     2401 cgaccgagag gaccaaacca gctcacgttc tggcagcctg gcggccctcg aaaaacgcca
     2461 ggcagagaag aagaaagagc tcatgaaggc acagagtctg cccaagacct cagcgtccca
     2521 agcacgcaag gccatgattg agaaactaga gaaggaaggc tcttcgggca gtcctggcac
     2581 accccgtaca gcggtacagc gttctaccag cttcggagtc cccaacgcca acagcatcaa
     2641 gcagatgttg ctggactggt gccgagccaa gacccgtggc tacgagcacg tggacatcca
     2701 gaacttctcc tccagctgga gtgatgggat ggctttctgt gccctggtgc acaatttctt
     2761 ccctgaggct tttgactatg gacagcttag cccacaaaac cggcgccaga actttgaaat
     2821 ggccttctca tctgctgaga cccatgcgga ctgcccgcag ctcctggata cagaggacat
     2881 ggtgcggctt cgagagcctg actggaagtg cgtgtacacg tacatccagg agttctaccg
     2941 ctgtctggtc cagaaggggc tggtaaaaac caaaaagtcc taacccctgc ttggggcccc
     3001 acggatgctg gtggactgtg tacccttggt ggaggtggag gacatgatga tcatgggcaa
     3061 aaagccagac cctaagtgcg tcttcaccta cgtgcaatcg ctgtacaacc acctgcggcg
     3121 ccatgagctg cgcctgcgcg gcaagaatgt ctagccactg ctcacaccgc ctgcgctgca
     3181 ggctgctgtc cccacgcccc cagcaccggc ccctcccagt gcgcctgccc actgctgccc
     3241 cgtctgtcga aacacctctc ccccttgtac acacgcagcg ttttgataaa ttattggttt
     3301 tcaacga
//
