LOCUS       NP_001013067             921 aa            linear   ROD 24-JUN-2024
DEFINITION  smoothelin [Rattus norvegicus].
ACCESSION   NP_001013067 XP_001061663 XP_001066720 XP_214078
VERSION     NP_001013067.2
DBSOURCE    REFSEQ: accession NM_001013049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 921)
  AUTHORS   Rensen,S.S., Niessen,P.M., van Deursen,J.M., Janssen,B.J.,
            Heijman,E., Hermeling,E., Meens,M., Lie,N., Gijbels,M.J.,
            Strijkers,G.J., Doevendans,P.A., Hofker,M.H., De Mey,J.G. and van
            Eys,G.J.
  TITLE     Smoothelin-B deficiency results in reduced arterial contractility,
            hypertension, and cardiac hypertrophy in mice
  JOURNAL   Circulation 118 (8), 828-836 (2008)
   PUBMED   18678771
REFERENCE   2  (residues 1 to 921)
  AUTHORS   Bar,H., Wende,P., Watson,L., Denger,S., van Eys,G., Kreuzer,J. and
            Jahn,L.
  TITLE     Smoothelin is an indicator of reversible phenotype modulation of
            smooth muscle cells in balloon-injured rat carotid arteries
  JOURNAL   Basic Res Cardiol 97 (1), 9-16 (2002)
   PUBMED   11998981
  REMARK    GeneRIF: Smoothelin is an indicator of reversible phenotype
            modulation of smooth muscle cells in balloon-injured rat carotid
            arteries.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Aug 29, 2008 this sequence version replaced
            XP_214078.4, XP_001061663.1, XP_001066720.1, NP_001013067.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.114170.1,
                                           SRR21887620.1377835.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..921
                     /product="smoothelin"
                     /calculated_mol_wt=99748
     Region          1..41
                     /region_name="Smoothelin"
                     /note="Smoothelin cytoskeleton protein; pfam12510"
                     /db_xref="CDD:463614"
     Region          73..122
                     /region_name="Smoothelin"
                     /note="Smoothelin cytoskeleton protein; pfam12510"
                     /db_xref="CDD:463614"
     Region          <173..455
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          573..620
                     /region_name="Smoothelin"
                     /note="Smoothelin cytoskeleton protein; pfam12510"
                     /db_xref="CDD:463614"
     Region          806..917
                     /region_name="CH_SMTNB"
                     /note="calponin homology (CH) domain found in smoothelin-B
                     and similar proteins; cd21259"
                     /db_xref="CDD:409108"
     Site            order(807,811,861,863..864,867..868,870,879..887,895,
                     897..898,900..901,904..905,908)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409108"
     CDS             1..921
                     /gene="Smtn"
                     /coded_by="NM_001013049.2:218..2983"
                     /db_xref="GeneID:289734"
                     /db_xref="RGD:1310216"
ORIGIN      
        1 madealagld egalrkllev tadlaerrri rsairelqrq elereegala skrfraerqd
       61 nkenwlhsqq reaeqqaala rlagrlesmn dveelttllr sageyeerkl iraairrvra
      121 qeieaatlag rlcsrlpssg sredsrrqaa htldpgkvpe eekqgqqtev reptptpedt
      181 sqdvttvtll lrappggtps spaspdsspt taspepllep agaqcpaaea pvsseplphp
      241 seapspeppm spappssqgr viskpllgst epsdtvdstr gssntkradl aepkpcqrsl
      301 svlsprqptq nqeptplags sqfrragsvr drvrkftsds pvvarlqdgp prtalasptp
      361 trlpgpslms ttlassssss nssspspsdt sshkkqrela hslaqlqscp qeegpggrsl
      421 aprslenrag gprpcseeps tpppvavgtg epggsmkttf tieikdgrgq astgrvvlpt
      481 gnqraeltlg lrapptllst ssggkntith vsspgtvtrl gsvthvttfs haspgnrggc
      541 nfkmepdpae ppsatveaan gteqtldkvn kgpegrspls aeelmaiede gildkmldqa
      601 tnfeerklir aalrelrqrk rdqrdkerer rlreararpg esrsnmatte tttrhsqraa
      661 dgsavstvtk terlvhsndg tqtartttve ssfvrrseng ssssssttvq tktfssssss
      721 skkmgsifdr edqtssrsgs laalekrqae kkkelmkaqs lpktsasqar kamiekleke
      781 gssgspgtpr tavqrstsfg vpnansikqm lldwcraktr gyehvdiqnf ssswsdgmaf
      841 calvhnffpe afdygqlspq nrrqnfemaf ssaethadcp qlldtedmvr lrepdwkcvy
      901 tyiqefyrcl vqkglvktkk s
//
