LOCUS       NM_001033899            1620 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus spermine synthase (Sms), mRNA.
ACCESSION   NM_001033899 XM_343789
VERSION     NM_001033899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Lemay,S.E., Grobs,Y., Romanet,C., Martineau,S., Salem,M.,
            Shimauchi,T., Breuils-Bonnet,S., Bourgeois,A., Theberge,C.,
            Pelletier,A., Potus,F., Provencher,S., Bonnet,S. and Boucherat,O.
  TITLE     Hypusine Signaling Promotes Pulmonary Vascular Remodeling in
            Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Crit Care Med 209 (11), 1376-1391 (2024)
   PUBMED   38261723
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Fiori,L.M., Wanner,B., Jomphe,V., Croteau,J., Vitaro,F.,
            Tremblay,R.E., Bureau,A. and Turecki,G.
  TITLE     Association of polyaminergic loci with anxiety, mood disorders, and
            attempted suicide
  JOURNAL   PLoS One 5 (11), e15146 (2010)
   PUBMED   21152090
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Wallace,H.M., Fraser,A.V. and Hughes,A.
  TITLE     A perspective of polyamine metabolism
  JOURNAL   Biochem J 376 (Pt 1), 1-14 (2003)
   PUBMED   13678416
  REMARK    Review article
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Lorenz,B., Francis,F., Gempel,K., Boddrich,A., Josten,M.,
            Schmahl,W., Schmidt,J., Lehrach,H., Meitinger,T. and Strom,T.M.
  TITLE     Spermine deficiency in Gy mice caused by deletion of the spermine
            synthase gene
  JOURNAL   Hum Mol Genet 7 (3), 541-547 (1998)
   PUBMED   9467015
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Shirahata,A., Takahashi,N., Beppu,T., Hosoda,H. and Samejima,K.
  TITLE     Effects of inhibitors of spermidine synthase and spermine synthase
            on polyamine synthesis in rat tissues
  JOURNAL   Biochem Pharmacol 45 (9), 1897-1903 (1993)
   PUBMED   8494549
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033899.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000021.1  41332003-41332082
            81-201              JAXUCZ010000021.1  41353221-41353341
            202-295             JAXUCZ010000021.1  41356018-41356111
            296-360             JAXUCZ010000021.1  41356650-41356714
            361-536             JAXUCZ010000021.1  41360282-41360457
            537-691             JAXUCZ010000021.1  41361329-41361483
            692-781             JAXUCZ010000021.1  41362196-41362285
            782-896             JAXUCZ010000021.1  41374938-41375052
            897-976             JAXUCZ010000021.1  41376573-41376652
            977-1092            JAXUCZ010000021.1  41384045-41384160
            1093-1620           JAXUCZ010000021.1  41385353-41385880
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..1620
                     /gene="Sms"
                     /note="spermine synthase"
                     /db_xref="GeneID:363469"
                     /db_xref="RGD:1564826"
     exon            1..80
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1132
                     /gene="Sms"
                     /EC_number="2.5.1.22"
                     /codon_start=1
                     /product="spermine synthase"
                     /protein_id="NP_001029071.1"
                     /db_xref="GeneID:363469"
                     /db_xref="RGD:1564826"
                     /translation="MAAARHSTLDFTLGAKADGEAILKGLQSIFQEQGMAESVHTWQD
                     HGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDSDVQGKQETDCLLNKIEEKMKELSQ
                     DSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGN
                     ILILSGDVNLAESDLAYTRAIMGNGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTM
                     VEIDQMVIDGCKKYMRRTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVIND
                     LTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGR
                     LYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP"
     exon            81..201
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            202..295
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            296..360
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            361..536
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            537..691
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            692..781
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            782..896
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            897..976
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1092
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1620
                     /gene="Sms"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccaggcat ggcacagggc ctcgccacac tatggcagca gcaaggcaca gcacgctcga
       61 cttcacgctc ggcgccaaag ctgatggtga ggccattctg aaaggccttc agtccatctt
      121 tcaggagcag gggatggcag agtcggtgca cacctggcag gaccatgggt atttagcaac
      181 ctacacgaac aagaatggca gctttgccaa tttgagaatt tatccacatg gattggtgtt
      241 gctggacctt cagagttacg acagtgatgt gcaaggcaaa caagaaactg actgcctttt
      301 gaataaaata gaagaaaaaa tgaaagaatt gagtcaagac agtactggtc gggtgaagcg
      361 attaccaccc atagttcgag gaggggccat tgacagatac tggcctactg ctgacgggcg
      421 cctggttgag tatgacatag atgaagtggt gtatgacgaa gactcacctt atcagaacat
      481 taaaattctt cactcaaagc agtttgggaa tattctcatc ctcagcgggg atgttaattt
      541 ggcagagagt gacttggcat ataccagggc catcatgggc aatggtaaag aagactacac
      601 tggcaaagat gtactgattc tgggaggcgg cgatggaggc atattatgtg aaattgtcaa
      661 actgaaacca aagatggtca ctatggtaga gattgaccag atggtaattg atggatgtaa
      721 gaaatacatg cgcagaacat gtggagatgt cttagacaat cttaaaggag attgctatca
      781 ggttcttata gaagactgta ttccagtact gaagaggtac gccaaagaag ggagagagtt
      841 tgattatgtg attaatgatt tgacagctgt ccctatctct acatctccag aagaagattc
      901 cacatgggag tttctcagac tgattcttga cctgtcaatg aaggttctga aacaggatgg
      961 aaaatatttc acacagggga actgtgtcaa cttgactgaa gccctgtcgc tctatgaaga
     1021 acagctgggg cgcctgtatt gtcctgtgga attctcaaaa gagattgtct gtgtcccttc
     1081 atacttggaa ttgtgggtat tttacactgt ttggaagaaa gctaagcctt aaagatgagc
     1141 atcccctgaa tgatgtgttc tgcaagccac cttcctgacc tccatatgct gtatatgcca
     1201 tcacatgagt caggcaactg ttcatgaatt ccttcaagtg gttttctttt taattatttt
     1261 taatttaaaa aagccaatgg gaaaaatgta tattttgatg agttagggtg ttaatttttg
     1321 aaagtcagcc ggaggacaat tagacagccc tgcaaagact acggaatgca ctgaccccct
     1381 agaatgtgat tttagtatct ttattttttc tctgtgtggg gtttgggttt ttgttttggt
     1441 tttagtagac ctttaatttg gacacgtgga ggaatgaaca tcattgtttt gttctggaga
     1501 gaagttcctg atagtgtttc tcccctctca cccccaaatt gacttagata ttaaaatttg
     1561 gtgcttttaa aggtttaaga agagtgattg gcagtgcttc aattaaagtg acaaaggaga
//
