LOCUS       NM_001025737            1923 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus sphingomyelin phosphodiesterase, acid-like 3B
            (Smpdl3b), mRNA.
ACCESSION   NM_001025737
VERSION     NM_001025737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Gorelik A, Heinz LX, Illes K, Superti-Furga G and Nagar B.
  TITLE     Crystal Structure of the Acid Sphingomyelinase-like
            Phosphodiesterase SMPDL3B Provides Insights into Determinants of
            Substrate Specificity
  JOURNAL   J Biol Chem 291 (46), 24054-24064 (2016)
   PUBMED   27687724
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Heinz LX, Baumann CL, Koberlin MS, Snijder B, Gawish R, Shui G,
            Sharif O, Aspalter IM, Muller AC, Kandasamy RK, Breitwieser FP,
            Pichlmair A, Bruckner M, Rebsamen M, Bluml S, Karonitsch T, Fauster
            A, Colinge J, Bennett KL, Knapp S, Wenk MR and Superti-Furga G.
  TITLE     The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate
            Immunity
  JOURNAL   Cell Rep 11 (12), 1919-1928 (2015)
   PUBMED   26095358
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG and Cooper GJ.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097983.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097983.1, SRR8487226.36320.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1923
                     /gene="Smpdl3b"
                     /note="sphingomyelin phosphodiesterase, acid-like 3B"
                     /db_xref="GeneID:362619"
                     /db_xref="RGD:1307458"
     exon            1..169
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1479
                     /gene="Smpdl3b"
                     /note="acid sphingomyelinase-like phosphodiesterase 3b"
                     /codon_start=1
                     /product="acid sphingomyelinase-like phosphodiesterase 3b
                     precursor"
                     /protein_id="NP_001020908.1"
                     /db_xref="GeneID:362619"
                     /db_xref="RGD:1307458"
                     /translation="MTLLGWLIFLASWGVAGAELGRFWHISDLHLDPNYTVSKDPLRV
                     CPSAGSQPVLNAGPWGDYLCDSPWALINSSIYAMKEIEPKPDFIFWTGDDTPHVPNER
                     LGEGAVLSMVDRLTNLIKEVFPGTKVYAALGNHDFHPKNQLPAQSNSIYTHVAELWRP
                     WLSNESFTLFKEGAFYSEKLPSPSKTGRVVVLNTNLYYSSNEQTAGMADPGQQFQWLG
                     DVLSNASRNGEMVYIIGHVPPGFFEKTQDKAWFRESFNEEYLKVVQQHHRVIAGQFFG
                     HHHTDSFRMFYSSTGAPISVMFLTPGVTPWKTTLPGVVDGANNPAIRIFEYDRATLNL
                     KDMVTYYLNLRQADTQETPQWEQEYRLTEAYEVQDASTSSMYTALTRIASEQHILQRY
                     YVYNSVSYSHQPCEDVCRREHVCAIQHVEFDTYATCLHGLGANLVPGFLLILTLLTSL
                     HVLEVL"
     exon            170..383
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     exon            384..481
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     exon            482..625
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     exon            626..798
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     exon            799..979
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1113
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1898
                     /gene="Smpdl3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaagttc tgctcagaca cgtgtctagc cacacgctgg tgggaacctg cggcgcggcg
       61 cggacagacc tggaggagct tcagccgccg tggtgtgatc tccagaggat gacgctgctc
      121 gggtggctga tattcctggc ttcctgggga gtcgcagggg ctgaattagg gaggttctgg
      181 cacatctccg acctccatct ggaccccaac tacacagtat ccaaagaccc cctccgggtg
      241 tgcccgtcag ccggctccca gcccgtgcta aatgcaggcc cctggggtga ctacctctgc
      301 gattctcctt gggcccttat caactcttcc atctatgcca tgaaggagat cgaaccaaag
      361 ccagacttca ttttctggac aggggatgac acaccacacg tccccaatga gaggctgggg
      421 gagggagctg tgctgtcgat ggtggaccgt ctgaccaacc tcatcaagga ggtctttcca
      481 ggtactaaag tctatgctgc tctgggaaat catgactttc accctaagaa ccagctccca
      541 gcccagagca acagcatcta cactcatgtg gcagagctgt ggagaccctg gcttagcaac
      601 gaatccttca ctctcttcaa agaaggtgcc ttctattctg agaagttgcc gagtcccagc
      661 aagacagggc gagttgtggt cctcaacacc aatctgtact acagcagcaa tgagcagaca
      721 gccggcatgg ccgacccagg ccagcagttc cagtggctag gagatgtcct aagcaatgca
      781 tctcggaacg gggagatggt gtacattatt ggccacgtgc ccccagggtt ctttgagaag
      841 acacaggaca aggcctggtt ccgagagagc ttcaacgagg agtatctgaa ggtggttcag
      901 cagcaccatc gcgtcatagc agggcagttc tttgggcacc accataccga cagcttccga
      961 atgttctaca gcagcacagg tgcccccata agcgtcatgt tcctcacacc cggggtcacc
     1021 ccgtggaaga ccacattacc tggagtggtc gatggggcca acaatccagc gatccgcatt
     1081 tttgagtatg accgagccac tctcaacttg aaggacatgg tgacttacta cttgaacctg
     1141 aggcaggcgg atacacaaga gaccccgcag tgggagcagg aataccgcct gacagaggcc
     1201 tacgaggtgc aggacgccag caccagttct atgtatacag cactgacccg catcgccagt
     1261 gagcagcaca tcctgcaacg ttattacgtc tacaactcgg tcagctacag ccatcagccc
     1321 tgtgaggacg tctgccgaag ggagcatgtg tgcgccatac agcacgtgga gttcgacact
     1381 tacgccacct gcttgcatgg tcttggtgcc aacctggtac ctggtttcct gctcatactg
     1441 actctgctga cgagcctaca cgtattggag gtgctatgac tgtaggcact gccagcctac
     1501 cctcttactt ggttcgtctt tctccctggt aaaactgggc aacattaccc aatggagaga
     1561 gagggagatg aattttgcca tcagtctgtg gagagtaagg tgggatggga catttggatt
     1621 caccagagag ggcgctaaga agcacatttc ttctgagttt tatgttttat ccacagagct
     1681 tgtttgcggt acatgtcttg gtgcattatt ccctttaata caaacatcaa actatcatgc
     1741 acttgatcgc cacagtaaag tgaacccgca ggaagatggg ccctggagag tctgtgcttt
     1801 tgagtccctg ctcaaggtct aaaactggga acccacgtgg tctgcaaaat cccttggtac
     1861 ttttaaataa aagacttttc tgatttggtt tcgcaacaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaa
//
