LOCUS       NM_001005539            1706 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus sphingomyelin phosphodiesterase, acid-like 3A
            (Smpdl3a), mRNA.
ACCESSION   NM_001005539 XM_215397
VERSION     NM_001005539.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Lim,S.M., Yeung,K., Tresaugues,L., Ling,T.H. and Nordlund,P.
  TITLE     The structure and catalytic mechanism of human sphingomyelin
            phosphodiesterase like 3a--an acid sphingomyelinase homologue with
            a novel nucleotide hydrolase activity
  JOURNAL   FEBS J 283 (6), 1107-1123 (2016)
   PUBMED   26783088
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Heinz,L.X., Baumann,C.L., Koberlin,M.S., Snijder,B., Gawish,R.,
            Shui,G., Sharif,O., Aspalter,I.M., Muller,A.C., Kandasamy,R.K.,
            Breitwieser,F.P., Pichlmair,A., Bruckner,M., Rebsamen,M., Bluml,S.,
            Karonitsch,T., Fauster,A., Colinge,J., Bennett,K.L., Knapp,S.,
            Wenk,M.R. and Superti-Furga,G.
  TITLE     The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate
            Immunity
  JOURNAL   Cell Rep 11 (12), 1919-1928 (2015)
   PUBMED   26095358
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Traini,M., Quinn,C.M., Sandoval,C., Johansson,E., Schroder,K.,
            Kockx,M., Meikle,P.J., Jessup,W. and Kritharides,L.
  TITLE     Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel
            nucleotide phosphodiesterase regulated by cholesterol in human
            macrophages
  JOURNAL   J Biol Chem 289 (47), 32895-32913 (2014)
   PUBMED   25288789
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Yang,Y., Yin,J., Baumgartner,W., Samapati,R., Solymosi,E.A.,
            Reppien,E., Kuebler,W.M. and Uhlig,S.
  TITLE     Platelet-activating factor reduces endothelial nitric oxide
            production: role of acid sphingomyelinase
  JOURNAL   Eur Respir J 36 (2), 417-427 (2010)
   PUBMED   19926744
  REMARK    GeneRIF: Platelet-activating factor reduces endothelial nitric
            oxide production: role of acid sphingomyelinase
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Wright,K.O., Messing,E.M. and Reeder,J.E.
  TITLE     Increased expression of the acid sphingomyelinase-like protein
            ASML3a in bladder tumors
  JOURNAL   J Urol 168 (6), 2645-2649 (2002)
   PUBMED   12442002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082029.1.
            
            On Oct 8, 2004 this sequence version replaced XM_215397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..1706
                     /gene="Smpdl3a"
                     /note="sphingomyelin phosphodiesterase, acid-like 3A"
                     /db_xref="GeneID:294422"
                     /db_xref="RGD:1359277"
     exon            1..117
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1352
                     /gene="Smpdl3a"
                     /EC_number="3.6.1.15"
                     /note="ASM-like phosphodiesterase 3a; acid
                     sphingomyelinase-like phosphodiesterase 3A; 2',3'-cGAMP
                     phosphodiesterase SMPDL3A; cyclic GMP-AMP
                     phosphodiesterase SMPDL3A"
                     /codon_start=1
                     /product="cyclic GMP-AMP phosphodiesterase SMPDL3A
                     precursor"
                     /protein_id="NP_001005539.1"
                     /db_xref="GeneID:294422"
                     /db_xref="RGD:1359277"
                     /translation="MALPGNFLCCLLVAWLCDPGLGVPLAPAYGAPAVGQFWHVTDLH
                     LDPTYHITDDHTKVCASSKGANVSNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFM
                     IWTGDSPPHVPVRELSTGSVIEVITNMTVTVQNLFPNLQVFPALGNHDYWPQDQLPIA
                     TSKVYSAVSDLWKPWLDEEAISTLRKGGFYSQKVASNPDLRIISLNTNLYYGPNIMTL
                     NKTDPANQFEWLENTLNSSLRNKEKVYVIAHVPVGYLPYATKTPAMRQYYNEKLVDIF
                     RRYSSVIAGQFYGHTHRDSLMVLSDKNGNPINSVFVAPAVTPVKGVLEKETNNPGVRL
                     FQYKPGDYTLLDMLQYYLNLTEANLKGESNWTLEYTLTQAYGVADLQPKSLHGLAQQL
                     ATIDSKQFLKYYHYFFVSYDSSAPCDQRCKTLQICAIMNLDLVSYEDCLKRHL"
     exon            118..331
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     exon            332..476
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     exon            477..573
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     exon            574..743
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     exon            744..924
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1049
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1661
                     /gene="Smpdl3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcagtgtc ctccatggcg ttgccgggca acttcctctg ctgcctgctg gttgcctggc
       61 tctgcgatcc ggggctcggg gtgcccttgg cgcccgcgta tggcgcccca gctgtggggc
      121 aattttggca cgtgactgac ttacatctag accctactta ccacattaca gatgaccata
      181 ccaaagtctg tgcttcatct aaaggtgcaa atgtctccaa tcccggccct tttggagatg
      241 tcctgtgtga ctctccatat caacttattt tatcagcctt tgattttatt aagaattcag
      301 gacaagaagc atctttcatg atatggacag gggacagccc acctcatgtc ccagtacgtg
      361 aactgtccac aggctctgtt atagaggtga tcactaacat gacagtgact gtccagaacc
      421 tgtttccaaa cctccaggtt ttccctgcac tgggcaatca tgactactgg ccacaggacc
      481 agctgccaat agccaccagt aaggtctaca gtgctgtcag tgacctctgg aaaccctggc
      541 ttgatgaaga agctattagc actttaagga aaggtggttt ttactcacag aaagttgcaa
      601 gtaatccaga cttgaggatc attagcctaa acacaaactt gtactatggc ccaaatatca
      661 tgaccctgaa caagacagac ccagcaaatc agtttgaatg gctggaaaat acactcaaca
      721 gctctctgcg aaataaggag aaggtatacg tcatagcaca tgtgccagtg ggctatctcc
      781 cttatgcaac caagacccca gcaatgaggc agtactataa tgagaaactg gttgatattt
      841 tcagaagata cagctccgtt attgccggac agttctatgg ccacacccat agagacagcc
      901 ttatggtcct ttcagataaa aacggtaatc caataaattc tgtgtttgtg gcacctgctg
      961 ttacaccagt gaaaggagtt ttagaaaaag agaccaacaa tcctggcgtc cgtctgtttc
     1021 agtacaagcc tggtgattac acactgctgg acatgttgca gtattacttg aacttgacag
     1081 aagccaatct aaaaggagaa tccaattgga ccctggagta caccttgact caggcctatg
     1141 gtgtcgcaga cctgcagcca aagagcttac atggattagc tcagcagctt gctaccatag
     1201 acagcaagca gttcctgaaa tactaccatt atttttttgt gagttatgac agcagcgcac
     1261 cttgtgatca acgatgtaag accttacaga tatgtgcaat tatgaatctt gaccttgttt
     1321 cctatgagga ttgccttaaa cgacatttat aaagcatagt cactggtatt ccagttgtgt
     1381 ttgtaggaaa agcagtcaca tcattggtgc tcctgtgatc agcttgtgga atactgaggg
     1441 cattggaaaa gttactttct gtgctgtgtt acttgtgacg ttcagaggca gacaccagta
     1501 acattcaaaa ttaatttcac acgctgtgta cctttaaacc gttcattaat ggagtggcat
     1561 ttggacataa atatcttgtc ttccgacttt atgtaattat acctaaagta tatgcttgta
     1621 aaacttgcca tctttgcaat aaagcaggtg acttctctgt gaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
