LOCUS       NM_001304747            1972 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus sphingomyelin phosphodiesterase 5 (Smpd5), mRNA.
ACCESSION   NM_001304747 XM_002726919 XM_002729839
VERSION     NM_001304747.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Wu BX, Rajagopalan V, Roddy PL, Clarke CJ and Hannun YA.
  TITLE     Identification and characterization of murine
            mitochondria-associated neutral sphingomyelinase (MA-nSMase), the
            mammalian sphingomyelin phosphodiesterase 5
  JOURNAL   J Biol Chem 285 (23), 17993-18002 (2010)
   PUBMED   20378533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166812.1.
            
            On or before Apr 28, 2015 this sequence version replaced
            XM_002729839.4, XM_002726919.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            inferred exon combination          :: based on alignments, homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1189              BC166812.1         1-1189
            1190-1279           BC166812.1         1259-1348
            1280-1972           BC166812.1         1349-2041
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1972
                     /gene="Smpd5"
                     /note="sphingomyelin phosphodiesterase 5"
                     /db_xref="GeneID:100359829"
                     /db_xref="RGD:2323312"
     exon            1..975
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1569
                     /gene="Smpd5"
                     /EC_number="3.1.4.12"
                     /note="RGD1565316 protein-like"
                     /codon_start=1
                     /product="sphingomyelin phosphodiesterase 5"
                     /protein_id="NP_001291676.1"
                     /db_xref="GeneID:100359829"
                     /db_xref="RGD:2323312"
                     /translation="MNLPDVPRLRSPVPQEPSPGWPQTPDPLRPSPFPNPVLQTLYSL
                     SRMLLFPAYWSLDRLLGCWAPVSRSGSLRWLKVLAGSGAALLPLVVVGLPLALVGLVL
                     WLPLQLCRRPFCYQPPPSCWVWPQPWRPPAERQRCFVFLTANLCLFPHGLAHFNNLSN
                     SQQRADAVGAVLLDGLRSSQYGVTEPRQPLPKVPGGVLKATLPMGLDFVCLQEVFDLR
                     AARRLVRILVPNLGPVLYDVGTFGLVAGPYIKVLGSGLLLASRYPLLRATFRCFPNAR
                     REDAMASKGLLSVQAQLGILDGRRIVGYLHCTHLQAPLEDGHIRCKQLTLLLEWVEEF
                     EAESRQSGEAVAFSVLLGDLNFDNCSQDHAKEQGHKFFSCFKDPCRLGPCQEQPWALG
                     TILNNSTLHQSIISSPEMLRRALEQEKGRRLYLAGPLHGNYSAQSWKGRRLDYITYRG
                     VPGSRLSPEAEQVTFSTAFAGLTDHLAMGLKLQVVCS"
     exon            976..1048
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1189
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1279
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1343
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1479
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1924
                     /gene="Smpd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcattacg agctgcgcac acaggttgtg ccacctggtc ttgacctccc ggcagctggc
       61 agctcgtgtg gtctcctaag gattcaactc tcacgctgga aaccaatgaa tctccctgac
      121 gttccgcggc tacggagccc tgtaccccaa gagccttcac ctggctggcc ccagacaccc
      181 gaccctctga ggccttcacc tttcccgaac cccgtgctgc aaaccctgta cagtttatcc
      241 cgcatgctgc tcttcccggc ttactggtct ctggaccggt tgctgggttg ctgggcgcca
      301 gtatcgcgat ccggcagctt gaggtggctc aaagtcctgg caggaagtgg ggcggcgttg
      361 ctacctctgg tggtggtcgg tctacccttg gcgttggttg gccttgtgct ctggctgccc
      421 ctccaacttt gtcgccgccc cttctgctat cagccccctc catcatgctg ggtgtggcca
      481 cagccctggc gcccgcccgc tgagcgccag cgttgctttg tctttctcac tgctaatctg
      541 tgcctgttcc cccacggact ggcacacttt aacaatttgt cgaatagtca gcagcgggcg
      601 gatgctgttg gggccgtact gctagatggc cttcggtcgt cacagtatgg ggttaccgaa
      661 cctaggcagc cgctgcctaa ggtgcctggt ggtgtgctga aggccacatt acctatgggt
      721 ttggacttcg tgtgtctgca ggaagtgttc gacctccgcg cagctcgtcg tctcgtgcgc
      781 attttggtac caaatctggg cccggttcta tatgatgtag gcacatttgg cttagtggcc
      841 gggccgtaca ttaaggtact gggtagtggg cttctactgg cctcgcgcta cccgctgctg
      901 cgtgccacct tccgttgctt tcctaacgct cgtcgcgagg acgccatggc ctccaaaggt
      961 ctattatccg tccaggcgca gctaggcatc ctggacgggc gccgcatcgt gggatacctt
     1021 cattgtacac acttgcaggc accccttgag gatggacata ttcgctgcaa acagctgacg
     1081 ctgctgctgg aatgggtgga ggagttcgag gctgagagcc gccagagtgg tgaggctgtg
     1141 gctttcagcg tccttctggg agatctaaac tttgacaact gctcccaaga tcatgcaaag
     1201 gagcagggac ataaattctt cagctgtttt aaggaccctt gccggctagg cccttgccag
     1261 gagcagccct gggccttggg gacaatcttg aataattcca cgctacacca gtccattatc
     1321 agctccccag agatgcttcg gagggccttg gagcaagaaa aagggcgccg cctctacctg
     1381 gctggacccc ttcatggaaa ttactcagct caatcctgga agggccggcg tctggactat
     1441 atcacctacc gcggagtacc tgggagtcgc ctgagtccag aggcggagca ggtgacattc
     1501 agtactgcgt ttgcgggact cacggaccac ttggctatgg gcctgaagct tcaagttgta
     1561 tgctcctgac gctggcgcac agacaagggg atgactatcg agaaagacta ccatggggag
     1621 cggagcccaa atatcgtgcg attcaaagga tctttattgt ggggcactca tacggcttcc
     1681 tgggcgcggc ggtactcgaa tacactgccg cgctcgggga aggctggaaa tagcgggggc
     1741 gagcctggtg gtggcgctgg atcctccggg tctccgtagc ccccaccccc aggcgtgtgg
     1801 aggcagaaca cgtcctgcga agagcaagtg caacacaggt gtggccttgt cccagtaaga
     1861 gacaaatcac tcaaccgccc tgtttccgtt tgggagccaa attaaatttt tgtatccctg
     1921 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
