LOCUS       NM_001006997            2334 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus sphingomyelin phosphodiesterase 1 (Smpd1), mRNA.
ACCESSION   NM_001006997 XM_219098
VERSION     NM_001006997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Acuna M, Castro-Fernandez V, Latorre M, Castro J, Schuchman EH,
            Guixe V, Gonzalez M and Zanlungo S.
  TITLE     Structural and functional analysis of the ASM p.Ala359Asp mutant
            that causes acid sphingomyelinase deficiency
  JOURNAL   Biochem Biophys Res Commun 479 (3), 496-501 (2016)
   PUBMED   27659707
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Babenko NA, Garkavenko VV, Storozhenko GV and Timofiychuk OA.
  TITLE     Role of acid sphingomyelinase in the age-dependent dysregulation of
            sphingolipids turnover in the tissues of rats
  JOURNAL   Gen Physiol Biophys 35 (2), 195-205 (2016)
   PUBMED   26830134
  REMARK    GeneRIF: summary, the data above strongly suggest that the
            age-dependent up-regulation of ASMase plays an important role in
            the modulation of ceramide and SM contents in rat tissues and that
            imipramine and zoledronic acid are useful tools for SM turnover.
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Nusshold C, Uellen A, Bernhart E, Hammer A, Damm S, Wintersperger
            A, Reicher H, Hermetter A, Malle E and Sattler W.
  TITLE     Endocytosis and intracellular processing of BODIPY-sphingomyelin by
            murine CATH.a neurons
  JOURNAL   Biochim Biophys Acta 1831 (12), 1665-1678 (2013)
   PUBMED   23973266
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Qin J and Dawson G.
  TITLE     Evidence for coordination of lysosomal (ASMase) and plasma membrane
            (NSMase2) forms of sphingomyelinase from mutant mice
  JOURNAL   FEBS Lett 586 (22), 4002-4009 (2012)
   PUBMED   23046545
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Qin J, Berdyshev E, Poirer C, Schwartz NB and Dawson G.
  TITLE     Neutral sphingomyelinase 2 deficiency increases hyaluronan
            synthesis by up-regulation of Hyaluronan synthase 2 through
            decreased ceramide production and activation of Akt
  JOURNAL   J Biol Chem 287 (17), 13620-13632 (2012)
   PUBMED   22383528
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Nassogne MC, Lizarraga C, N'Kuli F, Van Bambeke F, Van Binst R,
            Wallemacq P, Tulkens PM, Mingeot-Leclercq MP, Levade T and Courtoy
            PJ.
  TITLE     Cocaine induces a mixed lysosomal lipidosis in cultured
            fibroblasts, by inactivation of acid sphingomyelinase and
            inhibition of phospholipase A1
  JOURNAL   Toxicol Appl Pharmacol 194 (2), 101-110 (2004)
   PUBMED   14736491
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Gorska M, Dobrzyn A, Zendzian-Piotrowska M and Gorski J.
  TITLE     Effect of streptozotocin-diabetes on the functioning of the
            sphingomyelin-signalling pathway in skeletal muscles of the rat
  JOURNAL   Horm Metab Res 36 (1), 14-21 (2004)
   PUBMED   14983401
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Loidl A, Sevcsik E, Riesenhuber G, Deigner HP and Hermetter A.
  TITLE     Oxidized phospholipids in minimally modified low density
            lipoprotein induce apoptotic signaling via activation of acid
            sphingomyelinase in arterial smooth muscle cells
  JOURNAL   J Biol Chem 278 (35), 32921-32928 (2003)
   PUBMED   12816958
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Sikora J, Pavlu-Pereira H, Elleder M, Roelofs H and Wevers RA.
  TITLE     Seven novel acid sphingomyelinase gene mutations in Niemann-Pick
            type A and B patients
  JOURNAL   Ann Hum Genet 67 (Pt 1), 63-70 (2003)
   PUBMED   12556236
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Schissel SL, Schuchman EH, Williams KJ and Tabas I.
  TITLE     Zn2+-stimulated sphingomyelinase is secreted by many cell types and
            is a product of the acid sphingomyelinase gene
  JOURNAL   J Biol Chem 271 (31), 18431-18436 (1996)
   PUBMED   8702487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083780.1.
            
            On Nov 22, 2004 this sequence version replaced XM_219098.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083780.1, SRR8487227.9001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2334
                     /gene="Smpd1"
                     /note="sphingomyelin phosphodiesterase 1"
                     /db_xref="GeneID:308909"
                     /db_xref="RGD:1549719"
     exon            1..398
                     /gene="Smpd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1976
                     /gene="Smpd1"
                     /EC_number="3.1.4.12"
                     /note="sphingomyelin phosphodiesterase 1, acid lysosomal"
                     /codon_start=1
                     /product="sphingomyelin phosphodiesterase"
                     /protein_id="NP_001006998.1"
                     /db_xref="GeneID:308909"
                     /db_xref="RGD:1549719"
                     /translation="MPHHGASSGQGHLRAGWEQRLERSLPAPKLGLLWMGLGLALVLA
                     LFDSTVLWVPARAYPLPSQGHSVKFSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLK
                     KEPNVARVGSVAIKMCKMLNIAPLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLG
                     SSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGTDPN
                     CADPLCCRRGSGWPPNSRTGAGYWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGD
                     IPAHDVWQQSRQDQLRALNTITDLVWKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQ
                     SSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLI
                     NSTDPAGQLQWLVDELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAG
                     QFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSATTFINLNPGYRVYQIDGNYPGSSHV
                     VLDHETYILNLTQANAPGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRADEQLFQ
                     TFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDAHSLWSRP
                     LLC"
     exon            399..1171
                     /gene="Smpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1343
                     /gene="Smpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1420
                     /gene="Smpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1566
                     /gene="Smpd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..2310
                     /gene="Smpd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtctccaga gctactgggg ccccgagggc cagccagggc ctcggcctgc ggggcctgga
       61 ggggcgatcc agtcctgtct acgagcttgg caatgcccca ccacggagcg tcatccggcc
      121 agggccatct cagagccggc tgggagcaga gactggagag gtccttaccg gcacccaaat
      181 tgggactcct ttggatgggg ctgggcttgg ctctggtcct ggctctgttt gactccacgg
      241 ttctctgggt tcctgccaga gcttatcctc ttccctccca aggccattct gtcaaattca
      301 gtgcggtagc gccgcagctc cagaatgcct ttgggtggag gaacctcacc tgccccgcct
      361 gcaaagtctt atttactgct ctcaactatg ggctgaagaa ggagcccaat gtggcacgag
      421 taggctctgt ggccatcaag atgtgcaaga tgctgaacat agcgccacta aatgtgtgcc
      481 agtcagctgt tcatctcttt gaggacgatg tggtggacgt gtggacacgc tcagttctga
      541 gcccttcaga agcttgtggc ttgcttctgg gctcctcttg tgggcactgg gacatctttt
      601 caacttggaa catctctttg ccatcagtgc cgaagccacc cccaaagcca ccgagcccac
      661 cagccccagg tgcccctgtc agccgtgtcc tcttccttac tgaccttcac tgggaccatg
      721 actacctgga gggcacagac cctaactgtg cagatcccct ctgctgccgc agggggtctg
      781 gatggccgcc caactcacgg acaggggctg ggtactgggg agagtacagc aagtgtgacc
      841 tgcccctgcg aacgctagag agcctgttga aagggctggg ccccgccggc ccttttgaaa
      901 tggtgtactg gacaggagac atccctgccc atgatgtctg gcaacagtct cgacaagatc
      961 agctaagggc cctgaacacc atcacagacc tcgtgtggaa gttcttgggc cctgtaccgg
     1021 tgtaccctgc tgtgggcaac catgagagta ctcctgtcaa tggcttccct ccccccttca
     1081 taaagggaaa ccagtcttca caatggcttt atgaagccat ggccaaggca tgggaaccct
     1141 ggttaccagc tgacgccctt cacaccctca gaattggggg cttctatgcc ctcaccccac
     1201 gccctggcct ccgcctcatc tctctcaata tgaatttttg ttcccgtgag aacttttggc
     1261 tcttgatcaa ctccacagat cctgctggac aactccagtg gctggtggac gagcttcagg
     1321 ctgctgagaa tcgaggagac aaagtgcata taattgggca cattcctcca ggacattgcc
     1381 tcaagagctg gagttggaac tattacaaaa ttatagccag gtatgaaaac actctggctg
     1441 gtcagttctt tggccacact catgtggatg agtttgagat cttctatgat gaggaaactc
     1501 tgagccgccc actagccgta gccttcctgg gacccagtgc taccaccttt atcaacctta
     1561 atcctggcta ccgagtttac caaatagatg gaaactaccc gggaagctct catgtggtcc
     1621 tggaccatga gacctacatc ctgaatctga cccaggccaa tgcgccgggg ggcacgccca
     1681 gctggaagcg gctctacagg gctcgggaaa cctatggact tccagatgcg atgcctgcct
     1741 cctggcacaa cctggtctac cgcatgaggg ctgatgagca gctcttccag accttctggt
     1801 ttctctacca taagggccac ccaccttcag agccctgcgg cacaccctgc cgcctggcca
     1861 ctctgtgtgc ccagctctca gcacgtgcag acagccctgc tctgtgtcgc cacttgatgc
     1921 ccaatgggag cctcccagat gcccatagct tgtggtcacg gcccctgctg tgctagtgtg
     1981 ggaaaagttc acatattagc aaagggatgg attcctgagt atcgctgatc tacctgaggc
     2041 aaaagctttc ggggaaggag ccagccaggc cagggaacaa gcctcctcat gaaagcttgt
     2101 ttggctagac tgagggaggt tttggctgtc ctatttatgc ccagtatctg gattacccct
     2161 ggggctgatg tctttaaggc cacaaagccg aggtcttagt gctctggatt gtagacagga
     2221 gctattgccc cagcctgtgc tatgcacctc tgaactctgt actgttacct gatcctgcca
     2281 ggctgttaaa ataaagagac tcatacttca aaaaaaaaaa aaaaaaaaaa aaaa
//
