LOCUS       NM_001134854            2282 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus spermine oxidase (Smox), mRNA.
ACCESSION   NM_001134854 XM_001079707 XM_218704
VERSION     NM_001134854.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2282)
  AUTHORS   Han,Z., Mou,Z., Jing,Y., Jiang,R. and Sun,T.
  TITLE     CircSmox knockdown alleviates PC12 cell apoptosis and inflammation
            in spinal cord injury by miR-340-5p/Smurf1 axis
  JOURNAL   Immun Inflamm Dis 11 (4), e824 (2023)
   PUBMED   37102659
  REMARK    GeneRIF: CircSmox knockdown alleviates PC12 cell apoptosis and
            inflammation in spinal cord injury by miR-340-5p/Smurf1 axis.
REFERENCE   2  (bases 1 to 2282)
  AUTHORS   Murray-Stewart,T., Wang,Y., Goodwin,A., Hacker,A., Meeker,A. and
            Casero,R.A. Jr.
  TITLE     Nuclear localization of human spermine oxidase isoforms - possible
            implications in drug response and disease etiology
  JOURNAL   FEBS J 275 (11), 2795-2806 (2008)
   PUBMED   18422650
REFERENCE   3  (bases 1 to 2282)
  AUTHORS   Ferioli,M.E., Berselli,D. and Caimi,S.
  TITLE     Effect of mitoguazone on polyamine oxidase activity in rat liver
  JOURNAL   Toxicol Appl Pharmacol 201 (2), 105-111 (2004)
   PUBMED   15541750
REFERENCE   4  (bases 1 to 2282)
  AUTHORS   Cervelli,M., Bellini,A., Bianchi,M., Marcocci,L., Nocera,S.,
            Polticelli,F., Federico,R., Amendola,R. and Mariottini,P.
  TITLE     Mouse spermine oxidase gene splice variants. Nuclear subcellular
            localization of a novel active isoform
  JOURNAL   Eur J Biochem 271 (4), 760-770 (2004)
   PUBMED   14764092
REFERENCE   5  (bases 1 to 2282)
  AUTHORS   Wallace,H.M., Fraser,A.V. and Hughes,A.
  TITLE     A perspective of polyamine metabolism
  JOURNAL   Biochem J 376 (Pt 1), 1-14 (2003)
   PUBMED   13678416
  REMARK    Review article
REFERENCE   6  (bases 1 to 2282)
  AUTHORS   Vujcic,S., Liang,P., Diegelman,P., Kramer,D.L. and Porter,C.W.
  TITLE     Genomic identification and biochemical characterization of the
            mammalian polyamine oxidase involved in polyamine back-conversion
  JOURNAL   Biochem J 370 (Pt 1), 19-28 (2003)
   PUBMED   12477380
REFERENCE   7  (bases 1 to 2282)
  AUTHORS   Vujcic,S., Diegelman,P., Bacchi,C.J., Kramer,D.L. and Porter,C.W.
  TITLE     Identification and characterization of a novel flavin-containing
            spermine oxidase of mammalian cell origin
  JOURNAL   Biochem J 367 (Pt 3), 665-675 (2002)
   PUBMED   12141946
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161894.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_001134854.2.
            
            On or before Sep 11, 2008 this sequence version replaced
            XM_218704.4, XM_001079707.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132275, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2282
                     /gene="Smox"
                     /note="spermine oxidase"
                     /db_xref="GeneID:308652"
                     /db_xref="RGD:1306049"
     exon            1..510
                     /gene="Smox"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1970
                     /gene="Smox"
                     /EC_number="1.5.3.16"
                     /codon_start=1
                     /product="spermine oxidase"
                     /protein_id="NP_001128326.1"
                     /db_xref="GeneID:308652"
                     /db_xref="RGD:1306049"
                     /translation="MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAARALL
                     EQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYQLAEANGLLEET
                     TDGERSVGRISLYSKNGVACYLTNRGRRIPKDVVEEFSDLYNEVYNLTQEFFRNGKPV
                     NAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQYLKVESCESSSHSIDEVS
                     LSAFGEWTEIPGAHHIIPSGFMRVVELLAKGIPPHVIQLGKPVRCIHWDQASARPRGP
                     EIEPRGEGDHNHDAGEGGQSGENPQQGRWDEDEQWPVVVECEDCEVIPADHVIVTVSL
                     GVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEA
                     ESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEICTE
                     MLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSK
                     TAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGP"
     exon            511..737
                     /gene="Smox"
                     /inference="alignment:Splign:2.1.0"
     exon            738..911
                     /gene="Smox"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1671
                     /gene="Smox"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1832
                     /gene="Smox"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2256
                     /gene="Smox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcatctctt ctcaggtcac ctcttgtcct actttagact ggtggccagg gaactggcac
       61 agcttaaaga gatttgagag tgggattgat ggatttcacc tcttgacttg ttggtagatc
      121 ctaaaacacg tttcctcctt ggctgtcata tctctctgcc ctttgctgtc tccctttctg
      181 catttttgga gggtctctct tcttgatcag gtctttaggg agtgagggca gcttgcagtg
      241 agagccgacc cctacccctc ccctctcttg tcacaggctc ctagaaagtg agtacggacg
      301 gtatgcaaag ttgtgaatcc agtggcgaca gtgcggatga ccctctcagt cgtggcctac
      361 ggagaagggg acagcctcgt gtggtggtga tcggcgccgg cttggctggc ctggctgcag
      421 ctcgagcact tctggagcag ggcttcacgg atgtcactgt gcttgaggct tccagccaca
      481 ttgggggccg tgtgcagagc gtgaaacttg gacacgccac ctttgagctg ggagccacct
      541 ggatccatgg atcccacggg aaccctatct atcaactagc agaagccaat ggccttttgg
      601 aagagacaac agatggggag cgcagcgtgg gccgcatcag cctctactcc aagaatggcg
      661 tggcctgcta ccttaccaac cgtggccgcc gcatccccaa ggacgtggtt gaggaattca
      721 gtgatttata caacgaggtc tataacttga cccaggagtt cttccggaat ggtaaaccag
      781 tcaatgctga gagtcagaac agtgtcgggg tgttcacccg ggagaaggtg cggaatcgca
      841 tcagggatga ccctgacgac acagaggcca ccaagcgcct gaagctcgcc atgatccagc
      901 agtacctgaa ggtggagagc tgtgaaagca gctctcacag catagatgaa gtgtccctga
      961 gcgcctttgg agaatggacg gagatccctg gcgcccatca catcatcccc tccggcttca
     1021 tgcgagttgt ggagctgctg gctaagggca ttcccccaca tgtcatccag ctggggaaac
     1081 ccgtccgttg catccactgg gaccaggcct cggctcgccc ccggggtcct gagatcgagc
     1141 cccgtggtga gggtgaccac aatcacgacg ctggggaggg tggccagagt ggagagaatc
     1201 cccagcaggg gaggtgggac gaggatgagc agtggcctgt agtcgtggag tgcgaggatt
     1261 gtgaggtgat cccagcagac cacgtgattg tgaccgtttc gctgggcgtg ctcaagaggc
     1321 agtacaccag tttctttagg ccatgtctgc ccacagagaa ggtggccgcc atccaccgcc
     1381 tgggcattgg taccactgac aagatcttcc ttgaattcga ggagcccttt tggggccctg
     1441 agtgcaacag cctgcagttt gtgtgggagg atgaggcaga gagctgtacc ctcacctacc
     1501 cgcctgagct ctggtaccgc aagatctgtg gcttcgatgt cctttaccca ccagagcgct
     1561 atggccatgt gctgagtggc tggatctgtg gggaggaggc tctcgtcatg gagaggtgcg
     1621 atgacgaggc tgtagcggag atctgcacgg agatgcttcg acagttcaca gggaacccca
     1681 atataccaaa acctaggcga atcctgcgct cagcctgggg cagcaaccca tacttccggg
     1741 gttcctattc atacacacag gtgggctcaa gtggggcaga tgtggagaag ctggccaagc
     1801 ccctgcccta cacagagagc tccaagacag cgcccatgca ggtgctgttc tccggtgagg
     1861 ccacacaccg caagtactac tccaccaccc acggtgctct gctctctggc cagcgtgagg
     1921 ccgctcggct catcgagatg taccgagacc tcttccagca ggggccctga acggtgtcct
     1981 cactgccaaa cgtgttcctt aaagaaccac taactcgtga ctgctggtcc ccgtcccttg
     2041 cccccgtgct cttaacttcc tcattgtctg tagaatggga ttcgccttct gtagtggaca
     2101 ccgggctgac ttccgacctg gctctatagc ttttcttttt ctccaggctg ggtaacgacc
     2161 aggtgggatc ctgcttcctg ctttcctcct ctctccatgt tcttgcaagt gccttcaata
     2221 cttcgcattt ttgggataat aaaagaagtg acccttaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aa
//
