LOCUS       NM_001106215            2718 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus SPARC related modular calcium binding 2 (Smoc2),
            mRNA.
ACCESSION   NM_001106215 XM_001053050 XM_001053117 XM_001053196 XM_214777
VERSION     NM_001106215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2718)
  AUTHORS   Liu D, Li R, Xu S, Shi M, Kuang Y, Wang J, Shen C, Qiu Q, Liang L,
            Xiao Y and Xu H.
  TITLE     SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes
            in rheumatoid arthritis through transcriptional and
            post-transcriptional regulating MYO1C
  JOURNAL   Cell Death Dis 13 (12), 1035 (2022)
   PUBMED   36513634
  REMARK    GeneRIF: SMOC2 promotes aggressive behavior of fibroblast-like
            synoviocytes in rheumatoid arthritis through transcriptional and
            post-transcriptional regulating MYO1C.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2718)
  AUTHORS   Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C,
            Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D,
            Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N,
            Kimata K, Hayashizaki Y and Sekiguchi K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   3  (bases 1 to 2718)
  AUTHORS   Rocnik EF, Liu P, Sato K, Walsh K and Vaziri C.
  TITLE     The novel SPARC family member SMOC-2 potentiates angiogenic growth
            factor activity
  JOURNAL   J Biol Chem 281 (32), 22855-22864 (2006)
   PUBMED   16774925
REFERENCE   4  (bases 1 to 2718)
  AUTHORS   Vannahme C, Gosling S, Paulsson M, Maurer P and Hartmann U.
  TITLE     Characterization of SMOC-2, a modular extracellular calcium-binding
            protein
  JOURNAL   Biochem J 373 (Pt 3), 805-814 (2003)
   PUBMED   12741954
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168953.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001106215.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2718
                     /gene="Smoc2"
                     /note="SPARC related modular calcium binding 2"
                     /db_xref="GeneID:292401"
                     /db_xref="RGD:1306681"
     exon            1..248
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1508
                     /gene="Smoc2"
                     /note="SPARC-related modular calcium-binding protein 2"
                     /codon_start=1
                     /product="SPARC-related modular calcium-binding protein 2
                     precursor"
                     /protein_id="NP_001099685.1"
                     /db_xref="GeneID:292401"
                     /db_xref="RGD:1306681"
                     /translation="MLPPQLCWLPLLAALLPPVPAQKFSALTFLRVDQDKDRDCSLDC
                     PSSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAHRGNCKDVSRCVAERKYTQEQAR
                     KEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSINEK
                     LPQREGAGKADDAAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSASSCDQ
                     EHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRY
                     EQPKCDNTARAHPAKARDLYKNRPLQGCPGAKKHEFLTSVLDALSTDMVHAVSDPSSS
                     SGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKF
                     VEYCDMNNDKSITVQELMGCLGVTREEGKANTRKRHTPRGNAESTSSNRQPRKQG"
     exon            249..420
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..527
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..627
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..675
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..726
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..801
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..988
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1071
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1174
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1449
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1490
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..2714
                     /gene="Smoc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggccgga gcgcacggag gggccgtgcg gtctccacca gaggcggtag gaccgcagag
       61 cagttcttga cccctcgctc tcgcgttcgc acaccggatc ttcgccgagt gcctgggtgc
      121 agcgtgtggg gcgtctgcct cgcttggtcc cctccagcgt caccatgctg ccgccacagc
      181 tgtgctggct gccgctgctc gctgcgttgc tgccgccagt gcccgcgcag aagttctcgg
      241 cgctcacgtt cttgagagtc gatcaagaca aagacagaga ctgcagcctg gactgcccca
      301 gctcccctca gaagccgctc tgcgcctcag atgggaggac cttcctgtct agatgtgagt
      361 tccagcgggc caagtgcaaa gatccccagc tggagattgc ccaccgtggg aactgcaaag
      421 atgtgtccag gtgtgtggct gagaggaagt acacccagga gcaagcccgg aaggagttcc
      481 agcaagtgtt catcccagaa tgcaacgacg acggcaccta cagtcaggtc cagtgtcaca
      541 gctacacagg atactgttgg tgtgttacac caaatggaag gcccatcagt ggcaccgctg
      601 tggcccacaa gacacccagg tgccccggtt caataaatga aaagctgccc cagcgggaag
      661 gtgccggaaa agcagatgat gctgcagccc cagcattgga gactcagccc caaggagatg
      721 aagaagatat tgcctcacgc taccccaccc tctggaccga gcaagttaag agccggcaga
      781 acaagaccaa taaaaattca gcatcctcct gtgatcagga gcaccagtcg gctcttgagg
      841 aagccaagca acccaagaat gacaatgtag tgatccctga gtgtgcacac ggcggcctct
      901 acaagccagt gcaatgccac ccatccactg gatactgctg gtgtgtgctg gtagacactg
      961 ggcggcccat tcccgggacc tccacaaggt atgagcagcc caaatgtgat aacacagccc
     1021 gagctcaccc agcgaaggcc cgggacctgt acaagaacag gccactgcag ggttgtcctg
     1081 gtgccaaaaa gcacgagttt ctgacaagtg tcctggatgc gctctccact gacatggtcc
     1141 acgccgtctc tgacccctct tcctcatctg gcaggctgtc agagccagac cccagccaca
     1201 ccctggagga gagggttgtg cattggtact tcaagctgct tgataagaac tctagcggag
     1261 acattggcaa gaaggaaatc aaacccttta agaggttcct gcgaaagaaa tccaagccca
     1321 aaaagtgcgt gaagaagttt gttgaatact gcgatatgaa caacgataag tccatcacgg
     1381 tgcaggagct catgggctgc ttgggcgtca ccagagagga gggtaaagcc aacaccagga
     1441 agcgtcacac ccccagagga aatgccgaaa gtacttcttc gaatagacag cccaggaaac
     1501 aaggatgaat ggctgactac tcaagacagt tcctagacat gtgggaatct ccctcaccaa
     1561 agagcaatta aaaacgaaaa acatatagta tttgcacttt gtactttaaa tgtaaattca
     1621 ctttgtagaa atgagatatt taaacggact gttgtgatct gtgaaaatgg aaggctggct
     1681 tcgagaaatt aatcacatac aatgtatgtg tccttgtttg accttcgaga tctgtgctga
     1741 tggagtgggt ttttaaatgc atttcagctt cacttcctca tccctctgtg gagggcccgg
     1801 cttagccctt tgccctatcc tctgcctgca gtctccgttg gcttgctctt ggtcctcttg
     1861 atgcaagcca gagcctacgt gtccttagga gttttcagtg gtcgcctgtt tcatgaggtt
     1921 ttgctctcta gagatgtcac tcaggcacta gctcaggcat agccttaact cccagtagtg
     1981 cctgtttgag gctgtgccgt cagactctgt cagaggactc cagttttagc ttccacttga
     2041 gctttagctc tgctcgagtc aaccctactg ttaaatctcc agggagctga gtgggcaagc
     2101 agccagagag tcctccttcg gacagcaaat ctaactctgg ctgactggct ccatccgact
     2161 ggcccagaaa ggatacagtc tgcctgcctc acttctaagt gtccgggcca tcctgctagg
     2221 gaccattgga aaggaaaaat gccttctgca gagatcatgg accacatccc gtggaaggca
     2281 gagctagact ggatcgctcc aagagtgccg agcaacgggc agctgagaat gtcactttgg
     2341 ttctgtgggt gcctgggggt ttgaggggat tcatccaagg cccttatggg atgaaggtta
     2401 ggaactggat gaccacactg tgagggacgg gactgggctg ggctgtgtgc atagttggct
     2461 gccactctct gacctaggtc gatctgtact ctctgttctc aaggaacact tgcagatggg
     2521 gcagagttgg ggcaactctt tcagattggg gtttaatgga aaactgttca tggtccccag
     2581 cctctcagtc tacgtctgtg gctgcattgt gaacacacgt tgcggaaggc ctttgctcgt
     2641 ttgaactgtg tataggcaag aagtgaccag ctcacatcaa cgctgtctac caaaaaaaaa
     2701 aaaaaaaaaa aaaaaaaa
//
