LOCUS       NM_001002835            3448 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SPARC related modular calcium binding 1 (Smoc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001002835 XM_243307
VERSION     NM_001002835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Lu,G.F., Geng,F., Deng,L.P., Lin,D.C., Huang,Y.Z., Lai,S.M.,
            Lin,Y.C., Gui,L.X., Sham,J.S.K. and Lin,M.J.
  TITLE     Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1
            (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary
            Arterial Hypertension Rats
  JOURNAL   Hypertension 79 (11), 2465-2479 (2022)
   PUBMED   35997022
  REMARK    GeneRIF: Reduced CircSMOC1 Level Promotes Metabolic Reprogramming
            via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in
            Pulmonary Arterial Hypertension Rats.
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Okada,I., Hamanoue,H., Terada,K., Tohma,T., Megarbane,A.,
            Chouery,E., Abou-Ghoch,J., Jalkh,N., Cogulu,O., Ozkinay,F.,
            Horie,K., Takeda,J., Furuichi,T., Ikegawa,S., Nishiyama,K.,
            Miyatake,S., Nishimura,A., Mizuguchi,T., Niikawa,N., Hirahara,F.,
            Kaname,T., Yoshiura,K., Tsurusaki,Y., Doi,H., Miyake,N.,
            Furukawa,T., Matsumoto,N. and Saitsu,H.
  TITLE     SMOC1 is essential for ocular and limb development in humans and
            mice
  JOURNAL   Am J Hum Genet 88 (1), 30-41 (2011)
   PUBMED   21194678
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Choi,Y.A., Lim,J., Kim,K.M., Acharya,B., Cho,J.Y., Bae,Y.C.,
            Shin,H.I., Kim,S.Y. and Park,E.K.
  TITLE     Secretome analysis of human BMSCs and identification of SMOC1 as an
            important ECM protein in osteoblast differentiation
  JOURNAL   J Proteome Res 9 (6), 2946-2956 (2010)
   PUBMED   20359165
REFERENCE   4  (bases 1 to 3448)
  AUTHORS   Dreieicher,E., Beck,K.F., Lazaroski,S., Boosen,M.,
            Tsalastra-Greul,W., Beck,M., Fleming,I., Schaefer,L. and
            Pfeilschifter,J.
  TITLE     Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1
  JOURNAL   J Am Soc Nephrol 20 (9), 1963-1974 (2009)
   PUBMED   19578009
  REMARK    GeneRIF: NO attenuates SMOC-1 expression in acute glomerular
            inflammation, thereby limiting TGF-beta-mediated profibrotic
            signaling
REFERENCE   5  (bases 1 to 3448)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   6  (bases 1 to 3448)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   7  (bases 1 to 3448)
  AUTHORS   Vannahme,C., Smyth,N., Miosge,N., Gosling,S., Frie,C., Paulsson,M.,
            Maurer,P. and Hartmann,U.
  TITLE     Characterization of SMOC-1, a novel modular calcium-binding protein
            in basement membranes
  JOURNAL   J Biol Chem 277 (41), 37977-37986 (2002)
   PUBMED   12130637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 28, 2022 this sequence version replaced NM_001002835.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222878.1, SRR26360190.3184795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               JAXUCZ010000006.1  106432606-106432961
            357-522             JAXUCZ010000006.1  106513224-106513389
            523-635             JAXUCZ010000006.1  106514513-106514625
            636-735             JAXUCZ010000006.1  106543181-106543280
            736-783             JAXUCZ010000006.1  106545336-106545383
            784-840             JAXUCZ010000006.1  106558830-106558886
            841-921             JAXUCZ010000006.1  106560710-106560790
            922-1114            JAXUCZ010000006.1  106576514-106576706
            1115-1197           JAXUCZ010000006.1  106577236-106577318
            1198-1303           JAXUCZ010000006.1  106579208-106579313
            1304-1548           JAXUCZ010000006.1  106587245-106587489
            1549-1602           JAXUCZ010000006.1  106591666-106591719
            1603-3448           JAXUCZ010000006.1  106592111-106593956
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3448
                     /gene="Smoc1"
                     /note="SPARC related modular calcium binding 1"
                     /db_xref="GeneID:314280"
                     /db_xref="RGD:1303126"
     exon            1..356
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1619
                     /gene="Smoc1"
                     /function="protease inhibitor"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; SPARC-related modular calcium binding protein
                     1"
                     /codon_start=1
                     /product="SPARC-related modular calcium-binding protein 1
                     isoform 1 precursor"
                     /protein_id="NP_001002835.1"
                     /db_xref="GeneID:314280"
                     /db_xref="RGD:1303126"
                     /translation="MLPARVRLLTPHLLLLLVQLSPAGGHRTTGPRFLISDRDPPCNP
                     HCPRTQPKPICASDGRSYESMCEYQRAKCRDPALAVVHRGRCKDAGQSKCRLERAQAL
                     EQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGP
                     VTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNVR
                     NSEKVHSCDQERQSALEEARQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTG
                     RPLPGTSTRYVMPSCESDARAKSVEVDDPFKDRELPGCPEGKKMEFITSLLDALTTDM
                     VQAINSAAPTGGGRFSEPDPSHTLEERVAHWYFSQLDSNSSDDINKREMKPFKRYVKK
                     KAKPKKCARRFTDYCDLNKDKAISLPELKGCLGVSKEGGSLGSFPQGKRAGTNPFIGR
                     LV"
     exon            357..522
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..635
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..735
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..783
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..840
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..921
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1114
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1197
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1303
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1548
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1602
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3448
                     /gene="Smoc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatccaac ctgctgtcgc ccgggccaga ccgagcgcag caggcgccac gcgcagagca
       61 cacgctcgcg ctccagctcc cggcctccgc cgttcatgac cgtgaccccc ggacgcaggc
      121 tccgccagcc cctgctgcag gctcttccgc cactcccagc cgccgcaagg gtcccccccc
      181 accaccacca agtgctttga agctagcctg agacccccct gcccgctgcc cgctagtggc
      241 tgctcggctc ggctggcacc atgctgcccg cgcgcgtccg tctgctcacg ccccacttgc
      301 tgctcctgtt ggtgcagttg tccccggccg gcggccaccg caccaccggc cccaggtttc
      361 taataagtga ccgtgaccct ccgtgcaacc cccactgccc caggactcaa cccaagccca
      421 tctgcgcgtc tgacggcagg tcctatgagt ccatgtgtga gtaccagaga gccaagtgcc
      481 gagaccctgc cctggccgtg gtccatcgag gtagatgcaa agatgctggc caaagcaagt
      541 gtcgcctgga gagggctcag gccttggaac aagccaagaa gccccaggag gctgtgtttg
      601 tcccagagtg tggcgaggat ggttccttca cacaggtgca gtgtcatacg tacacagggt
      661 actgctggtg tgtcacccca gacgggaagc ccatcagtgg ctcgtccgtg cagaataaaa
      721 ctcctgtatg ttcaggtcca gtcactgaca agcccttgag ccagggtaac tcaggaagga
      781 aagatgatgg ctctaaaccc acgcccacga tggagaccca gcctgtgttc gatggagatg
      841 aaatcacagc ccctacctta tggattaagc acttggtaat caaagactcc aaattgaata
      901 acaccaatgt aagaaattca gagaaagtcc attcttgtga ccaggagaga cagagcgccc
      961 tggaagaggc ccggcagaat cctcgagagg gcattgtgat ccccgagtgt gctcctggtg
     1021 ggctctataa gccggtgcaa tgccaccaat ccacgggcta ctgctggtgt gtcctagtgg
     1081 acacaggacg cccattgccg gggacttcca cacgctatgt gatgccaagt tgtgagagtg
     1141 acgccagagc caagagtgta gaggtggatg accctttcaa ggacagggag ttaccaggct
     1201 gtcctgaagg gaagaagatg gaatttatca ccagcctgct ggatgccctc accacagaca
     1261 tggttcaggc cattaactca gcagcgccca ctggaggtgg gaggttctca gagccagacc
     1321 ccagccacac cctggaggag cgggtggcac actggtactt cagccagctg gatagcaaca
     1381 gcagtgatga cattaacaag cgggagatga aaccgttcaa gcgctatgtg aagaagaaag
     1441 ccaagcccaa gaagtgcgcc cggcgcttca ccgactactg tgacctgaac aaggataagg
     1501 ccatctcgct gcctgagctg aagggctgcc tgggtgttag caaagaaggt ggtagccttg
     1561 gcagcttccc tcagggaaaa cgagcaggca caaatccatt cattggacgt ctcgtctaaa
     1621 gagcagaaaa atcgaaaggc caatggagag tctgagaaga caggactgac catcagacac
     1681 ctaaccttca gcgctgcccg tggcccagcc acagcccatg taacataagt ggtgccctcc
     1741 atgtttgcac ttttaataac tcttatgtgt gtgttctgtt tctggttcca tttgtaaaca
     1801 ccagttatct aataccgcag tgggatcagg aaagggaaga aaagctgttt attctctctt
     1861 ttattgttaa gtttttggat ctgctactga caacttgtag gttatcaggg gaggggtggg
     1921 accaagaaga aagagattta tatactgtat ataaatatat atgtaaattg tatagatctt
     1981 ttgtacaggc attgacatca ctgtttgtcc cttcccttcc caatacttcc tctggactca
     2041 tagtccaact ctctcaaact gtatccttag cttacctgag tttcactgtg gatggactct
     2101 gtgagagtag ctaggagccc tgtgcttgtg ctgtggacac cacgttttct tctggtgaga
     2161 agagggtact ggtccatgcc attagctctc aaagttcagt cacttggctg ttggctggtt
     2221 aggaggggag cccagctcct gtgagggcca gcatggattc cagttctctg gtggccccca
     2281 catgttcttg ctattcggat cccttggcag tctatggtaa ataacggagc aaattatact
     2341 tgaaggggtt gaatttggct actttaaaca tttcctccca tgtttagcac ctcccccatg
     2401 taggacacga gaggtgagaa cccaagcatg tgaggaaaag gactcccagg gttttccttc
     2461 agcaggtgtt tggcatctga ggagatggtg aagagaacag aggatctgaa ccagccgttc
     2521 tgcaaaccca caagagagtc tccacaagca tgtagctccc aaaactagag tcagattagg
     2581 ctttacttcc atgctgtccc ttcatctctt gccctcgtcc tcactgattg ggccagccat
     2641 cttgttgacc aataccacag ttccttattc ctctggcttt tctcatggac ttccagaatt
     2701 ctaaaattga catggcatcc cttccttctg cttccccagg agtaatagga gctataggga
     2761 aagctaggtt ttagcacaga gtgtcacctg ggcagataag cagctttttc tgtctaggtg
     2821 acatgctgac tcagatgtcc ttcagtcaga gcagcaagtg acacttagca gctcgtccta
     2881 cggtcagccc tgatggcagt gagggaggcc aggactggtg cttttgctgg cttgctctct
     2941 gcaatctgcc ttgcctggga ttttatctca gtgtcctgta aatgtaccca ctttggtaaa
     3001 ccctattcta tcttgggtct ggaaagcctt ggcccctaat gctgcccaca tgtggggaac
     3061 attgcctcct cagggcttga tttgatgaag tcttggctcc agaaggcccc tgctgctcta
     3121 gtgaaagtca tgaccattcc atgatgatca gtggccctgg cctgcatggt aaggtggaaa
     3181 gaaccccttc tcttggagcc ttgagcagaa acactgcagc atcctggagc tgggtggtcc
     3241 tcaagcagac cccatccctg tctcctgacc tgaaggaaat gtgcacagag aagccacctc
     3301 tatgtaggag tttagaatct gaccagccgt cttctctctc acagatgggc gtaggctgtg
     3361 ctgtgtggtt ttcccttggg ggggcgggag caaggagaag tatttgtagc ttgttttata
     3421 aaaaataaaa aaaaatggat aaatcttg
//
