LOCUS       NM_012807               3852 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus smoothened, frizzled class receptor (Smo), mRNA.
ACCESSION   NM_012807
VERSION     NM_012807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Salem,G.A., Mohamed,A.A., Khater,S.I., Noreldin,A.E., Alosaimi,M.,
            Alansari,W.S., Shamlan,G., Eskandrani,A.A., Awad,M.M.,
            El-Shaer,R.A.A., Nassan,M.A., Mostafa,M. and Khamis,T.
  TITLE     Enhancement of biochemical and genomic pathways through
            lycopene-loaded nano-liposomes: Alleviating insulin resistance,
            hepatic steatosis, and autophagy in obese rats with non-alcoholic
            fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes
  JOURNAL   Gene 883, 147670 (2023)
   PUBMED   37516284
  REMARK    GeneRIF: Enhancement of biochemical and genomic pathways through
            lycopene-loaded nano-liposomes: Alleviating insulin resistance,
            hepatic steatosis, and autophagy in obese rats with non-alcoholic
            fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes.
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Ma,Z., Fan,Y., Peng,Y., Bian,L., Zhou,J., Wang,L., Xia,Y.,
            Zheng,S., Ji,Y., Han,Y., Feng,C. and Ba,Y.
  TITLE     miR-6315 silencing protects against spinal cord injury through the
            Smo and anti-ferroptosis pathway
  JOURNAL   Biosci Rep 43 (4) (2023)
   PUBMED   36946310
  REMARK    GeneRIF: miR-6315 silencing protects against spinal cord injury
            through the Smo and anti-ferroptosis pathway.
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Qiu,X., Chen,H., Feng,D. and Dong,W.
  TITLE     [G-protein coupled receptor Smo positively regulates proliferation
            and migration of adult neural stem cells in vitro]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 41 (10), 1588-1592 (2021)
   PUBMED   34755677
  REMARK    GeneRIF: [G-protein coupled receptor Smo positively regulates
            proliferation and migration of adult neural stem cells in vitro].
REFERENCE   4  (bases 1 to 3852)
  AUTHORS   Signorelli,D., Proto,C., Botta,L., Trama,A., Tiseo,M., Pasello,G.,
            Lo Russo,G., Fabbri,A., Imbimbo,M., Busico,A., Prelaj,A.,
            Ferrara,R., Galli,G., De Toma,A., Tamborini,E., Pastorino,U., de
            Braud,F., Gatta,G., Garassino,M.C. and Ganzinelli,M.
  TITLE     SMO mutations confer poor prognosis in malignant pleural
            mesothelioma
  JOURNAL   Transl Lung Cancer Res 9 (5), 1940-1951 (2020)
   PUBMED   33209614
REFERENCE   5  (bases 1 to 3852)
  AUTHORS   Li,P.J., Guo,Y.Q., Ding,P.Y., Liu,R.B., Deng,F., Feng,X.X. and
            Yan,W.J.
  TITLE     Neuroprotective effects of a Smoothened receptor agonist against
            postoperative cognitive dysfunction by promoting autophagy in the
            dentate gyrus of aged rats
  JOURNAL   Neurol Res 41 (10), 867-874 (2019)
   PUBMED   31221056
REFERENCE   6  (bases 1 to 3852)
  AUTHORS   Tojo,M., Mori,T., Kiyosawa,H., Honma,Y., Tanno,Y., Kanazawa,K.Y.,
            Yokoya,S., Kaneko,F. and Wanaka,A.
  TITLE     Expression of sonic hedgehog signal transducers, patched and
            smoothened, in human basal cell carcinoma
  JOURNAL   Pathol Int 49 (8), 687-694 (1999)
   PUBMED   10504535
REFERENCE   7  (bases 1 to 3852)
  AUTHORS   Carpenter,D., Stone,D.M., Brush,J., Ryan,A., Armanini,M.,
            Frantz,G., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Characterization of two patched receptors for the vertebrate
            hedgehog protein family
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13630-13634 (1998)
   PUBMED   9811851
REFERENCE   8  (bases 1 to 3852)
  AUTHORS   Kasarskis,A., Manova,K. and Anderson,K.V.
  TITLE     A phenotype-based screen for embryonic lethal mutations in the
            mouse
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7485-7490 (1998)
   PUBMED   9636176
REFERENCE   9  (bases 1 to 3852)
  AUTHORS   Xie,J., Murone,M., Luoh,S.M., Ryan,A., Gu,Q., Zhang,C.,
            Bonifas,J.M., Lam,C.W., Hynes,M., Goddard,A., Rosenthal,A.,
            Epstein,E.H. Jr. and de Sauvage,F.J.
  TITLE     Activating Smoothened mutations in sporadic basal-cell carcinoma
  JOURNAL   Nature 391 (6662), 90-92 (1998)
   PUBMED   9422511
REFERENCE   10 (bases 1 to 3852)
  AUTHORS   Stone,D.M., Hynes,M., Armanini,M., Swanson,T.A., Gu,Q.,
            Johnson,R.L., Scott,M.P., Pennica,D., Goddard,A., Phillips,H.,
            Noll,M., Hooper,J.E., de Sauvage,F. and Rosenthal,A.
  TITLE     The tumour-suppressor gene patched encodes a candidate receptor for
            Sonic hedgehog
  JOURNAL   Nature 384 (6605), 129-134 (1996)
   PUBMED   8906787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced NM_012807.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.15577.1, U84402.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-818               JAXUCZ010000004.1  59311084-59311901
            819-1024            JAXUCZ010000004.1  59333179-59333384
            1025-1234           JAXUCZ010000004.1  59334002-59334211
            1235-1407           JAXUCZ010000004.1  59334388-59334560
            1408-1627           JAXUCZ010000004.1  59334857-59335076
            1628-1751           JAXUCZ010000004.1  59335165-59335288
            1752-1844           JAXUCZ010000004.1  59336491-59336583
            1845-1953           JAXUCZ010000004.1  59336963-59337071
            1954-2139           JAXUCZ010000004.1  59338058-59338243
            2140-2288           JAXUCZ010000004.1  59338605-59338753
            2289-2423           JAXUCZ010000004.1  59339484-59339618
            2424-3852           JAXUCZ010000004.1  59339852-59341280
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3852
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /note="smoothened, frizzled class receptor"
                     /db_xref="GeneID:25273"
                     /db_xref="RGD:3726"
     exon            1..818
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..2857
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /function="candidate receptor for Sonic hedgehog"
                     /note="smoothened, frizzled family receptor; smoothened
                     protein; protein smoothened"
                     /codon_start=1
                     /product="protein smoothened precursor"
                     /protein_id="NP_036939.2"
                     /db_xref="GeneID:25273"
                     /db_xref="RGD:3726"
                     /translation="MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGP
                     RSAGGSARRNAPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDS
                     QEEAHSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAI
                     VERERGWPDFLRCMPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCG
                     IQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNA
                     CFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVV
                     WFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSG
                     ICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKIN
                     ETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPI
                     PDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKR
                     IKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFELNEPSADVSSAWAQ
                     HVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWLVEAEISPELEKRLGRKKKRRKR
                     KKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGEPCRQGAWTVVS
                     NPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAELLDADSDF"
     exon            819..1024
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1234
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1407
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1627
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1751
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1844
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1953
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2139
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2288
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2423
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..3852
                     /gene="Smo"
                     /gene_synonym="Smoh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcggcagg gagagctcag ggggctgcgg cgcgctcgcg cggaggtggc tgctgggccg
       61 cgggctggcg tgggggcgga gccggggagc gactcccgca ccccacggcc ggtgcctgcc
      121 ctccatcgag gggctgggag ttagttttaa tggtgggaga gggaatgggg ctgaagatcg
      181 gggccccaga gggttcccag ggttgaagac aattccaatc gaggcgaggg agtccggggt
      241 ccgtgcatcc tggcccgggc ctgcgcagct caacatgggg cccgggttcc aaagtttgca
      301 aagttgggag ccgaggggcc cggacgcgcg cggcgcctgg cgaaagctgg ccccagactt
      361 tcggggcgca ccggtcgcct aagtagcctc cgcggccccc ggggtcgtgt gtgtggccag
      421 gggactccgg ggagctcggg ggcgcctcag cttctgctga gttggcggtt tggccatggc
      481 tgctggccgc cccgtgcgtg ggcccgagct ggcgccccgg aggctgctgc agttgctgct
      541 gctggtactg cttgggggcc ggggccgggg ggcggccttg agcgggaacg tgaccgggcc
      601 tgggcctcgc agtgccggcg ggagcgcgag gaggaacgcg ccggtgacca gccctccgcc
      661 gccgctgctg agccactgcg gccgggccgc ccactgcgag cctttgcgct acaacgtgtg
      721 cctgggctcc gcgctgccct acggagccac cactacgctg ctggctgggg actcggactc
      781 gcaggaggaa gcgcacagca agctcgtgct ctggtccggc ctccggaatg ctccccgatg
      841 ctgggcagtg atccagcccc tgctgtgtgc tgtctacatg cccaagtgtg aaaatgaccg
      901 agtggagttg cccagccgta ccctctgcca ggccacccga ggcccctgtg ccattgtgga
      961 gcgggaacga gggtggcctg actttctgcg ttgcatgccg gaccacttcc ctgaaggctg
     1021 tccaaacgag gtacaaaaca tcaagttcaa cagttcaggc caatgtgaag cacccttggt
     1081 gaggacagac aaccccaaga gctggtacga ggacgtggag ggctgtggga tccagtgcca
     1141 gaacccgctg ttcaccgagg ctgagcacca ggacatgcac agttacatcg cagccttcgg
     1201 ggcggtcacc ggcctctgta cactcttcac cctggccacc tttgtggctg actggcggaa
     1261 ctccaatcgc taccctgcgg ttattctctt ctatgtcaat gcgtgtttct ttgtgggcag
     1321 cattggctgg ctggcccagt tcatggatgg tgcccgccgg gagattgttt gccgagcaga
     1381 tggcaccatg agatttgggg agcccacctc cagcgagacc ctatcctgtg tcatcatctt
     1441 tgtcatcgtg tactatgcct tgatggctgg agtagtgtgg ttcgtggtcc tcacctatgc
     1501 ctggcacacc tccttcaaag ccctgggcac cacttaccag cctctctcgg gcaagacatc
     1561 ctatttccac ctgctcacgt ggtcactccc cttcgtcctc actgtggcaa tccttgctgt
     1621 ggctcaggta gatggggact ccgtgagtgg catctgcttt gtaggctaca agaactatcg
     1681 gtaccgtgct ggctttgtac ttgccccaat tggcctggtg cttattgtgg gaggctactt
     1741 cctcatccga ggggtcatga ctctgttctc catcaagagc aaccaccctg ggcttctgag
     1801 tgagaaggca gccagcaaga tcaatgagac catgctgcgc ctgggcattt ttggcttcct
     1861 cgcctttggc ttcgtgctca tcaccttcag ctgccacttc tatgacttct tcaaccaggc
     1921 tgagtgggag cgtagcttcc gggactatgt gctatgccaa gccaatgtga ccattgggct
     1981 gcctaccaag aagcccattc ctgattgtga gatcaagaat cggcccagcc tcctggtgga
     2041 gaagatcaat ctgtttgcca tgtttggcac tggcattgcc atgagcacct gggtctggac
     2101 caaggccacc ctgctcatct ggaggcgcac ctggtgcagg ttgactgggc acagtgatga
     2161 tgaacccaag agaatcaaga aaagcaagat gattgccaag gccttctcta agcggcgtga
     2221 actgctgcag aacccgggcc aggagctctc cttcagcatg cacactgtct cccatgatgg
     2281 acctgttgcc ggtttggctt ttgaactcaa tgaaccctca gctgatgtct cctctgcctg
     2341 ggcccagcac gtcaccaaga tggtggctcg aagaggagcc atattacccc aggatgtgtc
     2401 tgtcacccct gtggcaactc cagtgccacc agaagaacaa gccaacctgt ggctggttga
     2461 ggcagagatc tccccagagt tagagaagcg tttaggccgg aagaagaagc ggaggaagag
     2521 gaagaaggag gtgtgcccct tggggccagc ccctgaactt caccactctg cccctgttcc
     2581 tgccaccagt gcagttcctc ggctgcctca gctgcctcgg cagaagtgcc tagtagctgc
     2641 aaatgcctgg ggaacaggag agccctgccg acagggagcc tggactgtag tctccaaccc
     2701 cttctgccca gagcctagtc cccatcaaga tccatttctc cctggtgcct cagcccccag
     2761 ggtctgggct cagggccgcc tccaggggct gggatccatt cattcccgca ctaacctaat
     2821 ggaggctgag ctcttggatg cagactcgga cttctgagct tgcagggcag gtcctaggat
     2881 ggggaagaca agtgcacgcc ttcctatagc tcttcctgag agcacacctc tggggtctca
     2941 tctgacagtc tatgggccat gtatctgcct acaagagctg tgtacgactg gctagaagca
     3001 gccagaccat agaaacaagc tgaacacagc cactgataga cctcacttca gaagcaagac
     3061 ctgcagttca ggacccttgc ctctgccccc caattagagt ctggctggca gtgttagtct
     3121 ccaacagagc ttgtactagg gtaggaacgg cagaggcagg ggtgatggta cccagagtgg
     3181 gctggggtgt ccagtgaggt aaccaagccc atgtctggca gatgagggct gactgccctt
     3241 ttctgtgcca atgagtgccc ttttctggcg ctctgagacc aaaagtgttt attgtgtcat
     3301 ttgtcctttt tctaggtggg aacaggactc tctttttcct cttcctggta gttgtaatga
     3361 ctactcccat aaggcctata actgctctca gtaggtggcc ctgtccaaaa cacatcttca
     3421 catcttagtt ccactaggcc aaactcttat tggttagcac cttaaaacac acacacacac
     3481 acacacacac acacacacac acacacaccc tcttacttct gagcttggtc tcaagagaga
     3541 gacaactggt tcagctccag gcctctgaga gtcatgtttt cttcctcaca tccatccagt
     3601 ggggatggat cctctgactt aaggggctac cttgggaagc ctctgtagct tcagccaggc
     3661 aagaaagctt cttccaactt ctgtatctgg tgggaaggag gactccctac tttttacaat
     3721 gtctagtcat tttcatagtg ccccacattc aagaaccaga cagcaggatg ccttagaagc
     3781 tggctgggtt ccaggtcaga ggctcagtat gagaagaaga aatatgaaca gtaaataaaa
     3841 catttttgta ta
//
