LOCUS       NM_022509               1226 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus survival of motor neuron 1, telomeric (Smn1),
            mRNA.
ACCESSION   NM_022509
VERSION     NM_022509.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Trepte,P., Kruse,S., Kostova,S., Hoffmann,S., Buntru,A.,
            Tempelmeier,A., Secker,C., Diez,L., Schulz,A., Klockmeier,K.,
            Zenkner,M., Golusik,S., Rau,K., Schnoegl,S., Garner,C.C. and
            Wanker,E.E.
  TITLE     LuTHy: a double-readout bioluminescence-based two-hybrid technology
            for quantitative mapping of protein-protein interactions in
            mammalian cells
  JOURNAL   Mol Syst Biol 14 (7), e8071 (2018)
   PUBMED   29997244
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Pletto,D., Capra,S., Finardi,A., Colciaghi,F., Nobili,P.,
            Battaglia,G.S., Locatelli,D. and Cagnoli,C.
  TITLE     Axon outgrowth and neuronal differentiation defects after a-SMN and
            FL-SMN silencing in primary hippocampal cultures
  JOURNAL   PLoS One 13 (6), e0199105 (2018)
   PUBMED   29902268
  REMARK    GeneRIF: -SMN and FL-SMN are needed for neuronal polarization and
            organization of axonal and dendritic compartments, processes that
            are fundamental for neuronal function and survival
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Saint-Marc,B., Elie,C., Manens,L., Tack,K., Benderitter,M.,
            Gueguen,Y. and Ibanez,C.
  TITLE     Chronic uranium contamination alters spinal motor neuron integrity
            via modulation of SMN1 expression and microglia recruitment
  JOURNAL   Toxicol Lett 254, 37-44 (2016)
   PUBMED   27153795
  REMARK    GeneRIF: Report decreased number of motor neurons and a decrease of
            SMN1 protein expression in spinal cords of rats exposed to uranyl
            nitrate.
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Zhao,D.Y., Gish,G., Braunschweig,U., Li,Y., Ni,Z., Schmitges,F.W.,
            Zhong,G., Liu,K., Li,W., Moffat,J., Vedadi,M., Min,J., Pawson,T.J.,
            Blencowe,B.J. and Greenblatt,J.F.
  TITLE     SMN and symmetric arginine dimethylation of RNA polymerase II
            C-terminal domain control termination
  JOURNAL   Nature 529 (7584), 48-53 (2016)
   PUBMED   26700805
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   Kye,M.J., Niederst,E.D., Wertz,M.H., Goncalves Ido,C., Akten,B.,
            Dover,K.Z., Peters,M., Riessland,M., Neveu,P., Wirth,B.,
            Kosik,K.S., Sardi,S.P., Monani,U.R., Passini,M.A. and Sahin,M.
  TITLE     SMN regulates axonal local translation via miR-183/mTOR pathway
  JOURNAL   Hum Mol Genet 23 (23), 6318-6331 (2014)
   PUBMED   25055867
  REMARK    GeneRIF: Reduced SMN protein level alters miRNA expression and
            distribution in neurons.
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Pellizzoni,L., Kataoka,N., Charroux,B. and Dreyfuss,G.
  TITLE     A novel function for SMN, the spinal muscular atrophy disease gene
            product, in pre-mRNA splicing
  JOURNAL   Cell 95 (5), 615-624 (1998)
   PUBMED   9845364
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   La Bella,V., Cisterni,C., Salaun,D. and Pettmann,B.
  TITLE     Survival motor neuron (SMN) protein in rat is expressed as
            different molecular forms and is developmentally regulated
  JOURNAL   Eur J Neurosci 10 (9), 2913-2923 (1998)
   PUBMED   9758161
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Battaglia,G., Princivalle,A., Forti,F., Lizier,C. and Zeviani,M.
  TITLE     Expression of the SMN gene, the spinal muscular atrophy determining
            gene, in the mammalian central nervous system
  JOURNAL   Hum Mol Genet 6 (11), 1961-1971 (1997)
   PUBMED   9302277
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Liu,Q. and Dreyfuss,G.
  TITLE     A novel nuclear structure containing the survival of motor neurons
            protein
  JOURNAL   EMBO J 15 (14), 3555-3565 (1996)
   PUBMED   8670859
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Lefebvre,S., Burglen,L., Reboullet,S., Clermont,O., Burlet,P.,
            Viollet,L., Benichou,B., Cruaud,C., Millasseau,P., Zeviani,M. et
            al.
  TITLE     Identification and characterization of a spinal muscular
            atrophy-determining gene
  JOURNAL   Cell 80 (1), 155-165 (1995)
   PUBMED   7813012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 3, 2020 this sequence version replaced NM_022509.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212707.1, BC062404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JAXUCZ010000002.1  33224115-33224223
            110-181             JAXUCZ010000002.1  33225904-33225975
            182-301             JAXUCZ010000002.1  33226154-33226273
            302-502             JAXUCZ010000002.1  33226998-33227198
            503-649             JAXUCZ010000002.1  33227409-33227555
            650-742             JAXUCZ010000002.1  33229375-33229467
            743-853             JAXUCZ010000002.1  33230389-33230499
            854-907             JAXUCZ010000002.1  33233143-33233196
            908-1226            JAXUCZ010000002.1  33234844-33235162
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1226
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /note="survival of motor neuron 1, telomeric"
                     /db_xref="GeneID:64301"
                     /db_xref="RGD:620755"
     exon            1..109
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..904
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /note="survival motor neuron 1"
                     /codon_start=1
                     /product="survival motor neuron protein"
                     /protein_id="NP_071954.2"
                     /db_xref="GeneID:64301"
                     /db_xref="RGD:620755"
                     /translation="MAMGSGGAGSEQEDTVLFRRGTGQSDDSDIWDDTALIKAYDKAV
                     ASFKHALKNGDMCETSDKPKGTARRKPAKKNKNQKKNATAPLKQWKAGDKCSAVWSED
                     GCVYPATITSVDLKRETCVVVYTGYGNKEEQNLSDLLSPTCEVANNTEQNTQENESQV
                     STDDSEHSSRSLRSKAHSKSKAAPWTSFLPPPPPVPGAGLGPGKPGLRFNGPPPPPPP
                     PPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDALGSMLISWYMSGYHTGYYMGFRQ
                     NKKEGKKCSHTN"
     exon            110..181
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            182..301
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            302..502
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            503..649
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            650..742
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            743..853
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            854..907
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1226
                     /gene="Smn1"
                     /gene_synonym="Smn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttgggcga gcccagcccc gtccgtggta gcaggccatg gcgatgggca gcggcggcgc
       61 gggctctgag caggaagaca ccgtgctgtt ccggcgtggc accggccaga gtgatgattc
      121 tgacatttgg gatgatacag cattgataaa agcttacgat aaagccgtgg cttcctttaa
      181 gcatgctcta aagaacggtg acatgtgtga aacttcagat aagccaaaag gcacagctag
      241 aagaaaacct gctaagaaga ataaaaacca aaagaagaat gccacagctc cattgaaaca
      301 gtggaaagct ggtgacaaat gctctgccgt ttggtcggaa gatggctgcg tttacccagc
      361 taccatcacg tcagttgacc ttaagagaga aacctgtgtc gtggtttata ctggatatgg
      421 aaacaaagag gagcaaaacc tatctgatct gctttccccg acctgtgaag tagctaacaa
      481 tacagaacag aacactcagg agaatgaaag ccaagtttcc acagacgaca gtgaacactc
      541 ctccagatcg ctcagaagta aagcacacag caagtccaaa gctgctccat ggacctcgtt
      601 tctccctcca cctcccccgg tgcccggggc gggattagga ccaggaaagc caggtctaag
      661 gttcaatggc ccaccgccgc cgccacctcc ccctcccccg ttcttgccgt gttggatgcc
      721 tccgttccct tcaggaccac caataattcc tccaccccct cccatatctc ccgactgtct
      781 ggatgacacg gatgctctgg gcagtatgct aatctcttgg tacatgagtg gttaccacac
      841 tggttactat atgggtttca gacaaaataa aaaagaagga aagaagtgct cacatacaaa
      901 ttaagaagtt cagctctctc ccaaggagat ggtttgttgg tgtccctggt cgataagaac
      961 agaagtctcc tcgtcacctt tgtggactct tggctaagtg gtgtcatcat cagggtctcc
     1021 ctgtcccggg agtccatcct gagtcagcag cagggcatgc atagagcagc agttggagga
     1081 accgatcaat cgatcgatca gtggcagtgt gagtgcatgg aagtcagcca aactgtgact
     1141 gagcacaaac ggacaattgc aattttctta gaatgtcaag atttgtatta atgcctttaa
     1201 aattaaataa aagccctttt ttgaaa
//
