LOCUS       NM_001134639             922 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus small integral membrane protein 20 (Smim20),
            mRNA.
ACCESSION   NM_001134639 XM_001055867 XM_577347
VERSION     NM_001134639.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 922)
  AUTHORS   Mohamed,Z.I., Sivalingam,M., Radhakrishnan,A.K., Jaafar,F. and
            Zainal Abidin,S.A.
  TITLE     Chronic unpredictable stress (CUS) reduced phoenixin expression,
            induced abnormal sperm and testis morphology in male rats
  JOURNAL   Neuropeptides 107, 102447 (2024)
   PUBMED   38870753
  REMARK    GeneRIF: Chronic unpredictable stress (CUS) reduced phoenixin
            expression, induced abnormal sperm and testis morphology in male
            rats.
REFERENCE   2  (bases 1 to 922)
  AUTHORS   Palasz,A., Zarczynski,P., Bogus,K., Mordecka-Chamera,K., Della
            Vecchia,A., Skalbania,J., Worthington,J.J., Krzystanek,M. and
            Zarczynska,M.
  TITLE     Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and
            NUCB2/nesfatin-1 gene expressions in the rat brainstem
  JOURNAL   Pharmacol Rep 73 (4), 1188-1194 (2021)
   PUBMED   33928538
  REMARK    GeneRIF: Modulatory effect of olanzapine on SMIM20/phoenixin,
            NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat
            brainstem.
REFERENCE   3  (bases 1 to 922)
  AUTHORS   Schalla,M.A., Goebel-Stengel,M., Friedrich,T., Kuhne,S.G.,
            Kobelt,P., Rose,M. and Stengel,A.
  TITLE     Restraint stress affects circulating NUCB2/nesfatin-1 and phoenixin
            levels in male rats
  JOURNAL   Psychoneuroendocrinology 122, 104906 (2020)
   PUBMED   33059202
  REMARK    GeneRIF: Restraint stress affects circulating NUCB2/nesfatin-1 and
            phoenixin levels in male rats.
REFERENCE   4  (bases 1 to 922)
  AUTHORS   Guvenc,G., Altinbas,B., Kasikci,E., Ozyurt,E., Bas,A., Udum,D.,
            Niaz,N. and Yalcin,M.
  TITLE     Contingent role of phoenixin and nesfatin-1 on secretions of the
            male reproductive hormones
  JOURNAL   Andrologia 51 (11), e13410 (2019)
   PUBMED   31637758
  REMARK    GeneRIF: phoenixin induced a significant enhancement in plasma FSH,
            LH and testosterone without inducing any alteration in plasma GnRH
            in the rats.
REFERENCE   5  (bases 1 to 922)
  AUTHORS   Dennerlein,S., Oeljeklaus,S., Jans,D., Hellwig,C., Bareth,B.,
            Jakobs,S., Deckers,M., Warscheid,B. and Rehling,P.
  TITLE     MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint
            during Cytochrome c Oxidase Assembly
  JOURNAL   Cell Rep 12 (10), 1644-1655 (2015)
   PUBMED   26321642
REFERENCE   6  (bases 1 to 922)
  AUTHORS   Yosten,G.L., Lyu,R.M., Hsueh,A.J., Avsian-Kretchmer,O., Chang,J.K.,
            Tullock,C.W., Dun,S.L., Dun,N. and Samson,W.K.
  TITLE     A novel reproductive peptide, phoenixin
  JOURNAL   J Neuroendocrinol 25 (2), 206-215 (2013)
   PUBMED   22963497
  REMARK    GeneRIF: Phoenixin may represent a new class of
            hypothalamically-derived pituitary priming factors that sensitize
            the pituitary to the action of other releasing factors.
REFERENCE   7  (bases 1 to 922)
  AUTHORS   Lee,N.H., Weinstock,K.G., Kirkness,E.F., Earle-Hughes,J.A.,
            Fuldner,R.A., Marmaros,S., Glodek,A., Gocayne,J.D., Adams,M.D.,
            Kerlavage,A.R. et al.
  TITLE     Comparative expressed-sequence-tag analysis of differential gene
            expression profiles in PC-12 cells before and after nerve growth
            factor treatment
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8303-8307 (1995)
   PUBMED   7667285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA685674.1, CB726498.1 and CV795217.1.
            
            On Feb 26, 2009 this sequence version replaced NM_001134639.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215060.1, FQ219849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AA685674.1         1-44
            45-476              CB726498.1         56-487
            477-922             CV795217.1         1-446               c
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..922
                     /gene="Smim20"
                     /gene_synonym="MITRAC7; PNX; RGD1565192"
                     /note="small integral membrane protein 20"
                     /db_xref="GeneID:501923"
                     /db_xref="RGD:1565192"
     exon            1..211
                     /gene="Smim20"
                     /gene_synonym="MITRAC7; PNX; RGD1565192"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..306
                     /gene="Smim20"
                     /gene_synonym="MITRAC7; PNX; RGD1565192"
                     /note="mitochondrial translation regulation assembly
                     intermediate of cytochrome c oxidase protein of 7 kDa;
                     phoenixin"
                     /codon_start=1
                     /product="small integral membrane protein 20"
                     /protein_id="NP_001128111.2"
                     /db_xref="GeneID:501923"
                     /db_xref="RGD:1565192"
                     /translation="MAAARNLRTALIFGGFISMVGAAFYPIYFRPLLRLEEYQKEQAV
                     NRAGIVQEDVQPPGLKVWSDPFGRK"
     exon            212..268
                     /gene="Smim20"
                     /gene_synonym="MITRAC7; PNX; RGD1565192"
                     /inference="alignment:Splign:2.1.0"
     exon            269..905
                     /gene="Smim20"
                     /gene_synonym="MITRAC7; PNX; RGD1565192"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgcctct tccgagccgg gtcgcgacct taaggctggg agtcgggttt cggagcgtgc
       61 cgggccttcg cccgccctgc agcccccttt ctcaccatgg ccgcggcccg gaacctgcgc
      121 accgcgctca tattcggagg cttcatctct atggtcggag ccgccttcta ccctatctac
      181 ttccggcccc ttctgcggct ggaagaatac cagaaggagc aggctgtaaa tcgagctggt
      241 atcgtccagg aagatgtgca gccaccaggg ttgaaagtgt ggtctgatcc gtttggcagg
      301 aaatgaggct gtcagcaagt ctgatgagga aagtggacat cttcatcctg tgcactctgc
      361 agtgaggaca atagatggct cactgtggca gcctggctga gagggaactc tcatgctgct
      421 agccagagcc cttgtgatag agactgtgtg caaagacagt gcttccctta actccctgga
      481 gaacctgaac agatgacacc attaagaagt accttgtggc tccattgact ttgcaggagc
      541 agagccagcc tgcaaggctg tttgcggatc tgcagctcat gcagtcttta tcacgtccca
      601 gctgagatgt gaacaccagc aacctgtggc tcaaggccct cggctgcttt gacaccttct
      661 gaataagcga ttttagtgca gatggcccag ccacactgcc tccaatggct ctttgaggat
      721 gtttcgattg ataaagctgt ttgaaaacag gatccttggc actgttcagg aatgtatact
      781 gctcagctta accatctcat cgaaagtcac cgtgtgtgga agtaaataga agcaagtcac
      841 tctagactgt accacacaca gttgaatcct gcgtgagcct gcagatatta aaatggtttc
      901 tcttaaaaaa aaaaaaaaaa aa
//
