LOCUS       NM_001014243            2131 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SMG9 nonsense mediated mRNA decay factor (Smg9),
            mRNA.
ACCESSION   NM_001014243 XM_344869
VERSION     NM_001014243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2131)
  AUTHORS   Jin,X., Yin,J., Zhu,H., Li,W., Yu,K., Liu,M., Zhang,X., Lu,M.,
            Wan,Z. and Huang,X.
  TITLE     SMG9 Serves as an Oncogene to Promote the Tumor Progression via EMT
            and Wnt/beta-Catenin Signaling Pathway in Hepatocellular Carcinoma
  JOURNAL   Front Pharmacol 12, 701454 (2021)
   PUBMED   34456727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2131)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2131)
  AUTHORS   Shaheen,R., Anazi,S., Ben-Omran,T., Seidahmed,M.Z., Caddle,L.B.,
            Palmer,K., Ali,R., Alshidi,T., Hagos,S., Goodwin,L., Hashem,M.,
            Wakil,S.M., Abouelhoda,M., Colak,D., Murray,S.A. and Alkuraya,F.S.
  TITLE     Mutations in SMG9, Encoding an Essential Component of
            Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital
            Anomaly Syndrome in Humans and Mice
  JOURNAL   Am J Hum Genet 98 (4), 643-652 (2016)
   PUBMED   27018474
REFERENCE   4  (bases 1 to 2131)
  AUTHORS   Fernandez,I.S., Yamashita,A., Arias-Palomo,E., Bamba,Y.,
            Bartolome,R.A., Canales,M.A., Teixido,J., Ohno,S. and Llorca,O.
  TITLE     Characterization of SMG-9, an essential component of the
            nonsense-mediated mRNA decay SMG1C complex
  JOURNAL   Nucleic Acids Res 39 (1), 347-358 (2011)
   PUBMED   20817927
REFERENCE   5  (bases 1 to 2131)
  AUTHORS   Yamashita,A., Izumi,N., Kashima,I., Ohnishi,T., Saari,B.,
            Katsuhata,Y., Muramatsu,R., Morita,T., Iwamatsu,A., Hachiya,T.,
            Kurata,R., Hirano,H., Anderson,P. and Ohno,S.
  TITLE     SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate
            remodeling of the mRNA surveillance complex during
            nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 23 (9), 1091-1105 (2009)
   PUBMED   19417104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087051.1.
            
            On Apr 20, 2005 this sequence version replaced XM_344869.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132296
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2131
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2131
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /note="SMG9 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:365215"
                     /db_xref="RGD:1309888"
     exon            1..69
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            70..225
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1638
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /note="protein SMG9; protein smg-9 homolog"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG9"
                     /protein_id="NP_001014265.1"
                     /db_xref="GeneID:365215"
                     /db_xref="RGD:1309888"
                     /translation="MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAP
                     WERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMK
                     PREEGKGPVAATGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPT
                     AMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKS
                     MVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSP
                     SILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFL
                     QTAEMVKPSTPSPSHESSSAAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMID
                     QLMAHSHLRYKGTLSMLQCNIFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGS
                     SPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKK
                     SSALAEYSRLLA"
     exon            226..300
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            301..565
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            566..663
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            664..776
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            777..888
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            889..984
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1070
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1177
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1285
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1414
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1559
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..2032
                     /gene="Smg9"
                     /gene_synonym="RGD1309888"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgctgggc gtctggccaa tgggagaagg aacctgaagg tctcagatta gtggcgccgt
       61 tggttggagg cgaccatgtc ggagtctggg cacagtcagc ctgggctcta cgggatagag
      121 cggcggcgga ggtggaaaga gccaggctcc agtggccccc agaatctttc tgggcctggc
      181 ggtcgggaaa gagactacat tgccccctgg gaaagagaga gacgggatgg cagcgaagac
      241 cccagcacca acgtcatgca gaaaaccccc atcatcctct caaagcctcc agctgagcgg
      301 tcaaagcagc caccacctag tacagcccca gctgcaccgc cagccccagc cccactggag
      361 aaacccattg tgctcatgaa gccacgtgag gaggggaagg ggcctgtggc tgcaacaggg
      421 gcttccaccc ccgaaggtac tgccccacca ccccccacgg cccctgcacc accaaaagga
      481 gagaaggagg ggcagagacc cacacagcct gtgtaccaga ttcagaaccg gggcatgggc
      541 actgctgccc caactgccat ggaccctgtg gtgggccagg ctaagctcct acccccggag
      601 cgcatgaagc acagcatcaa gctggtagac gaccagatga actggtgtga cagcgccatt
      661 gagtacctgc tggatcagac ggacgtgtta gtggtcggtg tcttaggcct ccaggggaca
      721 ggcaagtcca tggtcatgtc actgctgtca gcaaacactc cagaggaaga ccagagggcg
      781 tacgtcttcc gggctcagag tgcggagatg aaggaacgag ggggcaacca gaccagcggc
      841 attgacttct tcattaccca agagcggatt gtcttcctag acacgcagcc catcctcagc
      901 ccgtccatct tggaccacct catcaataac gaccgcaaac tgcctccgga gtataacctc
      961 cctcacacct atgtggaaat gcagtccctg cagatagctg ccttcctctt cacggtctgc
     1021 cacgtggtga tcgtcgtgca ggattggttc acggacctca gtctgtacag gttcctgcaa
     1081 acagcagaga tggtgaagcc atcgactcca tcccccagcc atgagtccag cagcgcggca
     1141 ggctcggatg agggcactga gtactacccg cacctcgtct tcctgcagaa caaggcacgt
     1201 agggaggact tctgtccccg gaagttacgt cagatgcacc taatgattga ccagcttatg
     1261 gcacattccc acctgcgcta caaggggacg ctgtccatgc tgcagtgcaa catcttccca
     1321 gggctgccgc ccgacttcct ggacgctgag gtcaacttgt tcctggtgcc cttcatggac
     1381 agtgaagctg agaatgagaa cccacctcga gcagggcctg gatccagccc cctcttctcc
     1441 ctgctgcctg ggtaccgagg tcaccctagc ttccagtccc tggtcagcaa gctccgcagc
     1501 caggtgatgt caatggctcg gccacagctg tcgcacacaa tcctcacgga gaagaactgg
     1561 ttccactatg ctgccagaat ctgggatggg gtgaagaagt cctcagccct ggcagagtac
     1621 agccgcttgc tggcctgagg ccgagggagg agcagcatgc aggggacctc cctgtcctgt
     1681 gggctgtccg gtggacagtg agggtacagc catcctccag caggggagga gagtaacagg
     1741 cctggcagag ggatcgtggc ttggcttccc gccagagatt cgaggtgtct gaggccagcc
     1801 cctccctcac atgggggctg ctcacagggt gaccaagaga tcccaccccc agcctggtat
     1861 gagcagcctt tcccaaatct ccatagagac cagcaggagg aagagtcagc atgtccccag
     1921 gaagcctgac cccactgagt cagactccag gccttcccag ggaaacaggg ttgaggctgg
     1981 agagcttttc acgggcgagg atctgatggt tcaaataaac gtggtcatag gaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
