LOCUS       NM_001398589            3212 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SMG8 nonsense mediated mRNA decay factor (Smg8),
            mRNA.
ACCESSION   NM_001398589 XM_213430
VERSION     NM_001398589.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3212)
  AUTHORS   Yamashita,A., Izumi,N., Kashima,I., Ohnishi,T., Saari,B.,
            Katsuhata,Y., Muramatsu,R., Morita,T., Iwamatsu,A., Hachiya,T.,
            Kurata,R., Hirano,H., Anderson,P. and Ohno,S.
  TITLE     SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate
            remodeling of the mRNA surveillance complex during
            nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 23 (9), 1091-1105 (2009)
   PUBMED   19417104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 20, 2021 this sequence version replaced XM_213430.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.42472.1,
                                           SRR26643287.25248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1783              JAXUCZ010000010.1  72391263-72393045   c
            1784-1929           JAXUCZ010000010.1  72389055-72389200   c
            1930-2802           JAXUCZ010000010.1  72385784-72386656   c
            2803-3212           JAXUCZ010000010.1  72384012-72384421   c
FEATURES             Location/Qualifiers
     source          1..3212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3212
                     /gene="Smg8"
                     /gene_synonym="RGD1306862"
                     /note="SMG8 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:287596"
                     /db_xref="RGD:1306862"
     exon            1..1783
                     /gene="Smg8"
                     /gene_synonym="RGD1306862"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..3000
                     /gene="Smg8"
                     /gene_synonym="RGD1306862"
                     /note="protein SMG8"
                     /codon_start=1
                     /product="nonsense-mediated mRNA decay factor SMG8"
                     /protein_id="NP_001385518.1"
                     /db_xref="GeneID:287596"
                     /db_xref="RGD:1306862"
                     /translation="MAGPVSLRELLMGASAWLGSESPGGPSAEGGGNAAAAPEPPWRE
                     DEICVVGIFGKTALRLNSEKFSLVNTVCDRQVFPLFHHQDPGDPGPGIKTKPVSVGEA
                     GGAGDPGAAAGDSLRGGMATAEGNRAEPGPQDFSLLQAYYNQESKVLYLILTSICDNS
                     QLLRACRALQSGEAGGGLSLPHAETHEFWKHQEKLQCLSLLYLFSVCHILLLVHPTCS
                     FDITYDRVFRALDGLRQKVLPLLKTAIKDCPVGKDWKLNCRPCPPRLLFLFQLNGALK
                     VEPPRSQDTAHPDKPKKHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPANQA
                     FVYIVPGSQEEDPIGMLLDQLRSHCTVKDPESLLVPAPLSGPRRYQAMRQHSRQQLSF
                     HIDSSTSSSSGQLVDFTLREFLWQHVELVLSKKGFDDSVGRNPQPSHFELPTYQKWIS
                     AAAKLYEVAIDGKEEDLGSPTGELTSKILSSIKVLEGFLDIDTKFSENRCQKALPMAH
                     SAYQSNLPHNYTMTVHKNQLAQALRVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLC
                     EERSLTDQHCVHKFHSLPKSGEKPEADRNPPVLYHNSRARSTGACNCGRKQAPRDDPF
                     DIKAANYDFYQLLEEKCCGKLDHINFPVFEPSTPDPAPAKNEPCPTPADSDAEKLKEK
                     EPQTQGEGTSLSLALSLGQSTDSLGTYPADPQAGGDNPDVHGQGEVKSEKRPNLVDRQ
                     ASTVEYLPGMLHSNCPKGLLPKFSSWSLVKLGPAKSYNFHTGLDQQGFVPGTNYLMPW
                     DIVIRTRAEDEGDLDTNSWPAPNKAIPGKRSAVVMGRGRRRDDIARAFVGFEYEDSRG
                     RRFMCSGPDKVMKVMGSGPKESALKALNSDMPLYILSSSQGRGLKPHYAQLMRLFVVV
                     PDAPLQIILMPQVQPGPPPCPVFYPEKQELTLPPDGLWVLRFPYAYVTERGPCFPPKE
                     NVQLMSYKVLRGVLRAVTQ"
     exon            1784..1929
                     /gene="Smg8"
                     /gene_synonym="RGD1306862"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2802
                     /gene="Smg8"
                     /gene_synonym="RGD1306862"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..3212
                     /gene="Smg8"
                     /gene_synonym="RGD1306862"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggaggaa gctctttctc tgccatggcg gggccggtca gcttgcgcga gcttctcatg
       61 ggggcgtcag cctggctggg ctctgagagt cccggaggtc cctccgctga aggcgggggg
      121 aacgcagctg ctgcgcccga gccaccgtgg agggaggatg agatctgcgt agtgggaatc
      181 ttcggcaaga cggctctgcg cctaaactca gagaagttct ctctggtgaa cactgtgtgc
      241 gatcggcagg ttttcccact ctttcaccat caggatcctg gggatccagg gcctggaatc
      301 aagaccaaac ctgtctctgt cggagaggcc gggggagccg gggacccggg ggctgctgcc
      361 ggggattcac ttcgcggagg tatggctacg gcggaaggta accgagctga gccaggtccc
      421 caggacttta gtcttctgca ggcctattac aatcaggaaa gcaaagttct gtatcttatt
      481 ctcacttcca tctgtgacaa ttcacagctt ttgcgtgctt gtcgggctct ccagagcggt
      541 gaagcaggtg ggggcctctc tttaccacat gcagaaacac acgagttctg gaagcatcag
      601 gagaagttgc aatgtctcag tctcctttac ctcttctctg tctgtcatat cttgctcctg
      661 gttcatccga cttgttcctt tgacatcact tatgatcgag tattcagagc cctggatgga
      721 ctgagacaga aagtactacc cctcctcaaa acagccatca aggattgtcc tgttggcaaa
      781 gattggaagt taaattgccg accttgccca cctagactcc ttttcctctt tcaactcaat
      841 ggagccctta aggtggaacc ccctcggagc caagatacag ctcatccaga taaacccaag
      901 aagcactctc ccaagagaag actgcagcat gccctggagg atcagatcta tagaatcttc
      961 cgcaagagtc gagtcttgac gaatcagagt atcaactgcc tctttacagt acctgccaac
     1021 caagcttttg tgtacatagt ccccggaagc caggaggagg acccaatcgg catgctgctg
     1081 gaccaactta ggagccattg taccgtgaaa gaccctgaat ctttgttggt gcccgcaccc
     1141 ctttctggac ctaggcggta ccaagcgatg agacagcaca gccggcagca gctttccttc
     1201 cacattgata gtagcacctc gagttcttca ggccagctag tggatttcac tcttcgagaa
     1261 ttcctgtggc agcacgtgga gctggtcctg agcaaaaaag gttttgatga cagtgtgggc
     1321 aggaacccac agccttccca ttttgaactg cctacttacc agaagtggat ctccgcagct
     1381 gcaaagctgt atgaggtggc tatcgatggg aaggaagagg acttgggctc acccactggg
     1441 gagctaacat ctaagatttt aagcagtatt aaagtcttag aagggttttt ggatatagac
     1501 acaaagttct cagaaaaccg gtgccaaaaa gctttgccca tggctcacag tgcctaccag
     1561 tcaaacttgc cgcacaatta caccatgaca gtccataaga atcagctcgc tcaggctctt
     1621 cgggtataca gtcaacatgc tcgaggtcca gcctttcaca aatacgccat gcagttgcac
     1681 gaagactgct acaaattttg gagcaatggc catcagctct gtgaagagag gagtttgacc
     1741 gaccaacact gtgtacacaa atttcactcc ttacctaaat caggagaaaa accagaggca
     1801 gataggaacc ctcctgtgct ctaccacaac agccgagccc gctccactgg agcctgcaac
     1861 tgtggaagga agcaggcccc tcgagacgac cccttcgata tcaaggctgc taactatgac
     1921 ttttaccagc ttctggaaga aaaatgttgt gggaaattgg atcatatcaa ttttcctgta
     1981 tttgagccaa gtactccaga ccctgctccg gctaaaaatg agccctgtcc caccccagca
     2041 gactcggatg ccgagaaact gaaagagaaa gaacctcaaa cccaaggaga gggcacaagc
     2101 ctcagtctgg ctttgagcct gggccagtca acagacagcc taggcaccta cccagctgat
     2161 ccgcaggcag gaggagacaa cccagacgtg catgggcaag gagaagtaaa atctgagaag
     2221 agaccaaact tggttgaccg gcaggcatcc acagttgaat atctcccagg catgctacat
     2281 tcaaattgcc caaaaggcct cttacccaaa ttctccagtt ggtctttggt taaactaggc
     2341 ccagccaagt cttacaactt tcatacaggt ttggaccaac agggctttgt cccaggaaca
     2401 aactatctta tgccttggga cattgtcatc aggactagag ctgaagacga aggagactta
     2461 gacacgaact cctggcctgc tccaaataaa gctattcctg gaaagagaag tgcggttgtg
     2521 atgggcagag gaaggcggag ggatgacata gctcgagctt ttgttggctt tgagtatgaa
     2581 gactctcgag gtcggagatt catgtgctca gggcctgaca aagtaatgaa agtgatggga
     2641 agtggaccga aggagtcggc tttaaaagcc ctcaacagcg acatgcccct gtacatcctg
     2701 tcctcgtcgc agggcagagg gctgaagcca cactatgctc aacttatgag gctttttgtt
     2761 gtagttcctg acgctccttt gcagataata ctgatgcctc aggttcaacc aggcccacca
     2821 ccgtgtccag tattttaccc agaaaaacaa gagctcactc tcccacctga tggcctttgg
     2881 gtcttgagat ttccttatgc atatgtgact gagagaggac cttgtttccc tcctaaggag
     2941 aacgtgcagc tcatgagcta caaggtgctc cgaggagtcc tcagagcagt tacacaatga
     3001 gtcttccagc cgctccgccc ctgactgaag ctgctgattg tcttcttgtt tttgatgttt
     3061 gtgaattttt ttaatgtgta ttctgtgttt tcccaaaacc caatgtgttt tggttacaag
     3121 tattcagtat ttggacaata attgttccat tatttcatta taattgatat ttattgtaaa
     3181 atcaataaaa gtttgttcta caaaaaagga ta
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