LOCUS       NM_001105808            6337 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6),
            mRNA.
ACCESSION   NM_001105808 XM_001080444 XM_220702
VERSION     NM_001105808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6337)
  AUTHORS   Sun,X., Xiao,T., Qin,J., Song,Y., Lu,K., Ding,R., Shi,W. and
            Bian,Q.
  TITLE     Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation
            via miR-570-3p in microplastics-induced emphysema
  JOURNAL   Environ Int 187, 108701 (2024)
   PUBMED   38685156
  REMARK    GeneRIF: Mechanism of circRNA_SMG6 mediating lung macrophage ECM
            degradation via miR-570-3p in microplastics-induced emphysema.
REFERENCE   2  (bases 1 to 6337)
  AUTHORS   Sealey,D.C., Kostic,A.D., LeBel,C., Pryde,F. and Harrington,L.
  TITLE     The TPR-containing domain within Est1 homologs exhibits
            species-specific roles in telomerase interaction and telomere
            length homeostasis
  JOURNAL   BMC Mol Biol 12, 45 (2011)
   PUBMED   22011238
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6337)
  AUTHORS   Kashima,I., Jonas,S., Jayachandran,U., Buchwald,G., Conti,E.,
            Lupas,A.N. and Izaurralde,E.
  TITLE     SMG6 interacts with the exon junction complex via two conserved
            EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
  JOURNAL   Genes Dev 24 (21), 2440-2450 (2010)
   PUBMED   20930030
REFERENCE   4  (bases 1 to 6337)
  AUTHORS   Eberle,A.B., Lykke-Andersen,S., Muhlemann,O. and Jensen,T.H.
  TITLE     SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human
            cells
  JOURNAL   Nat Struct Mol Biol 16 (1), 49-55 (2009)
   PUBMED   19060897
REFERENCE   5  (bases 1 to 6337)
  AUTHORS   Huntzinger,E., Kashima,I., Fauser,M., Sauliere,J. and Izaurralde,E.
  TITLE     SMG6 is the catalytic endonuclease that cleaves mRNAs containing
            nonsense codons in metazoan
  JOURNAL   RNA 14 (12), 2609-2617 (2008)
   PUBMED   18974281
REFERENCE   6  (bases 1 to 6337)
  AUTHORS   Azzalin,C.M., Reichenbach,P., Khoriauli,L., Giulotto,E. and
            Lingner,J.
  TITLE     Telomeric repeat containing RNA and RNA surveillance factors at
            mammalian chromosome ends
  JOURNAL   Science 318 (5851), 798-801 (2007)
   PUBMED   17916692
REFERENCE   7  (bases 1 to 6337)
  AUTHORS   Moriarty,T.J., Ward,R.J., Taboski,M.A. and Autexier,C.
  TITLE     An anchor site-type defect in human telomerase that disrupts
            telomere length maintenance and cellular immortalization
  JOURNAL   Mol Biol Cell 16 (7), 3152-3161 (2005)
   PUBMED   15857955
REFERENCE   8  (bases 1 to 6337)
  AUTHORS   Ohnishi,T., Yamashita,A., Kashima,I., Schell,T., Anders,K.R.,
            Grimson,A., Hachiya,T., Hentze,M.W., Anderson,P. and Ohno,S.
  TITLE     Phosphorylation of hUPF1 induces formation of mRNA surveillance
            complexes containing hSMG-5 and hSMG-7
  JOURNAL   Mol Cell 12 (5), 1187-1200 (2003)
   PUBMED   14636577
REFERENCE   9  (bases 1 to 6337)
  AUTHORS   Snow,B.E., Erdmann,N., Cruickshank,J., Goldman,H., Gill,R.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Functional conservation of the telomerase protein Est1p in humans
  JOURNAL   Curr Biol 13 (8), 698-704 (2003)
   PUBMED   12699629
REFERENCE   10 (bases 1 to 6337)
  AUTHORS   Reichenbach,P., Hoss,M., Azzalin,C.M., Nabholz,M., Bucher,P. and
            Lingner,J.
  TITLE     A human homolog of yeast Est1 associates with telomerase and uncaps
            chromosome ends when overexpressed
  JOURNAL   Curr Biol 13 (7), 568-574 (2003)
   PUBMED   12676087
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001080444.1, XM_220702.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6337
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /note="SMG6 nonsense mediated mRNA decay factor"
                     /db_xref="GeneID:287522"
                     /db_xref="RGD:1595918"
     exon            1..669
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..4838
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /EC_number="3.1.-.-"
                     /note="Smg-6 homolog, nonsense mediated mRNA decay factor"
                     /codon_start=1
                     /product="telomerase-binding protein EST1A"
                     /protein_id="NP_001099278.1"
                     /db_xref="GeneID:287522"
                     /db_xref="RGD:1595918"
                     /translation="MLLLPVRPPSFGEGRQEGAGKRVGVGERAPPVRRGFLAARGGGG
                     VAAAVAAAAKMAEGLERVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPD
                     LEIYKPGLSRLRNRPKTKEASGNEEFKDEIVNDRDASAVGNDTQLIKVCKELDSQQQN
                     GPIDAENSQAQETFSKTVGLEDRSLKIIKRIKKPDLQIYQPGRRLQTVTKESAGRADE
                     EEILNQVEQLTMEGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKG
                     EGSKKVTDDSVQGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRR
                     RQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQ
                     KSNGKENRGALRVTFDAEAMSKDSPVVRSVKENVDRMNSDKGSSSGGKGSEKQEFRNP
                     KQELRDRGRGILILPAHTALSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGTTRRL
                     WDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGDSRQAQASFYKFQNSDNPYYYPRT
                     PGPASQYPYTGYSPLQYPVGPTNGMYPGPYYPGYPAPSGQYVCSPLPASTMSPEEIEQ
                     HVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMAQLRTELLQLYERCILL
                     DIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNIENPEQIRNRLLELLDEGSDFFDS
                     LLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDT
                     ANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAK
                     ESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSH
                     SRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKV
                     LKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAASLGLA
                     MFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLG
                     YPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEE
                     DRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGG
                     KYVSVAPVPDTMGKEMGIQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKK
                     LALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLE
                     SRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCL
                     RALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLL
                     REVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG"
     exon            670..2425
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2618
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2729
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2836
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2915
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3026
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3239
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3301
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3447
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3564
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3733
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3935
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4112
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            4113..4259
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4413
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4625
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4707
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..6337
                     /gene="Smg6"
                     /gene_synonym="LRRGT00040; RGD1309609"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccaaacgt tacatggagc agtttacttc cactctctga gattcagttt atcagaaatg
       61 agaataataa ctactattaa aaagatcttt atgctgcaca atccaggcct acggtaagga
      121 gactttggcc taaaatgatt ggagaaggcc gggattgtat gatgtctccg tcaacccgag
      181 ccccagatca aaagcagtgt cctcggtggt aatcgcagca atactgtcac ccctagaccc
      241 gaatgcccac ctgacctggg cgagtcacac ctggccgcgc ctcacctcac ctcctgagag
      301 ctgcacctcc acctccaagc ctcggcgtac cttcccagcg ttacacctct gcgcacgcgc
      361 acatgtcgtc tccgccacca gctcgcttgc tctggcaagg gcctagttga acgtgctgaa
      421 tgcttttgct cccagtgcgg ccaccgtcgt ttggggaggg caggcaggag ggggcgggga
      481 aaagggtggg agtgggtgag cgcgcgccgc ccgtccgtcg tggtttcctg gctgcgcgcg
      541 gcggtggtgg agtcgccgca gctgtagcag ccgccgcgaa gatggcggag gggttggagc
      601 gtgtgcggat ctccgcgtcg gaactgcgag ggatcctggc cactctggct ccgcaggccg
      661 ggagcagaga aaacatgaag gaactaaagg aacccaggca gcgcaaagat aacaggcgcc
      721 cagatttgga aatctacaag cctgggcttt ctcgactgag aaacagacct aaaaccaagg
      781 aggcttctgg gaatgaggaa ttcaaagatg agattgtgaa tgacagagat gcttctgctg
      841 ttgggaatga tacacaactt attaaagttt gcaaggaatt ggacagccaa cagcaaaatg
      901 gccctataga tgcagaaaat agtcaggcac aggagacttt ctcaaagact gttggactag
      961 aggaccgaag tctaaaaatc atcaagagaa tcaagaaacc agacctgcag atctaccagc
     1021 ctggaaggcg gttgcagact gttaccaaag agtcagcggg tagggcagat gaagaagaaa
     1081 tcctcaacca agtggagcag ttgacgatgg aaggggatga gtgtagggga gaagctataa
     1141 aagaagaagt tatcaacaaa ccggataaaa ccgagataga aaagagccaa agtaatgacc
     1201 gtgtaagaac tgccaaggga gaaaagggga aaaagattga taagggggag gggtcaaaaa
     1261 aggtgactga tgactctgtc caaggaaagc ctggctctgt aaagaggtac tcacgatcag
     1321 acaagagaag gaaccgctat cgcacttgca gtaccagctc agctggtagc aacaacagtg
     1381 cagagggagc tggcctgact gataatggat gtcgccggcg gcgccaggac cggaccaaag
     1441 agaggccacg actgaagaaa caggtatcta tgtcctcaac tgattcctta gatgaggaca
     1501 gagttactga gcctgatgga ttagggtcca ggaggagctc agaaaggaag aagcatttag
     1561 acagaaattg gtctggccga ggtgagggtg aacagaaaag caatggtaaa gaaaaccgag
     1621 gcgcccttcg tgtcactttt gatgcagaag ccatgagtaa agactcccct gtggtaaggt
     1681 cagtcaagga gaatgtggat agaatgaatt ctgacaaagg ctcaagcagt gggggtaagg
     1741 gctctgagaa gcaggagttc agaaacccga aacaagaact tcgagatcgt ggtcgtggta
     1801 ttctgattct gcctgcccac actgccctat ctgtcagttc atcaggttct ccggagtcta
     1861 cacctttggg acctagactt ttatttggat ctggtagtaa gggatctcgg agttggggcc
     1921 gtggaggcac aacccgccga ctatgggacc caaacaatcc tgatcagaag cctgctctga
     1981 aaagccagac acctcagcta catttcttgg acacagatga tgaaattagc cctacatcct
     2041 ggggtgattc acgtcaggcc caagcatctt tctataaatt tcaaaactct gacaacccct
     2101 attattatcc tcggacacca ggccctgcct ctcagtatcc ctatacaggc tatagtcctc
     2161 tgcaataccc agtgggccct acaaatggta tgtatccagg gccttactac ccaggctatc
     2221 ctgccccctc aggacagtat gtatgtagcc ctctccctgc tagtaccatg agtcctgagg
     2281 aaatagaaca gcacgtgcgg aacatgcagc aacaggagct ccataggctt ctccgagtgg
     2341 ctgacaacca ggaactgcag ctcagcaacc tgctttccag ggaccgcatc agcactgagg
     2401 gcatggagaa gatggctcag ctaagaacgg aactcctgca gctgtacgag cgctgtattc
     2461 tattggatat tgaattctct gacagtcaga atgtagatca gatcctgtgg aagaatgctt
     2521 tctatcaggt gattgagaaa ttcaggcagc ttctcaagga tccaaatatt gagaacccag
     2581 aacagattcg gaacagactc ttggaactct tagatgaggg cagtgacttc tttgatagtt
     2641 tgcttcagaa actacaggtt acttacaagt tcaaactgga ggactacatg gatgggcttg
     2701 ccattcgaag caaaccatta cgaaaaacag tgaaatatgc cttgatcagt gctcagcgca
     2761 gtatgatatg tcaaggagat atctctaggt atcgggagca agccaatgac acagcaaact
     2821 atgggaaggc tcgcagttgg tatctgaagg cccagcatat tgctcccaag aatgggcgcc
     2881 cctataacca gttggcttta ctggcagtgt atacgaggag gaagcttgat gctgtgtatt
     2941 actatatgcg cagtttagca gccagcaacc ctatcctgac tgccaaggag agtctcatga
     3001 gtttatttga agagactaag cgaaaagccg aacagatgga aaagaagcag catgaggagt
     3061 ttgatctgag tcctgatcag tggcgtaaag gaaagaagtc tactttccgg catgttgggg
     3121 atgacactac tcgcctggag atctggattc atccatcaca ttctcggtcc tcccagggca
     3181 ctgagtctgg gaaggattct gagcaggaga atggtctggg cagcctgagc cccagtgatc
     3241 tgaacaaaag gttcatcctc agttttctcc atgcccatgg gaagctgttt acccggattg
     3301 ggatggagac attccctgca gtggctgaga aggtccttaa ggagttccaa gtattgctgc
     3361 agcacagccc atctcctatt ggaagcactc gtatgctgca gctcatgacc atcaacatgt
     3421 ttgctgtaca taattcccag ttgaaagact gcttctcaga ggagtgtcgt tctgtgatcc
     3481 aggaacaagc tgcatccttg ggcttggcta tgttttctct actggtccag cgctgcacat
     3541 gcttacttaa ggactctgcc aaagctcagc tgtcctctcc tgaggaccaa gaggaccaag
     3601 atgacatcaa ggtatcttcc ttcgtcccgg acctaaagga gctgctcccc agtgtgaaag
     3661 tctggtcaga ttggatgctt ggctacccag acacctggaa tcctccgccc acatctttgg
     3721 atctgccctt gcaggttgct gtggatgtat ggtcaacact tgctgatttc tgtaacatac
     3781 tgactgcagt gaatcagtct gaggtgccac tgtacaagga cccagatgat gacctcaccc
     3841 tgcttatcct ggaagaggat cggcttctct ctggctttgt ccccttgctg gctgcccctc
     3901 aggacccctg ctacgtggag aaaacctcgg ataaggttat tgcagctgac tgcaaaaggg
     3961 tcacagtgct gaagtatttt ctggaagccc tttgtggaca agaagagcct ctgctggcat
     4021 tcaagggtgg aaaatatgtg tcagtggcac ccgtcccaga caccatggga aaggaaatgg
     4081 gaatccaaga gggaaaacaa ctggaagatg aggaagaaga tgtggtgatt gaagactttg
     4141 aggaagattc agaggctgaa ggtagtgggg gtgaggatga catcagggaa cttcgggcca
     4201 agaagctggc tctagcaagg aaaatagctg aacagcagcg tcgccaggaa aagatccagg
     4261 ctgttttgga agaccagagt cagatgagac agatggagct ggagatcaga cccttgttcc
     4321 tcgtaccaga taccaacggc ttcattgacc acctggccag tctagctcgg ctgctggaga
     4381 gcaggaagta catcctggtg gtgcccctca tcgtgatcaa tgagctggat ggcctcgcca
     4441 aagggcagga gacagaccac cgggctgggg gctatgcccg tgtggtgcaa gaaaaggccc
     4501 gaaaatccat cgagttcctt gaacggagat ttgagagtcg ggactcctgc ctgcgggcct
     4561 tgaccagccg tggcaatgaa cttgaatcta tcgccttccg aagtgaggac attactggac
     4621 agctgggcaa caacgatgac ctgatccttt cctgctgcct gcactactgc aaagacaaag
     4681 ctaaggacta catgcccacc agcaaagagg agcccatccg cttgctacgg gaagtggtgt
     4741 tgctgacgga tgatcggaac cttcgtgtaa aggcactaac aaggaatgtg cctgtgaggg
     4801 acatcccagc cttccttacg tgggcccagg tgggctgagg gggccacact ggggcccacc
     4861 cccatggaac cattcctgag aggccaccag gcgcccagtg taacacggaa gatgtccacg
     4921 ggcctgagct accaatccac ccagacaata aaccatcctc ttccaacctc acgccgtggc
     4981 cgtgctgtgg gggagccgct cctcacagag cccctcccaa gggtcaggcg gaagctgccg
     5041 ggaccctcct gggctgccaa gatttagcag ggaggtgact ggctacaatg acaacaggtg
     5101 gacaagccaa ataggccacc aagctcccac tctttctccc tcctgtctgg ttccagggct
     5161 ggagggaggc ctactcaccc cgaggaccca gctactctat agtggcaagg ggcagaggtt
     5221 ctagagtttt catcagatgc aagagaactg ataggcccct cagtctgcac agtctccgtc
     5281 ctgaacacct gagaggcttt ggctgtcagg aagagtgccc aggtgtctcc atctccctga
     5341 ggcctgaggc cttacggacc cttgctgagt tcagcagcag cagcagcagc cctagccctt
     5401 cgacatgcac acgcgcacac acacatgtgc acacacacat acgtgtgcac atgtttcttt
     5461 tcctgtccac gtcttgcact ttgcccttgt tttcctttgg ggcagtcatg ggcctagagg
     5521 gaagggacat ctggtcttgg gctcatgctt cctgagtggc cttccaccag cacatactcc
     5581 tgtccctggc cttcctttca ctctgctacc catcttgggg aaatttcctc agacccttcc
     5641 tgttccttct ttgcctgcct tccttttttg gcccctttca acactccaaa gcccctaaac
     5701 ttcctcactt cagttccttg tggggcttct cattctgaat cttatcccac cacctgtgac
     5761 aggaaccaaa taaagttttc ccagctgtcc ttccttccca gtccctcaca cctcacctct
     5821 gagaagcctc cagactggca gaggtgcctg gggtgttgag cctgtttccg gctttgccac
     5881 tgtacttctc tacacagaag aggggacaca gggcccttta gcctttgagg gttttggctc
     5941 ttttgggttt tttttctgcc tctctgttca caacctcact tggaggctcc ctaccaggaa
     6001 taaattcctt cgttctagca cagaagtaaa ggagcattga gaaggccttc tcaggcagag
     6061 caggagtgaa tctcgatagg gtcacacaac ccaccttagg aggagcagtg cttcaccacg
     6121 ggtgctgtgc aggagagccc aggacagtgc acaggggtcg gagcttaaaa gacaggttct
     6181 catgaatgta aggcccaggc tgcttccttt gaggtcctct cctctggctg tgaaggccat
     6241 tgacttgggg ctggggggaa aatggggaga acctttcttc tttctgtccc atttggaatt
     6301 ctggttttgt ttccttaata aatttttagt tatgaaa
//
