LOCUS       XM_039101163           15574 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus SMG1, nonsense mediated mRNA decay
            associated PI3K related kinase (Smg1), transcript variant X2, mRNA.
ACCESSION   XM_039101163
VERSION     XM_039101163.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039101163.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15574
                     /gene="Smg1"
                     /note="SMG1, nonsense mediated mRNA decay associated PI3K
                     related kinase; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 mRNAs, 113 ESTs, 7
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 150 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:691397"
                     /db_xref="RGD:1563508"
     CDS             467..11371
                     /gene="Smg1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SMG1 isoform X2"
                     /protein_id="XP_038957091.1"
                     /db_xref="GeneID:691397"
                     /db_xref="RGD:1563508"
                     /translation="MRFLRTDSASADPDTLKYSSSRDRGVSSSYGLQPSNSAVVSRQR
                     HDDTRGHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRINNVTSPEFTSVQHGSRAL
                     ATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPENKLVLV
                     KQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKFSSSA
                     KDEVKLLYLCATYRALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCILL
                     VARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTL
                     LGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSP
                     IRGPPITEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCD
                     MVITYGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLR
                     YHKEKEVVAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPDACSEI
                     KHEAFQNHVFNIDNANFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVH
                     SDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFS
                     IILNLLGILLKKDNLNQDTRKLLMTWALEVAVLMKKSETYAPLFSLPSFHKFSKGLLA
                     NTLVEDVNICLQACSSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSI
                     PLDVVLSNNNHTEIQEISLALRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNW
                     LERLFYSCQRLDKRDQSTIPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTF
                     QTIEGIIRSLAAHTLNPDQDVSQWTTADNDEGHGSNQLRLVLLLQYLENLEKLMYNAY
                     EGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLT
                     EMKTNSLSQGNELEVTIMMVVEALCELHCPEAIQGIAVWSSSAVGKNLLWINSVAQQA
                     EGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLTLANAGRNSASPKHSLNGESRKTVL
                     SKSIDSSPEVINYLGNKACECYISIADWAAVQEWQNAVHDLKKNANSTSLNLKADFNY
                     IKSLSSFESGEFVECTEQLELLPGENINLLAGGSKEKIDMKKLLPNMLSPDPRELQKS
                     IEVQLLRSSVFLATALNHVEQDQKWQSLTENVVKYLKQTSRIAIGPLRLSTLTVSQSL
                     PVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSDALRSCKQHDVRPWMQALRYTMYQN
                     QLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSLATRLLAQCSEVQLGKTTTAQDL
                     VQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEMLSSCAISFCKSAKAEYA
                     VAKSILTLAKWVQAEWKEISGQLRQVYRAQQQQNLSGLSTLSRNILALIELPSANTVG
                     EEHPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDN
                     ASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRPAGIQDEDITLQITE
                     SEDNEDDDMVDVIWRQLISSCPWLSELDENATEGVIKVWRKVVDRIFSLYKLSCSAYF
                     TFLKLNAGQVLLDEDDPRLHLSHRAEQSTDDVIVMATLRLLRLLVKHAGELRQYLEHG
                     LETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPAIVGTISLS
                     SESQASGNKYSSAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLNEDQAMM
                     QDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQL
                     EDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQD
                     NYGDAIDNALEKLKTPSNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLDEISPWLA
                     AMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLE
                     DLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFG
                     LYKRWQQREAALQAQKAQDSYQTPQNPSIVPRPSELYYSKIGPALKTVGLSLDVSRRD
                     WPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIG
                     LGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEG
                     VFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESK
                     QSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDSSLDEYLSLQEQLTDVE
                     KLQGKLLEEIEFLEGAEGVDHPSRTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWI
                     THYQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGE
                     VGTLLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRIEQWKAWMEELICNTTVERC
                     QELYRKYEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVC
                     EDQLKEIERCIKVFLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDL
                     TSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPVEASEAVHLANGVYTSL
                     QELNSNFRQIIFPEALRCLMKGECTLESMLHELDSLIEQTTDGVPLQTLVESLQAYLR
                     NTAMGLEEETHAHYIDVARMLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQ
                     VETAFGLLVEKLNKMEIPVAWRKIDIIREARSTQANFFDDDNHRQVLEEIFFLKRLQT
                     IKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFT
                     ADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEH
                     NIQVGRFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQW
                     QHEDLLINRPQAMSVTPPRSAILTSMKKKLHALSQIETSIGTVQEKLAALEASIEQRL
                     KWAGGANPALAPVLQDFEATIAERRNLVLKESQRANQVTFLCSNIIHFESLRTRTAEA
                     LSLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTTLEHPIGSSEWLLSAHK
                     QLTQDMSTQRAVQTEKEQQIETVCETIQSLVDSVKTVLTGHNRQLGDVKHLLKAMAKD
                     EEAALADAEDIPYESSVRQFLAEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEIT
                     PTLKELKTQSQSIYNNLVSFASPLVTDAANECSSPTSSATYQPSFAAAVRSNTGQKTQ
                     PDVMSQNAKKLIQKNLATSADTPPSTIPGTGKSIACSPKKAIRDPKTGKAVQERNSYA
                     VSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV"
ORIGIN      
        1 gccgtggccg tgtgagcgtg aggagccgcc gccaccgcct cctcgctgtc ctcgtcctcc
       61 tgggccccag cgtcgcgggc cgcgcgctgc cctggaagag acgtcgcctc gcctgcctcc
      121 gcctccccct cgccgcgccg ctcccgcctc ctgctcctgc gttgcgggct ccagcggaac
      181 ccggaacggc cgtccgcctc ccccgccctc cgccgccccc tccgcggctt cctcctcagc
      241 cccgggccag atcgcagtgt cggcggcggc cggttcaggc ggcgattcgc gcttcttcgg
      301 gcggcggcgc ttggccatgt cgtgtcgggg aaggtaatga gccgcagagc cccggggtct
      361 cggctgagca gcggcggcgg cggcaccaag tacccgcgga gctggaatga ctggcaaccc
      421 agattgactt gatgcaaaac accacaaagg ctccatatta cacagtatgc gatttttgag
      481 aactgatagt gcatcagccg acccagatac tttaaaatac tcctcatcca gagatagggg
      541 tgtttcttcc tcttatggac tgcaaccttc aaattcagct gtggtgtctc ggcaaaggca
      601 cgatgatacc agaggccatg ctgacataca gaatgacgaa aagggtggct acagtgtcaa
      661 tggaggatct ggggaaaata cttatggtcg gaagtcgttg gggcaagagc tgaggattaa
      721 caatgtgacc agccctgagt ttaccagtgt tcagcatggc agtcgtgcgt tagccaccaa
      781 agacatgagg aaatcacagg agcgatcgat gtcgtactct gatgagtctc gactgtcgaa
      841 tcttcttcgg aggatcaccc gggaagatga cagagaccga agactggcta ctgtaaagca
      901 gctgaaggag tttattcagc agccagaaaa taaactggta ctagttaaac agttggataa
      961 tatcttggct gctgtgcatg atgtactaaa tgaaagtagt aagttgcttc aggagttgag
     1021 gcaagaggga gcttgctgtc ttggtcttct ctgtgcttct ctgagctacg aggctgagaa
     1081 gatcttcaag tggattttta gcaaatttag ctcatctgcg aaagatgagg tgaagctcct
     1141 ctacctgtgt gccacttaca gagcactgga gactgttggc gagaagaaag ccttttcttc
     1201 ggtgatgcag cttgtgatga ccagcctaca atccattctt gaaaatgtgg atacaccaga
     1261 attactttgc aaatgtgtta agtgcattct tttggtggct cgatgctacc ctcatatttt
     1321 cagcactaat tttagggata cagttgatat attagttgga tggcacatag atcatactca
     1381 gaaaccctcc cttacacagc aggtgtctgg gtggttgcag agtttggagc cattttgggt
     1441 agctgacctt gcattttcta ccactcttct tggtcaattt ttagaagaca tggaggcata
     1501 cgctgaggac ctcagccatg tggcctctgg ggagtcagtg gatgaagatg ttcctcctcc
     1561 atcagtgtca ttaccaaagc tggcagcgct tctccgtgtg ttcagtactg tggtgaggag
     1621 cattggggag cgctttagcc caattcgggg tccaccaatt accgaggcat atgtaacaga
     1681 tgttctatac agagtaatga gatgcgtgac ggctgcaaac caagtgtttt tttctgaggc
     1741 tgtgttgaca gctgctaatg agtgtgttgg tgttttgctc ggcagcttgg atcctagcat
     1801 gactatacat tgtgacatgg tcattacata tggattagac caactggaga attgccagac
     1861 ttgtggtacc gattatatca tctcagtctt gaatttgctc acattgattg ttgagcagat
     1921 aaatacaaaa ctcccatcat catttgtaga aaagcttttt ataccatcat ctaaactact
     1981 atttctacga taccacaaag aaaaagaggt tgttgctgta gctcatgctg tttatcaagc
     2041 agtgctcagc ttgaagaaca tccccgttct ggagactgcc tataaattaa ttttgggaga
     2101 aatgacttgt gcactaaaca atttgctaca cagtctccag cttcctgatg cctgttctga
     2161 gattaaacat gaggcttttc agaatcatgt gttcaacatt gacaatgcca actttgtagt
     2221 catatttgat ctcagtgccc tgactacaat tggaaatgcc aaaaactcat taattgggat
     2281 gtgggcactg tctccaactg tatttgcact gctgagtaag aatctgatga tagtgcacag
     2341 tgacctggct gttcacttcc ctgccattca gtatgcggtg ctctacaccc tatattccca
     2401 ttgtaccaga cacgatcact tcatttccag tagtcttagt tcttcatccc cttccttatt
     2461 tgatggcgcg gtgattagta ctgtaactac agccacaaag aaacatttct caattatatt
     2521 aaatcttttg ggaatattac taaagaaaga taatcttaac caggacacaa ggaaactgtt
     2581 aatgacatgg gctttggaag tagctgtatt aatgaagaag tctgaaacat atgcaccttt
     2641 attctccctt ccatcttttc ataaattctc caaaggcctt ttagctaaca ctcttgttga
     2701 agatgtgaat atctgcttgc aagcatgtag cagtctccat gctctgtcct cttccttgcc
     2761 agatgatctg ctacagaggt gtgttgatgt ctgccgtgtt cagcttgtcc atagtggaac
     2821 tcgtattcga caggcctttg gaaagctgtt gaagtcaatt cctttagatg ttgtactaag
     2881 caataacaat cacacagaga ttcaggagat ttctttagca ttgagaagcc acatgagtaa
     2941 agcaccaagt aacacgttcc accctcagga cttttctgat gtcatcagtt tcattttgta
     3001 tggaaactct caccgaacag ggaaggacaa ttggttagaa agattgttct atagctgcca
     3061 gaggctggat aagcgtgacc aatccacaat tccccgcaat cttctaaaga cagatgctgt
     3121 cctgtggcag tgggctattt gggaagctgc acagttcact gttctttcaa agttgcgaac
     3181 cccactgggc agagctcagg acacgttcca gacaattgaa ggtatcatta gaagtcttgc
     3241 agcccacaca ctaaaccctg accaggatgt tagtcagtgg accactgcag ataatgatga
     3301 aggccatggg agcaatcagc ttagacttgt tcttctgctt cagtatctgg agaacctgga
     3361 gaaactaatg tataacgcct atgaggggtg tgccaatgca ttaacatcac ctcccaaggt
     3421 cattaggact tttttctata ccaatcgaca gacttgccaa gactggctca ctcggatccg
     3481 tctttccatc atgagggtcg gattgttggc aggtcagcct gcagtgacag tgaggcacgg
     3541 ctttgactta cttactgaaa tgaaaacaaa tagtctgtct caggggaatg aattggaagt
     3601 gactatcatg atggtggtag aagcgctgtg tgagctccac tgtcctgaag ctatacaggg
     3661 gattgctgtc tggtcatctt cagctgttgg taaaaacctt ctctggatta actcagtggc
     3721 ccaacaggct gaagggaggt ttgaaaaggc ctctgtggag taccaggagc acctgtgtgc
     3781 catgacaggt gttgattgct gcatctccag ctttgacaag tctgttctca cattggccaa
     3841 tgctggacgt aacagtgcca gccccaaaca ctctctaaat ggtgaatcca gaaaaactgt
     3901 gctgtccaaa tcaatcgact cttcccctga agttatcaac tacctaggaa ataaggcatg
     3961 tgagtgttac atctccattg ctgactgggc tgctgtgcag gagtggcaga acgcggtcca
     4021 cgacctgaag aagaatgcca acagcacctc actcaatctg aaagccgatt tcaactacat
     4081 caagtcacta agcagcttcg agtctggaga gtttgttgaa tgcactgagc agttggaatt
     4141 attgccagga gaaaatatta atctgcttgc tggagggtca aaagaaaaaa tagatatgaa
     4201 aaagctgctt cctaacatgc taagcccaga cccacgggag cttcagaaat ccattgaagt
     4261 ccaattgttg agaagctccg tgttcctggc aactgctcta aaccatgtgg aacaagatca
     4321 gaaatggcag tccttaaccg aaaatgtggt aaagtacttg aagcaaacct cacgcatcgc
     4381 tattggacca ctaagattgt ctacgctaac ggtgtcacag tccttgccag tactgagtac
     4441 cctgcagctc tactgctcct ctgcactgga gaacacagtt tctaatagac tttcaacaga
     4501 ggactgtctt atcccactct ttagtgatgc tcttcgctca tgtaaacagc atgatgtgcg
     4561 gccttggatg caggcgttga gatataccat gtaccagaat caactgttag agaaaattaa
     4621 agaacaaaca gtaccaatta gaagccatct catggaacta ggtctgacag ctgcaaaatt
     4681 tgctagaaaa cgggggaatg tgtcactggc aacaagactg ttggcacagt gcagtgaggt
     4741 tcagctggga aagacaacca ctgcccagga cttagtccag cattttaaaa aactgtctac
     4801 tcaaggtcaa gtggatgaaa aatgggggcc tgagcttgat attgaaaaaa ccaaattgtt
     4861 atacacagca ggccagtcaa cacacgcaat ggaaatgttg agttcttgtg ctatatcttt
     4921 ctgcaaatct gcgaaagctg aatatgctgt ggctaagtca attctgaccc tggctaaatg
     4981 ggtccaggca gaatggaaag agatttcggg acagctgagg caggtgtacc gagctcagca
     5041 gcagcagaac ctttcaggcc tttctacttt gtctaggaat atactcgctc ttatagagct
     5101 accgtctgct aatacagtgg gagaagagca ccctcggatt gagagtgagt ctacagtgca
     5161 tattggagtt ggagaacctg acttcatttt gggacagttg tatcacctgt cttcagtgca
     5221 ggcacctgaa gtagccaaat cttgggcagc attggctagt tgggcttata ggtggggcag
     5281 aaaggtggtt gacaatgcca gtcagggaga aggtgttcgt ctgttgccta gagaaaaatc
     5341 tgaagttcaa aatctgcttc cagatactat aactgaagaa gagaaagaga gaatatatgg
     5401 tattcttgga caagcagtat gtcggccagc aggaattcag gatgaagata taacactaca
     5461 gataacagag agtgaagata atgaggatga tgacatggtc gatgttatct ggcggcagtt
     5521 aatatcaagc tgtccctggc tttctgaact ggatgaaaat gcaacggaag gtgttattaa
     5581 agtgtggagg aaagttgtgg acagaatctt cagcctgtac aaattgtctt gcagtgcata
     5641 ttttactttc cttaagctga atgctggtca ggttctgtta gatgaggatg accccaggct
     5701 ccatttaagt cacagagctg agcagagcac tgatgatgtg attgtgatgg ctaccctgcg
     5761 actgctcaga ttgctagtga agcatgctgg tgagcttcgg cagtatctgg aacatggctt
     5821 ggagacaacc cctactgctc catggagagg aattattcca cagcttttct cacgcttaaa
     5881 ccaccctgaa gtgtatgtac gccagagtat ttgtaacctc ctttgccgtg tagcccaaga
     5941 ttcccctcac ctcatattgt atcctgcaat agtaggaacc atatcactta gcagtgaatc
     6001 ccaggcttca ggaaataagt attcctctgc aatcccaact ttacttggaa atattcaagg
     6061 agaagaactg ctggtttctg aatgtgaagg aggaagtcct cctgcttctc aggatagcaa
     6121 caaagatgaa cctaaaagtg gtttaaatga agatcaggcc atgatgcagg attgctacag
     6181 caaaattgta gataaactat cctctgcaaa tccaacgatg gttttacagg tccagatgct
     6241 tgtggcagag ctacgtaggg tcactgtact ctgggatgag ctctggctgg gagttttgtt
     6301 acagcagcat atgtacgtcc tgaggcgaat tcagcagctg gaggatgagg tgaagagagt
     6361 ccagaacaac aacaccttgc gcaaagaaga gaaaattgcc atcatgcgag agaagcacac
     6421 agcactgatg aagcccatcg tgtttgcttt ggagcacgtg cggagcatca ctgctgcccc
     6481 tgcagagacc cctcatgaaa agtggtttca ggataactat ggtgatgcca ttgacaatgc
     6541 ccttgaaaaa ctaaagaccc catccaaccc tgccaagcct ggaagcagct ggattccatt
     6601 taaagagata atgctgagtt tgcaacagag agcgcagaaa cgagcaagct acatcttgcg
     6661 acttgatgag atcagtcctt ggttggctgc catgactaac actgaaattg cactccctgg
     6721 agaagtctct gccagagaca ctgtgacaat tcacagtgtg ggtggaacta tcactatctt
     6781 accaactaaa accaagccca agaaactcct ctttcttgga tcagatggaa agagctatcc
     6841 ttaccttttc aaaggtctag aagatttgca tctggatgag agaatcatgc agtttttatc
     6901 tattgtgaat actatgtttg ctacaattaa tcggcaggaa acaccccgat tccatgcacg
     6961 gcactattct gtaacaccac tggggacgag atcggggctg atccagtggg tggatggagc
     7021 cacaccattg ttcgggcttt acaaacgatg gcaacagcgg gaggctgcct tacaagcaca
     7081 aaaggcccaa gattcctacc agactcctca gaatcccagc attgtaccgc gtcctagtga
     7141 actttactat agtaaaattg gtcctgcttt gaaaacagtt ggccttagcc tggatgtgtc
     7201 aaggagggat tggcccctcc atgtgatgaa ggcagtgttg gaggagttaa tggaggccac
     7261 acccccaaac cttctggcca aagaactctg gtcatcttgc accactcccg atgagtggtg
     7321 gagagtcaca cagtcctatg caagatccac cgctgtcatg tctatggttg gctacataat
     7381 tggccttgga gacagacatc tggataacgt cctcatagat atgacaactg gagaagtagt
     7441 tcacatagat tataatgttt gctttgaaaa aggtaaaagc cttagagttc ctgagaaagt
     7501 gccttttcga atgacacaaa acattgaaac agcactgggt gtaactggag tagaaggtgt
     7561 ttttaggctt tcctgtgagc aggttctcca catcatgcga cgaggccgag agactctgct
     7621 gacactcttg gaggcttttg tgtatgaccc actggtggac tggacagccg gcggtgaggc
     7681 tgggtttgca ggtgctgtct atggtggagg tggccaacag gccgagagca agcagagtaa
     7741 gcgagagatg gagcgtgaga ttacccgcag cctcttttct tccagagttg ctgagattaa
     7801 ggtgaactgg tttaagaacc gggatgagat gctagttgtg cttcccaagc tggacagcag
     7861 cttagatgaa tacctaagcc tgcaggagca gctgacagat gttgaaaagc tgcagggcaa
     7921 actgctggag gaaatagagt ttctagaagg agctgaagga gtggatcatc catctcgcac
     7981 tctgcaacac agatattctg agcatactca actacagacc cagcaaagag ctgttcagga
     8041 agcaatccag gtgaagctga atgagtttga acaatggata acacattatc aggctgcatt
     8101 caataactta gaagcaactc agcttgcaag tttgcttcaa gagataagca cacaaatgga
     8161 ccttggtccc ccaagctatg ttccagcaac agcttttcta cagaatgctg gccaagcaca
     8221 cctcatcagc cagtgtgagc agctagaggg ggaagttggt actctgctgc agcagaggcg
     8281 ctctgtgctc cgtggctgtc tggaacagct gcatcactat gcaactgtcg ctctgcagta
     8341 tccgaaagca atattccaga aacatcgaat tgaacagtgg aaggcctgga tggaagagct
     8401 catctgcaac accacagtag aacgctgcca agaactctat aggaaatatg agatgcagta
     8461 tgctcctcag ccccctccaa cagtctgtca gttcattact gccactgaaa tgacccttca
     8521 gcggtatgca gcagacataa acagcagact tattagacaa gtggaacgct tgaagcaaga
     8581 agctgtcact gtgccagttt gtgaggatca gttgaaagaa attgagcgtt gcattaaagt
     8641 ttttcttcat gagaatggag aagaaggatc tctgagtcta gcaagtgtca ttatttctgc
     8701 cctttgtact cttacaaggc gcaaccttat gatggaaggt gcagcttcaa gtgctggaga
     8761 gcagctggtt gatctgacat ccagagatgg agcctggttc ctagaggagc tgtgtagtat
     8821 gagtggaaat gtcacctgct tggtgcagtt actgaagcag tgccacctgg taccacagga
     8881 cttggatatt cccaacccag tggaagcatc tgaggctgtt catttagcca atggagtgta
     8941 tacatctctg caggaattaa attcaaattt ccggcaaatc atattcccag aagctcttag
     9001 atgtttaatg aagggggagt gcactttaga aagtatgcta catgaactag acagtctcat
     9061 cgagcagact actgatggag ttcctctgca gactctggtg gagtcgcttc aagcctactt
     9121 aagaaacaca gccatgggac ttgaagaaga aactcatgct cattatattg atgttgccag
     9181 aatgctacat gctcaatatg gtgaattaat ccaaccaaga aatggttcag ttgatgaaac
     9241 accaaaaatg tcagctggcc agatgctttt ggtagcattt gatggcatgt ttgcccaagt
     9301 tgaaactgct tttggcttat tagttgagaa gttaaacaag atggagattc ccgttgcttg
     9361 gaggaagatt gacattatcc gggaagccag gagcacccag gccaattttt ttgatgatga
     9421 caatcaccgg caggtgctag aagagatttt ctttttaaaa agactgcaga caattaagga
     9481 gttcttcagg ctctgtggta ccttttctaa aacattgtca ggatcaagtt cacttgaaga
     9541 tcagaatact gtaaatggac ctgttcagat tgtcaatgtg aaaacccttt ttagaaattc
     9601 ttgctttagt gaagaccaaa tggccaagcc tatcaaggcc tttacagctg actttgtaag
     9661 acagctcttg ataggactcc caaaccaagc cctcggactc acattgtgta gctttatcag
     9721 tgccctgggc gtagacatca ttgctcaggt agaggcaaag gatttcggag ctgaaagcaa
     9781 agtctctgtg gacgatctgt gtaagaaagc tgtggagcac aacatccagg ttgggagatt
     9841 ctcacagttg gtgatgaaca gagctaccgt gttagccagc tcctatgata cagcctggaa
     9901 gaagcatgac ctggtgcgca ggctggaaac cagcatttct tcctgtaaga caagcttaca
     9961 gcgggtgcaa ctgcacattg ccatgttcca gtggcaacat gaagacctcc ttatcaacag
    10021 accacaagcc atgtcagtca ccccacctcg gtctgcaatc ctgaccagca tgaagaagaa
    10081 actgcatgct ctcagtcaga ttgagacttc aatcgggact gttcaggaga aactagcagc
    10141 tcttgaagca agcattgagc agcggctgaa gtgggcaggt ggtgccaatc ctgccctggc
    10201 accagtacta caagattttg aagcaacaat agctgaaaga agaaatcttg ttctcaaaga
    10261 gagccagaga gcaaaccagg tcacttttct ctgcagcaat atcattcatt ttgaaagtct
    10321 acgaacaaga actgccgaag ccttaagcct ggatgctgcc ttatttgaac tcatcaaacg
    10381 gtgtcagcag atgtgttcat ttgcatcaca gttcaacagt tcagtttctg agttagagct
    10441 tcgtttatta cagagagtgg acacgactct tgaacatcct attggcagtt ctgagtggct
    10501 tttatcagca cataaacagt tgacccagga tatgtccacc caaagggctg ttcagacaga
    10561 gaaggagcag cagatcgaga ctgtttgtga gaccatccag agcctggttg acagcgtaaa
    10621 gactgtgctc acgggtcaca accggcagct tggagatgta aaacatctcc tgaaagccat
    10681 ggctaaggac gaagaggccg ctctagcaga tgctgaagat atcccctatg agagcagtgt
    10741 caggcagttc ctggccgagt acaaatcatg gcaagacaac attcagacgg ttttgttcac
    10801 actggtccag gccatgggtc aggttcgaag tcaagaacat gttgaaatgc tgcaggaaat
    10861 cactcccacc ttgaaagagc tgaagacaca aagccagagt atctataata atttagtgag
    10921 ttttgcatca cccttagtca ccgacgcagc aaacgaatgt tcaagtccaa catcatctgc
    10981 tacttaccag ccgtcctttg ctgcagcggt taggagtaac actggccaga agactcagcc
    11041 tgatgtcatg tctcagaatg ctaaaaagct gattcagaaa aatctggcta catcagcaga
    11101 tactccacca agcaccatcc caggaactgg caagagcatc gcctgtagtc ccaaaaaggc
    11161 tatcagagac cctaaaactg ggaaagctgt gcaagagaga aactcctatg cagtgagtgt
    11221 gtggaagaga gtgaaagcca agctagaagg ccgagatgtt gatccaaaca ggaggatgtc
    11281 agttgctgag caggttgact atgtcattaa ggaagcaact aatctagata acttggctca
    11341 gctgtatgaa ggttggacag cctgggtgtg aatggcaaga cagtagatga gtctggttaa
    11401 gcgaggtcag acatccacca gaatcaactc agcctcaggc atccaaagcc acatcacagt
    11461 cggtggtgat gcaactgggg gcttactctg aggaaaccta ggaaatctcg gtgtactagg
    11521 aagtgaatcc tgcaggacag ctgcactcag ggatacgccc aacaccatgg ccagggtcaa
    11581 aggtgaagaa agcaagctca ctgcctgcac acggagattg tctttctgcc acagaacagc
    11641 tgcaaacgtg ccaggaggtt agctgagaaa gaaatcgggc tgctgcggag cacagagtga
    11701 cttggaactc cattccacct gaccctgtgt gtacaatcca ggaaaacaaa ccccgatcag
    11761 aaacagagaa aattggggcc gcgaagaact cacagccacg gaagagttgt tgcattcaga
    11821 ttctcgagaa acatttgttg ctcggcaaca gtactggtcg ggttgaccag ttaagtacca
    11881 aaaggctatg ctgtatgaat ttcagaaatg gactgaaaaa aatgggagag cagtgtaata
    11941 gacacacact acattggaag aacttgactt ctgaaatgaa gagaaaagca cctatggatc
    12001 ccactccttc ccatcgctta cctgttcccc tgctcccctg ctccccgttg acccgccctg
    12061 gtagattagc tggctgtcag actcactttt atttcaatcc ttacacttca taaacttttg
    12121 tctccacatt gttaccatat ttggagacag aaacaggagc ttctccaaat ccaatgagaa
    12181 catggaaaat tcaaggattg tttaaaggtc tgtgatcatc acatacaaga tgtaactctg
    12241 gttatttcag tcatatctgt gactctatca tgtacagttt cctgaattgt cactgtgcat
    12301 ccaaacgtaa tgagtctaac agacactgat ttcatgtgca ctcccctctg cttacaatgt
    12361 gcattttttg gaggtcattc aaattttccc tcttctgtga ttgctgtagt ttctttcata
    12421 gaaagtagct gatctgatgt aatcttttac cttttaaaca accaggatag agaacctatt
    12481 ggagtttgag ttgttgatga caggttcaca ataaagtgat gttctggtgg aggtagagtg
    12541 aaatgttttt taattcagtt ttctctttga tacttttaat ttacaaagtg taattttctt
    12601 ttgttttaaa gtgtaaatta aaaatgcttt agtttacctg gcctttggga atatgcagta
    12661 atgcctacca gcagcacctt ttaagttcag cttgtgacct gtaatgggtt ctgtttacct
    12721 attgcaacgt ttatagcttg ctgttgagtg actagtgtgt agtgagtcac gatcaaggca
    12781 tccttcaggt tagcattttc agtactcact gctgatcctt gatagaagtg cagactagaa
    12841 tagagctaaa aatcacgtat caacacagaa tagcacacag tattttgagt cttttccctg
    12901 cattttagca actagtggtg gccacttaat ttgccagcct ctataagcct gaaaggctct
    12961 tctctgactg ctagagttga attgtaatcc tcacaggttg gatgccagtg tcagcatttt
    13021 cttaattacg actattggaa ggtgctgttt ttcagtctcc acgtgtccac tgacaagtta
    13081 aagaatctag cacattgcat ttgattttat ttgtggattt tgggccttat tttcacaaaa
    13141 cagcctagcc tggaatattg ataccatact gtattttgca tgctattttc ttcccttgag
    13201 gcattgagag taactgcact tttgctctct caagatgtgt cattttcaaa cattcttcat
    13261 gccaggagga acttttgttg taaggagaaa accagctcag acttttgtcc ctgtaggtgg
    13321 tggtagtggt cagaaatggc ttttgctttg gtaataggtg aattttattc ctcaagagtc
    13381 tcaggcatca gaagtactag gtgtcttaat ccaagcaaaa ataagacagc ttaaaaaaca
    13441 accagaagaa agtgcctctg atgaactatc catccttatt tttaaactgg tctttgagag
    13501 gagaatagta cgtggttata tatagggcaa gataagagca actaggactt caaagcttgt
    13561 tgatggctgc actctggata aagtcctcat ttgtatggtt gggctttctg atcaaatagc
    13621 ctttccaggt ttaacttctg taaggagcct caagtgaaaa aaccagggcc actggggatt
    13681 tttatgaaat catgtagagt gctgtagttt tgaagtcatc ctttcatgat aaaataccta
    13741 tggaaaacca gggatatttt tttctccaac tcttcctctc tttactcctt acccctctac
    13801 tctctacttc tgtcttcctt ccctccaccc ttttaagatt cagcgggtac agaacaacct
    13861 cttctatttc agagtaccct tgaggattaa aatgtattgt gattagttgt ctttaattag
    13921 ctagctggag tcagttgata tctctgccaa gctgaagcct agtacctacg aagctgtttc
    13981 tttaccaaag tgtcttgttt ctgtttatgg tcatgagctg atcatgcagt ttgctagatg
    14041 atttgacact ggtagtgagt tcttttgagg tgtgagattt ctacttgaaa ctgatagatc
    14101 ttgatctact ttattagatc actgattcag agctcaaatc ccaggttcag ggtaagaatt
    14161 tgtaacacaa aggaaaaact cccttcactt tgcccttaac acttgcctct gttatatcta
    14221 agcttcatta gatttcttaa tatcatccag tgtttgatgt tacctgcatt gttttttcgt
    14281 tttaattgtg gttgttctga tgtgtgaaat ttaaggaaag agccatttaa taaatgccaa
    14341 gcagggcaat gcagccaaat attagagttg atgtgcagtc ttaggtcctt tttaatctgg
    14401 ggtattatag gcagtacttt aaatcagagt cttcctggcc tatttccctc cacctttttg
    14461 tagttactcg ggggcttact tgtgcagtac taaaatcaaa ggagctggtt cttcttttcc
    14521 cccaatcttt tcttagtaat gaacacacct acaactagcc tgctactcct attcatacac
    14581 agcagatgtc agtgctgtgc tgctaatatt agctggattt cctgcagtgc agggatggaa
    14641 ccttgcacat gctaggcaag ctttctaacc ctgagctaca tacatcctag ctcttagaac
    14701 tagcaccctg aagcatcttt gtttcatgtg tcaagatgcg gacaaagacc aacattgttt
    14761 ttataaaaat gctagtaatt tagaaccctg ccccaccccc taccccccaa tcaaggaggc
    14821 aaaaattaat gcactagtca ctgaagactc catcttcagt tacctggata ggatagattc
    14881 ctcctaacaa gtactggtga gcatcacagt gctttgcaaa gatttaagag gaggcagtta
    14941 ctgtacttcg cctgcttttg ggcctagata acatcactgt ttatttacaa aaagcaaaca
    15001 gcttgggttt gaaaaggcag ccatgtagag aaaacttgag aattggggct cactgggaag
    15061 ttctagtgct aatgttaaaa cctcaaatca gctggatatt tgaagatggt aaagaattgg
    15121 atatagtcct gaaacatttt atttttctaa aacaggctga ttagcagtgg tggttttccc
    15181 tttttctgac agtgtgtttt agctcctgtt tcagatttct gtgttatttt ttccaattta
    15241 caagtccctt aagtttccac ctggaatgtc aggtggcaat gacatcgtgt tcttttttta
    15301 aacccttatt taagaacaag ttgagttgaa ctgaatcttc cttgtcttag taacattgta
    15361 caaacagtgg ctttttttta agttgtaatg ccttctgatg gatataattt tgtgcttgta
    15421 tttaagatta aaagttgagt aaataacacc agcttcctga aaatgtccat aatgcatctt
    15481 ttgaaaaaca aaacacctgc ctactttaca ttaacatggt aaagattgta tgaaatacct
    15541 gtttttcaaa aaataaaggt tcaagataac agta
//
