LOCUS       XM_039101162           15516 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus SMG1, nonsense mediated mRNA decay
            associated PI3K related kinase (Smg1), transcript variant X1, mRNA.
ACCESSION   XM_039101162
VERSION     XM_039101162.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_001427295.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15516
                     /gene="Smg1"
                     /note="SMG1, nonsense mediated mRNA decay associated PI3K
                     related kinase; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 mRNAs, 113 ESTs, 13
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 158 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:691397"
                     /db_xref="RGD:1563508"
     CDS             337..11313
                     /gene="Smg1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SMG1 isoform X1"
                     /protein_id="XP_038957090.1"
                     /db_xref="GeneID:691397"
                     /db_xref="RGD:1563508"
                     /translation="MSRRAPGSRLSSGGGGTKYPRSWNDWQPRTDSASADPDTLKYSS
                     SRDRGVSSSYGLQPSNSAVVSRQRHDDTRGHADIQNDEKGGYSVNGGSGENTYGRKSL
                     GQELRINNVTSPEFTSVQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDR
                     DRRLATVKQLKEFIQQPENKLVLVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGL
                     LCASLSYEAEKIFKWIFSKFSSSAKDEVKLLYLCATYRALETVGEKKAFSSVMQLVMT
                     SLQSILENVDTPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLT
                     QQVSGWLQSLEPFWVADLAFSTTLLGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVS
                     LPKLAALLRVFSTVVRSIGERFSPIRGPPITEAYVTDVLYRVMRCVTAANQVFFSEAV
                     LTAANECVGVLLGSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIVEQ
                     INTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAVAHAVYQAVLSLKNIPVLETAYKLI
                     LGEMTCALNNLLHSLQLPDACSEIKHEAFQNHVFNIDNANFVVIFDLSALTTIGNAKN
                     SLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLS
                     SSSPSLFDGAVISTVTTATKKHFSIILNLLGILLKKDNLNQDTRKLLMTWALEVAVLM
                     KKSETYAPLFSLPSFHKFSKGLLANTLVEDVNICLQACSSLHALSSSLPDDLLQRCVD
                     VCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQEISLALRSHMSKAPSNTFH
                     PQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRNLLKTDAVLWQWA
                     IWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTTADNDEGHG
                     SNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRL
                     SIMRVGLLAGQPAVTVRHGFDLLTEMKTNSLSQGNELEVTIMMVVEALCELHCPEAIQ
                     GIAVWSSSAVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLT
                     LANAGRNSASPKHSLNGESRKTVLSKSIDSSPEVINYLGNKACECYISIADWAAVQEW
                     QNAVHDLKKNANSTSLNLKADFNYIKSLSSFESGEFVECTEQLELLPGENINLLAGGS
                     KEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVFLATALNHVEQDQKWQSLTENVVK
                     YLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSD
                     ALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNV
                     SLATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQ
                     STHAMEMLSSCAISFCKSAKAEYAVAKSILTLAKWVQAEWKEISGQLRQVYRAQQQQN
                     LSGLSTLSRNILALIELPSANTVGEEHPRIESESTVHIGVGEPDFILGQLYHLSSVQA
                     PEVAKSWAALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIY
                     GILGQAVCRPAGIQDEDITLQITESEDNEDDDMVDVIWRQLISSCPWLSELDENATEG
                     VIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQVLLDEDDPRLHLSHRAEQSTDDVIV
                     MATLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNL
                     LCRVAQDSPHLILYPAIVGTISLSSESQASGNKYSSAIPTLLGNIQGEELLVSECEGG
                     SPPASQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTV
                     LWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIV
                     FALEHVRSITAAPAETPHEKWFQDNYGDAIDNALEKLKTPSNPAKPGSSWIPFKEIML
                     SLQQRAQKRASYILRLDEISPWLAAMTNTEIALPGEVSARDTVTIHSVGGTITILPTK
                     TKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARH
                     YSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPSIVPRPS
                     ELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPD
                     EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLR
                     VPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVD
                     WTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEML
                     VVLPKLDSSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSRTLQHRYSEHT
                     QLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPPSYV
                     PATAFLQNAGQAHLISQCEQLEGEVGTLLQQRRSVLRGCLEQLHHYATVALQYPKAIF
                     QKHRIEQWKAWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQRYA
                     ADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVIISAL
                     CTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQ
                     DLDIPNPVEASEAVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGECTLESMLHELD
                     SLIEQTTDGVPLQTLVESLQAYLRNTAMGLEEETHAHYIDVARMLHAQYGELIQPRNG
                     SVDETPKMSAGQMLLVAFDGMFAQVETAFGLLVEKLNKMEIPVAWRKIDIIREARSTQ
                     ANFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIV
                     NVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQ
                     VEAKDFGAESKVSVDDLCKKAVEHNIQVGRFSQLVMNRATVLASSYDTAWKKHDLVRR
                     LETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPRSAILTSMKKKLHALS
                     QIETSIGTVQEKLAALEASIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQR
                     ANQVTFLCSNIIHFESLRTRTAEALSLDAALFELIKRCQQMCSFASQFNSSVSELELR
                     LLQRVDTTLEHPIGSSEWLLSAHKQLTQDMSTQRAVQTEKEQQIETVCETIQSLVDSV
                     KTVLTGHNRQLGDVKHLLKAMAKDEEAALADAEDIPYESSVRQFLAEYKSWQDNIQTV
                     LFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDAANECSS
                     PTSSATYQPSFAAAVRSNTGQKTQPDVMSQNAKKLIQKNLATSADTPPSTIPGTGKSI
                     ACSPKKAIRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKE
                     ATNLDNLAQLYEGWTAWV"
ORIGIN      
        1 gccgtggccg tgtgagcgtg aggagccgcc gccaccgcct cctcgctgtc ctcgtcctcc
       61 tgggccccag cgtcgcgggc cgcgcgctgc cctggaagag acgtcgcctc gcctgcctcc
      121 gcctccccct cgccgcgccg ctcccgcctc ctgctcctgc gttgcgggct ccagcggaac
      181 ccggaacggc cgtccgcctc ccccgccctc cgccgccccc tccgcggctt cctcctcagc
      241 cccgggccag atcgcagtgt cggcggcggc cggttcaggc ggcgattcgc gcttcttcgg
      301 gcggcggcgc ttggccatgt cgtgtcgggg aaggtaatga gccgcagagc cccggggtct
      361 cggctgagca gcggcggcgg cggcaccaag tacccgcgga gctggaatga ctggcaaccc
      421 agaactgata gtgcatcagc cgacccagat actttaaaat actcctcatc cagagatagg
      481 ggtgtttctt cctcttatgg actgcaacct tcaaattcag ctgtggtgtc tcggcaaagg
      541 cacgatgata ccagaggcca tgctgacata cagaatgacg aaaagggtgg ctacagtgtc
      601 aatggaggat ctggggaaaa tacttatggt cggaagtcgt tggggcaaga gctgaggatt
      661 aacaatgtga ccagccctga gtttaccagt gttcagcatg gcagtcgtgc gttagccacc
      721 aaagacatga ggaaatcaca ggagcgatcg atgtcgtact ctgatgagtc tcgactgtcg
      781 aatcttcttc ggaggatcac ccgggaagat gacagagacc gaagactggc tactgtaaag
      841 cagctgaagg agtttattca gcagccagaa aataaactgg tactagttaa acagttggat
      901 aatatcttgg ctgctgtgca tgatgtacta aatgaaagta gtaagttgct tcaggagttg
      961 aggcaagagg gagcttgctg tcttggtctt ctctgtgctt ctctgagcta cgaggctgag
     1021 aagatcttca agtggatttt tagcaaattt agctcatctg cgaaagatga ggtgaagctc
     1081 ctctacctgt gtgccactta cagagcactg gagactgttg gcgagaagaa agccttttct
     1141 tcggtgatgc agcttgtgat gaccagccta caatccattc ttgaaaatgt ggatacacca
     1201 gaattacttt gcaaatgtgt taagtgcatt cttttggtgg ctcgatgcta ccctcatatt
     1261 ttcagcacta attttaggga tacagttgat atattagttg gatggcacat agatcatact
     1321 cagaaaccct cccttacaca gcaggtgtct gggtggttgc agagtttgga gccattttgg
     1381 gtagctgacc ttgcattttc taccactctt cttggtcaat ttttagaaga catggaggca
     1441 tacgctgagg acctcagcca tgtggcctct ggggagtcag tggatgaaga tgttcctcct
     1501 ccatcagtgt cattaccaaa gctggcagcg cttctccgtg tgttcagtac tgtggtgagg
     1561 agcattgggg agcgctttag cccaattcgg ggtccaccaa ttaccgaggc atatgtaaca
     1621 gatgttctat acagagtaat gagatgcgtg acggctgcaa accaagtgtt tttttctgag
     1681 gctgtgttga cagctgctaa tgagtgtgtt ggtgttttgc tcggcagctt ggatcctagc
     1741 atgactatac attgtgacat ggtcattaca tatggattag accaactgga gaattgccag
     1801 acttgtggta ccgattatat catctcagtc ttgaatttgc tcacattgat tgttgagcag
     1861 ataaatacaa aactcccatc atcatttgta gaaaagcttt ttataccatc atctaaacta
     1921 ctatttctac gataccacaa agaaaaagag gttgttgctg tagctcatgc tgtttatcaa
     1981 gcagtgctca gcttgaagaa catccccgtt ctggagactg cctataaatt aattttggga
     2041 gaaatgactt gtgcactaaa caatttgcta cacagtctcc agcttcctga tgcctgttct
     2101 gagattaaac atgaggcttt tcagaatcat gtgttcaaca ttgacaatgc caactttgta
     2161 gtcatatttg atctcagtgc cctgactaca attggaaatg ccaaaaactc attaattggg
     2221 atgtgggcac tgtctccaac tgtatttgca ctgctgagta agaatctgat gatagtgcac
     2281 agtgacctgg ctgttcactt ccctgccatt cagtatgcgg tgctctacac cctatattcc
     2341 cattgtacca gacacgatca cttcatttcc agtagtctta gttcttcatc cccttcctta
     2401 tttgatggcg cggtgattag tactgtaact acagccacaa agaaacattt ctcaattata
     2461 ttaaatcttt tgggaatatt actaaagaaa gataatctta accaggacac aaggaaactg
     2521 ttaatgacat gggctttgga agtagctgta ttaatgaaga agtctgaaac atatgcacct
     2581 ttattctccc ttccatcttt tcataaattc tccaaaggcc ttttagctaa cactcttgtt
     2641 gaagatgtga atatctgctt gcaagcatgt agcagtctcc atgctctgtc ctcttccttg
     2701 ccagatgatc tgctacagag gtgtgttgat gtctgccgtg ttcagcttgt ccatagtgga
     2761 actcgtattc gacaggcctt tggaaagctg ttgaagtcaa ttcctttaga tgttgtacta
     2821 agcaataaca atcacacaga gattcaggag atttctttag cattgagaag ccacatgagt
     2881 aaagcaccaa gtaacacgtt ccaccctcag gacttttctg atgtcatcag tttcattttg
     2941 tatggaaact ctcaccgaac agggaaggac aattggttag aaagattgtt ctatagctgc
     3001 cagaggctgg ataagcgtga ccaatccaca attccccgca atcttctaaa gacagatgct
     3061 gtcctgtggc agtgggctat ttgggaagct gcacagttca ctgttctttc aaagttgcga
     3121 accccactgg gcagagctca ggacacgttc cagacaattg aaggtatcat tagaagtctt
     3181 gcagcccaca cactaaaccc tgaccaggat gttagtcagt ggaccactgc agataatgat
     3241 gaaggccatg ggagcaatca gcttagactt gttcttctgc ttcagtatct ggagaacctg
     3301 gagaaactaa tgtataacgc ctatgagggg tgtgccaatg cattaacatc acctcccaag
     3361 gtcattagga cttttttcta taccaatcga cagacttgcc aagactggct cactcggatc
     3421 cgtctttcca tcatgagggt cggattgttg gcaggtcagc ctgcagtgac agtgaggcac
     3481 ggctttgact tacttactga aatgaaaaca aatagtctgt ctcaggggaa tgaattggaa
     3541 gtgactatca tgatggtggt agaagcgctg tgtgagctcc actgtcctga agctatacag
     3601 gggattgctg tctggtcatc ttcagctgtt ggtaaaaacc ttctctggat taactcagtg
     3661 gcccaacagg ctgaagggag gtttgaaaag gcctctgtgg agtaccagga gcacctgtgt
     3721 gccatgacag gtgttgattg ctgcatctcc agctttgaca agtctgttct cacattggcc
     3781 aatgctggac gtaacagtgc cagccccaaa cactctctaa atggtgaatc cagaaaaact
     3841 gtgctgtcca aatcaatcga ctcttcccct gaagttatca actacctagg aaataaggca
     3901 tgtgagtgtt acatctccat tgctgactgg gctgctgtgc aggagtggca gaacgcggtc
     3961 cacgacctga agaagaatgc caacagcacc tcactcaatc tgaaagccga tttcaactac
     4021 atcaagtcac taagcagctt cgagtctgga gagtttgttg aatgcactga gcagttggaa
     4081 ttattgccag gagaaaatat taatctgctt gctggagggt caaaagaaaa aatagatatg
     4141 aaaaagctgc ttcctaacat gctaagccca gacccacggg agcttcagaa atccattgaa
     4201 gtccaattgt tgagaagctc cgtgttcctg gcaactgctc taaaccatgt ggaacaagat
     4261 cagaaatggc agtccttaac cgaaaatgtg gtaaagtact tgaagcaaac ctcacgcatc
     4321 gctattggac cactaagatt gtctacgcta acggtgtcac agtccttgcc agtactgagt
     4381 accctgcagc tctactgctc ctctgcactg gagaacacag tttctaatag actttcaaca
     4441 gaggactgtc ttatcccact ctttagtgat gctcttcgct catgtaaaca gcatgatgtg
     4501 cggccttgga tgcaggcgtt gagatatacc atgtaccaga atcaactgtt agagaaaatt
     4561 aaagaacaaa cagtaccaat tagaagccat ctcatggaac taggtctgac agctgcaaaa
     4621 tttgctagaa aacgggggaa tgtgtcactg gcaacaagac tgttggcaca gtgcagtgag
     4681 gttcagctgg gaaagacaac cactgcccag gacttagtcc agcattttaa aaaactgtct
     4741 actcaaggtc aagtggatga aaaatggggg cctgagcttg atattgaaaa aaccaaattg
     4801 ttatacacag caggccagtc aacacacgca atggaaatgt tgagttcttg tgctatatct
     4861 ttctgcaaat ctgcgaaagc tgaatatgct gtggctaagt caattctgac cctggctaaa
     4921 tgggtccagg cagaatggaa agagatttcg ggacagctga ggcaggtgta ccgagctcag
     4981 cagcagcaga acctttcagg cctttctact ttgtctagga atatactcgc tcttatagag
     5041 ctaccgtctg ctaatacagt gggagaagag caccctcgga ttgagagtga gtctacagtg
     5101 catattggag ttggagaacc tgacttcatt ttgggacagt tgtatcacct gtcttcagtg
     5161 caggcacctg aagtagccaa atcttgggca gcattggcta gttgggctta taggtggggc
     5221 agaaaggtgg ttgacaatgc cagtcaggga gaaggtgttc gtctgttgcc tagagaaaaa
     5281 tctgaagttc aaaatctgct tccagatact ataactgaag aagagaaaga gagaatatat
     5341 ggtattcttg gacaagcagt atgtcggcca gcaggaattc aggatgaaga tataacacta
     5401 cagataacag agagtgaaga taatgaggat gatgacatgg tcgatgttat ctggcggcag
     5461 ttaatatcaa gctgtccctg gctttctgaa ctggatgaaa atgcaacgga aggtgttatt
     5521 aaagtgtgga ggaaagttgt ggacagaatc ttcagcctgt acaaattgtc ttgcagtgca
     5581 tattttactt tccttaagct gaatgctggt caggttctgt tagatgagga tgaccccagg
     5641 ctccatttaa gtcacagagc tgagcagagc actgatgatg tgattgtgat ggctaccctg
     5701 cgactgctca gattgctagt gaagcatgct ggtgagcttc ggcagtatct ggaacatggc
     5761 ttggagacaa cccctactgc tccatggaga ggaattattc cacagctttt ctcacgctta
     5821 aaccaccctg aagtgtatgt acgccagagt atttgtaacc tcctttgccg tgtagcccaa
     5881 gattcccctc acctcatatt gtatcctgca atagtaggaa ccatatcact tagcagtgaa
     5941 tcccaggctt caggaaataa gtattcctct gcaatcccaa ctttacttgg aaatattcaa
     6001 ggagaagaac tgctggtttc tgaatgtgaa ggaggaagtc ctcctgcttc tcaggatagc
     6061 aacaaagatg aacctaaaag tggtttaaat gaagatcagg ccatgatgca ggattgctac
     6121 agcaaaattg tagataaact atcctctgca aatccaacga tggttttaca ggtccagatg
     6181 cttgtggcag agctacgtag ggtcactgta ctctgggatg agctctggct gggagttttg
     6241 ttacagcagc atatgtacgt cctgaggcga attcagcagc tggaggatga ggtgaagaga
     6301 gtccagaaca acaacacctt gcgcaaagaa gagaaaattg ccatcatgcg agagaagcac
     6361 acagcactga tgaagcccat cgtgtttgct ttggagcacg tgcggagcat cactgctgcc
     6421 cctgcagaga cccctcatga aaagtggttt caggataact atggtgatgc cattgacaat
     6481 gcccttgaaa aactaaagac cccatccaac cctgccaagc ctggaagcag ctggattcca
     6541 tttaaagaga taatgctgag tttgcaacag agagcgcaga aacgagcaag ctacatcttg
     6601 cgacttgatg agatcagtcc ttggttggct gccatgacta acactgaaat tgcactccct
     6661 ggagaagtct ctgccagaga cactgtgaca attcacagtg tgggtggaac tatcactatc
     6721 ttaccaacta aaaccaagcc caagaaactc ctctttcttg gatcagatgg aaagagctat
     6781 ccttaccttt tcaaaggtct agaagatttg catctggatg agagaatcat gcagttttta
     6841 tctattgtga atactatgtt tgctacaatt aatcggcagg aaacaccccg attccatgca
     6901 cggcactatt ctgtaacacc actggggacg agatcggggc tgatccagtg ggtggatgga
     6961 gccacaccat tgttcgggct ttacaaacga tggcaacagc gggaggctgc cttacaagca
     7021 caaaaggccc aagattccta ccagactcct cagaatccca gcattgtacc gcgtcctagt
     7081 gaactttact atagtaaaat tggtcctgct ttgaaaacag ttggccttag cctggatgtg
     7141 tcaaggaggg attggcccct ccatgtgatg aaggcagtgt tggaggagtt aatggaggcc
     7201 acacccccaa accttctggc caaagaactc tggtcatctt gcaccactcc cgatgagtgg
     7261 tggagagtca cacagtccta tgcaagatcc accgctgtca tgtctatggt tggctacata
     7321 attggccttg gagacagaca tctggataac gtcctcatag atatgacaac tggagaagta
     7381 gttcacatag attataatgt ttgctttgaa aaaggtaaaa gccttagagt tcctgagaaa
     7441 gtgccttttc gaatgacaca aaacattgaa acagcactgg gtgtaactgg agtagaaggt
     7501 gtttttaggc tttcctgtga gcaggttctc cacatcatgc gacgaggccg agagactctg
     7561 ctgacactct tggaggcttt tgtgtatgac ccactggtgg actggacagc cggcggtgag
     7621 gctgggtttg caggtgctgt ctatggtgga ggtggccaac aggccgagag caagcagagt
     7681 aagcgagaga tggagcgtga gattacccgc agcctctttt cttccagagt tgctgagatt
     7741 aaggtgaact ggtttaagaa ccgggatgag atgctagttg tgcttcccaa gctggacagc
     7801 agcttagatg aatacctaag cctgcaggag cagctgacag atgttgaaaa gctgcagggc
     7861 aaactgctgg aggaaataga gtttctagaa ggagctgaag gagtggatca tccatctcgc
     7921 actctgcaac acagatattc tgagcatact caactacaga cccagcaaag agctgttcag
     7981 gaagcaatcc aggtgaagct gaatgagttt gaacaatgga taacacatta tcaggctgca
     8041 ttcaataact tagaagcaac tcagcttgca agtttgcttc aagagataag cacacaaatg
     8101 gaccttggtc ccccaagcta tgttccagca acagcttttc tacagaatgc tggccaagca
     8161 cacctcatca gccagtgtga gcagctagag ggggaagttg gtactctgct gcagcagagg
     8221 cgctctgtgc tccgtggctg tctggaacag ctgcatcact atgcaactgt cgctctgcag
     8281 tatccgaaag caatattcca gaaacatcga attgaacagt ggaaggcctg gatggaagag
     8341 ctcatctgca acaccacagt agaacgctgc caagaactct ataggaaata tgagatgcag
     8401 tatgctcctc agccccctcc aacagtctgt cagttcatta ctgccactga aatgaccctt
     8461 cagcggtatg cagcagacat aaacagcaga cttattagac aagtggaacg cttgaagcaa
     8521 gaagctgtca ctgtgccagt ttgtgaggat cagttgaaag aaattgagcg ttgcattaaa
     8581 gtttttcttc atgagaatgg agaagaagga tctctgagtc tagcaagtgt cattatttct
     8641 gccctttgta ctcttacaag gcgcaacctt atgatggaag gtgcagcttc aagtgctgga
     8701 gagcagctgg ttgatctgac atccagagat ggagcctggt tcctagagga gctgtgtagt
     8761 atgagtggaa atgtcacctg cttggtgcag ttactgaagc agtgccacct ggtaccacag
     8821 gacttggata ttcccaaccc agtggaagca tctgaggctg ttcatttagc caatggagtg
     8881 tatacatctc tgcaggaatt aaattcaaat ttccggcaaa tcatattccc agaagctctt
     8941 agatgtttaa tgaaggggga gtgcacttta gaaagtatgc tacatgaact agacagtctc
     9001 atcgagcaga ctactgatgg agttcctctg cagactctgg tggagtcgct tcaagcctac
     9061 ttaagaaaca cagccatggg acttgaagaa gaaactcatg ctcattatat tgatgttgcc
     9121 agaatgctac atgctcaata tggtgaatta atccaaccaa gaaatggttc agttgatgaa
     9181 acaccaaaaa tgtcagctgg ccagatgctt ttggtagcat ttgatggcat gtttgcccaa
     9241 gttgaaactg cttttggctt attagttgag aagttaaaca agatggagat tcccgttgct
     9301 tggaggaaga ttgacattat ccgggaagcc aggagcaccc aggccaattt ttttgatgat
     9361 gacaatcacc ggcaggtgct agaagagatt ttctttttaa aaagactgca gacaattaag
     9421 gagttcttca ggctctgtgg taccttttct aaaacattgt caggatcaag ttcacttgaa
     9481 gatcagaata ctgtaaatgg acctgttcag attgtcaatg tgaaaaccct ttttagaaat
     9541 tcttgcttta gtgaagacca aatggccaag cctatcaagg cctttacagc tgactttgta
     9601 agacagctct tgataggact cccaaaccaa gccctcggac tcacattgtg tagctttatc
     9661 agtgccctgg gcgtagacat cattgctcag gtagaggcaa aggatttcgg agctgaaagc
     9721 aaagtctctg tggacgatct gtgtaagaaa gctgtggagc acaacatcca ggttgggaga
     9781 ttctcacagt tggtgatgaa cagagctacc gtgttagcca gctcctatga tacagcctgg
     9841 aagaagcatg acctggtgcg caggctggaa accagcattt cttcctgtaa gacaagctta
     9901 cagcgggtgc aactgcacat tgccatgttc cagtggcaac atgaagacct ccttatcaac
     9961 agaccacaag ccatgtcagt caccccacct cggtctgcaa tcctgaccag catgaagaag
    10021 aaactgcatg ctctcagtca gattgagact tcaatcggga ctgttcagga gaaactagca
    10081 gctcttgaag caagcattga gcagcggctg aagtgggcag gtggtgccaa tcctgccctg
    10141 gcaccagtac tacaagattt tgaagcaaca atagctgaaa gaagaaatct tgttctcaaa
    10201 gagagccaga gagcaaacca ggtcactttt ctctgcagca atatcattca ttttgaaagt
    10261 ctacgaacaa gaactgccga agccttaagc ctggatgctg ccttatttga actcatcaaa
    10321 cggtgtcagc agatgtgttc atttgcatca cagttcaaca gttcagtttc tgagttagag
    10381 cttcgtttat tacagagagt ggacacgact cttgaacatc ctattggcag ttctgagtgg
    10441 cttttatcag cacataaaca gttgacccag gatatgtcca cccaaagggc tgttcagaca
    10501 gagaaggagc agcagatcga gactgtttgt gagaccatcc agagcctggt tgacagcgta
    10561 aagactgtgc tcacgggtca caaccggcag cttggagatg taaaacatct cctgaaagcc
    10621 atggctaagg acgaagaggc cgctctagca gatgctgaag atatccccta tgagagcagt
    10681 gtcaggcagt tcctggccga gtacaaatca tggcaagaca acattcagac ggttttgttc
    10741 acactggtcc aggccatggg tcaggttcga agtcaagaac atgttgaaat gctgcaggaa
    10801 atcactccca ccttgaaaga gctgaagaca caaagccaga gtatctataa taatttagtg
    10861 agttttgcat cacccttagt caccgacgca gcaaacgaat gttcaagtcc aacatcatct
    10921 gctacttacc agccgtcctt tgctgcagcg gttaggagta acactggcca gaagactcag
    10981 cctgatgtca tgtctcagaa tgctaaaaag ctgattcaga aaaatctggc tacatcagca
    11041 gatactccac caagcaccat cccaggaact ggcaagagca tcgcctgtag tcccaaaaag
    11101 gctatcagag accctaaaac tgggaaagct gtgcaagaga gaaactccta tgcagtgagt
    11161 gtgtggaaga gagtgaaagc caagctagaa ggccgagatg ttgatccaaa caggaggatg
    11221 tcagttgctg agcaggttga ctatgtcatt aaggaagcaa ctaatctaga taacttggct
    11281 cagctgtatg aaggttggac agcctgggtg tgaatggcaa gacagtagat gagtctggtt
    11341 aagcgaggtc agacatccac cagaatcaac tcagcctcag gcatccaaag ccacatcaca
    11401 gtcggtggtg atgcaactgg gggcttactc tgaggaaacc taggaaatct cggtgtacta
    11461 ggaagtgaat cctgcaggac agctgcactc agggatacgc ccaacaccat ggccagggtc
    11521 aaaggtgaag aaagcaagct cactgcctgc acacggagat tgtctttctg ccacagaaca
    11581 gctgcaaacg tgccaggagg ttagctgaga aagaaatcgg gctgctgcgg agcacagagt
    11641 gacttggaac tccattccac ctgaccctgt gtgtacaatc caggaaaaca aaccccgatc
    11701 agaaacagag aaaattgggg ccgcgaagaa ctcacagcca cggaagagtt gttgcattca
    11761 gattctcgag aaacatttgt tgctcggcaa cagtactggt cgggttgacc agttaagtac
    11821 caaaaggcta tgctgtatga atttcagaaa tggactgaaa aaaatgggag agcagtgtaa
    11881 tagacacaca ctacattgga agaacttgac ttctgaaatg aagagaaaag cacctatgga
    11941 tcccactcct tcccatcgct tacctgttcc cctgctcccc tgctccccgt tgacccgccc
    12001 tggtagatta gctggctgtc agactcactt ttatttcaat ccttacactt cataaacttt
    12061 tgtctccaca ttgttaccat atttggagac agaaacagga gcttctccaa atccaatgag
    12121 aacatggaaa attcaaggat tgtttaaagg tctgtgatca tcacatacaa gatgtaactc
    12181 tggttatttc agtcatatct gtgactctat catgtacagt ttcctgaatt gtcactgtgc
    12241 atccaaacgt aatgagtcta acagacactg atttcatgtg cactcccctc tgcttacaat
    12301 gtgcattttt tggaggtcat tcaaattttc cctcttctgt gattgctgta gtttctttca
    12361 tagaaagtag ctgatctgat gtaatctttt accttttaaa caaccaggat agagaaccta
    12421 ttggagtttg agttgttgat gacaggttca caataaagtg atgttctggt ggaggtagag
    12481 tgaaatgttt tttaattcag ttttctcttt gatactttta atttacaaag tgtaattttc
    12541 ttttgtttta aagtgtaaat taaaaatgct ttagtttacc tggcctttgg gaatatgcag
    12601 taatgcctac cagcagcacc ttttaagttc agcttgtgac ctgtaatggg ttctgtttac
    12661 ctattgcaac gtttatagct tgctgttgag tgactagtgt gtagtgagtc acgatcaagg
    12721 catccttcag gttagcattt tcagtactca ctgctgatcc ttgatagaag tgcagactag
    12781 aatagagcta aaaatcacgt atcaacacag aatagcacac agtattttga gtcttttccc
    12841 tgcattttag caactagtgg tggccactta atttgccagc ctctataagc ctgaaaggct
    12901 cttctctgac tgctagagtt gaattgtaat cctcacaggt tggatgccag tgtcagcatt
    12961 ttcttaatta cgactattgg aaggtgctgt ttttcagtct ccacgtgtcc actgacaagt
    13021 taaagaatct agcacattgc atttgatttt atttgtggat tttgggcctt attttcacaa
    13081 aacagcctag cctggaatat tgataccata ctgtattttg catgctattt tcttcccttg
    13141 aggcattgag agtaactgca cttttgctct ctcaagatgt gtcattttca aacattcttc
    13201 atgccaggag gaacttttgt tgtaaggaga aaaccagctc agacttttgt ccctgtaggt
    13261 ggtggtagtg gtcagaaatg gcttttgctt tggtaatagg tgaattttat tcctcaagag
    13321 tctcaggcat cagaagtact aggtgtctta atccaagcaa aaataagaca gcttaaaaaa
    13381 caaccagaag aaagtgcctc tgatgaacta tccatcctta tttttaaact ggtctttgag
    13441 aggagaatag tacgtggtta tatatagggc aagataagag caactaggac ttcaaagctt
    13501 gttgatggct gcactctgga taaagtcctc atttgtatgg ttgggctttc tgatcaaata
    13561 gcctttccag gtttaacttc tgtaaggagc ctcaagtgaa aaaaccaggg ccactgggga
    13621 tttttatgaa atcatgtaga gtgctgtagt tttgaagtca tcctttcatg ataaaatacc
    13681 tatggaaaac cagggatatt tttttctcca actcttcctc tctttactcc ttacccctct
    13741 actctctact tctgtcttcc ttccctccac ccttttaaga ttcagcgggt acagaacaac
    13801 ctcttctatt tcagagtacc cttgaggatt aaaatgtatt gtgattagtt gtctttaatt
    13861 agctagctgg agtcagttga tatctctgcc aagctgaagc ctagtaccta cgaagctgtt
    13921 tctttaccaa agtgtcttgt ttctgtttat ggtcatgagc tgatcatgca gtttgctaga
    13981 tgatttgaca ctggtagtga gttcttttga ggtgtgagat ttctacttga aactgataga
    14041 tcttgatcta ctttattaga tcactgattc agagctcaaa tcccaggttc agggtaagaa
    14101 tttgtaacac aaaggaaaaa ctcccttcac tttgccctta acacttgcct ctgttatatc
    14161 taagcttcat tagatttctt aatatcatcc agtgtttgat gttacctgca ttgttttttc
    14221 gttttaattg tggttgttct gatgtgtgaa atttaaggaa agagccattt aataaatgcc
    14281 aagcagggca atgcagccaa atattagagt tgatgtgcag tcttaggtcc tttttaatct
    14341 ggggtattat aggcagtact ttaaatcaga gtcttcctgg cctatttccc tccacctttt
    14401 tgtagttact cgggggctta cttgtgcagt actaaaatca aaggagctgg ttcttctttt
    14461 cccccaatct tttcttagta atgaacacac ctacaactag cctgctactc ctattcatac
    14521 acagcagatg tcagtgctgt gctgctaata ttagctggat ttcctgcagt gcagggatgg
    14581 aaccttgcac atgctaggca agctttctaa ccctgagcta catacatcct agctcttaga
    14641 actagcaccc tgaagcatct ttgtttcatg tgtcaagatg cggacaaaga ccaacattgt
    14701 ttttataaaa atgctagtaa tttagaaccc tgccccaccc cctacccccc aatcaaggag
    14761 gcaaaaatta atgcactagt cactgaagac tccatcttca gttacctgga taggatagat
    14821 tcctcctaac aagtactggt gagcatcaca gtgctttgca aagatttaag aggaggcagt
    14881 tactgtactt cgcctgcttt tgggcctaga taacatcact gtttatttac aaaaagcaaa
    14941 cagcttgggt ttgaaaaggc agccatgtag agaaaacttg agaattgggg ctcactggga
    15001 agttctagtg ctaatgttaa aacctcaaat cagctggata tttgaagatg gtaaagaatt
    15061 ggatatagtc ctgaaacatt ttatttttct aaaacaggct gattagcagt ggtggttttc
    15121 cctttttctg acagtgtgtt ttagctcctg tttcagattt ctgtgttatt ttttccaatt
    15181 tacaagtccc ttaagtttcc acctggaatg tcaggtggca atgacatcgt gttctttttt
    15241 taaaccctta tttaagaaca agttgagttg aactgaatct tccttgtctt agtaacattg
    15301 tacaaacagt ggcttttttt taagttgtaa tgccttctga tggatataat tttgtgcttg
    15361 tatttaagat taaaagttga gtaaataaca ccagcttcct gaaaatgtcc ataatgcatc
    15421 ttttgaaaaa caaaacacct gcctacttta cattaacatg gtaaagattg tatgaaatac
    15481 ctgtttttca aaaaataaag gttcaagata acagta
//
