LOCUS       NM_001108014            3819 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 6 (Smc6),
            mRNA.
ACCESSION   NM_001108014 XM_001068591 XM_233970
VERSION     NM_001108014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3819)
  AUTHORS   Raschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N,
            Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S,
            Mailand N and Mann M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (bases 1 to 3819)
  AUTHORS   Taylor EM, Copsey AC, Hudson JJ, Vidot S and Lehmann AR.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   3  (bases 1 to 3819)
  AUTHORS   Potts PR and Yu H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   4  (bases 1 to 3819)
  AUTHORS   Taylor EM, Moghraby JS, Lees JH, Smit B, Moens PB and Lehmann AR.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233970.4, XM_001068591.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q15"
     gene            1..3819
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /note="structural maintenance of chromosomes 6"
                     /db_xref="GeneID:313961"
                     /db_xref="RGD:1311214"
     exon            1..124
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            125..267
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3423
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /note="SMC6 structural maintenance of chromosomes 6-like
                     1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 6"
                     /protein_id="NP_001101484.1"
                     /db_xref="GeneID:313961"
                     /db_xref="RGD:1311214"
                     /translation="MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTS
                     TLTAAEVGIIESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGK
                     AVATNRGSSLKGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSY
                     KLKSEKGTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMK
                     ATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTN
                     LEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQQVRLNDAEKKYKDI
                     QDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCK
                     RIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQENTVNQEVEQFEQAIEKDKQE
                     HVRIKREDVEVRHTLSYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTH
                     KPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRP
                     QIIVSEFRNEVYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNS
                     VARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIE
                     NKKGHIMNLQHRLSALEKDIKRNEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQ
                     SVDIATLEDEAEENKIKMQMVEKNMEQQKENMENLKTLKIEAENKYDTIKLKINQLSE
                     LADPLKDELNLADSEVDSQKRGKQHYEDKQKEHMDTLNKKRRELDMKEKELQEKMSQA
                     RQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDLDSK
                     VRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNET
                     LSISVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMV
                     NRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPV
                     TQEEDDSAS"
     exon            268..385
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..491
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..628
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..690
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..771
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..873
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..993
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1092
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1239
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1328
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1493
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1672
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1877
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1992
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2153
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2289
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2370
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2541
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2679
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2825
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2951
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3057
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3210
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3308
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3819
                     /gene="Smc6"
                     /gene_synonym="Smc6l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcgggcgg gtgtgccctg cttggcggcc gagcggtggc cgaggtccga cgcccttagg
       61 gtggccttcg tgtcgtgaca gccgtgcgga ctagcttccc cgaggtgacc gcgacttgtt
      121 ggagatctga tggccaaaag aaaggaagaa aatttttgct ctcctgaaaa tgctaaaaga
      181 ccaagacagg aagaactgga agattttgat aaagatggag atgaggatga atgtacaatt
      241 tctttcacaa atggaacctc cactttgact gcagcagaag ttggaataat tgagagtatt
      301 cagctaagaa atttcatgtg ccattcaatg cttggacctt ttaagtttgg ttctaatgtc
      361 aactttgtgg ttggcaataa tggaagtggg aagagtgctg tgctcactgc actcatagtt
      421 ggtcttggtg gaaaagcagt tgctactaac agaggatcct ctttaaaagg ttttgtgaaa
      481 gctggacaga actcagcaga tatctcaata acattaagga acagaggaga tgatgccttc
      541 agggcaaacg tgtatggtga ctccatagtt gtgcaacaac acattagcgt ggatggaagt
      601 cgatcttaca aactaaaaag tgaaaaaggc accgtggttt ctacaaggaa ggaagagctg
      661 atcgcaattc ttgaccattt taacatccag gtggataatc cagtttccgt tttaacacaa
      721 gagatgagca agcaattctt acaatccaaa aatgagggag acaaatacaa attcttcatg
      781 aaagcaaccc aattggaaca gatgaaggaa gattattcat atattatgga aacgaaagaa
      841 agaacaaagg agcaaataaa tcagggagaa gagcgactta ctgagctaaa gcgccagtgc
      901 ttggagaaag aggaacgttt tcaaaatatt gctggtttaa gtacaatgaa gacgaattta
      961 gagtatttga aacatgaaat ggcatgggct gtggtcaatg aaattgaaaa acagttgaat
     1021 gctattcgag ataatatcaa aattggagaa gaacgcgctg ccaaacttga caggaaaatg
     1081 gaagagcagc aggtcagact taatgatgca gaaaaaaaat acaaagatat acaagataaa
     1141 ctagaaaaaa ttagtgaaga gacaaatgca cgagcaccag aatgtatggc cttgaaaaca
     1201 gatgtcattg caagaacaag agcctttaat gatgctgagg ttttatataa tcgttcccta
     1261 aatgaatata aagcattaaa aaaagatggt gaacagcttt gtaaaagaat tgaagagctg
     1321 aagaaaagta ccgaccagtc attagaacca gagcgattgg aaaggcaaaa aaggatctgc
     1381 tggttaaaag agaaagtaaa ggccttacag gatcaggaaa atacagtcaa tcaggaggtt
     1441 gaacagttcg agcaagccat agaaaaggac aaacaagaac acgtccgaat taagagagaa
     1501 gatgtagaag tgagacatac actcagctat aatcagagac aattgaaaga actgaaagat
     1561 agtaaaactg atcgactaaa aagatttggt cctcatgttc cagctcttct ggaagcaata
     1621 gatgatgctt acagacggag acagtttacc cataaaccta ttggcccttt aggtgcttgc
     1681 attcatctac gggaccctga acttgcattg gccattgagt cttgcttaaa aggacttctg
     1741 caagcctatt gctgccataa tcatgctgat gaaagagtac ttcagtcatt gatgaaaaag
     1801 ttttatccac cagggacctc tcgaccacag ataatcgttt cggaatttcg gaatgaggta
     1861 tatgatgtga gactcagagc tgcttaccat ccagagtttc caactgttct gacagcttta
     1921 gaaatagaca atgctgttgt tgcaaacagt ctgattgaca tgcggagcat agagacagtg
     1981 ctgctgatca aaaataattc tgtagctcgt gcagtcatgc agtcccaaaa gccacccaaa
     2041 aattgtagag aagcttttac tgctgacggt gatcaagttt ttgcaggacg ttattattca
     2101 tctgaaagta caagacccaa gtttctaagc agagatgtgg attctgaaat aagtgacttg
     2161 gaaactgaga ttgaaaataa aaagggccac ataatgaacc ttcagcaccg tctgtctgct
     2221 cttgagaagg atattaaacg caatgaagaa cttcttaaaa ggtgccaact acattataaa
     2281 gaaataaaga tgaaaataag aaaaaatatt tctgaaattc gggaacttga gaacatagaa
     2341 gaacaccaat ctgtagatat tgcaaccttg gaagatgaag cggaggaaaa taaaataaaa
     2401 atgcaaatgg tggagaaaaa tatggagcaa caaaaagaaa acatggagaa tcttaaaact
     2461 ctaaaaattg aagcagaaaa caagtatgat acaattaaat tgaagattaa tcagctatca
     2521 gagctagcag atccacttaa ggatgaatta aatcttgctg actctgaagt ggatagccag
     2581 aaacggggaa agcagcatta tgaagataaa cagaaagaac atatggatac cctaaataaa
     2641 aagagaagag agcttgacat gaaggaaaag gagctacagg agaaaatgtc gcaagcaaga
     2701 cagatctgcc cagaacgcat agaagtaaaa aaatctgcat caattctaga caaagaaatt
     2761 aatcgattaa gacaaaaaat tcaggcagaa catgctagtc atggagatcg ggaagaaata
     2821 atgaagcagt accaggaagc aagagaaacc tatcttgatc tggatagtaa agtaaggact
     2881 ttaagaaggt tcattaaatt acttgaagaa ataatgaccc ataggtacaa aacataccaa
     2941 caatttagaa ggtgtctgac actacgatgc aagttatact ttgacaactt attatctcag
     3001 cgtgcttatt gtggaaaaat gaattttgac cacaagaatg aaactcttag tatatcagtt
     3061 cagcccggag agggaaacaa agcctccttc aatgacatgc gtgctttgtc cggcggcgag
     3121 cgctcttttt ccacagtgtg cttcattctt tccctgtggt ccattgctga atcacctttc
     3181 agatgcctgg atgagtttga tgtctacatg gatatggtta ataggagaat tgcgatggac
     3241 atgatcctta agatggcaga ttcccaacgt tttagacagt ttatcttgct tacccctcaa
     3301 agcatgagct cacttccttc aagtaaactg attcgaattc ttcgaatgtc tgaccctgaa
     3361 agagggcaaa ccaccttgcc cttccgacct gtgactcaag aagaagatga cagtgcaagc
     3421 tgacagctta gtgccttgcc ctcgtactga aagattgtga ggggaataat ctggactggt
     3481 ggatgaagta aagtgggatg agaggtactc tgaaataaag aagctccttt aatatgacct
     3541 atcaaaagtg taaataagcc tagaaaacca gctgctgcca agagtttaaa attatgattg
     3601 cttttccttg tgaaaatcag tttcataata ctggttttaa atctttttct gtttgtttgc
     3661 tttggagttt ctgtatttcg tttgttgttt ttaccatcta cttttataaa ttttttcagg
     3721 agtaaaattt tgtacataat gcacatgtac atatctgttc agtttgggtt catttctata
     3781 gtattttgta agaatttaaa taaaagtctg agcacctga
//
