LOCUS       NM_001106357            5930 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 5 (Smc5),
            mRNA.
ACCESSION   NM_001106357 XM_001078644 XM_215254
VERSION     NM_001106357.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5930)
  AUTHORS   Raschle,M., Smeenk,G., Hansen,R.K., Temu,T., Oka,Y., Hein,M.Y.,
            Nagaraj,N., Long,D.T., Walter,J.C., Hofmann,K., Storchova,Z.,
            Cox,J., Bekker-Jensen,S., Mailand,N. and Mann,M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (bases 1 to 5930)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   3  (bases 1 to 5930)
  AUTHORS   Brouwer,A.K., Schimmel,J., Wiegant,J.C., Vertegaal,A.C., Tanke,H.J.
            and Dirks,R.W.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   4  (bases 1 to 5930)
  AUTHORS   Behlke-Steinert,S., Touat-Todeschini,L., Skoufias,D.A. and
            Margolis,R.L.
  TITLE     SMC5 and MMS21 are required for chromosome cohesion and mitotic
            progression
  JOURNAL   Cell Cycle 8 (14), 2211-2218 (2009)
   PUBMED   19502785
REFERENCE   5  (bases 1 to 5930)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   6  (bases 1 to 5930)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (bases 1 to 5930)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (bases 1 to 5930)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001106357.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000001.1  230265372-230265621 c
            251-392             JAXUCZ010000001.1  230260591-230260732 c
            393-445             JAXUCZ010000001.1  230258553-230258605 c
            446-608             JAXUCZ010000001.1  230257157-230257319 c
            609-743             JAXUCZ010000001.1  230254913-230255047 c
            744-884             JAXUCZ010000001.1  230253016-230253156 c
            885-1046            JAXUCZ010000001.1  230251195-230251356 c
            1047-1118           JAXUCZ010000001.1  230248476-230248547 c
            1119-1374           JAXUCZ010000001.1  230242698-230242953 c
            1375-1529           JAXUCZ010000001.1  230241244-230241398 c
            1530-1624           JAXUCZ010000001.1  230227615-230227709 c
            1625-1757           JAXUCZ010000001.1  230225850-230225982 c
            1758-1931           JAXUCZ010000001.1  230223379-230223552 c
            1932-2101           JAXUCZ010000001.1  230223126-230223295 c
            2102-2225           JAXUCZ010000001.1  230220574-230220697 c
            2226-2348           JAXUCZ010000001.1  230220012-230220134 c
            2349-2474           JAXUCZ010000001.1  230211473-230211598 c
            2475-2519           JAXUCZ010000001.1  230208551-230208595 c
            2520-2615           JAXUCZ010000001.1  230208051-230208146 c
            2616-2720           JAXUCZ010000001.1  230207469-230207573 c
            2721-2840           JAXUCZ010000001.1  230207167-230207286 c
            2841-3020           JAXUCZ010000001.1  230199842-230200021 c
            3021-3116           JAXUCZ010000001.1  230199669-230199764 c
            3117-5930           JAXUCZ010000001.1  230195894-230198707 c
FEATURES             Location/Qualifiers
     source          1..5930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..5930
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="structural maintenance of chromosomes 5"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
     exon            1..250
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..3260
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /note="SMC5 structural maintenance of chromosomes 5-like
                     1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 5"
                     /protein_id="NP_001099827.1"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
                     /translation="MATPSGKAAAPNPQASKRSLPRDASSEFPSKRKNSNPTSTLPRP
                     SGLFVEGSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPA
                     FMGRADKVGFFVKRGCSKGLVEIELFRTSGNLIITREIDVIKNQSFWFINKKPVTQKI
                     VEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHRYHCELKNF
                     REKEKQLETSCKEKTEYLDKMIQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE
                     NVRQEYEGVKLVRDRVKEEVRKLKEGQIPMTRRIEEIERQRRTLEVRIKEKATDIKEA
                     SQKCKQRQDLIERKDRHIKELQQALTVKQNEEQDRQKRISNTRKMIEDLQNELRTAEN
                     CENLQPQIDAITNDLRRVQEEKALCEGEIIDKQREKEMLEKQKRSVSDHITRFDNLMN
                     QKEDKLRQRYRDTYDAVLWLRNNRDRFKQRVCEPIMLTVRDNKKLRVNAVIAPKISYA
                     DKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTERTRERIERVI
                     QETRLKQIYTAEEKYVLKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEI
                     NRKLEAVDSGLVALRDTNRHLELKDNELRLKKKELLERKTKKRQLEQKISSKLASIRL
                     MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSLHIQKVDLILQNTTVI
                     SEKNKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKRARQVCNLSADQAVP
                     QEFQTQVPTIPNGHSSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPSVVEEYT
                     KREIEIQQLTEELKGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQC
                     AGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQEL
                     NRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTV
                     LFVYNGPHMLEPNRWNLKAFQRRRRRITFTQPSQ"
     exon            251..392
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..445
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..608
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..743
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..884
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1046
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1118
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1374
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1529
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1624
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1757
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1931
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2101
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2225
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2348
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2474
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2519
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2615
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2720
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2840
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..3020
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3116
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..5930
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggctc ctgggctgcg gctcgccggg aacggaagcc gctgcgggac gcggaggaag
       61 ccaggatggc gactccgagt gggaaagctg ctgcccctaa cccccaggct tccaagaggt
      121 ctctcccgag agatgcttcc tccgagttcc cgagcaagag aaagaactcg aacccgacgt
      181 cgacgctgcc gcggccgtcc ggactcttcg tggagggctc aatcgtccgc atcgccatgg
      241 agaacttctt aacatatgac atctgtgaag tgtctcctgg gccccatctg aatatgatta
      301 ttggagccaa tggaacaggg aagtcaagca tagtgtgtgc catttgcctt ggcctagcag
      361 gcaagcctgc tttcatgggg cgtgcagata aggttgggtt tttcgtgaag agaggatgtt
      421 ccaaaggttt ggttgaaatt gaactgttca ggacttctgg aaatcttata atcacccgtg
      481 aaattgatgt gataaaaaat cagtcctttt ggttcatcaa caaaaaacct gtaacccaga
      541 agatagtgga agagcaagtc gcggccttga acatccaagt gggcaacctc tgccagttct
      601 tgcctcagga caaagttgga gaatttgcta aactcagtaa aattgaactc ctcgaagcta
      661 ctgagaagtc aattggtcct ccagagatgc acagatacca ctgtgaactc aagaacttca
      721 gggagaagga gaagcagcta gagacttctt gcaaagagaa aactgaatac ctagacaaaa
      781 tgattcagag aaatgaaagg tacaaacaag atgtagaaag attctatgaa cgaaaacgac
      841 atttagattt aattgagatg cttgaggcaa aaagaccatg ggtggaatat gagaatgtgc
      901 gtcaggaata tgaaggtgtg aaactagtcc gtgaccgagt gaaggaagag gtcagaaaac
      961 tcaaagaagg gcagattcct atgacacggc ggattgagga aattgaaagg cagcgtcgca
     1021 ctttggaagt tcgaatcaaa gaaaaggcaa ctgatattaa ggaagcgtct cagaaatgca
     1081 aacaaaggca ggacttgatt gagcggaagg acagacatat taaggaactt cagcaagcat
     1141 taacagtcaa gcagaatgag gagcaggacc ggcagaagag aataagtaac acccgcaaga
     1201 tgatagaaga cttgcagaat gagctcagga ctgcagaaaa ctgcgagaac cttcagcctc
     1261 agattgatgc catcacaaat gatctaaggc gtgttcaaga ggagaaggca ttatgtgaag
     1321 gcgagatcat tgataaacag agagaaaagg aaatgctgga gaagcagaaa cggagtgtga
     1381 gtgatcatat cacacgtttt gacaatctta tgaatcagaa ggaagataag ctgagacaga
     1441 ggtaccggga tacgtacgat gcagtcttgt ggctgagaaa taacagagac aggtttaaac
     1501 aaagagtctg tgagcccata atgctcacgg ttcgtgacaa taagaagttg agagtaaatg
     1561 ctgttattgc tcccaagatt tcatatgcag acaaagcacc ttcacgatct ctgaatgagt
     1621 taaaacagta tggctttttt tcataccttc gagagttatt tgatgcaccc gatcctgtga
     1681 tgagttacct ttgctgccaa tatcatattc atgaagttcc tgtgggaact gaaaggaccc
     1741 gagaaagaat tgaacgggta atacaagaaa ctcgattaaa acagatttat acagcagaag
     1801 aaaagtatgt gttaaaaact tctttctatt ccaataaagt tatctctagt aatacatctc
     1861 tgaaagtagc ccagttcctc actgtcactg tggacctaga gcaaaggaga cacttggaag
     1921 aacagctaaa ggaaattaat agaaagctgg aagcagtgga ctcaggattg gtagccttgc
     1981 gggatacaaa caggcatctc gagctcaaag acaatgagct aaggctgaag aagaaggagc
     2041 ttcttgaaag aaaaaccaag aaaagacaac tggaacagaa aattagctcc aagctggcaa
     2101 gtataaggct gatggaacag gatacttgca atctggaaga ggaagaacga aaagcaagta
     2161 ccaaaataaa agaaataaat gttcaaaaag caaaacttgt tactgaatta acgggccttg
     2221 taaagatatg cacttctttg catattcaaa aagttgattt gattcttcaa aatactacag
     2281 tgatctctga gaagaacaag ttagaagcag attacatggc gtcctcctca cagctgcgtg
     2341 tcacagaaca acagtttatt gaattggatg acaataggca gagattgtta cagaagtgca
     2401 aggaacttat gaagagagct aggcaagtat gtaacctgag tgcagaccaa gccgttcccc
     2461 aagaatttca gacacaagta cccaccattc caaatggaca cagctcctca ccccccatgg
     2521 cttttcaaga tctcccaaac acattggatg aaatcgatgc attattaact gaagaaagat
     2581 caagagcgtc ctgcttcaca ggactgaatc cttcggtggt tgaggagtac acaaaaagag
     2641 aaatagaaat acagcagtta actgaagaac taaaggggaa gaaagttgaa ttagatgaat
     2701 acagggaaaa catttcgcag gtgaaagaaa ggtggctgaa ccccttaaaa gagctagtag
     2761 agaaaatcaa tgagaagttc agcaactttt ttagttccat gcagtgtgct ggtgaagttg
     2821 atcttcatac agaaaatgag gaagattatg ataaatatgg aatccggatt agagtaaaat
     2881 ttcgcagtag tactcagctg catgaattaa ctcctcatca tcaaagtggc ggtgaaagaa
     2941 gtgtttctac catgctgtac ttgatggcac ttcaggagct taacagatgt ccattcagag
     3001 tggttgatga aattaatcag ggtatggacc caattaatga acggagggtg tttgaaatgg
     3061 ttgtgaacac cgcctgtaaa gagaacacat cgcagtactt cttcatcaca ccgaagcttc
     3121 tacagaatct gccttattct gaaaagatga cggtattgtt tgtctacaat ggtcctcata
     3181 tgctggaacc aaaccgatgg aatttaaagg cttttcaaag gcggcggcga aggatcacat
     3241 ttactcaacc ttctcagtga aaggaaaggg aggggcctgc cgaggttttc atttaactgt
     3301 ttatacctgt cgctcaagtg aataaaagtt agcagattta ttgaaagaga aagattggtt
     3361 atttttggaa gcctgctttt aaaaacaaat aggttaatga agcggagacc atagtgactc
     3421 tggaccattt ctagtgaaaa ctaagtcttc agttttggtg gaccttgtct cattagtcct
     3481 ctgtgagcat tgttgtgtga agctttgtgc tgcctcaggt gtggtggcac acatctagtc
     3541 cagcatttag gagacggagg cagaaagatc atgagtttga gtggtttcat gtgtcttaac
     3601 agaaaaagct atttccggtt gcaaatcaga ggtacggcag aatggggttt cattcacaga
     3661 gcgtttacaa acaatagccg ccctgagtgc tgattgcaga acatcctgac tcttagtgct
     3721 taaaggtaac tcagaattag aaatcccatt tgccttcagt attgtattta gtttttaaaa
     3781 actagtatga gaatgtctgc ttagtagata gtgatttatg gcagatctgt tcatttcttt
     3841 gtgtttagaa gaagggttcc cttattttca tagaaaatat gttatcgtag aaaattgatg
     3901 ctataatttt attgttattt caaagaattg ggaagacata tacacgtgag gcttcaaaat
     3961 gacaggagga ctttgagagg tcacaaggta aagatgatac agaatgtggc ccaaacattg
     4021 gcagagtgaa atcaggtgac aggagttaaa gtataattgt tgtgtgtgtt tgtcgggggt
     4081 gggttctttg tttgtttgtt taatttaaag tcaaatgtat tttacatctt aaatttctac
     4141 aaaggcattt ttataatttt agtaagattt ttcttaagat ttcatatatg agattttaca
     4201 atttgtattt gaaatttctc agtgctatgt aaagagtgaa ggcaaagaat tgattggttt
     4261 caaatcataa tatttttaga atttgtatgt ccttccttct acccagtatt ttagaaaact
     4321 ctcatctaaa ttgttttctt ccagcttgaa aatattaatt gaaaaccatt tatttttctc
     4381 tgagaatgct aattaacaat gccaaacaaa ttctgtttgt ttgttttttt tttaaacaaa
     4441 tcttgaaaga aagtagaaat gtctttgaat agtggactga actgtatcct tgctggtact
     4501 gacaaaatta tttttgtgac tagctagcct gaataaagtt tgggctttgt atattattgt
     4561 aatagccaat gagatttgca ttcttattag gtcaaaaaat agtgaaacat gagtttatgt
     4621 ctgctcactt agacattttc tcttttagaa gttgtatttc tttttaacac ttgtaaaaga
     4681 acccttccct cttaaactac atctcataca tgtagtataa agatattttt aataacattt
     4741 ttatcagcat gaacaagtca aaaaattaaa aactaggtag gatagtagtg aagggtgttt
     4801 ctaaacattt gtgtcgttgc ttggatttct gacataatta atatcttcac tgatatatgc
     4861 ttaatatagt ttggttttat catgtcaatg tgaaacaaaa acaaaccgta cttaaaactc
     4921 aacatcagca atcccatttc agtttacata tgtcaaaaat gattctatat catgcttata
     4981 aactttcaga gagcaaaatt aatgttcgtt ttatattgac tttgggctgg gaaggataaa
     5041 ttatgtatca tttattatat taaaaatagt catactataa tgtcattttc tgcaactgtt
     5101 gatttttaag attatattat aattgtaaaa attccaagta aaagcttgat ttgataaata
     5161 aaatatttaa aacctgacag ttacaaatat ttgtaatgac gaaatgttta cattgatttg
     5221 cccaaggtca gtctctgtta gaaggtttct cattttcaaa aaaaggttgt tttgtttttt
     5281 gtaaggttta tttattttat gtgagtcggt tttttctgca tgtatgtatt atacccggtg
     5341 cttgttaagg ccagaagaga gcatcagatc ccctaggagt agaggtaaag gtagtcgtga
     5401 gctgctgtat tgagtgttgg gtatagaagc tgggtcctgt ggaagagcag ccaggaggtt
     5461 taaccactga gccatctctc cagtcccaaa aagagatttc ttgctgcttt cccatagcct
     5521 tggacataag tctatagcac aggaggggca tcacttcact ctggtttgtg taaatgtaat
     5581 tgattaaaac tatgttgtaa atgctacttc attggtaata aataatatat tttcccattg
     5641 gtataggtta tttaagatga gagtatttta atactttaaa ttttcttaaa agtctttttt
     5701 tttatctctc tttttttttt ttttttaaag atttattcat ttattatata taagtacact
     5761 gtagttgtct tcagatacac cagaagaggg caccggatct ctttacagat ggttgtgagc
     5821 caccatgtgg ttgctgggaa ttgaactcat gacctctgga agagcagtcg ggtgctctta
     5881 accgctgagc catctctcca gcccaaaagt cattttttat tttcaggatt
//
