LOCUS       NP_001099827            1064 aa            linear   ROD 24-JUN-2024
DEFINITION  structural maintenance of chromosomes protein 5 [Rattus
            norvegicus].
ACCESSION   NP_001099827 XP_001078644 XP_215254
VERSION     NP_001099827.1
DBSOURCE    REFSEQ: accession NM_001106357.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1064)
  AUTHORS   Raschle,M., Smeenk,G., Hansen,R.K., Temu,T., Oka,Y., Hein,M.Y.,
            Nagaraj,N., Long,D.T., Walter,J.C., Hofmann,K., Storchova,Z.,
            Cox,J., Bekker-Jensen,S., Mailand,N. and Mann,M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (residues 1 to 1064)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   3  (residues 1 to 1064)
  AUTHORS   Brouwer,A.K., Schimmel,J., Wiegant,J.C., Vertegaal,A.C., Tanke,H.J.
            and Dirks,R.W.
  TITLE     Telomeric DNA mediates de novo PML body formation
  JOURNAL   Mol Biol Cell 20 (22), 4804-4815 (2009)
   PUBMED   19793919
REFERENCE   4  (residues 1 to 1064)
  AUTHORS   Behlke-Steinert,S., Touat-Todeschini,L., Skoufias,D.A. and
            Margolis,R.L.
  TITLE     SMC5 and MMS21 are required for chromosome cohesion and mitotic
            progression
  JOURNAL   Cell Cycle 8 (14), 2211-2218 (2009)
   PUBMED   19502785
REFERENCE   5  (residues 1 to 1064)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   6  (residues 1 to 1064)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   7  (residues 1 to 1064)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   8  (residues 1 to 1064)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_215254.4, XP_001078644.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     Protein         1..1064
                     /product="structural maintenance of chromosomes protein 5"
                     /note="SMC5 structural maintenance of chromosomes 5-like
                     1"
                     /calculated_mol_wt=124323
     Region          51..>196
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          53..1014
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Site            80..87
                     /site_type="other"
                     /note="Walker A/P-loop"
                     /db_xref="CDD:213179"
     Site            178..181
                     /site_type="other"
                     /note="Q-loop/lid"
                     /db_xref="CDD:213179"
     Region          <937..1039
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            953..962
                     /site_type="other"
                     /note="ABC transporter signature motif"
                     /db_xref="CDD:213179"
     Site            977..982
                     /site_type="other"
                     /note="Walker B"
                     /db_xref="CDD:213179"
     Site            985..988
                     /site_type="other"
                     /note="D-loop"
                     /db_xref="CDD:213179"
     Site            1012..1018
                     /site_type="other"
                     /note="H-loop/switch region"
                     /db_xref="CDD:213179"
     CDS             1..1064
                     /gene="Smc5"
                     /gene_synonym="Smc5l1"
                     /coded_by="NM_001106357.2:66..3260"
                     /db_xref="GeneID:293967"
                     /db_xref="RGD:1307492"
ORIGIN      
        1 matpsgkaaa pnpqaskrsl prdassefps krknsnptst lprpsglfve gsivriamen
       61 fltydicevs pgphlnmiig angtgkssiv caiclglagk pafmgradkv gffvkrgcsk
      121 glveielfrt sgnliitrei dviknqsfwf inkkpvtqki veeqvaalni qvgnlcqflp
      181 qdkvgefakl skielleate ksigppemhr yhcelknfre kekqletsck ekteyldkmi
      241 qrnerykqdv erfyerkrhl dliemleakr pwveyenvrq eyegvklvrd rvkeevrklk
      301 egqipmtrri eeierqrrtl evrikekatd ikeasqkckq rqdlierkdr hikelqqalt
      361 vkqneeqdrq krisntrkmi edlqnelrta encenlqpqi daitndlrrv qeekalcege
      421 iidkqrekem lekqkrsvsd hitrfdnlmn qkedklrqry rdtydavlwl rnnrdrfkqr
      481 vcepimltvr dnkklrvnav iapkisyadk apsrslnelk qygffsylre lfdapdpvms
      541 ylccqyhihe vpvgtertre rierviqetr lkqiytaeek yvlktsfysn kvissntslk
      601 vaqfltvtvd leqrrhleeq lkeinrklea vdsglvalrd tnrhlelkdn elrlkkkell
      661 erktkkrqle qkissklasi rlmeqdtcnl eeeerkastk ikeinvqkak lvteltglvk
      721 ictslhiqkv dlilqnttvi seknkleady masssqlrvt eqqfielddn rqrllqkcke
      781 lmkrarqvcn lsadqavpqe fqtqvptipn ghsssppmaf qdlpntldei dallteersr
      841 ascftglnps vveeytkrei eiqqlteelk gkkveldeyr enisqvkerw lnplkelvek
      901 inekfsnffs smqcagevdl hteneedydk ygirirvkfr sstqlheltp hhqsggersv
      961 stmlylmalq elnrcpfrvv deinqgmdpi nerrvfemvv ntackentsq yffitpkllq
     1021 nlpysekmtv lfvyngphml epnrwnlkaf qrrrrritft qpsq
//
