LOCUS       NM_031583               4158 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 3 (Smc3),
            mRNA.
ACCESSION   NM_031583
VERSION     NM_031583.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Dong,X., Chen,G., Cai,Z., Li,Z., Qiu,L., Xu,H., Yuan,Y., Liu,X.L.
            and Liu,J.
  TITLE     CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor
            Prognosis of Hepatocellular Carcinoma Patients
  JOURNAL   Cell Physiol Biochem 47 (6), 2602-2612 (2018)
   PUBMED   29996118
REFERENCE   2  (bases 1 to 4158)
  AUTHORS   Gil-Rodriguez,M.C., Deardorff,M.A., Ansari,M., Tan,C.A.,
            Parenti,I., Baquero-Montoya,C., Ousager,L.B., Puisac,B.,
            Hernandez-Marcos,M., Teresa-Rodrigo,M.E., Marcos-Alcalde,I.,
            Wesselink,J.J., Lusa-Bernal,S., Bijlsma,E.K., Braunholz,D.,
            Bueno-Martinez,I., Clark,D., Cooper,N.S., Curry,C.J., Fisher,R.,
            Fryer,A., Ganesh,J., Gervasini,C., Gillessen-Kaesbach,G., Guo,Y.,
            Hakonarson,H., Hopkin,R.J., Kaur,M., Keating,B.J., Kibaek,M.,
            Kinning,E., Kleefstra,T., Kline,A.D., Kuchinskaya,E., Larizza,L.,
            Li,Y.R., Liu,X., Mariani,M., Picker,J.D., Pie,A., Pozojevic,J.,
            Queralt,E., Richer,J., Roeder,E., Sinha,A., Scott,R.H., So,J.,
            Wusik,K.A., Wilson,L., Zhang,J., Gomez-Puertas,P., Casale,C.H.,
            Strom,L., Selicorni,A., Ramos,F.J., Jackson,L.G., Krantz,I.D.,
            Das,S., Hennekam,R.C., Kaiser,F.J., FitzPatrick,D.R. and Pie,J.
  TITLE     De novo heterozygous mutations in SMC3 cause a range of Cornelia de
            Lange syndrome-overlapping phenotypes
  JOURNAL   Hum Mutat 36 (4), 454-462 (2015)
   PUBMED   25655089
REFERENCE   3  (bases 1 to 4158)
  AUTHORS   Liu,H., Rankin,S. and Yu,H.
  TITLE     Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects
            sororin and centromeric cohesion during mitosis
  JOURNAL   Nat Cell Biol 15 (1), 40-49 (2013)
   PUBMED   23242214
  REMARK    Erratum:[Nat Cell Biol. 2013 Feb;15(2):229]
REFERENCE   4  (bases 1 to 4158)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   5  (bases 1 to 4158)
  AUTHORS   Bermudez,V.P., Farina,A., Higashi,T.L., Du,F., Tappin,I.,
            Takahashi,T.S. and Hurwitz,J.
  TITLE     In vitro loading of human cohesin on DNA by the human Scc2-Scc4
            loader complex
  JOURNAL   Proc Natl Acad Sci U S A 109 (24), 9366-9371 (2012)
   PUBMED   22628566
REFERENCE   6  (bases 1 to 4158)
  AUTHORS   Eijpe,M., Heyting,C., Gross,B. and Jessberger,R.
  TITLE     Association of mammalian SMC1 and SMC3 proteins with meiotic
            chromosomes and synaptonemal complexes
  JOURNAL   J Cell Sci 113 (Pt 4), 673-682 (2000)
   PUBMED   10652260
REFERENCE   7  (bases 1 to 4158)
  AUTHORS   Darwiche,N., Freeman,L.A. and Strunnikov,A.
  TITLE     Characterization of the components of the putative mammalian sister
            chromatid cohesion complex
  JOURNAL   Gene 233 (1-2), 39-47 (1999)
   PUBMED   10375619
REFERENCE   8  (bases 1 to 4158)
  AUTHORS   Schmiesing,J.A., Ball,A.R. Jr., Gregson,H.C., Alderton,J.M.,
            Zhou,S. and Yokomori,K.
  TITLE     Identification of two distinct human SMC protein complexes involved
            in mitotic chromosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 12906-12911 (1998)
   PUBMED   9789013
REFERENCE   9  (bases 1 to 4158)
  AUTHORS   Wu,R.R. and Couchman,J.R.
  TITLE     cDNA cloning of the basement membrane chondroitin sulfate
            proteoglycan core protein, bamacan: a five domain structure
            including coiled-coil motifs
  JOURNAL   J Cell Biol 136 (2), 433-444 (1997)
   PUBMED   9015313
REFERENCE   10 (bases 1 to 4158)
  AUTHORS   Couchman,J.R., Kapoor,R., Sthanam,M. and Wu,R.R.
  TITLE     Perlecan and basement membrane-chondroitin sulfate proteoglycan
            (bamacan) are two basement membrane chondroitin/dermatan sulfate
            proteoglycans in the Engelbreth-Holm-Swarm tumor matrix
  JOURNAL   J Biol Chem 271 (16), 9595-9602 (1996)
   PUBMED   8621634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE109731.1, EV773232.1, BF396983.1, EV776219.1, CA511001.1,
            BP486487.1, BP499171.1, CO395251.1 and CA509998.1.
            
            On Oct 20, 2007 this sequence version replaced NM_031583.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               BE109731.1         29-339
            312-904             EV773232.1         76-668
            905-1289            BF396983.1         11-395              c
            1290-1851           EV776219.1         42-603
            1852-2307           CA511001.1         170-625
            2308-2705           BP486487.1         23-420
            2706-3238           BP499171.1         103-635
            3239-3706           CO395251.1         209-676
            3707-4158           CA509998.1         1-452               c
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4158
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /note="structural maintenance of chromosomes 3"
                     /db_xref="GeneID:29486"
                     /db_xref="RGD:62006"
     exon            1..137
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..3776
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /note="chondroitin sulfate proteoglycan 6; chromosome
                     segregation protein SmcD; basement membrane-associated
                     chondroitin proteoglycan; SMC protein 3; basement membrane
                     chondroitin sulfate proteoglycan; structural maintenace of
                     chromosomes 3"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 3"
                     /protein_id="NP_113771.2"
                     /db_xref="GeneID:29486"
                     /db_xref="RGD:62006"
                     /translation="MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYA
                     IQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVI
                     GAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLR
                     EVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDK
                     MRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRE
                     LKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL
                     EKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERD
                     KWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE
                     LDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNG
                     IDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSD
                     EVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFK
                     HVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDV
                     RKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMK
                     MLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVD
                     ALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGG
                     TVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDA
                     INHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC
                     NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQ
                     LTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVP
                     SVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEID
                     QALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAE
                     MAKDFVEDDTTHG"
     exon            138..213
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            214..252
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            253..320
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            321..392
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..472
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..551
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..669
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..845
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..926
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1091
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1213
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1427
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1531
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1631
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1792
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1934
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2085
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2238
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2390
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2549
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2657
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2766
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..3014
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3227
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3419
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3597
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3704
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..4145
                     /gene="Smc3"
                     /gene_synonym="bamacan; Cspg6; SMC-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagcgag cgggagcgat cggaacccag tgagaggggc cggtctgcgt ctctcctgac
       61 cctgccgccg cgctgttgcg gttctgaggt gaagctttcc tcctgcggag gggcgcggag
      121 ccatgtacat caagcaggtg attatccagg gcttccgaag ttaccgagat caaacaattg
      181 tagatccctt cagttcaaaa cataatgtta ttgtgggcag aaatggatct ggaaaaagca
      241 acttttttta tgcaatccag tttgttctca gtgatgaatt tagtcatctt cgtccagagc
      301 agcgattggc tttgttgcac gagggtacag gtcctcgtgt tatttctgct tttgtggaaa
      361 tcatttttga caattcagac aaccggttac caattgataa agaggaagtt tcgcttcgaa
      421 gagttattgg tgccaaaaaa gatcagtatt tcctagataa gaagatggtc acgaaaaatg
      481 atgtgatgaa tctccttgaa agtgctgggt tttcgagaag taatccttat tacattgtta
      541 aacaaggaaa gatcaaccaa atggcaacag caccggattc tcagagatta aagctgttga
      601 gagaagtagc tggcactcga gtgtatgacg agcgcaaaga ggaaagcatc tccctgatga
      661 aagaaacaga gggcaaacgg gaaaagatca atgagttgtt aaaatacatt gaagagcgat
      721 tacatactct agaggaggag aaggaggaac tggcccagta tcagaagtgg gataaaatga
      781 ggcgtgccct ggagtacacc atctacaacc aggagctcaa cgagactcgc gccaagcttg
      841 atgagctttc tgctaagcga gaaacaagcg gagagaaatc cagacaatta agagatgccc
      901 agcaggatgc aagagataaa atggaggata ttgagcgcca agttagagaa ctgaaaacaa
      961 aaatttcagc catgaaagaa gaaaaagaac agctcagtgc ggagagacaa gagcagatta
     1021 agcaaaggac caagctggag cttaaagcca aggacttaca ggatgagctg gcagggaaca
     1081 gtgagcagcg gaaacgttta ttaaaagaaa gacagaagct gcttgaaaaa atagaagaaa
     1141 agcagaaaga actggcagaa acagaaccga aattcaacag cgtaaaggaa aaagaagagc
     1201 gaggaattgc tagattggct caagctacac aggaaagaac tgatctttat gcaaagcagg
     1261 gtcgaggaag ccagtttaca tcaaaagaag aaagagataa gtggattaag aaggaactga
     1321 agtctttaga tcaggctatt aatgataaga aaagacagat tgctgctata cacaaggatt
     1381 tggaggatac cgaggccaat aaagagaaaa atctggagca atataataaa ctggatcagg
     1441 atctcaatga agtcaaagct cgagttgaag aactggacag aaaatattat gaagtgaaaa
     1501 ataagaaaga tgaactacaa agtgaaagaa attacttgtg gagagaggag aatgcagaac
     1561 agcaagcact tgccgctaag agagaagacc ttgagaagaa gcagcagctt cttagagcgg
     1621 caacaggaaa ggccatttta aatggaatcg acagcattaa caaagtgtta gaccatttcc
     1681 ggcggaaggg tataaaccag catgtgcaaa atggctacca tggcatcgtg atgaataact
     1741 ttgagtgcga accagctttc tatacttgtg tggaagtcac tgccggtaac aggttattct
     1801 atcacattgt cgattcagat gaagtcagca cgaagatctt aatggagttc aataaaatga
     1861 atcttcctgg agaggtgact ttcctgcctc ttaacaagtt agatgtgagg gacactgcct
     1921 atcctgaaac taacgatgct attcctatga tcagtaagct gaggtacaat cccagattcg
     1981 acaaagcttt caaacatgtg tttggaaaga cactcatctg tcggagcatg gaggtttcca
     2041 ctcagctagc tcgtgccttc actatggact gcattactct ggaaggtgat caagtcagcc
     2101 atcgaggtgc tctgactgga ggctattacg acacaagaaa gtctcgcctt gagttacaga
     2161 aggatgttag gaaagcagag gaggagctgg gtgagctcga agctaagctc aatgaaaacc
     2221 tgcgcagaaa cattgaaagg attaataatg aaattgatca attgatgaac caaatgcagc
     2281 agatagagac ccaacagaga aaatttaaag catccagaga tagcatctta tcagagatga
     2341 agatgctaaa agagaagaga cagcagtcag aaaagacctt catgccaaag caacgcagtt
     2401 tgcagagtct ggaggccagt ctgcacgcta tggagtcgac cagagagtcg ctgaaggcag
     2461 agctagggac agatttgctc tctcagctca gcctggaaga ccagaaaaga gtcgacgcac
     2521 tgaatgacga gatccggcag cttcagcagg aaaacagaca gctgctgaat gaaagaatta
     2581 aactagaagg cattattact cgagtagaga cttacctcaa tgagaatctg aggaaacgtc
     2641 tggaccaagt agagcaggaa cttaatgaac tgagagagac agaaggtggc actgttctta
     2701 ctgccaccac gtcagaactt gaagctatta ataaaagagt gaaagatact atggcaagat
     2761 cagaagattt ggataattcc attgacaaaa cagaagctgg aattaaagag ctccagaaaa
     2821 gcatggagcg ctggaagaac atggagaagg agcacatgga tgccataaat cacgacacta
     2881 aagagctgga gaagatgacc aaccgacagg gcatgctgtt gaagaagaaa gaggagtgca
     2941 tgaagaagat ccgagagctg gggtcccttc cccaggaagc atttgaaaag taccagacac
     3001 tgagcctgaa gcagttgttt cggaaacttg agcagtgcaa cacagagttg aagaagtaca
     3061 gccatgtcaa caagaaggct ctggaccagt ttgtgaattt ctctgagcag aaggagaaac
     3121 tgataaagcg acaggaagaa ttggacaggg gctacaagtc aatcatggag ttgatgaatg
     3181 tactcgaact tagaaaatat gaagctatcc agttaacctt caaacaggta tctaagaact
     3241 ttagtgaagt tttccagaag ttggtacctg ggggaaaagc gaccttggtg atgaagaaag
     3301 gagacgtgga gggcagccag tctcaggacg aaggagaggg gagcggcgag agcgagaggg
     3361 gctctgggtc acaaagcagc gttccatcag ttgaccagtt cacaggagtc gggatcaggg
     3421 tatcatttac aggaaagcaa ggcgagatga gagaaatgca gcagctttca ggagggcaga
     3481 agtctctggt agcccttgct ctcatttttg ccattcagaa gtgtgaccct gctcctttct
     3541 acctgtttga tgagatcgac caagctttgg atgctcagca cagaaaagct gtgtcagata
     3601 tgattatgga actagctgta cacgcccagt ttatcactac cacttttagg cctgaactgc
     3661 ttgagtctgc tgataaattc tacggtgtaa agttcagaaa taaggttagt cacatcgacg
     3721 tgatcacagc agagatggcc aaagactttg tagaagacga taccacgcat ggttaactga
     3781 aagataacgc ctgccgtctt ggaagatgtg tatagtaatg tggtccgtac ctgggaactg
     3841 taaattttaa aaataataat tggttattac tgagtttttg gatttagaat acacagtcct
     3901 tttatacttg tctttgtatt ttataagctc ccctgtaatg ttacatttct acgtatagtc
     3961 gaggaatttt atttcctaca cgactttttg taagtgtcct cctattttaa atcttttgag
     4021 attctaaata ttcccaatta ttttatagct tctattaaat aattggtttg tgactaactt
     4081 agtgtaaatg tggccttttg tctttgtaat tgttagaaac attcaataaa tattttgcat
     4141 aagaaaaaaa aaaaaaaa
//
