LOCUS       NM_001108666            5273 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 2 (Smc2),
            mRNA.
ACCESSION   NM_001108666 XM_001053521 XM_342837
VERSION     NM_001108666.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5273)
  AUTHORS   Baergen,A.K., Jeusset,L.M., Lichtensztejn,Z. and McManus,K.J.
  TITLE     Diminished Condensin Gene Expression Drives Chromosome Instability
            That May Contribute to Colorectal Cancer Pathogenesis
  JOURNAL   Cancers (Basel) 11 (8), 1066 (2019)
   PUBMED   31357676
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5273)
  AUTHORS   Nishide,K. and Hirano,T.
  TITLE     Overlapping and non-overlapping functions of condensins I and II in
            neural stem cell divisions
  JOURNAL   PLoS Genet 10 (12), e1004847 (2014)
   PUBMED   25474630
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5273)
  AUTHORS   Je,E.M., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational and expressional analysis of SMC2 gene in gastric and
            colorectal cancers with microsatellite instability
  JOURNAL   APMIS 122 (6), 499-504 (2014)
   PUBMED   24483990
REFERENCE   4  (bases 1 to 5273)
  AUTHORS   Pan,X., Papasani,M., Hao,Y., Calamito,M., Wei,F., Quinn Iii,W.J.,
            Basu,A., Wang,J., Hodawadekar,S., Zaprazna,K., Liu,H., Shi,Y.,
            Allman,D., Cancro,M. and Atchison,M.L.
  TITLE     YY1 controls Igkappa repertoire and B-cell development, and
            localizes with condensin on the Igkappa locus
  JOURNAL   EMBO J 32 (8), 1168-1182 (2013)
   PUBMED   23531880
REFERENCE   5  (bases 1 to 5273)
  AUTHORS   Davalos,V., Suarez-Lopez,L., Castano,J., Messent,A., Abasolo,I.,
            Fernandez,Y., Guerra-Moreno,A., Espin,E., Armengol,M., Musulen,E.,
            Ariza,A., Sayos,J., Arango,D. and Schwartz,S. Jr.
  TITLE     Human SMC2 protein, a core subunit of human condensin complex, is a
            novel transcriptional target of the WNT signaling pathway and a new
            therapeutic target
  JOURNAL   J Biol Chem 287 (52), 43472-43481 (2012)
   PUBMED   23095742
REFERENCE   6  (bases 1 to 5273)
  AUTHORS   Cobbe,N. and Heck,M.M.
  TITLE     The evolution of SMC proteins: phylogenetic analysis and structural
            implications
  JOURNAL   Mol Biol Evol 21 (2), 332-347 (2004)
   PUBMED   14660695
REFERENCE   7  (bases 1 to 5273)
  AUTHORS   Przewloka,M.R., Pardington,P.E., Yannone,S.M., Chen,D.J. and
            Cary,R.B.
  TITLE     In vitro and in vivo interactions of DNA ligase IV with a subunit
            of the condensin complex
  JOURNAL   Mol Biol Cell 14 (2), 685-697 (2003)
   PUBMED   12589063
REFERENCE   8  (bases 1 to 5273)
  AUTHORS   Kimura,K., Cuvier,O. and Hirano,T.
  TITLE     Chromosome condensation by a human condensin complex in Xenopus egg
            extracts
  JOURNAL   J Biol Chem 276 (8), 5417-5420 (2001)
   PUBMED   11136719
REFERENCE   9  (bases 1 to 5273)
  AUTHORS   Schmiesing,J.A., Gregson,H.C., Zhou,S. and Yokomori,K.
  TITLE     A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a
            homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone
            H3 during the early stage of mitotic chromosome condensation
  JOURNAL   Mol Cell Biol 20 (18), 6996-7006 (2000)
   PUBMED   10958694
  REMARK    GeneRIF: Demonstrates that the human Smc2l1 ortholog, hCAP-E, is a
            member of the condensin complex that is involved in mitotic
            chromosome condensation.
REFERENCE   10 (bases 1 to 5273)
  AUTHORS   Schmiesing,J.A., Ball,A.R. Jr., Gregson,H.C., Alderton,J.M.,
            Zhou,S. and Yokomori,K.
  TITLE     Identification of two distinct human SMC protein complexes involved
            in mitotic chromosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 12906-12911 (1998)
   PUBMED   9789013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2008 this sequence version replaced NM_001108666.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.162316.1,
                                           SRR21887620.525888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000005.1  71602405-71602465
            62-281              JAXUCZ010000005.1  71603243-71603462
            282-431             JAXUCZ010000005.1  71604541-71604690
            432-554             JAXUCZ010000005.1  71607676-71607798
            555-593             JAXUCZ010000005.1  71609370-71609408
            594-704             JAXUCZ010000005.1  71610741-71610851
            705-749             JAXUCZ010000005.1  71611031-71611075
            750-983             JAXUCZ010000005.1  71612232-71612465
            984-1133            JAXUCZ010000005.1  71612659-71612808
            1134-1367           JAXUCZ010000005.1  71619568-71619801
            1368-1527           JAXUCZ010000005.1  71620687-71620846
            1528-1645           JAXUCZ010000005.1  71621270-71621387
            1646-1784           JAXUCZ010000005.1  71622082-71622220
            1785-1904           JAXUCZ010000005.1  71622897-71623016
            1905-2109           JAXUCZ010000005.1  71624573-71624777
            2110-2245           JAXUCZ010000005.1  71626754-71626889
            2246-2370           JAXUCZ010000005.1  71628048-71628172
            2371-2564           JAXUCZ010000005.1  71629858-71630051
            2565-2708           JAXUCZ010000005.1  71630854-71630997
            2709-2903           JAXUCZ010000005.1  71635166-71635360
            2904-3104           JAXUCZ010000005.1  71637037-71637237
            3105-3221           JAXUCZ010000005.1  71638549-71638665
            3222-3382           JAXUCZ010000005.1  71642959-71643119
            3383-3530           JAXUCZ010000005.1  71645293-71645440
            3531-5273           JAXUCZ010000005.1  71646894-71648636
FEATURES             Location/Qualifiers
     source          1..5273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q23"
     gene            1..5273
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /note="structural maintenance of chromosomes 2"
                     /db_xref="GeneID:362519"
                     /db_xref="RGD:1305227"
     exon            1..61
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..281
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3689
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /note="chromosome-associated protein E; SMC2 structural
                     maintenance of chromosomes 2-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 2"
                     /protein_id="NP_001102136.2"
                     /db_xref="GeneID:362519"
                     /db_xref="RGD:1305227"
                     /translation="MYVKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDS
                     ICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEIT
                     VTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE
                     ILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL
                     EYQKVMREIEHLSRLYIAYQFLLAEDTKERSAGELKEMQDKILKLQEVLSENEKKIKA
                     LNCEIEELEKRKDKETGGILRSLEDAFAEAQRVNTKSQSAFDLKKKNLASEETKRKEL
                     EKNMAEDSKALAAKEKEVKKLTDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSNED
                     GAEATLAGQMMACKNDISKAQTGAKQAQMKLKHAQQELKNKQAEVRKMDSGYKKDQEA
                     FEAVKKVKEKLETEMKKLNYEDNKEERLLEKHRQVSRDISNLKGTYEALLAKFPNLRF
                     AYKDPEKNWNRNCVKGLVASLINVKDNSTATALELVAGERLYNVVVDTEVTGKKLLEK
                     GELKRRYTIIPLNKISARCIAPETLRVAQNLVGPNNVHVALSLVDYKPELQKAMEFVF
                     GTTFVCNNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELK
                     DVQAELRTKEKELQALEEELAGLKNVAEKYRQLKQQWEMKTEEGDLLQTKLQQSSYHK
                     QQEELDALKKTIEESEETLKNTKEIQKKAEEKYEALENKMKNAEAEREKELKDAQKKL
                     DCAKTKADASSKKMKEKQQEVEAITLELEELKREHASNEQQLDAVNEAIKAYEGQIEI
                     MAAEVAKNKESVNKAQNELMKQKEIISAQDNIIKDKCAEVAKHNLQNNDSQLKIKELD
                     HSISKHKREADDAAAKVSKMLNDYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQKL
                     QEVKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILATIEDLDQKKNQAL
                     NIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGG
                     QRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLK
                     EGMFNNANVLFKTKFVDGVSTVARFTQSQNGRIPKEAKAKGKGPS"
     exon            282..431
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..554
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..593
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..704
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..749
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..983
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1133
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1367
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1527
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1645
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1784
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1904
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2109
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2245
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2370
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2564
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2708
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2903
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3104
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3221
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3382
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3530
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..5273
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcccgcctc cgcgtcgagt cggaactttg ctggtacccc tggccggcca cttggtggtt
       61 gacctggcct gtagcttgct gcctaacagg cttaacccaa gacagtataa aaaatgtatg
      121 ttaaatcaat cattctcgaa ggattcaagt cctatgcaca aaggactgaa gtcaatggtt
      181 ttgaccccct cttcaatgcg atcactggtt tgaatggtag tggaaaatcc aatatattgg
      241 attccatatg ctttctccta ggcatctcca acctgtctca ggttcgggct tcaaatttac
      301 aagatctggt ttataaaaac ggacaggctg gaatcaccaa agcctctgtt tcaatcactt
      361 ttgataattc tgacaaaaag cagagtccat taggatttga agctcatgat gaaatcactg
      421 taacaagaca ggtggttatt ggtggcagaa ataaatactt aatcaatgga gtgaatgcca
      481 acaacaccag agtccaggat ctcttttgtt ctgtgggcct gaacgtgaat aaccctcact
      541 ttctcatcat gcagggcaga attacgaaag tattaaatat gaaaccacca gagatattat
      601 ccatgatcga agaagctgct ggaaccagga tgtatgagta caaaaaaata gctgcccaga
      661 aaactataga aaaaaaggag gctaagctga aagaaataaa aacgatactg gaagaagaga
      721 ttacgccaac aattcaaaaa ttaaaagagg aaagatcttc ttacttggag taccagaaag
      781 tgatgcgtga gatcgagcat ctgagccgtt tatatattgc ctatcagttt ttgctggctg
      841 aagataccaa ggaacgctca gctggggagc taaaggaaat gcaggataaa atattaaagc
      901 ttcaagaagt actgtcagag aatgaaaaaa agataaaggc tctcaattgt gaaatagaag
      961 aattggagaa gagaaaagat aaggaaactg gaggcatcct ccgatcttta gaggatgctt
     1021 ttgcagaagc tcagcgagtt aatactaagt ctcaaagtgc atttgacctc aagaagaaaa
     1081 acctagccag tgaagaaacc aagcgcaaag agctagagaa aaacatggct gaggactcta
     1141 aagcattagc agcaaaggaa aaggaagtta agaagctaac cgatggactg cacggccttc
     1201 aagaagcaag caataaagat gcggaagctc tggccgccgc ccagcagcac ttcaatgcag
     1261 tgtctgctgg cttgtccagt aatgaagatg gagcagaggc aactctggcc gggcagatga
     1321 tggcctgtaa gaacgacatc agcaaagcgc agaccggggc caagcaggct cagatgaagt
     1381 tgaaacatgc ccaacaggaa ctgaagaata aacaagcaga agttaggaag atggatagtg
     1441 ggtacaagaa ggatcaagaa gcttttgaag ctgtgaaaaa agttaaagaa aaacttgaaa
     1501 ccgaaatgaa gaagctaaat tacgaagaca acaaagagga aaggcttttg gaaaagcaca
     1561 ggcaggtgtc tcgtgacatc agtaatctaa aaggaaccta cgaagctctc ttggccaagt
     1621 ttcccaatct tcgatttgca tacaaggacc cagagaagaa ctggaatcga aattgtgtaa
     1681 aaggacttgt agcttctctg ataaatgtga aagataattc tacagccaca gctctggaat
     1741 tggtggctgg agaacgactc tacaatgttg tagtagacac agaggttact ggtaagaaac
     1801 tattagaaaa gggggaattg aagcgtcgat acacaataat tcctctcaat aagatttcag
     1861 ccagatgtat tgctcctgaa actctgaggg tcgctcagaa tcttgttggt cctaacaatg
     1921 ttcatgtagc tctttccttg gttgactaca aaccagaact tcagaaagcg atggaatttg
     1981 tcttcggaac aacatttgtt tgtaacaata tggataatgc caaaaaagtg gcctttgata
     2041 aaagaataat gaccagaact gtaacccttg ggggtgatgt atttgatcct catggaacat
     2101 tgagtggagg tgctaggtcc caggcggctt ctattttaac caagtttcaa gaactcaaag
     2161 atgttcaagc tgagctgagg acaaaggaga aagaactgca ggctctggaa gaggaattgg
     2221 ctggtcttaa aaatgtcgct gaaaagtatc gccaactgaa acagcagtgg gagatgaaga
     2281 cagaggaggg agatttgttg caaaccaaac ttcagcaaag ctcttaccat aagcagcaag
     2341 aagaattaga tgcccttaaa aaaaccattg aggaaagtga ggagacatta aaaaacacaa
     2401 aagaaatcca aaagaaagct gaagaaaaat atgaggcatt ggagaataaa atgaaaaatg
     2461 cagaagctga aagagagaaa gaactgaagg atgctcagaa aaaactggat tgtgccaaaa
     2521 caaaggctga tgcatctagc aagaaaatga aagaaaagca acaggaggtt gaagctatca
     2581 ctctggagct agaggagctc aaaagagagc atgcatctaa cgaacagcag cttgatgctg
     2641 tgaatgaagc catcaaagcc tatgaagggc agattgaaat aatggcagct gaggtggcca
     2701 aaaacaagga atcagttaat aaagctcaaa atgagctgat gaagcaaaaa gaaataataa
     2761 gtgcccagga caacataatt aaagataaat gtgcggaagt ggcaaaacac aatttgcaaa
     2821 acaatgattc tcagcttaaa attaaggagt tagaccacag cataagcaaa cacaagcggg
     2881 aagctgacga cgctgctgcg aaggtatcca aaatgttgaa tgattatgac tggattaatg
     2941 ctgagaaaca cctctttggc caacctaata gtgcctatga tttcaaaaca aacaacccca
     3001 aagaagctgg ccagagactt cagaagttgc aagaagtaaa agagaaacta gggagaaatg
     3061 tcaacatgag agctatgaat gtgctgacag aagcggaaga gcggtataat gatttgatga
     3121 agaagaaaag aattgtagaa aatgacaaat ccaaaatcct tgcaactata gaagatcttg
     3181 accagaagaa aaatcaggcc ctaaatattg cttggcaaaa ggtgaacaaa gactttggct
     3241 ctattttttc tacccttttg cctggtgcca atgctatgct tgcaccacca gaagggcaga
     3301 cagttttaga tggtctggag ttcaaggttg ccttaggaaa tacatggaaa gaaaacctaa
     3361 ctgagcttag tggtggtcag aggtctctgg tggctctctc actaatattg tccatgctcc
     3421 tcttcaaacc tgctccaatt tatatcttgg acgaggtgga tgcggcctta gatctttctc
     3481 atacccagaa catcggacag atgctgcgaa ctcacttcac acattctcaa ttcattgtgg
     3541 tatccctcaa agaaggtatg ttcaacaatg caaacgttct cttcaaaacc aagtttgtgg
     3601 atggtgtttc tacagtagcc agatttacac agagtcaaaa tgggaggatt ccaaaggagg
     3661 caaaggccaa gggcaaagga cccagctgag tgcatgccag aagttcagag tgcgggcgtc
     3721 tcaccttgac cttttacaca tgaacgtttt caaggatttg ggatctaaag ttgtttatat
     3781 aataatgtta acattatttc cataagtaat ttttgtagca ccggtaaaag agcagattcc
     3841 tcttttttta cctagtgtga ttatggtcca attattgtag ttgtgattgc atatttttct
     3901 tacaaaaatc ttttttatgt attaaagaac ctgaggtaca tcgagttggt aaattctgta
     3961 tgcaaatgcc aaaatacaaa gaaacagatg aagttatagg ataaatatag ctgatagtca
     4021 gcttttaact agtttaattt ctaaggacag tattaatgag tcttcttttg cttataaaat
     4081 cattcgaata cagagtattt ataaagaaag tcactgggcc aacaaagggg gaacatagca
     4141 attatgcata cacaaagcta tttgaggtcg gtccttgtag ggatgcaatg ccagatcctt
     4201 ggatgggaaa tggacctgga aacaattttt cactgtaatg atgttggact atcatgttta
     4261 tgcatgttta ataattgatc tcacaagctt gaaatttgca tgttttttat ctttgagtat
     4321 tttagtagaa acctgggaag aaatgtgtta catagtatta tacctagatt gctctatctg
     4381 aagtcctgta atatttttta agatttttat cagactctca tagtctaatc aataattttt
     4441 tggacctagc agattaaatg aaaagtatat tttataagag tctgataaac ctaaataagt
     4501 ctgccttttc taccaagaaa gtctccaaag cttgatgatt gctgaaattc ttggtgcctt
     4561 cggcttgtcc aggttgaaag taaactcctt tagaaagcag gagggggcca gtacacaccc
     4621 tgagagcctg cagctcgtac tgtctctaca gacatttcca cgtcagcaca gtcatgctcg
     4681 tagttttcag agctctaatg tgacctgatc tgatttaatg attgtggccc tatttcttcc
     4741 tgatacttag ccttcagtgt tttgctgttc tactttcttt gatgcaccat acaggccctg
     4801 agttggacat ttctcaaact tcatttgcca tatatatctg tgatgttaca tagaccttaa
     4861 gtaatttgta cccttggaca ttttggaaat tatttcatct ggagggaaga gacagtaagc
     4921 tgtaatattc actgagcgat agtaaagatc acagataatg aacctacaca atgttttgtt
     4981 ttccaaggtc ttataaactg ttggtcaaaa cagttgtgtt tattacactg tcactgatac
     5041 agtattctaa tttgatcaca atctaatcaa tgccagctgc taatattttg tattaggcag
     5101 ttataaaaca gcattgaatt cctgtcttaa caaactactt tgtttgattt cctttgtgta
     5161 taaattattt ccttgtatgc atttctgttt tgtgttcttt tgtttttgta ttatatatag
     5221 tttcactctt gaaatttttg tgcatatatt aaatttcttt gaggcatatt aaa
//
