LOCUS       NP_001102136            1191 aa            linear   ROD 28-MAR-2024
DEFINITION  structural maintenance of chromosomes protein 2 [Rattus
            norvegicus].
ACCESSION   NP_001102136 XP_001053521 XP_342838
VERSION     NP_001102136.2
DBSOURCE    REFSEQ: accession NM_001108666.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1191)
  AUTHORS   Baergen,A.K., Jeusset,L.M., Lichtensztejn,Z. and McManus,K.J.
  TITLE     Diminished Condensin Gene Expression Drives Chromosome Instability
            That May Contribute to Colorectal Cancer Pathogenesis
  JOURNAL   Cancers (Basel) 11 (8), 1066 (2019)
   PUBMED   31357676
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1191)
  AUTHORS   Nishide,K. and Hirano,T.
  TITLE     Overlapping and non-overlapping functions of condensins I and II in
            neural stem cell divisions
  JOURNAL   PLoS Genet 10 (12), e1004847 (2014)
   PUBMED   25474630
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1191)
  AUTHORS   Je,E.M., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational and expressional analysis of SMC2 gene in gastric and
            colorectal cancers with microsatellite instability
  JOURNAL   APMIS 122 (6), 499-504 (2014)
   PUBMED   24483990
REFERENCE   4  (residues 1 to 1191)
  AUTHORS   Pan,X., Papasani,M., Hao,Y., Calamito,M., Wei,F., Quinn Iii,W.J.,
            Basu,A., Wang,J., Hodawadekar,S., Zaprazna,K., Liu,H., Shi,Y.,
            Allman,D., Cancro,M. and Atchison,M.L.
  TITLE     YY1 controls Igkappa repertoire and B-cell development, and
            localizes with condensin on the Igkappa locus
  JOURNAL   EMBO J 32 (8), 1168-1182 (2013)
   PUBMED   23531880
REFERENCE   5  (residues 1 to 1191)
  AUTHORS   Davalos,V., Suarez-Lopez,L., Castano,J., Messent,A., Abasolo,I.,
            Fernandez,Y., Guerra-Moreno,A., Espin,E., Armengol,M., Musulen,E.,
            Ariza,A., Sayos,J., Arango,D. and Schwartz,S. Jr.
  TITLE     Human SMC2 protein, a core subunit of human condensin complex, is a
            novel transcriptional target of the WNT signaling pathway and a new
            therapeutic target
  JOURNAL   J Biol Chem 287 (52), 43472-43481 (2012)
   PUBMED   23095742
REFERENCE   6  (residues 1 to 1191)
  AUTHORS   Cobbe,N. and Heck,M.M.
  TITLE     The evolution of SMC proteins: phylogenetic analysis and structural
            implications
  JOURNAL   Mol Biol Evol 21 (2), 332-347 (2004)
   PUBMED   14660695
REFERENCE   7  (residues 1 to 1191)
  AUTHORS   Przewloka,M.R., Pardington,P.E., Yannone,S.M., Chen,D.J. and
            Cary,R.B.
  TITLE     In vitro and in vivo interactions of DNA ligase IV with a subunit
            of the condensin complex
  JOURNAL   Mol Biol Cell 14 (2), 685-697 (2003)
   PUBMED   12589063
REFERENCE   8  (residues 1 to 1191)
  AUTHORS   Kimura,K., Cuvier,O. and Hirano,T.
  TITLE     Chromosome condensation by a human condensin complex in Xenopus egg
            extracts
  JOURNAL   J Biol Chem 276 (8), 5417-5420 (2001)
   PUBMED   11136719
REFERENCE   9  (residues 1 to 1191)
  AUTHORS   Schmiesing,J.A., Gregson,H.C., Zhou,S. and Yokomori,K.
  TITLE     A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a
            homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone
            H3 during the early stage of mitotic chromosome condensation
  JOURNAL   Mol Cell Biol 20 (18), 6996-7006 (2000)
   PUBMED   10958694
  REMARK    GeneRIF: Demonstrates that the human Smc2l1 ortholog, hCAP-E, is a
            member of the condensin complex that is involved in mitotic
            chromosome condensation.
REFERENCE   10 (residues 1 to 1191)
  AUTHORS   Schmiesing,J.A., Ball,A.R. Jr., Gregson,H.C., Alderton,J.M.,
            Zhou,S. and Yokomori,K.
  TITLE     Identification of two distinct human SMC protein complexes involved
            in mitotic chromosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 12906-12911 (1998)
   PUBMED   9789013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Oct 26, 2007 this sequence version replaced NP_001102136.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.162316.1,
                                           SRR21887620.525888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q23"
     Protein         1..1191
                     /product="structural maintenance of chromosomes protein 2"
                     /note="chromosome-associated protein E; SMC2 structural
                     maintenance of chromosomes 2-like 1"
                     /calculated_mol_wt=134150
     Region          2..1167
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; pfam02463"
                     /db_xref="CDD:426784"
     CDS             1..1191
                     /gene="Smc2"
                     /gene_synonym="CAP-E; CAPE; Smc2l1"
                     /coded_by="NM_001108666.3:114..3689"
                     /db_xref="GeneID:362519"
                     /db_xref="RGD:1305227"
ORIGIN      
        1 myvksiileg fksyaqrtev ngfdplfnai tglngsgksn ildsicfllg isnlsqvras
       61 nlqdlvykng qagitkasvs itfdnsdkkq splgfeahde itvtrqvvig grnkylingv
      121 nanntrvqdl fcsvglnvnn phflimqgri tkvlnmkppe ilsmieeaag trmyeykkia
      181 aqktiekkea klkeiktile eeitptiqkl keerssyley qkvmreiehl srlyiayqfl
      241 laedtkersa gelkemqdki lklqevlsen ekkikalnce ieelekrkdk etggilrsle
      301 dafaeaqrvn tksqsafdlk kknlaseetk rkeleknmae dskalaakek evkkltdglh
      361 glqeasnkda ealaaaqqhf navsaglssn edgaeatlag qmmackndis kaqtgakqaq
      421 mklkhaqqel knkqaevrkm dsgykkdqea feavkkvkek letemkklny ednkeerlle
      481 khrqvsrdis nlkgtyeall akfpnlrfay kdpeknwnrn cvkglvasli nvkdnstata
      541 lelvagerly nvvvdtevtg kkllekgelk rrytiiplnk isarciapet lrvaqnlvgp
      601 nnvhvalslv dykpelqkam efvfgttfvc nnmdnakkva fdkrimtrtv tlggdvfdph
      661 gtlsggarsq aasiltkfqe lkdvqaelrt kekelqalee elaglknvae kyrqlkqqwe
      721 mkteegdllq tklqqssyhk qqeeldalkk tieeseetlk ntkeiqkkae ekyealenkm
      781 knaeaereke lkdaqkkldc aktkadassk kmkekqqeve aitleleelk rehasneqql
      841 davneaikay egqieimaae vaknkesvnk aqnelmkqke iisaqdniik dkcaevakhn
      901 lqnndsqlki keldhsiskh kreaddaaak vskmlndydw inaekhlfgq pnsaydfktn
      961 npkeagqrlq klqevkeklg rnvnmramnv lteaeerynd lmkkkriven dkskilatie
     1021 dldqkknqal niawqkvnkd fgsifstllp ganamlappe gqtvldglef kvalgntwke
     1081 nltelsggqr slvalslils mllfkpapiy ildevdaald lshtqnigqm lrthfthsqf
     1141 ivvslkegmf nnanvlfktk fvdgvstvar ftqsqngrip keakakgkgp s
//
