LOCUS       NM_001130498            4026 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 1B (Smc1b),
            mRNA.
ACCESSION   NM_001130498 XM_001078226 XM_217011
VERSION     NM_001130498.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4026)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   2  (bases 1 to 4026)
  AUTHORS   Herran,Y., Gutierrez-Caballero,C., Sanchez-Martin,M., Hernandez,T.,
            Viera,A., Barbero,J.L., de Alava,E., de Rooij,D.G., Suja,J.A.,
            Llano,E. and Pendas,A.M.
  TITLE     The cohesin subunit RAD21L functions in meiotic synapsis and
            exhibits sexual dimorphism in fertility
  JOURNAL   EMBO J 30 (15), 3091-3105 (2011)
   PUBMED   21743440
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4026)
  AUTHORS   Gutierrez-Caballero,C., Herran,Y., Sanchez-Martin,M., Suja,J.A.,
            Barbero,J.L., Llano,E. and Pendas,A.M.
  TITLE     Identification and molecular characterization of the mammalian
            alpha-kleisin RAD21L
  JOURNAL   Cell Cycle 10 (9), 1477-1487 (2011)
   PUBMED   21527826
REFERENCE   4  (bases 1 to 4026)
  AUTHORS   Lee,J. and Hirano,T.
  TITLE     RAD21L, a novel cohesin subunit implicated in linking homologous
            chromosomes in mammalian meiosis
  JOURNAL   J Cell Biol 192 (2), 263-276 (2011)
   PUBMED   21242291
REFERENCE   5  (bases 1 to 4026)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   6  (bases 1 to 4026)
  AUTHORS   Hamer,G., Gell,K., Kouznetsova,A., Novak,I., Benavente,R. and
            Hoog,C.
  TITLE     Characterization of a novel meiosis-specific protein within the
            central element of the synaptonemal complex
  JOURNAL   J Cell Sci 119 (Pt 19), 4025-4032 (2006)
   PUBMED   16968740
REFERENCE   7  (bases 1 to 4026)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   8  (bases 1 to 4026)
  AUTHORS   Lee,J., Iwai,T., Yokota,T. and Yamashita,M.
  TITLE     Temporally and spatially selective loss of Rec8 protein from
            meiotic chromosomes during mammalian meiosis
  JOURNAL   J Cell Sci 116 (Pt 13), 2781-2790 (2003)
   PUBMED   12759374
REFERENCE   9  (bases 1 to 4026)
  AUTHORS   Revenkova,E., Eijpe,M., Heyting,C., Gross,B. and Jessberger,R.
  TITLE     Novel meiosis-specific isoform of mammalian SMC1
  JOURNAL   Mol Cell Biol 21 (20), 6984-6998 (2001)
   PUBMED   11564881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 27, 2008 this sequence version replaced
            XM_217011.4, XM_001078226.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4026
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /note="structural maintenance of chromosomes 1B"
                     /db_xref="GeneID:300121"
                     /db_xref="RGD:1308791"
     exon            1..132
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3767
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /note="SMC; structural maintenace of chromosomes 1B"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein
                     1B"
                     /protein_id="NP_001123970.1"
                     /db_xref="GeneID:300121"
                     /db_xref="RGD:1308791"
                     /translation="MGHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDA
                     LSFVMGEKTTNLRVKNIQELIHGAHIGKPVSSSASVTIIYVEDSGEEKTFTRIIRGGC
                     SEFHFGDKPVSRSVYVAQLENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEIST
                     SGEFIGEYEAKKKKLQKAEEDAQFHFNRKKNVAAERKHAKIEKEEAEHYQSLLEELKT
                     NKIQLMLFQLYYNEEKINVLNTELEHMDRNLSVVKDTLSHHENIIKAKKKDYGMLTRQ
                     LQQTAKELKSVEAVLNQKRPQYIKAKENTSHHLKKLDLSKKLITDNEKQCAKQEDGIR
                     ALVAELVDLDRAWRSFEKQMEEKILHKGRDIELENSQLDRYKELKEQVRRRVGIMTQQ
                     LEKLQWEQKAEKERLAFERRRHGDTQGNLKQIKEQIEEHKKRIEKLEEYTKTCMDCLE
                     DKKQQEEALIKEIDNTKSRMSEVNEELSLIRNELQNAGIDNHEGKRQRKRAEVLEHLK
                     RLYPDSVFGRLLDLCHPIHKKYQLAVTKLFGRYMVAIVVASEKVAKDCIRFLKEERAE
                     PETFLALDYLDIKPINERLREIKGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEE
                     ARHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLKHKALCWDEKELHSLRDKRNQLV
                     QELKELMKTLRKETDLKQIQALVQGTNTRLKYSQNELEMIKKKHLATFYREQSQLQSE
                     LLNIDSQCTMLSEGINKQQQKIEEFQDKIDKVEDDIFQDFCEEIGVENIREFENKHVK
                     QQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNKIDTLKTTIQKGREDIDNLKKTE
                     EECLKIVEELMVKQEQVKEVLATQSSNIEKIHIQIEEERKKFLAVDREVGKLQKEVVI
                     IQGSLEQKQLEKHNLLLDCKVQDIDISLMLGSLEDIIEVELTETESTQATADIYEKEA
                     SIQIDYSPLREDWKALQSDKEVEAHLTLLLQQVASQENTLLKTAAPNLRAQENLKAVR
                     DKFQESADAFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQIYKKLCRNNS
                     AQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAP
                     FFVLDEVDAALDNTNIGKVSGYIKEQSQEQFQMIIISLKEEFYSRADALIGVYPEHDE
                     CMFSHVLTLDLSKYPDTEDQEGSRSHRKPRARVSQSPQSPQSR"
     exon            133..321
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..434
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..638
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..877
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1136
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1277
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1360
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1568
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1754
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1934
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2081
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2219
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2336
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2443
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2585
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2731
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2885
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2981
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3138
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3293
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3294..3445
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3515
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3626
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..4026
                     /gene="Smc1b"
                     /gene_synonym="Smc1l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctgaggc acggagcgca gccatggggc accttgagtt gctgctcgtg gagaatttca
       61 agtcgtggcg aggccgccag gtcatcggcc ctttcaagag gttcacctgt atcatcggcc
      121 ccaacggctc gggaaagtct aatgtaatgg atgcacttag ttttgtaatg ggagaaaaaa
      181 caactaattt aagagtaaaa aacattcaag aacttattca tggagcacac attggaaaac
      241 ctgtttcttc ttctgcaagt gtgaccatta tatacgtaga agacagtgga gaagagaaaa
      301 cattcacaag gattatccga ggggggtgct cagaatttca ttttggggat aaacctgtga
      361 gtcgttctgt gtatgtagcc cagttggaaa acataggcat aatagtcaaa gcacagaact
      421 gtctagtttt tcagggaact gtagagtcaa tatccatgaa aaaacccaaa gagagaaccc
      481 aattttttga agaaatcagt acttcaggag agtttatagg agaatatgag gcaaagaaaa
      541 agaagttaca aaaagccgaa gaagatgcac aatttcattt taacaggaaa aaaaatgtag
      601 ctgcagaacg gaagcatgca aaaatagaga aagaagaggc agaacattat caaagtctcc
      661 ttgaagaatt gaaaacaaac aagatacaac tgatgctttt ccaactatat tataatgagg
      721 aaaaaatcaa tgttttaaac actgaattag agcatatgga caggaattta agtgttgtaa
      781 aagacactct ttctcaccat gaaaacataa ttaaagctaa gaaaaaggat tatggaatgt
      841 taactagaca actacagcaa acagcaaaag aactgaaatc tgtcgaagca gttttaaatc
      901 agaagaggcc tcagtacatt aaagctaaag aaaacacttc tcaccatcta aaaaaattgg
      961 atttgtctaa gaaattgata acagacaatg aaaaacaatg tgctaagcag gaagatggca
     1021 ttcgagcctt agtggcagaa ctggttgatt tagatagagc atggagaagt tttgaaaagc
     1081 agatggaaga gaaaatctta cacaaaggaa gagacattga attggaaaat agtcagctgg
     1141 accgttataa agagcttaag gaacaagtca gacggagggt aggtataatg acacaacaac
     1201 tggaaaaact acagtgggaa cagaaggcag aaaaagaaag actggcattt gaaaggagga
     1261 ggcatggaga cactcaggga aatctaaaac aaataaaaga acaaatagaa gagcataaaa
     1321 aacgaataga gaaattggag gaatatacaa agacgtgcat ggattgcttg gaagataaaa
     1381 aacagcaaga agaagccctg ataaaagaaa ttgacaatac aaaatcaaga atgtctgaag
     1441 ttaatgaaga attgagtctt attagaaatg aattgcagaa tgctggaatt gataaccatg
     1501 aaggaaaacg tcagcggaaa agagcagaag ttctcgaaca ccttaaaaga ctttacccag
     1561 attctgtgtt tggaagactt cttgatctat gtcatcctat tcataagaaa taccagctgg
     1621 ctgtgactaa gctttttggc cggtacatgg ttgccattgt tgttgcctca gaaaaggtag
     1681 caaaagattg tattcggttt ctgaaggagg aaagagctga acctgagaca ttccttgctc
     1741 tagattacct tgatatcaag ccaatcaatg aacgactaag ggaaattaaa ggctgtaaga
     1801 tgatgatcga tgttataaag acccagtttc ctcagctgaa gaaagtgatt cagtttgttt
     1861 gtggaaatgg ccttgtctgt gagactgtgg aagaggcaag acatattgca tttggtggac
     1921 ctgaaagacg aaaggcagta gcacttgatg gaacactgtt tttgaaatct ggagtgatct
     1981 caggagggtc aagtgactta aagcacaaag ctctgtgttg ggatgagaag gagttacaca
     2041 gtctaagaga taaaagaaac caacttgtcc aagagctaaa ggagttaatg aagacgctcc
     2101 gcaaggaaac agatctgaaa caaatacagg cattagtaca aggaaccaat acacgactca
     2161 aatattcaca aaatgaacta gagatgatta aaaagaagca ccttgctaca ttttaccggg
     2221 aacaatctca gctacaaagt gaattactga atattgattc tcagtgtaca atgttgagcg
     2281 aaggaatcaa caaacagcaa caaaagattg aagaatttca agataagata gacaaggtag
     2341 aagatgacat attccaagac ttctgtgaag aaattggtgt ggaaaatatc cgtgaatttg
     2401 agaacaaaca tgttaaacag cagcaagaaa atgatcaaaa aagattagag tttgaaaaac
     2461 aaaaaactcg gctcaatatt cagcttgaat atagtcgaaa tcaacttaag aagaaactga
     2521 ataagatcga cacattaaaa acaacaatcc agaagggcag agaagacatt gataacctaa
     2581 agaagaccga agaagagtgt ctgaaaattg ttgaagaact catggtgaaa caagaacaag
     2641 ttaaggaagt gcttgccaca cagagttcca acattgagaa aattcatatt caaattgaag
     2701 aggaacgcaa gaagtttttg gctgttgata gggaagttgg aaaattacag aaggaagttg
     2761 taatcattca gggttctttg gaacagaaac aactagagaa gcataacttg ctcctggact
     2821 gcaaagttca agacattgac ataagtctca tgctggggtc attggaggac atcattgaag
     2881 tggagctaac tgaaacagaa agtacccagg caacggctga tatctatgaa aaagaagcat
     2941 ccatccaaat agactacagc cctctaaggg aggattggaa ggctctacaa tcagataagg
     3001 aggtggaggc ccacctcaca ctccttctac agcaagtagc atcccaagaa aatactctac
     3061 tgaagactgc agctccaaac ctgcgagcac aggagaactt aaaggctgtc agagacaaat
     3121 ttcaagaatc tgcagatgct tttgaggcca gcagaaagga agccagaata tgtaggcaag
     3181 agtttgaaca ggtgaaaaga cggaggtacg atgctttcag tcagtgtttt gagcacatct
     3241 cggtctcaat tgatcaaatc tacaagaagc tctgcaggaa caacagtgcc caggcatttc
     3301 ttagcccaga gaaccctgaa gaaccttact tagatggaat tagctataat tgtgtggctc
     3361 caggcaaacg gttcatgcct atggacaact tgtcaggggg agaaaagtgt gtggctgctc
     3421 tggctcttct gtttgctgta cacagttttc gacctgctcc attctttgta ttagatgaag
     3481 tagatgcagc cctggacaat actaacatcg gcaaagtctc aggttacatc aaagagcaga
     3541 gtcaggaaca atttcagatg ataatcattt ccctgaaaga ggagttttac tccagagctg
     3601 atgcactgat aggcgtctac ccagagcacg atgaatgcat gttcagccat gtgttgactc
     3661 tggacctttc caagtatcca gacactgaag accaagaagg cagcaggagc caccggaaac
     3721 ccagagcacg agtatcacag tccccgcagt ctccccagtc tcgttagaaa tgaaacagcc
     3781 accagctgta gaagctttac cctgagcctg tggaggtcag gtcagtctct gtttataccc
     3841 atgtgtcata gaagaaaaat ttcttaccat tttggtagaa caagttatag cccactccag
     3901 ctaaggagtg ctcaacccca ttccaataga ggtttcttat gacaacaatg aatgaggtat
     3961 atggttttct tttgctttta aggacttctg ttttgaaata aattggttat aaaattctgc
     4021 aacatc
//
