LOCUS       NM_031683               3925 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus structural maintenance of chromosomes 1A (Smc1a),
            mRNA.
ACCESSION   NM_031683
VERSION     NM_031683.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3925)
  AUTHORS   Kiefer,K.C., Cremer,S., Pardali,E., Assmus,B., Abou-El-Ardat,K.,
            Kirschbaum,K., Dorsheimer,L., Rasper,T., Berkowitsch,A., Serve,H.,
            Dimmeler,S., Zeiher,A.M. and Rieger,M.A.
  TITLE     Full spectrum of clonal haematopoiesis-driver mutations in chronic
            heart failure and their associations with mortality
  JOURNAL   ESC Heart Fail 8 (3), 1873-1884 (2021)
   PUBMED   33779075
REFERENCE   2  (bases 1 to 3925)
  AUTHORS   Kilarkaje,N., Al-Qaryyan,M. and Al-Bader,M.D.
  TITLE     Trans-resveratrol imparts disparate effects on transcription of DNA
            damage sensing/repair pathway genes in euglycemic and hyperglycemic
            rat testis
  JOURNAL   Toxicol Appl Pharmacol 418, 115510 (2021)
   PUBMED   33775663
REFERENCE   3  (bases 1 to 3925)
  AUTHORS   Ma,Z., Lin,M., Li,K., Fu,Y., Liu,X., Yang,D., Zhao,Y., Zheng,J. and
            Sun,B.
  TITLE     Knocking down SMC1A inhibits growth and leads to G2/M arrest in
            human glioma cells
  JOURNAL   Int J Clin Exp Pathol 6 (5), 862-869 (2013)
   PUBMED   23638217
  REMARK    GeneRIF: These results suggest that SMC1A upregulation is involved
            in the pathogenesis of glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3925)
  AUTHORS   Liu,H., Rankin,S. and Yu,H.
  TITLE     Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects
            sororin and centromeric cohesion during mitosis
  JOURNAL   Nat Cell Biol 15 (1), 40-49 (2013)
   PUBMED   23242214
  REMARK    Erratum:[Nat Cell Biol. 2013 Feb;15(2):229]
REFERENCE   5  (bases 1 to 3925)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3925)
  AUTHORS   Gregson,H.C., Schmiesing,J.A., Kim,J.S., Kobayashi,T., Zhou,S. and
            Yokomori,K.
  TITLE     A potential role for human cohesin in mitotic spindle aster
            assembly
  JOURNAL   J Biol Chem 276 (50), 47575-47582 (2001)
   PUBMED   11590136
REFERENCE   7  (bases 1 to 3925)
  AUTHORS   Sumara,I., Vorlaufer,E., Gieffers,C., Peters,B.H. and Peters,J.M.
  TITLE     Characterization of vertebrate cohesin complexes and their
            regulation in prophase
  JOURNAL   J Cell Biol 151 (4), 749-762 (2000)
   PUBMED   11076961
REFERENCE   8  (bases 1 to 3925)
  AUTHORS   Eijpe,M., Heyting,C., Gross,B. and Jessberger,R.
  TITLE     Association of mammalian SMC1 and SMC3 proteins with meiotic
            chromosomes and synaptonemal complexes
  JOURNAL   J Cell Sci 113 (Pt 4), 673-682 (2000)
   PUBMED   10652260
REFERENCE   9  (bases 1 to 3925)
  AUTHORS   Darwiche,N., Freeman,L.A. and Strunnikov,A.
  TITLE     Characterization of the components of the putative mammalian sister
            chromatid cohesion complex
  JOURNAL   Gene 233 (1-2), 39-47 (1999)
   PUBMED   10375619
REFERENCE   10 (bases 1 to 3925)
  AUTHORS   Schmiesing,J.A., Ball,A.R. Jr., Gregson,H.C., Alderton,J.M.,
            Zhou,S. and Yokomori,K.
  TITLE     Identification of two distinct human SMC protein complexes involved
            in mitotic chromosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 12906-12911 (1998)
   PUBMED   9789013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ005113.1, SRR26643293.32441.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000021.1  24582732-24582883
            153-341             JAXUCZ010000021.1  24588706-24588894
            342-454             JAXUCZ010000021.1  24588986-24589098
            455-658             JAXUCZ010000021.1  24591938-24592141
            659-897             JAXUCZ010000021.1  24592232-24592470
            898-1156            JAXUCZ010000021.1  24593402-24593660
            1157-1297           JAXUCZ010000021.1  24593740-24593880
            1298-1380           JAXUCZ010000021.1  24594652-24594734
            1381-1588           JAXUCZ010000021.1  24594875-24595082
            1589-1774           JAXUCZ010000021.1  24599569-24599754
            1775-1954           JAXUCZ010000021.1  24599850-24600029
            1955-2101           JAXUCZ010000021.1  24600134-24600280
            2102-2239           JAXUCZ010000021.1  24600372-24600509
            2240-2356           JAXUCZ010000021.1  24601396-24601512
            2357-2463           JAXUCZ010000021.1  24601617-24601723
            2464-2605           JAXUCZ010000021.1  24606693-24606834
            2606-2751           JAXUCZ010000021.1  24611447-24611592
            2752-2905           JAXUCZ010000021.1  24611685-24611838
            2906-3016           JAXUCZ010000021.1  24612651-24612761
            3017-3173           JAXUCZ010000021.1  24623898-24624054
            3174-3328           JAXUCZ010000021.1  24624468-24624622
            3329-3480           JAXUCZ010000021.1  24624737-24624888
            3481-3550           JAXUCZ010000021.1  24626455-24626524
            3551-3661           JAXUCZ010000021.1  24626772-24626882
            3662-3925           JAXUCZ010000021.1  24627199-24627462
FEATURES             Location/Qualifiers
     source          1..3925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..3925
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /note="structural maintenance of chromosomes 1A"
                     /db_xref="GeneID:63996"
                     /db_xref="RGD:61991"
     exon            1..152
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..3745
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /note="SMC-protein; SMC protein 1A; SMC-like 1; SMC
                     (segregation of mitotic chromosomes 1)-like 1; structural
                     maintenance of chromosomes 1 like 1; segregation of
                     mitotic chromosomes-like 1; DXhXs423e"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein
                     1A"
                     /protein_id="NP_113871.2"
                     /db_xref="GeneID:63996"
                     /db_xref="RGD:61991"
                     /translation="MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDA
                     ISFVLGEKTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGS
                     SEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISR
                     SGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVR
                     AQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMRE
                     QQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMD
                     ELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQE
                     LEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLE
                     EQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK
                     RLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGE
                     PETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVED
                     ARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLT
                     EELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESE
                     LANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVK
                     RQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEE
                     QRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTA
                     IETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGGSQGEESVSGSQRTSSI
                     YAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEK
                     LESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKAL
                     SRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHS
                     YKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVY
                     PEQGDCVISKVLTFDLTKYPDANPNPNEQ"
     exon            153..341
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..454
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..658
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..897
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1156
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1297
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1380
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1588
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1774
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1954
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2101
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2239
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2356
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2463
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2605
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2751
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2905
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3016
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3173
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3328
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3480
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3550
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3661
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3925
                     /gene="Smc1a"
                     /gene_synonym="SB1.8; SMC-1A; Smc1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctaggagta aggcgcggcc tcttctacgc tagcgccttt gccatgggtt tcctgaaact
       61 gattgagatt gagaacttta aatcgtacaa gggtcgacaa attatcggac catttcagag
      121 gttcaccgcc atcattggac ccaatggctc tggtaagtca aatctcatgg atgccatcag
      181 ctttgtgctt ggtgaaaaaa ccagcaacct gagggtaaag accctgaggg acctgataca
      241 cggagctcct gtgggcaagc cggctgccaa ccgagccttt gtcagcatgg tctactccga
      301 ggagggtgct gaggaccgca cctttgcccg agtcattgta gggggctctt ctgagtacaa
      361 gatcaataac aaagttgtcc agctacatga atacagtgaa gagttagaga agttgggcat
      421 tctcatcaaa gctcgtaact tcctcgtctt ccagggtgca gtggaatcta ttgccatgaa
      481 gaaccccaag gagaggacag ctttatttga agaaattagt cgctctgggg aacttgcaca
      541 ggagtatgac aagcgaaaga aagaaatggt gaaggctgaa gaagacacac agtttaatta
      601 tcatcgcaag aaaaatattg cagctgaacg caaggaggcc aaacaagaaa aggaagaggc
      661 tgaccgctac cagcgcctga aggatgaggt agtacgcgca caggtacaat tgcagctttt
      721 taaactctac cacaacgaag tggagattga gaagctcaac aaggaactgg cctcgaagaa
      781 caaggaaatt gagaaggaca aaaagcggat ggacaaggta gaggatgaac tgaaggagaa
      841 gaagaaagag ctgggcaaaa tgatgcggga acagcagcag attgagaagg agatcaagga
      901 aaaggactca gaattgaatc agaagaggcc tcagtacatc aaagcaaaag agaatacatc
      961 ccacaaaatc aagaagcttg aagcagccaa gaaatctctg cagaatgctc agaaacatta
     1021 taagaaacgt aaaggtgaca tggatgagct ggagaaagag atgctgtcag tggagaaggc
     1081 ccgacaggag tttgaagagc ggatggagga agagagtcag agtcaaggca gagacttgac
     1141 cctggaggag aaccaggtaa agaaatacca ccgattaaaa gaggaagcta gcaagagagc
     1201 agccactttg gctcaggagc tggagaagtt taatcgagac cagaaagctg accaggaccg
     1261 tctagatcta gaagagcgga agaaagtaga gacagaggcc aagatcaagc aaaaactgcg
     1321 ggagattgaa gagaatcaga aacggattga gaagctagag gaatatatta ccactagcaa
     1381 gcagtctcta gaggaacaga agaagctaga gggagaattg acagaagaag tagagatggc
     1441 caagcgtcgt attgatgaga tcaataagga gctgaaccag gtgatggagc aattggggga
     1501 tgcgcgcatt gaccggcagg agagcagccg ccagcagagg aaggcagaaa taatggaaag
     1561 catcaagcgt ctctaccctg gttctgtgta tggccgcctc attgacctct gccagcctac
     1621 acaaaagaag tatcagattg ctgtgaccaa ggttttagga aagaacatgg atgctattat
     1681 tgtagactcc gagaagacag gtcgggattg tattcagtat atcaaggagc aacgtggaga
     1741 gcctgagacc ttcttgcctc ttgactacct ggaggtgaaa cctactgatg agaaactccg
     1801 agaactgaag ggggccaagc tagtgattga tgtgattcgc tatgagccac ctcacatcaa
     1861 aaaagctctg cagtatgctt gtggcaatgc ccttgtttgt gacaatgtgg aggatgcgcg
     1921 acgaattgcc tttggaggtc accaacgcca caagacagtg gcattggatg gcaccctgtt
     1981 ccagaagtca ggagttatct ctggtggagc cagtgatctc aaggcaaagg cacgacgctg
     2041 ggatgagaag gcagtagaca aactaaaaga aaaaaaagaa cgtttgacgg aggagctaaa
     2101 agagcagatg aaggcaaaac gaaaagaggc agagctgcgt caggtgcagt ctcaggccca
     2161 tgggctacaa atgcggctga agtactcaca gagtgaccta gaacagacta agacaaggca
     2221 tcttgccctg aatctccagg aaaaatctaa gctggagagt gaactagcca acttcgggcc
     2281 tcgaattaat gatatcaaga gaatcataca gagccgagag agggaaatga aagacttgaa
     2341 ggagaagatg aaccaggtgg aagatgaggt gtttgaagag ttttgtcggg agattggtgt
     2401 gcgtaacatc cgcgaatttg aggaagaaaa ggtgaagcgg cagaatgaaa ttgccaagaa
     2461 acgcttggaa tttgagaatc agaagactcg cttgggcatc cagttggatt ttgaaaagaa
     2521 tcagttgaag gaggaccagg ataaagtaca catgtgggag cagacagtaa aaaaggatga
     2581 aaatgagata gaaaagctta agaaggagga gcaaagacac atgaagataa tagatgaaac
     2641 catggctcag ctccaagacc ttaagaatca gcacctggcc aaaaagtcag aagtgaatga
     2701 caagaatcat gagatggaag aaattcgcaa gaagcttggg ggtgccaata aggaaatgac
     2761 tcacttacag aaggaagtga cagccattga gaccaagctt gaacagaagc gcagtgaccg
     2821 ccacaacctg ctacaggcct gtaagatgca ggacatcaaa ttgccactgt caaagggcac
     2881 catggatgat attagtcagg aagaaggtgg ctcccaggga gaagagtcag tgagtggttc
     2941 ccagagaaca tctagtatct atgcacgaga ggccctcatt gagattgact acggtgacct
     3001 gtgtgaagat ctgaaggatg cacaggcgga agaagaaatc aagcaagaga tgaacacact
     3061 ccagcaaaag ctgaatgagc agcagagtgt gcttcagagg attgctgccc ctaacatgaa
     3121 ggccatggaa aagctggaaa gtgtccgaga caagttccag gagacctcag atgaatttga
     3181 ggcagcacga aagcgagcaa agaaagccaa gcaggcattt gaacagataa agaaggagcg
     3241 ctttgaccga ttcaatgctt gttttgaatc tgtggctacc aatattgatg agatctacaa
     3301 ggctctgtcc cgtaacagca gtgcccaggc attcttgggc cccgagaatc ctgaagagcc
     3361 ctatttggat ggtatcaact acaactgtgt agctcctggc aaacgtttcc ggcctatgga
     3421 caatttgtca ggcggggaga agacagttgc cgcactggcc ttgctttttg ccattcacag
     3481 ctacaagcca gcccccttct tcgtcctgga tgagattgat gctgccttgg ataacaccaa
     3541 cattggcaag gtggcaaatt acatcaagga gcagtcaact tgcaacttcc aggccattgt
     3601 tatctctctc aaggaggaat tctacaccaa ggctgagagc ctcattggag tctatcctga
     3661 gcaaggagac tgtgtgatca gcaaagtcct gaccttcgac ctcaccaagt atccagatgc
     3721 caaccctaac cccaatgaac aatagcagga attctgtctt cttgtctgga tccctgaact
     3781 gcccttctat ccatcttctc tcctggatct catcacccac tatcatggat cgcctggcac
     3841 cataccccct tatgtttgtg tgcatgtgtg attgattgtg tgcatgttaa tttgtttgca
     3901 aaaataaata ctggagactg gtttt
//
