LOCUS       NM_134368               5568 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus SWI/SNF related BAF chromatin remodeling complex
            subunit ATPase 4 (Smarca4), mRNA.
ACCESSION   NM_134368 XM_001073453 XM_343358
VERSION     NM_134368.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5568)
  AUTHORS   Yijian,L., Weihan,S., Lin,Y., Heng,Z., Yu,W., Lin,S., Shuo,M.,
            Mengyang,L. and Jianxun,W.
  TITLE     CircNCX1 modulates cardiomyocyte proliferation through promoting
            ubiquitination of BRG1
  JOURNAL   Cell Signal 120, 111193 (2024)
   PUBMED   38679350
  REMARK    GeneRIF: CircNCX1 modulates cardiomyocyte proliferation through
            promoting ubiquitination of BRG1.
REFERENCE   2  (bases 1 to 5568)
  AUTHORS   Forini,F., Nicolini,G., Kusmic,C., D'Aurizio,R., Mercatanti,A.,
            Iervasi,G. and Pitto,L.
  TITLE     T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac
            MHC Switch: Role of an Epigenetic Cross-Talk
  JOURNAL   Cells 9 (10), 2155 (2020)
   PUBMED   32987653
  REMARK    GeneRIF: T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the
            Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5568)
  AUTHORS   Sun,W., Yu,J. and Kang,Q.
  TITLE     Upregulation of heme oxygenase-1 by Brahma-related gene 1 through
            Nrf2 signaling confers protective effect against high
            glucose-induced oxidative damage of retinal ganglion cells
  JOURNAL   Eur J Pharmacol 875, 173038 (2020)
   PUBMED   32105681
  REMARK    GeneRIF: Upregulation of heme oxygenase-1 by Brahma-related gene 1
            through Nrf2 signaling confers protective effect against high
            glucose-induced oxidative damage of retinal ganglion cells.
REFERENCE   4  (bases 1 to 5568)
  AUTHORS   Hong,Q., Liu,J., Lin,Z., Zhuang,D., Xu,W., Xu,Z., Lai,M., Zhu,H.,
            Zhou,W. and Liu,H.
  TITLE     Histone 3 lysine 9 acetylation of BRG1 in the medial prefrontal
            cortex is associated with heroin self-administration in rats
  JOURNAL   Mol Med Rep 21 (1), 405-412 (2020)
   PUBMED   31939625
  REMARK    GeneRIF: Histone 3 lysine 9 acetylation of BRG1 in the medial
            prefrontal cortex is associated with heroin selfadministration in
            rats.
REFERENCE   5  (bases 1 to 5568)
  AUTHORS   Wang,C., Tang,Y., Wang,Y., Li,G., Wang,L. and Li,Y.
  TITLE     Label-free quantitative proteomics identifies Smarca4 is involved
            in vascular calcification
  JOURNAL   Ren Fail 41 (1), 220-228 (2019)
   PUBMED   30973285
  REMARK    GeneRIF: Study using calcific rat aorta model of vascular smooth
            muscle cells stimulated with beta-glycerophosphate demonstrates
            that Smarca4 is involved in hyperphosphorus-induced vascular
            calcification.
REFERENCE   6  (bases 1 to 5568)
  AUTHORS   Ostlund Farrants,A.K., Blomquist,P., Kwon,H. and Wrange,O.
  TITLE     Glucocorticoid receptor-glucocorticoid response element binding
            stimulates nucleosome disruption by the SWI/SNF complex
  JOURNAL   Mol Cell Biol 17 (2), 895-905 (1997)
   PUBMED   9001244
REFERENCE   7  (bases 1 to 5568)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   8  (bases 1 to 5568)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   9  (bases 1 to 5568)
  AUTHORS   Chiba,H., Muramatsu,M., Nomoto,A. and Kato,H.
  TITLE     Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and
            Drosophila brahma are transcriptional coactivators cooperating with
            the estrogen receptor and the retinoic acid receptor
  JOURNAL   Nucleic Acids Res 22 (10), 1815-1820 (1994)
   PUBMED   8208605
REFERENCE   10 (bases 1 to 5568)
  AUTHORS   Khavari,P.A., Peterson,C.L., Tamkun,J.W., Mendel,D.B. and
            Crabtree,G.R.
  TITLE     BRG1 contains a conserved domain of the SWI2/SNF2 family necessary
            for normal mitotic growth and transcription
  JOURNAL   Nature 366 (6451), 170-174 (1993)
   PUBMED   8232556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_343358.3, XM_001073453.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ504723.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000008.1  28443819-28444112
            295-544             JAXUCZ010000008.1  28460283-28460532
            545-677             JAXUCZ010000008.1  28462195-28462327
            678-1082            JAXUCZ010000008.1  28463022-28463426
            1083-1181           JAXUCZ010000008.1  28463691-28463789
            1182-1440           JAXUCZ010000008.1  28465265-28465523
            1441-1567           JAXUCZ010000008.1  28466762-28466888
            1568-1741           JAXUCZ010000008.1  28467351-28467524
            1742-1915           JAXUCZ010000008.1  28469465-28469638
            1916-2083           JAXUCZ010000008.1  28471005-28471172
            2084-2134           JAXUCZ010000008.1  28471274-28471324
            2135-2265           JAXUCZ010000008.1  28476619-28476749
            2266-2323           JAXUCZ010000008.1  28476855-28476912
            2324-2445           JAXUCZ010000008.1  28486848-28486969
            2446-2596           JAXUCZ010000008.1  28489824-28489974
            2597-2760           JAXUCZ010000008.1  28492149-28492312
            2761-2827           JAXUCZ010000008.1  28497004-28497070
            2828-2938           JAXUCZ010000008.1  28498263-28498373
            2939-3181           JAXUCZ010000008.1  28499652-28499894
            3182-3295           JAXUCZ010000008.1  28501672-28501785
            3296-3403           JAXUCZ010000008.1  28502303-28502410
            3404-3490           JAXUCZ010000008.1  28503138-28503224
            3491-3537           JAXUCZ010000008.1  28504952-28504998
            3538-3704           JAXUCZ010000008.1  28505977-28506143
            3705-3868           JAXUCZ010000008.1  28508249-28508412
            3869-4096           JAXUCZ010000008.1  28510614-28510841
            4097-4174           JAXUCZ010000008.1  28511479-28511556
            4175-4393           JAXUCZ010000008.1  28512078-28512296
            4394-4647           JAXUCZ010000008.1  28519111-28519364
            4648-4753           JAXUCZ010000008.1  28531734-28531839
            4754-4855           JAXUCZ010000008.1  28531960-28532061
            4856-4988           JAXUCZ010000008.1  28532701-28532833
            4989-5131           JAXUCZ010000008.1  28532935-28533077
            5132-5568           JAXUCZ010000008.1  28534635-28535071
FEATURES             Location/Qualifiers
     source          1..5568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..5568
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit ATPase 4"
                     /db_xref="GeneID:171379"
                     /db_xref="RGD:621728"
     exon            1..294
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..544
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..5164
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /note="SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily A member 4; BAF190A;
                     SNF2-beta; protein brahma homolog 1; BRG1-associated
                     factor 190A; ATP-dependent helicase SMARCA4; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin, subfamily a, member 4"
                     /codon_start=1
                     /product="transcription activator BRG1"
                     /protein_id="NP_599195.1"
                     /db_xref="GeneID:171379"
                     /db_xref="RGD:621728"
                     /translation="MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMG
                     PSPGPPSAGHPMPTQGPGGYPQDNMHQMHKPMESMHEKGMPDDPRYNQMKGMGMRSGA
                     HTGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGSDPQ
                     ALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMP
                     TLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP
                     PGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPG
                     QPAQPAPLVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSL
                     AGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
                     RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFREYHRSVTGKLQKLTKAVATYH
                     ANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTE
                     LVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVES
                     GKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQPAQPPTL
                     PVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTE
                     RVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLME
                     HKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVL
                     LTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPL
                     QNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVL
                     RPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKG
                     GTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRI
                     LPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPG
                     SEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRL
                     CTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDE
                     VPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAE
                     VERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSR
                     KRKRDSEAGSSTPTTSTRSRDKDEESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAV
                     IKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKD
                     VMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGS
                     ESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSDEEQEEDRSGSGS
                     EED"
     exon            545..677
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1082
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1181
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1440
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1567
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1741
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1915
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2083
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2134
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2265
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2323
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2445
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2596
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2760
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2827
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2938
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3181
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3295
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3403
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3490
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3537
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3704
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3868
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4096
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4174
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4393
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4394..4647
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4753
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4754..4855
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4856..4988
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5131
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5568
                     /gene="Smarca4"
                     /gene_synonym="brg-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagggtg ggctggcgcg cgcacgaggc cggacgggca gcggaagcag gggaagtgga
       61 ctgggtagaa agggaggcgg gggcgcgcat agcgggcgcg cgggctgcgt gtgtgctggg
      121 gggggcggcc agccgaagcc gagcgggcac gcgcgcgagg ctttcccact agcttggcag
      181 cggcggcgac ggcttctttg tttcgtgagg agaagcgaga cgcccactct gtccccgacc
      241 cctcgtggag ggttgggggc ggcgccagga aggttacggc gccggtacct ccaggagacc
      301 actgcctgta gcttctgaaa agatgtctac tccagaccca cccctgggtg gaacccctcg
      361 gcctggtcct tccccaggcc ctggtccttc acctggtgca atgctgggtc ctagccctgg
      421 cccctcacca ggttctgccc acagcatgat ggggccaagc ccaggacctc cttcagcagg
      481 acatcccatg cccacccagg ggcctggagg gtacccccag gacaacatgc atcaaatgca
      541 caagcctatg gagtccatgc acgagaaggg catgcctgat gacccacgat acaaccaaat
      601 gaaagggatg ggcatgcgat caggggccca cacaggtatg ggacctccgc ctagtcccat
      661 ggaccagcat tctcaaggtt acccctcacc cttaggtggc tctgaacatg cctccagtcc
      721 tgtcccggcc agcggcccat cttcaggccc tcagatgtcc tctgggccag gaggggcccc
      781 actagatggt tctgaccccc aggccttggg gcagcaaaac agaggcccaa ccccatttaa
      841 ccagaaccag ctgcatcaac tcagagctca gataatggcc tataagatgt tggccagggg
      901 ccagccattg cccgaccacc tgcagatggc cgttcaaggc aagcggccga tgcctggaat
      961 gcagcagcag atgccaacac tacctccacc ttcagtgtct gccacaggac ctggacccgg
     1021 ccctggccct ggccctggcc caggtccagg accagcccct ccgaattaca gtagacccca
     1081 tggtatggga gggcccaaca tgcctcctcc aggaccctca ggtgtgcccc ccgggatgcc
     1141 tggtcagcct cctggagggc ctcccaagcc atggcctgaa ggacccatgg ccaatgctgc
     1201 tgcccccaca agcaccccac agaagctgat tcccccgcaa ccaacaggcc gcccttcacc
     1261 tgcacctcct gctgtcccgc ctgctgcctc acctgtaatg ccaccacaaa cacagtcccc
     1321 agggcagcca gcccagcctg ctccattggt gccattgcac cagaagcaga gccgcatcac
     1381 ccccatccag aagccccggg gcctggaccc tgtggagatc ctacaggagc gggagtacag
     1441 gctgcaggct cgaatcgcac acagaattca ggaacttgaa aacctccctg ggtccctggc
     1501 tggggacctt cgaaccaaag caaccatcga actcaaggcc cttaggttgc tgaacttcca
     1561 gaggcagctg cgccaggagg tggtggtgtg catgcgaaga gacacagccc tagagacagc
     1621 cctcaatgcc aaggcttata agcgcagcaa acggcagtca ctgcgggagg cccgcatcac
     1681 tgagaagctg gagaagcagc agaagattga acaggaacgc aagcgtcgtc agaagcacca
     1741 ggagtacctc aacagcattc tgcagcatgc caaggacttc agggagtatc acagatcagt
     1801 cacaggcaaa ctccagaaac tcaccaaggc tgtggccacc taccatgcca acactgagcg
     1861 ggagcaaaag aaagaaaatg agcgcatcga gaaggaacgg atgcgaaggc ttatggctga
     1921 agacgaggag ggctaccgca agctcattga ccagaagaag gacaagcgcc tggcctacct
     1981 cctgcagcag acagatgagt atgtggccaa cctcacagag ctggtgcggc agcacaaagc
     2041 tgcccaggta gccaaggaga agaagaagaa aaagaaaaag aagaaggcag aaaatgctga
     2101 agggcagaca cctgccattg gacccgacgg tgagcctctg gatgagacca gccagatgag
     2161 tgacctccct gtgaaggtga tccatgtgga gagtggcaag atcctcactg gcacagatgc
     2221 cccaaaagcc gggcagctgg aagcctggct tgagatgaac ccagggtatg aagtagctcc
     2281 cagatcagat agtgaagaaa gtggctctga agaggaggag gaggaggagg aagaggagca
     2341 gcctcagccc gcacagcccc ctacactgcc tgtggaagaa aagaagaaga ttccagaccc
     2401 agacagcgat gatgtctctg aggtggacgc tcgacacatt attgagaacg ccaagcagga
     2461 tgtggacgat gagtacggcg tgtcccaggc ccttgctcgt ggtctgcagt cctactatgc
     2521 tgtggcccat gcagtgacag agagagtaga taagcagtca gccctcatgg tcaacggtgt
     2581 cctcaaacag taccagatca agggtctgga gtggctggtg tccctgtaca acaacaacct
     2641 gaacggcatc ctggctgatg agatggggct ggggaagacc atccaaacca ttgcactcat
     2701 cacgtacctc atggagcaca agcgcatcaa tgggcccttc ctcatcatcg ttcctctctc
     2761 gacgctgtca aactgggcat atgaatttga caagtgggcc ccctctgtgg tgaaggtttc
     2821 ctacaagggc tctccagctg ccagacgagc ttttgtcccc cagcttcgca gcggcaagtt
     2881 caatgtctta ttgaccacct acgagtatat catcaaagac aaacatatcc tggccaagat
     2941 ccgctggaag tacatgattg tggatgaagg ccaccgcatg aagaaccacc actgcaaatt
     3001 gacacaggtc cttaatacac actacgtggc ccctcggcgc ctgcttctca caggcacgcc
     3061 actgcagaac aagctacctg agctctgggc actgctgaac ttcctgctcc ccactatctt
     3121 caagagctgc agcaccttcg aacagtggtt caatgcaccc tttgccatga ctggagagaa
     3181 ggtggacctg aatgaggagg agaccatcct cattattcgt cgtctacaca aggtgctacg
     3241 gcccttcctg ctgcggcgtc tcaagaagga agttgaagcc cagctccctg agaaggtaga
     3301 atatgtcatc aaatgtgaca tgtcagccct gcagcgtgtg ctctaccgtc acatgcaggc
     3361 caaaggtgtg ctgttgactg acggctctga gaaggacaag aagggcaaag gtggcaccaa
     3421 gacgctgatg aacactatca tgcagctgcg caagatctgc aaccacccct acatgttcca
     3481 gcacattgag gagtccttct ctgagcacct ggggttcacc ggtggcatcg tgcaaggatt
     3541 ggacctatat cgtgcctcag ggaaatttga acttcttgat agaattctac ccaaactccg
     3601 tgcaacaaac cataaagtgc tactcttctg ccaaatgacc tccctcatga ccatcatgga
     3661 agactacttt gcataccgtg gcttcaaata cctcaggctt gacggaacca caaaagcaga
     3721 agaccggggc atgctgttga aaacctttaa tgagcctggc tctgagtatt tcattttcct
     3781 actcagtacc cgtgctgggg ggctgggcct gaatctgcag tcagctgaca ctgtgatcat
     3841 ctttgacagt gactggaatc ctcaccagga cctgcaagca caggatcgtg cccatcggat
     3901 tgggcagcag aatgaggtgc gtgtgcttcg cctgtgcacc gtcaacagtg tggaagagaa
     3961 gatactggct gctgctaaat acaaactcaa tgtggatcag aaggtcatcc aggcaggcat
     4021 gtttgaccag aagtcttcca gccatgagag gcgtgccttc ctgcaggcca tcctggagca
     4081 cgaggagcag gacgaggagg aagatgaggt gcctgatgat gagaccgtca accagatgat
     4141 tgcccggcac gaagaagaat ttgacctctt catgcgcatg gacttggacc gccggcgtga
     4201 agaagcccgc aaccccaagc ggaagccacg cctgatggaa gaggatgagc ttccatcctg
     4261 gatcatcaag gatgatgcag aggtagagcg gctgacatgt gaagaggaag aggaaaagat
     4321 gttcggccgt ggttctcgcc accgcaagga ggtagactac agcgactcac tgacagagaa
     4381 gcagtggctc aaggctatcg aggagggcac gctggaggag atcgaagagg aggtccggca
     4441 gaagaaatct tcacgtaagc gtaagcgaga cagcgaggcc ggctcctcca ccccgaccac
     4501 cagcacccgc agccgtgaca aggacgagga gagcaaaaag cagaagaaac gtgggcggcc
     4561 acctgccgag aagctgtccc caaacccacc taacctcacc aagaagatga agaagatcgt
     4621 ggacgctgtg atcaagtaca aagacagtag tggacgtcag ctcagtgagg tgttcattca
     4681 gctcccctct cgcaaggaac ttcctgagta ctatgagctc atccggaaac ctgtggactt
     4741 caagaagatc aaggaacgca tccgaaacca caagtaccgc agcctcaatg acctggagaa
     4801 ggacgtgatg ttgctgtgcc agaatgctca gaccttcaac ctcgagggct ccctgatcta
     4861 cgaggactcc atcgtcctgc agtctgtctt caccagcgtg cggcagaaaa tcgagaagga
     4921 ggatgacagt gaaggcgagg aaagcgagga ggaagaagag ggcgaggagg aaggctctga
     4981 gtctgagtcc cgctctgtca aggtaaagat caagctgggt cgaaaggaga aggcccagga
     5041 ccgactcaag gggggcaggc ggcggccaag ccgggggtcc cgggccaagc ctgtcgtgag
     5101 tgacgatgac agtgatgagg agcaggagga ggaccgctca ggaagtggca gcgaggaaga
     5161 ctgaaccaga cattcctgag ttctgacccc gaggcgctcg tcccggccaa gatggagtaa
     5221 cccttagcag tgatgggtag caccagatgt agtttcgaac ttggagaact gtacacatgc
     5281 aaccttccac atttttaggc agagaagtat aggcctgtct gttggccctg gtctggcctc
     5341 gagtctctac cagcattaac tgtctagaga ggggacctcc tgggagcacc atccacctcc
     5401 ccaggcccca gtcactgtag ctcagtgtgg atgcatgcgc gtgccgtcca ctccttgtac
     5461 tgtatcttac tggacagggc cgactctccg ggaggctcac aggccccgcg ggtatgtcag
     5521 tgtcactgga gtcagacagt aataaattaa accaatgaca aaccatca
//
