LOCUS       NM_001004446            5928 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SWI/SNF related, matrix associated, actin
            dependent regulator of chromatin, subfamily a, member 2 (Smarca2),
            mRNA.
ACCESSION   NM_001004446 XM_342039
VERSION     NM_001004446.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5928)
  AUTHORS   Sanchez,R., Meslamani,J. and Zhou,M.M.
  TITLE     The bromodomain: from epigenome reader to druggable target
  JOURNAL   Biochim Biophys Acta 1839 (8), 676-685 (2014)
   PUBMED   24686119
  REMARK    Review article
REFERENCE   2  (bases 1 to 5928)
  AUTHORS   Singh,A.P. and Archer,T.K.
  TITLE     Analysis of the SWI/SNF chromatin-remodeling complex during early
            heart development and BAF250a repression cardiac gene transcription
            during P19 cell differentiation
  JOURNAL   Nucleic Acids Res 42 (5), 2958-2975 (2014)
   PUBMED   24335282
REFERENCE   3  (bases 1 to 5928)
  AUTHORS   Mathiyalagan,P., Okabe,J., Chang,L., Su,Y., Du,X.J. and El-Osta,A.
  TITLE     The primary microRNA-208b interacts with Polycomb-group protein,
            Ezh2, to regulate gene expression in the heart
  JOURNAL   Nucleic Acids Res 42 (2), 790-803 (2014)
   PUBMED   24137001
REFERENCE   4  (bases 1 to 5928)
  AUTHORS   Staahl,B.T., Tang,J., Wu,W., Sun,A., Gitler,A.D., Yoo,A.S. and
            Crabtree,G.R.
  TITLE     Kinetic analysis of npBAF to nBAF switching reveals exchange of
            SS18 with CREST and integration with neural developmental pathways
  JOURNAL   J Neurosci 33 (25), 10348-10361 (2013)
   PUBMED   23785148
REFERENCE   5  (bases 1 to 5928)
  AUTHORS   Shain,A.H. and Pollack,J.R.
  TITLE     The spectrum of SWI/SNF mutations, ubiquitous in human cancers
  JOURNAL   PLoS One 8 (1), e55119 (2013)
   PUBMED   23355908
REFERENCE   6  (bases 1 to 5928)
  AUTHORS   Wang,S., Zhang,B. and Faller,D.V.
  TITLE     Prohibitin requires Brg-1 and Brm for the repression of E2F and
            cell growth
  JOURNAL   EMBO J 21 (12), 3019-3028 (2002)
   PUBMED   12065415
REFERENCE   7  (bases 1 to 5928)
  AUTHORS   Xue,Y., Canman,J.C., Lee,C.S., Nie,Z., Yang,D., Moreno,G.T.,
            Young,M.K., Salmon,E.D. and Wang,W.
  TITLE     The human SWI/SNF-B chromatin-remodeling complex is related to
            yeast rsc and localizes at kinetochores of mitotic chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 97 (24), 13015-13020 (2000)
   PUBMED   11078522
REFERENCE   8  (bases 1 to 5928)
  AUTHORS   Reyes,J.C., Barra,J., Muchardt,C., Camus,A., Babinet,C. and
            Yaniv,M.
  TITLE     Altered control of cellular proliferation in the absence of
            mammalian brahma (SNF2alpha)
  JOURNAL   EMBO J 17 (23), 6979-6991 (1998)
   PUBMED   9843504
REFERENCE   9  (bases 1 to 5928)
  AUTHORS   LeGouy,E., Thompson,E.M., Muchardt,C. and Renard,J.P.
  TITLE     Differential preimplantation regulation of two mouse homologues of
            the yeast SWI2 protein
  JOURNAL   Dev Dyn 212 (1), 38-48 (1998)
   PUBMED   9603422
REFERENCE   10 (bases 1 to 5928)
  AUTHORS   Chiba,H., Muramatsu,M., Nomoto,A. and Kato,H.
  TITLE     Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and
            Drosophila brahma are transcriptional coactivators cooperating with
            the estrogen receptor and the retinoic acid receptor
  JOURNAL   Nucleic Acids Res 22 (10), 1815-1820 (1994)
   PUBMED   8208605
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY643746.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by
            NM_001004446.2.
            
            On Sep 17, 2004 this sequence version replaced XM_342039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY643746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..5928
                     /gene="Smarca2"
                     /note="SWI/SNF related, matrix associated, actin dependent
                     regulator of chromatin, subfamily a, member 2"
                     /db_xref="GeneID:361745"
                     /db_xref="RGD:1302988"
     exon            1..115
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            116..376
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..4945
                     /gene="Smarca2"
                     /codon_start=1
                     /product="probable global transcription activator SNF2L2"
                     /protein_id="NP_001004446.1"
                     /db_xref="GeneID:361745"
                     /db_xref="RGD:1302988"
                     /translation="MATPTDPAAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMM
                     GPSPGPPSVSHPMSTMGSADFPQEGLHQLHKPMDGIHDKGIVEGVHCGSMKGTSMRPP
                     HPGVGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPISGGGPTPPQMPPSQPGTLIPGD
                     LQAMNQPDRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGIQQQ
                     QQQQQQQQQQQQQQQPQQPQQPQQQTQAQPQQQQQQQQQPPTLVSYNRPSGPGQELLM
                     TAQNTQRKLSAPAPSGRPSPAPPAATQPTATAVPGPSVQEPAPGQPSPVLQLQQKQSR
                     ISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRL
                     LNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERK
                     RRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKE
                     RMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKR
                     RRRRKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQL
                     DAWLEMNPGYEVAPRSDSEESESDYEEEDEEEESSRQETEEKILLDPNSKEVSEKDAR
                     QIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLE
                     WMVSLYNNNLNGILADEMGPGKTIQTIALITYLMEHKGLNGPYLIIVPLSTLSNWTYE
                     FDKWAPSAVKISYKGTPAMRRSLVPQLRSGKFNALLTTYEYIIKDKHILAKIRWKYMI
                     VDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCS
                     TFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYV
                     IKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQ
                     HIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTI
                     MEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAAD
                     TVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQK
                     VIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMR
                     MDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRD
                     VDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEKAKKRRGRP
                     PAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPCNSQLEIEGNSSGRQLSEVFIQ
                     LPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQ
                     IYEDSIVLQSVFKSARQKIAKEEESEEESNEEEEEEDEEESEAEAKSVKVKIKLNKKE
                     EKGRDTGKGKKRPNRGKAKPVVSDFDSDEEQDENEQSEASGTDDE"
     exon            377..506
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..956
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1218
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1345
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1519
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1693
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1864
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1918
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2049
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2107
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2208
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2356
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2520
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2587
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2698
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2941
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3055
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3163
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3250
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3297
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3464
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3628
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3856
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3934
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4153
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4371
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4372..4425
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4426..4531
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..4633
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4634..4766
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..4909
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
     exon            4910..5928
                     /gene="Smarca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacggctg tcatcaatga agtcatattc ataatctagt cctcgctccc tctgtttctg
       61 tactctgggt gactcagaga gggaagattc agccagcaca ctgctcgcga gcaagtgtca
      121 gtctgctgac tggcagagcc aggagacgta gatggccaca cccacagacc cagctgcaat
      181 gccccatcct gggccctccc cggggcctgg accttctcct ggaccaattc tggggcctag
      241 tccaggacca ggaccgtccc caggttctgt gcacagtatg atggggccca gtcctggacc
      301 tcccagtgtc tcacatccta tgtcgacaat gggctcggca gacttcccac aggaaggctt
      361 gcaccagctg cataagccca tggatgggat acatgacaag gggattgtag aaggtgtcca
      421 ctgtggatcc atgaagggta ccagtatgcg cccaccacac ccaggagtgg gccctccaca
      481 gagcccaatg gatcagcaca gtcaaggtta tatgtcacca catccatctc ctttgggagc
      541 cccagagcat gtctccagcc ctatatctgg aggaggccca accccacccc agatgccgcc
      601 gagccagcca gggacactca tcccaggaga tctgcaggcc atgaaccagc ctgacagagg
      661 tccctcgcct ttcagtcctg tacagctgca tcagcttcga gctcagattt tagcttacaa
      721 aatgttggcc aggggccagc ccctccctga aactctgcag cttgcagtcc agggaaaaag
      781 gaccttgcct ggtatacaac agcaacagca gcagcagcag caacaacaac agcagcagca
      841 acaacagcag ccccagcagc cccagcagcc tcagcagcag acacaggcac agccacagca
      901 gcagcaacag cagcagcagc agccgccaac tcttgttagc tacaatagac catctggccc
      961 tgggcaggag ctgctgatga ctgctcagaa cacccagcgg aagctgtcgg cacccgcacc
     1021 cagcggccga ccttcacctg cacctccagc ggctacccag cccacggcca cagcagtgcc
     1081 tgggccctcg gtgcaggagc ctgccccagg gcagccatct cccgtcctgc agctgcaaca
     1141 gaagcagagc cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggagatcct
     1201 gcaggaacgg gagtacagac ttcaggctcg catagctcat aggatacaag aactggaaag
     1261 tctgcctggc tccttgccac cagatttacg aaccaaagca accgtagagc tgaaagcact
     1321 tcgcttgctc aactttcaac gtcagctgag acaggaggtg gtggcctgca tgcgaaggga
     1381 caccaccctg gagacagccc tcaactccaa ggcgtacaag cggagtaagc gccaaaccct
     1441 tcgagaggca cgcatgacgg agaaactgga gaagcagcag aagatagagc aggagaggaa
     1501 acgccgccag aagcaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa
     1561 ggaataccac cggtctgtgg ctgggaagat ccagaagctg tccaaagcag tggcgacttg
     1621 gcatgctaac accgaaaggg agcagaagaa ggagacggag cggatcgaga aggagagaat
     1681 gcgaaggctg atggctgaag atgaagaggg ctacaggaag ctcatcgacc aaaagaaaga
     1741 cagacgcctg gcctacctat tgcagcagac tgatgagtat gtcgccaatc tgaccaacct
     1801 ggtttgggag cacaagcagg cccaagcagc caaagagaag aagaagagga ggaggaggag
     1861 gaagaaggcc gaagagaatg cagagggagg ggagcctgcc ctgggaccag atggagagcc
     1921 aatagacgaa agcagccaga tgagcgacct gcctgtcaaa gtgacgcaca cggaaactgg
     1981 caaggtcctc tttggaccag aagcacccaa agcaagtcag ctggacgcct ggctggagat
     2041 gaatcctggt tacgaagtgg cacccagatc ggacagtgaa gagagtgaat cagactatga
     2101 ggaagaggat gaagaagaag agtccagtag gcaggaaaca gaggagaaga tactgctgga
     2161 tccaaacagc aaagaagttt ccgaaaagga cgccaggcag atcattgaga ctgcgaaaca
     2221 ggatgtggac gacgagtaca gcatgcagta cagtgccaga gggtcccagt cctactacac
     2281 ggtggctcac gccatctccg agagggtgga gaagcagtct gccctcctca ttaatggcac
     2341 cctgaagcac taccagctac agggcctgga atggatggtt tccctgtata ataacaatct
     2401 gaatggaatc ttagctgatg aaatggggcc aggcaagacc atccagacca ttgcactcat
     2461 cacgtatctg atggagcaca aagggctcaa tggcccctac ctcatcatcg tccccctctc
     2521 gactctgtct aactggacat atgaatttga caaatgggct ccttctgcgg tgaaaatttc
     2581 ctacaagggt acccctgcca tgcgacgctc ccttgttccc cagttacgga gtggcaaatt
     2641 caatgccctc ctgactacct acgagtacat tataaaagac aagcacattc ttgcaaagat
     2701 taggtggaaa tacatgatag tggacgaagg tcaccgaatg aagaaccatc actgcaagct
     2761 gacccaggtc ctgaacacac actacgtggc ccccagaagg atccttctga ctgggacccc
     2821 gctgcagaat aagctccccg aactctgggc cctcctcaac ttcctcctcc ctacaatctt
     2881 caagagttgc agcacatttg agcagtggtt taatgctccg tttgccatga ccggcgaaag
     2941 ggtggacctg aacgaagaag aaaccatttt gatcatcagg cgtctacaca aggtgttgag
     3001 acccttttta ctgaggaggc tgaagaaaga ggttgagtct cagcttccag aaaaggttga
     3061 gtatgtgatc aagtgtgata tgtccgctct gcagaagatc ctgtaccgtc atatgcaggc
     3121 caagggcatc ctcctcacgg acgggtctga gaaggataag aaggggaaag gaggtgccaa
     3181 gacgcttatg aacactatca tgcagctgcg aaagatatgc aaccacccat atatgtttca
     3241 gcacattgag gaatcctttg ctgaacacct gggctattcg aatggggtca tcaatggggc
     3301 cgagctgtat cgggcctcag gaaagtttga gctacttgat cgtattctgc ccaaattgag
     3361 agcgactaac caccgcgtgc tgcttttctg ccagatgacg tcactcatga ccatcatgga
     3421 ggattacttt gcttttcgga acttccttta cctgcgcctt gatggcacca ccaagtctga
     3481 agatcgtgct gctttgctga agaaattcaa tgaacctggg tcccagtatt tcattttctt
     3541 gctgagcaca cgagctgggg gcctgggctt aaatcttcag gccgcagaca ctgtggtcat
     3601 ctttgacagc gactggaatc ctcatcagga tctgcaggcc caagaccgag ctcaccgcat
     3661 tggccaacaa aatgaggtcc gggtgctgag gctttgcacc gtcaacagtg ttgaggaaaa
     3721 gattctcgcg gctgccaagt acaagctgaa tgtggaccag aaggttattc aggcgggcat
     3781 gtttgaccag aagtcatcca gccatgagcg gagggcattc ctacaggcca tcctggagca
     3841 cgaagaggag aatgaggaag aagatgaggt accagacgac gagaccctga accagatgat
     3901 tgctcgccgg gaagaagagt ttgatctttt tatgcgcatg gacatggacc ggcggagaga
     3961 ggacgccaga aacccgaagc gcaagcctcg cttgatggag gaagatgagc tgccctcctg
     4021 gataattaag gatgatgctg aagtggaaag gctcacctgc gaagaggagg aggagaagat
     4081 atttgggagg ggctctcgac agcgccggga tgtggactac agcgatgccc tcaccgagaa
     4141 gcagtggctc agggccatcg aagacggaaa tttggaagaa atggaagagg aggtacggct
     4201 gaagaagagg aaaagacgaa gaaacgtgga taaagatccc gtgaaggaag atgtggaaaa
     4261 agcaaagaaa agaagaggcc gccccccagc tgagaagttg tcaccaaatc cccccaaact
     4321 gacgaagcag atgaacgcca tcattgatac tgtgataaac tacaaggaca ggtgtaacgt
     4381 ggagaaggtg ccctgtaatt ctcagttgga aatagaagga aacagttcag ggcgacagct
     4441 cagtgaagtc ttcattcagt taccttccag aaaagagtta ccagaatact atgaattaat
     4501 taggaagcca gtggatttca aaaagataaa ggaaagaatc cgtaatcata agtaccgaag
     4561 cctgggagac ctggagaaag atgtcatgct tctctgtcac aatgcacaga cattcaactt
     4621 ggaaggatcc cagatctacg aagactccat tgtcctccag tcagtgttta agagtgctcg
     4681 gcagaaaatt gccaaagaag aagagagtga ggaggaaagc aatgaggagg aggaggaaga
     4741 ggatgaagag gagtcagagg cagaggcaaa atctgtgaag gtgaaaatca aactgaataa
     4801 aaaggaagag aaaggccggg atacagggaa gggcaagaaa aggccaaacc gaggcaaagc
     4861 caaacctgtt gtgagcgatt ttgacagcga tgaggagcag gatgagaacg aacagtcaga
     4921 agcaagtggg actgacgacg agtgaacagc ctggacatga gcttcctgcg gcagcggctg
     4981 cggcaggcag ccaaaccgaa tgctttcttc cccctctcct tcctccccag tgagttcact
     5041 tgccatttgg gcacactggg ttatttctcc gtcctcactg tcatctagaa ctagctttag
     5101 ggtagtgcca gacaaacata tgatatcatg gtgtaaaaaa aaaaaaaaag agacgcgcgc
     5161 gtgtacacac acacacacac acacacacac acacacacac acacacacac acacacggat
     5221 atttgtaaca tattgtgacc aaatgggcct caaagattca aagattaaaa acaaaaagct
     5281 tttgatggga aagatgtggg tggatagtat atttctacag gtgggtcgag tctggtcgca
     5341 gtttggtggg ctcggttctg ccatctgttc tgatgggaag attttcatct tctgcagcgc
     5401 cgatggccag ggggaaccgt tcaaagccac tggttatttt atttttcatc aggcgatttt
     5461 caagattttc atttgtttca gtattgttgg gtttttgggg ttttttgttt gtttgtttgt
     5521 tttttgtttt tttttttaca ctgtggtaca tataagcgac tttactagtg acaattgtac
     5581 agtagttaga tatcacctac atatacattt ttccatttta tgctctatga tctgaagaac
     5641 aacaacaaca acaaaaaaaa gctttttgac ttgtataaga tttatgtcta ctgtaaacat
     5701 tgctgaaact tttttttttt tttggttctc gttttattga caacgctatt gaatattaca
     5761 gtgtctagag tgtcccggat ggcttctttt gtccacccga tctcctgtgt taccgatgtg
     5821 tatggtctcc ttctccctaa agtgtactta atctttgctt tctttgcaca atgtctttgg
     5881 ttgcaagtca taagagcctg aggcaaataa aattccagta atttccaa
//
