LOCUS       NM_138872               5353 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SMAD family member 9 (Smad9), mRNA.
ACCESSION   NM_138872 XM_017591145 XM_017595808
VERSION     NM_138872.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5353)
  AUTHORS   Hou,F., Liu,R., Liu,X., Cui,L., Wen,Y., Yan,S. and Yin,C.
  TITLE     Attenuation of liver fibrosis by herbal compound 861 via
            upregulation of BMP-7/Smad signaling in the bile duct ligation
            model rat
  JOURNAL   Mol Med Rep 13 (5), 4335-4342 (2016)
   PUBMED   27035233
  REMARK    GeneRIF: Cpd 861 markedly upregulated the gene expression of BMP7
            and Smad5, as well as the protein expression of BMP7 and Smad1/5.
            In addition, p-Smad1/5/8 protein expression was markedly increased
            by Cpd 861 in the liver fibrosis model.
REFERENCE   2  (bases 1 to 5353)
  AUTHORS   Chen,W., Xia,J., Hu,P., Zhou,F., Chen,Y., Wu,J., Lei,W. and Shen,Z.
  TITLE     Follistatin-like 1 protects cardiomyoblasts from injury induced by
            sodium nitroprusside through modulating Akt and Smad1/5/9 signaling
  JOURNAL   Biochem Biophys Res Commun 469 (3), 418-423 (2016)
   PUBMED   26687945
  REMARK    GeneRIF: Taken together, these results indicated that FSTL1
            protects the SNP-induced injury in cardiac H9c2 cells through, at
            least in part, the activation of Akt and inhibition of Smad1/5/9
            signaling.
REFERENCE   3  (bases 1 to 5353)
  AUTHORS   Rath,B., Nam,J., Deschner,J., Schaumburger,J., Tingart,M.,
            Grassel,S., Grifka,J. and Agarwal,S.
  TITLE     Biomechanical forces exert anabolic effects on osteoblasts by
            activation of SMAD 1/5/8 through type 1 BMP receptor
  JOURNAL   Biorheology 48 (1), 37-48 (2011)
   PUBMED   21515935
  REMARK    GeneRIF: biomechanical stimulation of osteoblasts activates SMAD
            1/5/8 in the BMP signaling pathway through BMPR1 and may enhance
            osteogenesis by upregulating SMAD-dependent osteogenic genes
REFERENCE   4  (bases 1 to 5353)
  AUTHORS   Morikawa,Y., Zehir,A., Maska,E., Deng,C., Schneider,M.D.,
            Mishina,Y. and Cserjesi,P.
  TITLE     BMP signaling regulates sympathetic nervous system development
            through Smad4-dependent and -independent pathways
  JOURNAL   Development 136 (21), 3575-3584 (2009)
   PUBMED   19793887
REFERENCE   5  (bases 1 to 5353)
  AUTHORS   Meynard,D., Kautz,L., Darnaud,V., Canonne-Hergaux,F., Coppin,H. and
            Roth,M.P.
  TITLE     Lack of the bone morphogenetic protein BMP6 induces massive iron
            overload
  JOURNAL   Nat Genet 41 (4), 478-481 (2009)
   PUBMED   19252488
REFERENCE   6  (bases 1 to 5353)
  AUTHORS   Horvath,L.G., Henshall,S.M., Kench,J.G., Turner,J.J., Golovsky,D.,
            Brenner,P.C., O'Neill,G.F., Kooner,R., Stricker,P.D., Grygiel,J.J.
            and Sutherland,R.L.
  TITLE     Loss of BMP2, Smad8, and Smad4 expression in prostate cancer
            progression
  JOURNAL   Prostate 59 (3), 234-242 (2004)
   PUBMED   15042598
REFERENCE   7  (bases 1 to 5353)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 5353)
  AUTHORS   Vrljicak,P., Myburgh,D., Ryan,A.K., van Rooijen,M.A., Mummery,C.L.
            and Gupta,I.R.
  TITLE     Smad expression during kidney development
  JOURNAL   Am J Physiol Renal Physiol 286 (4), F625-F633 (2004)
   PUBMED   14656760
REFERENCE   9  (bases 1 to 5353)
  AUTHORS   van Grunsven,L.A., Michiels,C., Van de Putte,T., Nelles,L.,
            Wuytens,G., Verschueren,K. and Huylebroeck,D.
  TITLE     Interaction between Smad-interacting protein-1 and the corepressor
            C-terminal binding protein is dispensable for transcriptional
            repression of E-cadherin
  JOURNAL   J Biol Chem 278 (28), 26135-26145 (2003)
   PUBMED   12714599
REFERENCE   10 (bases 1 to 5353)
  AUTHORS   Chen,Y., Bhushan,A. and Vale,W.
  TITLE     Smad8 mediates the signaling of the ALK-2 [corrected] receptor
            serine kinase
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12938-12943 (1997)
   PUBMED   9371779
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Feb 17;95(4):1968]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Dec 3, 2020 this sequence version replaced
            XM_017591145.1, XM_017595808.1, NM_138872.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.9732.1,
                                           SRR26643429.8069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000002.1  141106668-141106816
            150-767             JAXUCZ010000002.1  141136636-141137253
            768-1025            JAXUCZ010000002.1  141138969-141139226
            1026-1247           JAXUCZ010000002.1  141141989-141142210
            1248-1504           JAXUCZ010000002.1  141147019-141147275
            1505-5353           JAXUCZ010000002.1  141152629-141156477
FEATURES             Location/Qualifiers
     source          1..5353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..5353
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /note="SMAD family member 9"
                     /db_xref="GeneID:85435"
                     /db_xref="RGD:71004"
     exon            1..149
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            150..767
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1648
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /EC_number="2.4.1.117"
                     /note="SMAD 9; mothers against DPP homolog 9; MAD homolog
                     9"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 9"
                     /protein_id="NP_620227.2"
                     /db_xref="GeneID:85435"
                     /db_xref="RGD:71004"
                     /translation="MHPSTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKK
                     LKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ
                     SHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKF
                     RSASLHSEPLMPHNATYPDSFQQSLGPAPPSSPGHVFPQSPCPTSYPQSPGSPSESDS
                     PYQHSDFRPVCYEEPLHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCL
                     GLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPA
                     TVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQ
                     DVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS"
     exon            768..1025
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1247
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1504
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..5353
                     /gene="Smad9"
                     /gene_synonym="Madh9; Smad8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgcactc acgcgggcgg ccgaggagga ggctccagcc tgactgacgc ctctggagcc
       61 gctgtctcgg tcccgccgcc gcccggccgg ccctgcagct acccgcacaa ccggagtgcg
      121 cgggggcacg cgtggcactg cgcggacaga gtcagctggc cccacctccc aagggctttg
      181 gaagaagccg gcccatctcc caatttgaat tggtccccac tgcttccaga aggaaaggca
      241 agtttgttcc tatgacatcc ctggacagat acttgccgct gacctgccca gggccctgca
      301 agccttgaaa ggtctcatct tcttttcccg agcaggagcc tgaggtctgc ctcctatgca
      361 ccccagcacc cccatcagct ccctcttctc cttcaccagc cccgcagtga agaggctgct
      421 gggctggaag cagggagatg aagaggagaa gtgggcagag aaggcagtgg actctttggt
      481 gaagaagtta aagaaaaaga aaggcgccat ggatgaactg gagagggcgc tgagctgccc
      541 gggccagcct agcaagtgcg ttaccatccc acgctccctg gatggacgcc tccaggtgtc
      601 ccaccggaag gggctgcccc atgtcatcta ctgccgcgtg tggcgctggc cagatctgca
      661 atcccatcat gagctgaagc ccttggaatg ctgcgagttc ccgtttggct ctaagcagaa
      721 ggaggtctgc atcaacccat accattaccg cagagtggag accccagttc tgcctccagt
      781 gctggtacca agacacagcg agtacaaccc tcagctcagc ctcctggcca agttccgaag
      841 tgcctcgctg cacagcgaac cgctcatgcc gcacaacgcc acctaccctg actctttcca
      901 gcagtctctc ggtcccgcac cgccctcctc gccaggacac gtgtttccgc agtctccatg
      961 ccccaccagc tacccgcagt cccccggaag tccttccgag tcagacagtc cttatcaaca
     1021 ctcagacttc cggccagttt gctacgagga gcccctgcac tggtgctctg ttgcctacta
     1081 cgaactgaac aaccgggtcg gagagacttt ccaggcatcc tcccggagtg tgctcataga
     1141 tggcttcaca gacccctcca ataacaggaa taggttctgt cttgggcttc tttcaaatgt
     1201 aaacagaaat tcgacgatag aaaacaccag aaggcacatt ggaaagggtg tgcatttgta
     1261 ctacgttggg ggcgaggtgt acgcggagtg cgtgagcgac agcagcatct ttgtccagag
     1321 ccggaactgc aactaccagc acggcttcca cccggccact gtctgcaaga tccccagtgg
     1381 ctgcagcctc aaggtcttca acaaccagct cttcgcccag ctgctcgccc agtcagtgca
     1441 ccacggcttt gaagttgtct atgaactgac gaagatgtgc acgattcgga tgagctttgt
     1501 gaagggctgg ggagccgagt atcatcgcca ggatgtcaca agcaccccct gctggattga
     1561 gattcatctt catggaccac tgcagtggtt ggacaaggtg ctaactcaga tgggctcccc
     1621 acacaaccct atttcttcag tgtcttaagt catgtgctca gctgcatttc cacagaatag
     1681 acgaaggcag gggcttctac cactgcaact cgcagctagt acaagaccct ggacgcagat
     1741 gtaaacacgt acgatgcaca cgattcccat ttctatcccc attggttctg tgctacctac
     1801 ttaacctgag gctagtgctg tgtggttgaa gaagcacgtt ttccagaccg gtgtctgatt
     1861 agaagccaag tcttttgtga gagggcaagc ggcatgtgaa gcccactggg tcagctcgtc
     1921 actctgcaga aggttgtgcc ccagaaggaa aacacagagc tgcttacata ggaaaataca
     1981 cgagcactag agcaaaacca gtcaaaccca catgattgca aaaagacctc acttgcaatg
     2041 tgaatggcaa gaaaggagac caagcttgtt caaggacctg cgagagaggc cccagaaacc
     2101 ttctctctgc agctgaactg tgcgtggccg cgtactgcgc tgatgtcagg tacagttaac
     2161 cggatttaaa ctgtgattgg aaagggggaa actgtgaagc ctggagtcag gctgcctcca
     2221 tctaccactg ctgaaacatc cagcaagcaa gcagcaagca aacaaaacca aggctcatga
     2281 gggaagacag cccgagatga gccttggtcc ccaggccagg gctagcccag aattcaggcc
     2341 caggagcaca ggggctcctg cttccactct gggcgtcagc ttcccacctt ccagctcctc
     2401 ctgtctgacc ttgcagatgg ctgtctgccc tgtgtacacg gcgaaccctg tgctgaggtg
     2461 aagctgcaga tggaagactg ggagcgaagt cgcatggcga cctacactac taggtggggc
     2521 atcctttgcc tcatcttctc tcctggtgac aaacactaag tgattacaga tgatttaaac
     2581 gacagcaaag ccatggggga gagctagagg catcactggg tcgtgtacat gtatttctca
     2641 atccagtacc tgagttgatt aagttattag ctggttacat ctgtggcagc ctcttctaaa
     2701 gctatgaaat acctggatag agcctcccag gtgaggtagg aatgtttcat atgccctaca
     2761 attttttgag gaaacagtgg tagtgaataa taaagcattt ttaaaaacac cttatgtata
     2821 tatacacata tatacatata aacatatatg tacatttaca cacacatgca tatttagcat
     2881 gcatgcatta acgcttgtta tttcctttgt tggacgataa agggaaacat cctccagact
     2941 tcagggtaca tgcacttgtt aatcacccca ctgcttctaa gtttacttcg ggccctttga
     3001 gaagcacatt atttaggatg gcattcatgg tttccagggt agagcgtcca ctgtccgaga
     3061 tgccttcgtt caatccactc tgcctagcat cgatgtatac acactgtttg ttccccatac
     3121 aactgtattt taagatagag atgatgatca caagtcacac acaatgccca ctctatctat
     3181 aaaacctacc attcttatat atacatatta tgtcagaaaa cacacatttc gtctcaaact
     3241 accacttaga ttgtataata cccaagcatg ttaattcata cagtctgtct tgtgcctttg
     3301 tgtgtactgg gtacgatgtc aggtgctgtg gaatcaaatg tacattagcg gtagtagccc
     3361 ccaactcccc aacgccctat atctaacatt tgcatagaca aataggacaa cataggactt
     3421 taaaaaccca cacatgtgaa ctttcttggg cttgaaaaat aatgtaacca agttcttaat
     3481 tattattata ttggaatttc acatcgcttc agaacaatta ggtaatttgt ctttgcataa
     3541 ctactttcat ccctagtcac tccacctcct ggaaccccta tttttctggt atttctcctg
     3601 gcctcttcct tggaaaagcc atgcatatga cagatctccg agtacccatc caaggacgca
     3661 aagtgtttgt cccagatttc taacaagtgg ccaaatatct ctggcaatgt gtagctttat
     3721 ggaactattc agaagtagaa gcttccaggt atggtggagc ctgactttaa tctcagcagg
     3781 gaagagaaac agatggatcc ctgagaattc agggctgacc tggtctacat aaggagttac
     3841 aggacagcca gggctatacc ttgagaccct gtctcaaagc aaagcaaagc aaaacaaaaa
     3901 aagaagctta aaaacaaaac taaaaaacca aataaattac ttggctttcc tggcagtgtt
     3961 aagaaatcag agaaaatact gaaatgtgtc tgagttcttt gagaaaggaa tcacaacata
     4021 ggttcatatg tatattatca gagaatttag catcaaaggg atgtaagtcc tatgctctat
     4081 aacatagtca cattttaatg agtttccccc ttggcggcta agagatcaaa aatatcataa
     4141 atgtaatcct ttgactttaa ctcctctgag tgaccatgtg gcaatcaccc catgaaactg
     4201 acaagcaaaa ctatgctgca tgtgttgttt tacagggtaa caggaaaagt gggtagccag
     4261 gcctttacac tgcaaatgtg cctcctgttg ccctgggcag tggagaactg tatcagtttg
     4321 gcctgcccac aagacccaga atgcttatca ctgtgtacaa gtaggtattt gtgagtctta
     4381 acaaataaga catggtcagt ttgtttcagc taaatgatgc cacctgcttc aggactaaga
     4441 agacaccacc tttttgaaca catgcttcgg tgttgtgtag tcagcaaacg cagcaaactc
     4501 tctagcattt agaatactct tttcattgtt ttctgaggat ggggttattc ccaggacaac
     4561 agaaagaaga gggtagtgaa aacatcttat aaacactgct tgctggactt gaagctccag
     4621 cttaactccg aatggtccag atattttgtg tatatataat aagtaaaata taccgtgcat
     4681 tccacatcaa cttacctgct aggagtcaag agctgcactg tgcaagggta ggtgactgtc
     4741 acatatgtga cagctaagtt caaatgaaaa taagcagact actgggagtg ctttgatgcc
     4801 cagcagcctg gcctcccgtc ctggaaatga caaacaccgt catctggtag tttgtggtag
     4861 acagtgaaac acctttgggc ttatttttct tccgaactct aggaaatact tgtatctgat
     4921 ctgtggctcc ttaagatgct taatcataag ctgttctact tagacatggg atttttaaga
     4981 attcttcatg ctgtaaaaaa gctttggtgg cactataaaa aaaaggcatt gtggactatt
     5041 tggcattatg tgtgtaattt taatgatact ttgcagaatt tttagagatg tttaactact
     5101 cctccgcagc ttagcaccag accgcacagc tcaaaccctt tatggtgatg ttattgttat
     5161 taaagagtga atttaataca cattgtcatt tgagcacctt accgtagcag ctcatcaagg
     5221 agcatgtctg tattaagatg gttagcatgt gatgcttaaa acccctggat acagagggaa
     5281 actgtcacta aaaatcattt attttcatat gccatgaaat atgtttaact gattaaaaca
     5341 ttttctaaga gaa
//
