LOCUS       NM_030858               4297 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus SMAD family member 7 (Smad7), mRNA.
ACCESSION   NM_030858 XM_001054518
VERSION     NM_030858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Lin,W., Hou,L., Tang,J., Huang,A. and Jia,Z.
  TITLE     Mir-195-5p targets Smad7 regulation of the Wnt/beta-catenin pathway
            to promote osteogenic differentiation of vascular smooth muscle
            cells
  JOURNAL   BMC Cardiovasc Disord 24 (1), 221 (2024)
   PUBMED   38654161
  REMARK    GeneRIF: Mir-195-5p targets Smad7 regulation of the
            Wnt/beta-catenin pathway to promote osteogenic differentiation of
            vascular smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4297)
  AUTHORS   Li,Z., Zhang,B., Shang,J., Wang,Y., Jia,L., She,X., Xu,X.,
            Zhang,D., Guo,J. and Zhang,F.
  TITLE     Diabetic and nondiabetic BMSC-derived exosomes affect bone
            regeneration via regulating miR-17-5p/SMAD7 axis
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111190 (2023)
   PUBMED   37976598
  REMARK    GeneRIF: Diabetic and nondiabetic BMSC-derived exosomes affect bone
            regeneration via regulating miR-17-5p/SMAD7 axis.
REFERENCE   3  (bases 1 to 4297)
  AUTHORS   Li,B., Lu,Z.Y., Jiang,S.D., Jiang,L.S. and Zheng,X.F.
  TITLE     Smad7 Is Highly Expressed in Human Degenerative Discs and
            Participates in IL-1beta-Induced Apoptosis of Rat AF Cells via the
            Mitochondria Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 2912276 (2022)
   PUBMED   35795857
  REMARK    GeneRIF: Smad7 Is Highly Expressed in Human Degenerative Discs and
            Participates in IL-1beta-Induced Apoptosis of Rat AF Cells via the
            Mitochondria Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4297)
  AUTHORS   Han,N., Qian,F., Niu,X. and Chen,G.
  TITLE     Circ_0058792 regulates osteogenic differentiation through
            miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the
            femoral head
  JOURNAL   Bioengineered 13 (5), 12807-12822 (2022)
   PUBMED   35611880
  REMARK    GeneRIF: Circ_0058792 regulates osteogenic differentiation through
            miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the
            femoral head.
REFERENCE   5  (bases 1 to 4297)
  AUTHORS   Jia,G., Liang,C., Li,W. and Dai,H.
  TITLE     MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy
            by targeting Smad7
  JOURNAL   Bioengineered 13 (1), 119-127 (2022)
   PUBMED   34951337
  REMARK    GeneRIF: MiR-410-3p facilitates Angiotensin II-induced cardiac
            hypertrophy by targeting Smad7.
REFERENCE   6  (bases 1 to 4297)
  AUTHORS   Wang,D., Kanuma,T., Mizumuma,H., Ibuki,Y. and Takenoshita,S.
  TITLE     Mutation analysis of the Smad6 and Smad7 gene in human ovarian
            cancers
  JOURNAL   Int J Oncol 17 (6), 1087-1091 (2000)
   PUBMED   11078792
REFERENCE   7  (bases 1 to 4297)
  AUTHORS   Uchida,K., Nitta,K., Kobayashi,H., Kawachi,H., Shimizu,F.,
            Yumura,W. and Nihei,H.
  TITLE     Localization of Smad6 and Smad7 in the rat kidney and their
            regulated expression in the anti-Thy-1 nephritis
  JOURNAL   Mol Cell Biol Res Commun 4 (2), 98-105 (2000)
   PUBMED   11170839
REFERENCE   8  (bases 1 to 4297)
  AUTHORS   Stopa,M., Benes,V., Ansorge,W., Gressner,A.M. and Dooley,S.
  TITLE     Genomic locus and promoter region of rat Smad7, an important
            antagonist of TGFbeta signaling
  JOURNAL   Mamm Genome 11 (2), 169-176 (2000)
   PUBMED   10656934
REFERENCE   9  (bases 1 to 4297)
  AUTHORS   Kleeff,J., Ishiwata,T., Maruyama,H., Friess,H., Truong,P.,
            Buchler,M.W., Falb,D. and Korc,M.
  TITLE     The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in
            pancreatic cancer
  JOURNAL   Oncogene 18 (39), 5363-5372 (1999)
   PUBMED   10498890
REFERENCE   10 (bases 1 to 4297)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030858.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF159626.1, AF042499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2035              JAXUCZ010000018.1  71263508-71265542
            2036-2089           JAXUCZ010000018.1  71266887-71266940
            2090-2164           JAXUCZ010000018.1  71272181-71272255
            2165-4297           JAXUCZ010000018.1  71289712-71291844
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..4297
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /note="SMAD family member 7"
                     /db_xref="GeneID:81516"
                     /db_xref="RGD:69314"
     exon            1..2035
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     CDS             1423..2703
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /note="MAD (mothers against decapentaplegic, Drosophila)
                     homolog 7; SMAD 7; mothers against DPP homolog 7; MAD
                     homolog 7"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 7"
                     /protein_id="NP_110485.1"
                     /db_xref="GeneID:81516"
                     /db_xref="RGD:69314"
                     /translation="MFRTKRSALVRRLWRSRAPGGEDEEEGVGGGGGGGDLRGEGATD
                     GRAYGAGGGGAGRAGCCLGKAVRGAKGHHHPHPPSSGAGAAGGAEADLKALTHSVLKK
                     LKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLC
                     KVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDF
                     LKPTADCPDAVPSSDETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRL
                     YCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYN
                     RSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTG
                     FTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR"
     exon            2036..2089
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2164
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..4297
                     /gene="Smad7"
                     /gene_synonym="Madh7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagtgcggc gcggcgagcc cccagcggcg gcagaaggac tcgagcgcca ggagagggcg
       61 gacgggggac gaggaggctc ccgggcgcga cgaagagagt ctcggaggaa gaggctgcga
      121 gaggacaccc gggcctcctg ccgccactgt cgggtcgggg ccagcagctt atgcgagcag
      181 ccccagcgac caccctcggc caggagaagg ggcaccggca gcccccacgc tagctagcct
      241 gccgcctgtg ccctcggggg cgagagcttg cgacccgccg gagcccgccg ccgcgccgcc
      301 ctcccccgcg ctgacagccc cccggggcgc agccgccgcc gcagcatctt ctgtccctgc
      361 ttccccagcg cggaggaagt ccccgccgag gacctgggcc cccgggagcg caggaggaaa
      421 gaccagagac tctaaaacac ccagatacgc aagattgaag cagcctaacc agacctttct
      481 gtggattaaa agaaatacga tttttttttt tgacagaaga aaaggaaagg aagaccggcg
      541 gggttcagca aggaaaaaaa ggggatgtaa ctcgtggata cggtttttcc ccccaccctt
      601 ccaacatctt gttctacttt gtaaacattt tctcttttta aaccccggct ccatccggtg
      661 ccctccagac ctccgaggtg cgagaaggtg gtgtgttttt tcactggggg ctttgcatat
      721 ttggttttgg ggtttttgag agaccctcca gacatctcac gaggggtgaa gtctactcgg
      781 ccccctccct caagtcttcg cgtgcacaga attcgaggag atccggttac taaggatata
      841 gaagaaaaaa ataaatcgtg tgcctgcctt tttttttttt aattgcctgc ttctccccac
      901 ccccaaatta agttgcttag caagggggaa agaggctttt tcctcccttc agtagctcag
      961 cctaacgtct ttcgtttttt gcccctgagg atcttccatg taggaagccg aggctggcga
     1021 gcccgacact cgggagccac tgtagggggg cctttttggg gagaggcgtc gaccggggct
     1081 gcctcggccg cccccaggga agcggcggcc gcgttcctca ggggcacgcc ggggcccgag
     1141 agccgcgcag ggcgcgggcc gcgccgggtg gggcagccga agcgcaggcc cccgatcccc
     1201 ggcgggcgcc cctgggcccc cgcgcgcgcc ccggcctccg ggagactggc gcatgccacg
     1261 gagcgcccct cgggccgccg ccgcttctgc ccgggcccct gctgttgttg ctgtcgcctg
     1321 cgcctgctgc cccaactcgg cgcccgactt cttcatggtg tgcggaggtc atgttcgctc
     1381 cttagccggc aaacgacttt tctcctcgcc tcctcgcccc gcatgttcag gaccaaacga
     1441 tctgcgctcg tccggcgtct ctggaggagc cgtgcgcccg gcggcgagga cgaggaggag
     1501 ggcgtggggg gtggcggcgg cggaggcgac ctgcggggag aaggggcgac ggacggccgg
     1561 gcttatgggg ctggtggcgg cggtgcgggc agggctggct gctgcctggg taaggcagtc
     1621 cgaggtgcca aaggtcacca ccatccccat cccccatcct cgggtgccgg ggcggccggg
     1681 ggcgccgagg cggatctgaa ggcgctcacg cactcggtgc tcaagaaact caaggagcgg
     1741 cagctggagc tgctgcttca ggccgtggag tcccgcggcg gtacgcgcac cgcgtgcctc
     1801 ctgctgcccg gccgcctgga ctgcaggctg ggcccggggg cgcccgccag cgcgcagccc
     1861 gcgcagccgc cctcgtccta ctcgctcccc ctcctgctgt gcaaagtgtt caggtggccg
     1921 gatctcaggc attcctcgga agtcaagagg ctgtgttgct gtgaatctta cgggaagatc
     1981 aaccccgagc tggtgtgctg caacccccat caccttagtc gactctgtga actagagtct
     2041 ccccctcctc cttactccag atacccgatg gattttctca aaccaactgc agactgtcca
     2101 gacgctgtac cttcctccga tgaaaccggg ggaacgaatt atctggcccc tggggggctt
     2161 tcagattccc aacttcttct ggagcctggg gatcggtcac actggtgcgt ggtggcatac
     2221 tgggaggaga agactcgagt ggggaggctc tactgtgtcc aagagccctc cctggatatc
     2281 ttctatgatc tacctcaggg gaatggcttt tgcctcggac agctcaattc ggacaacaag
     2341 agtcagctgg tacagaaagt gaggagcaag atcggctgtg gcatccagct gacaagggaa
     2401 gtggatggcg tgtgggttta caaccgcagc agttacccca tcttcatcaa gtccgccaca
     2461 ctggacaacc cggactccag gacgctgttg gtgcacaaag tgttccctgg tttctccatc
     2521 aaggcttttg actatgaaaa ggcctacagc ctgcagcggc ccaatgacca cgagttcatg
     2581 cagcagccat ggacgggctt caccgtgcag attagcttcg tgaagggctg gggccagtgc
     2641 tacacccgcc agttcatcag cagttgcccg tgctggctgg aggtcatctt caacagccgg
     2701 tagtctcccg gtgtggggag aagaggacag gacggagggg tgagccgagc aggccaccgt
     2761 tcaaactact tgctgctaat ctttcatgca aaactctttc ggtcggtttt gttgtttgcc
     2821 attcattgtt ggttctgttt tgttttgttt tccttttttt ttttcttcct tcttcttttt
     2881 cctcctttct tgtcactctt gtgtcctgtg tgtctcgttc tttgagaaaa tatgatgcgg
     2941 atttttggtt gtgtttttgt ttgtttgttt gtttgtttgt tgttgttgtt tgtgttttga
     3001 ggtggtggtg ggtgcggttg gcaggacacc ccgatacaaa aacgggaagc aagagtcagc
     3061 actgccaagc gtggtgtgcg aaagtgggta ccaccttccc ctttggatca gcatttcagt
     3121 tgtcagtgtg tgtgtgtgag gggggtgtac gtgaatgaca gatgggggaa tggcgtgctt
     3181 tttttgtgtt ctttatggat gtccccagct gagaggcttg cagttccaag ctgtgtgtct
     3241 ctcactgtgt gtctctctca tgagcctttc ggacatgctc ggtggggcag aggctgtacc
     3301 tgggcagact ggcagcaggt gtcccagcag gtgccgagct ctgctccgct gaagctcccc
     3361 cgcccccgcc cccttcccca caggacacgg gcctatccac aggcttctga gaagccagcc
     3421 tgctagaagg ctgaaccaga accaattgtt ttcatccctg tcttactgcc tcctgtcacc
     3481 cgctgccatt gtcgaaggct gtcttttttg gccatctgct cctggatctc tcttgagatg
     3541 ggcttcccaa gggctgccgg gacagcccca gtcacagtat tgctacccca gtaccttctc
     3601 aggcccttcc accggtccca gccgtggttt tttcatcagg tttctcccag atctggaaag
     3661 tcagctcagc accccatccc ccagcctgtg tgctgagctc tgtagaccag cgaggggcat
     3721 cagggaggga cctgctcagt gcccacccac ccccctttcc cgctgagaag ggtgtagccc
     3781 cgtcataaca aaggtaccat cgtaggctgg ctcccagccc ttctctcggc tcatacactc
     3841 gtatgatact ctgacactgt tcttggctca atgagcatgc tcacacttta atataagcta
     3901 tttttctaac tacaaaggtt taaaaatgaa caagagaggc gttctcatcg gaaatttagc
     3961 atcgtagtgc tttgagagag gaaaggactc cttaaaagag aaaaaaaaag ctgagattta
     4021 ttaaagaaaa aaatgtattt tatgttatat ataaatatat tattacttgt aaatataaag
     4081 acgttttata agcatcatta tttatgtatt gtgcaatgtg tataaacgag aataaagaaa
     4141 agatgcactt tgctttaata taaacgcaaa taacatgcca aattaaaaaa aaaaagataa
     4201 acacaagatt ggtgtttttt tctatgggtg ttatcaccta gctgaatgtt tttctaaagg
     4261 agtttatgtt ccattaaaca atttttaaaa tgtataa
//
