LOCUS       NM_001109002            2255 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus SMAD family member 6 (Smad6), mRNA.
ACCESSION   NM_001109002 XM_001075935 XM_006243241 XM_345947
VERSION     NM_001109002.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Pan,X., Huang,X., Zhang,B., Pei,F., Zhao,Z. and Cen,X.
  TITLE     miR-20a-5p regulated SMAD6 to inhibit chondrogenesis of hDPSCs
  JOURNAL   Oral Dis 29 (8), 3433-3446 (2023)
   PUBMED   35917232
  REMARK    GeneRIF: miR-20a-5p regulated SMAD6 to inhibit chondrogenesis of
            hDPSCs.
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Han,T., Song,P., Wu,Z., Xiang,X., Liu,Y., Wang,Y., Fang,H., Niu,Y.
            and Shen,C.
  TITLE     MSC secreted extracellular vesicles carrying TGF-beta upregulate
            Smad 6 expression and promote the regrowth of neurons in spinal
            cord injured rats
  JOURNAL   Stem Cell Rev Rep 18 (3), 1078-1096 (2022)
   PUBMED   34449013
  REMARK    GeneRIF: MSC secreted extracellular vesicles carrying TGF-beta
            upregulate Smad 6 expression and promote the regrowth of neurons in
            spinal cord injured rats.
REFERENCE   3  (bases 1 to 2255)
  AUTHORS   Wang,C.J., Li,B.B., Tan,Y.J., Zhang,G.M., Cheng,G.L. and Ren,Y.S.
  TITLE     MicroRNA-31/184 is involved in transforming growth
            factor-beta-induced apoptosis in A549 human alveolar adenocarcinoma
            cells
  JOURNAL   Life Sci 242, 117205 (2020)
   PUBMED   31874165
REFERENCE   4  (bases 1 to 2255)
  AUTHORS   Xu,S. and Wu,X.
  TITLE     miR-134 inhibits chondrogenic differentiation of bone marrow
            mesenchymal stem cells by targetting SMAD6
  JOURNAL   Biosci Rep 39 (1) (2019)
   PUBMED   30135141
  REMARK    GeneRIF: MiR-134 directly targetted the 3'-UTRs of SMAD6 in the
            bone marrow mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2255)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 2255)
  AUTHORS   Wang,D., Kanuma,T., Mizumuma,H., Ibuki,Y. and Takenoshita,S.
  TITLE     Mutation analysis of the Smad6 and Smad7 gene in human ovarian
            cancers
  JOURNAL   Int J Oncol 17 (6), 1087-1091 (2000)
   PUBMED   11078792
REFERENCE   7  (bases 1 to 2255)
  AUTHORS   Galvin,K.M., Donovan,M.J., Lynch,C.A., Meyer,R.I., Paul,R.J.,
            Lorenz,J.N., Fairchild-Huntress,V., Dixon,K.L., Dunmore,J.H.,
            Gimbrone,M.A. Jr., Falb,D. and Huszar,D.
  TITLE     A role for smad6 in development and homeostasis of the
            cardiovascular system
  JOURNAL   Nat Genet 24 (2), 171-174 (2000)
   PUBMED   10655064
REFERENCE   8  (bases 1 to 2255)
  AUTHORS   Brodin,G., ten Dijke,P., Funa,K., Heldin,C.H. and Landstrom,M.
  TITLE     Increased smad expression and activation are associated with
            apoptosis in normal and malignant prostate after castration
  JOURNAL   Cancer Res 59 (11), 2731-2738 (1999)
   PUBMED   10363999
REFERENCE   9  (bases 1 to 2255)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   10 (bases 1 to 2255)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Nov 27, 2020 this sequence version replaced
            XM_006243241.3, NM_001109002.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM056091.1, SRR22582424.671754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1157              JAXUCZ010000008.1  73412993-73414149   c
            1158-1214           JAXUCZ010000008.1  73405257-73405313   c
            1215-1292           JAXUCZ010000008.1  73400939-73401016   c
            1293-2255           JAXUCZ010000008.1  73345460-73346422   c
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2255
                     /gene="Smad6"
                     /note="SMAD family member 6"
                     /db_xref="GeneID:367100"
                     /db_xref="RGD:1305069"
     exon            1..1157
                     /gene="Smad6"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1825
                     /gene="Smad6"
                     /note="MAD homolog 6"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 6"
                     /protein_id="NP_001102472.2"
                     /db_xref="GeneID:367100"
                     /db_xref="RGD:1305069"
                     /translation="MFRSKRSGLVRRLWRSRVVPDREEGSGGGCGGDEDGSLGSRAEP
                     APRAREGGGCGRSEVRSVAPRRLRDAVGPRGALIAGRRRRTGGPPRPVSEPGAGAGGS
                     PLDVVEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSR
                     EARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGG
                     QPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESP
                     PPPYSRLSPPDQHKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCS
                     VAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGI
                     LLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQH
                     ADAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR"
     exon            1158..1214
                     /gene="Smad6"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1292
                     /gene="Smad6"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..2255
                     /gene="Smad6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggtgtc tctagcatcg tttcgccggt ggcttcccta aagttccagg gcagctggag
       61 ttgagcagtc ccggccccat cgcgatccat gtagcccgct ggtccctcgc ggactgccgc
      121 tcagcgcgcg cgtgtgcccg gccaggcgcg agctccctca tgttgcagcc ctgcggtgcc
      181 ccttcgacga caggctgtgc gcagtctgca cggcgccccg cggcagagct tcatgtgggg
      241 ctgcggcccg cgcaacccgc gcctcgttga gggaacggac ccccggtaac cggagaccgc
      301 ctcccctccc accaccccag gcgccaaagg gtatcgtatg ttcaggtcta aacgctcggg
      361 gctggtgcgg cgactttggc gaagtcgtgt ggtccctgat cgggaggaag gcagcggcgg
      421 cggctgtggt ggcgacgagg atgggagcct gggcagccga gctgagcctg ccccgcgggc
      481 acgagagggc ggaggttgcg gccgctccga agtccgctcg gtagccccgc ggcggctccg
      541 ggacgcggtg ggaccgcgag gcgccctgat cgcgggcagg cgccggcgca cagggggccc
      601 cccgaggccc gtgtcggagc cgggggccgg agctgggggc tccccgctgg atgtggtgga
      661 gcctggaggc ccgggctggc tgcctgagag tgactgcgag acggtgactt gctgtctctt
      721 ctccgagcgg gacgctgcag gcgcgccccg ggactctggc gatccccaag ccaggcagtc
      781 cccggagccg gaggagggcg gcgggcctcg gagtcgcgaa gcccgctcgc ggctgctgct
      841 tctggagcag gagctcaaga cagtcacgta ctcgctgctc aagcggctca aggagcgttc
      901 gctggacaca ctgttggagg ctgtagagtc ccgaggcggc gtgccgggcg gctgcgtgct
      961 ggtgccgcgc gccgacctcc gtctgggcgg ccagcccgcg ccaccgcagc tgctgctcgg
     1021 tcgcctgttc cgctggccag acctgcagca cgcagtggag ctgaaacccc tgtgcggctg
     1081 ccacagcttt gccgccgccg ctgacgggcc cacggtgtgt tgcaacccct accacttcag
     1141 ccggctctgc gggccagaat caccgccgcc cccctattct cggctgtctc ctcctgacca
     1201 gcacaagcca ctggatctgt ccgattctac attgtcttac actgaaaccg aggccaccaa
     1261 ctccctcatc actgctccgg gtgaattctc agatgccagc atgtctccag atgccaccaa
     1321 gccaagccac tggtgcagcg tggcatactg ggagcaccgg acacgcgtgg gccgcctcta
     1381 tgcggtgtat gaccaggctg tcagcatctt ctacgaccta cctcagggca gcggcttctg
     1441 cctgggccag ctcaacctgg agcagcgcag tgagtcggtg cggcgcacac ggagcaagat
     1501 cggttttggc atcctgctca gcaaggagcc cgatggcgtg tgggcctaca accggggcga
     1561 gcaccccatc ttcgtcaact ccccgacgct ggatgcgccc ggaggccgcg ccctggtcgt
     1621 gcgcaaggtg ccaccgggct actccatcaa ggtgttcgac tttgagcgct cagggctgct
     1681 gcagcacgca gacgccgctc atggccccta tgacccgcac agcgtgcgca tcagcttcgc
     1741 caagggctgg ggaccctgct actcgcgaca gttcatcacc tcctgcccct gttggctgga
     1801 gatcctcctc aacaaccaca gatagcaaag cggctgccac tgcgccgcag cgtcccccaa
     1861 cctctggggg ccagcgccca gagacgccgc cccagggaca acctcgccct ccccccagat
     1921 atcatctacc tagatttaat ataaagtttt atatattata tggaaatata tattatactt
     1981 gtaattatgg agtcattttt acaacgtaat tatttatata tggtgcaatg tgtgtatatg
     2041 gagaaacaag aaaaacgcac tttggcttgt aattctttca atacagatat attttttctt
     2101 tctttccctc tttccttttt taaagagaat tatacagcag aactaggtgg aaagcctggg
     2161 tttggtgtat ggttttttaa aaaatattaa tgcccagacc aaaaaaaaaa aacaaaacta
     2221 ataccagtca ctcttgataa taaagtgttt gcatt
//
