LOCUS       NM_021692               1685 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus SMAD family member 5 (Smad5), mRNA.
ACCESSION   NM_021692
VERSION     NM_021692.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Liu,Y., Ma,Z., Huang,Z., Zou,D., Li,J. and Feng,P.
  TITLE     MiR-122-5p promotes peritoneal fibrosis in a rat model of
            peritoneal dialysis by targeting Smad5 to activate Wnt/beta-catenin
            pathway
  JOURNAL   Ren Fail 44 (1), 191-203 (2022)
   PUBMED   35170385
  REMARK    GeneRIF: MiR-122-5p promotes peritoneal fibrosis in a rat model of
            peritoneal dialysis by targeting Smad5 to activate Wnt/beta-catenin
            pathway.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Chai,N., Li,W.X., Wang,J., Wang,Z.X., Yang,S.M. and Wu,J.W.
  TITLE     Structural basis for the Smad5 MH1 domain to recognize different
            DNA sequences
  JOURNAL   Nucleic Acids Res 45 (10), 6255-6257 (2017)
   PUBMED   28369590
  REMARK    Correction to:[Nucleic Acids Res. 2015 Oct 15;43(18):9051-64. doi:
            10.1093/nar/gkv848.. PMID: 26304548]
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Wang,H., Jiang,Y., Lu,M., Sun,B., Qiao,X., Xue,D. and Zhang,W.
  TITLE     STX12 lncRNA/miR-148a/SMAD5 participate in the regulation of
            pancreatic stellate cell activation through a mechanism involving
            competing endogenous RNA
  JOURNAL   Pancreatology 17 (2), 237-246 (2017)
   PUBMED   28202235
  REMARK    GeneRIF: The activation and regulation of STX12, miR-148a and SMAD5
            in pancreatic stellate cells may serve as a new gene therapy
            strategy for the treatment of chronic pancreatitis and reversal of
            pancreatic fibrosis.
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Hou,F., Liu,R., Liu,X., Cui,L., Wen,Y., Yan,S. and Yin,C.
  TITLE     Attenuation of liver fibrosis by herbal compound 861 via
            upregulation of BMP-7/Smad signaling in the bile duct ligation
            model rat
  JOURNAL   Mol Med Rep 13 (5), 4335-4342 (2016)
   PUBMED   27035233
  REMARK    GeneRIF: Cpd 861 markedly upregulated the gene expression of BMP7
            and Smad5, as well as the protein expression of BMP7 and Smad1/5.
            In addition, p-Smad1/5/8 protein expression was markedly increased
            by Cpd 861 in the liver fibrosis model.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Chen,W., Xia,J., Hu,P., Zhou,F., Chen,Y., Wu,J., Lei,W. and Shen,Z.
  TITLE     Follistatin-like 1 protects cardiomyoblasts from injury induced by
            sodium nitroprusside through modulating Akt and Smad1/5/9 signaling
  JOURNAL   Biochem Biophys Res Commun 469 (3), 418-423 (2016)
   PUBMED   26687945
  REMARK    GeneRIF: Taken together, these results indicated that FSTL1
            protects the SNP-induced injury in cardiac H9c2 cells through, at
            least in part, the activation of Akt and inhibition of Smad1/5/9
            signaling.
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Korchynskyi,O. and ten Dijke,P.
  TITLE     Identification and functional characterization of distinct
            critically important bone morphogenetic protein-specific response
            elements in the Id1 promoter
  JOURNAL   J Biol Chem 277 (7), 4883-4891 (2002)
   PUBMED   11729207
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Chang,H. and Matzuk,M.M.
  TITLE     Smad5 is required for mouse primordial germ cell development
  JOURNAL   Mech Dev 104 (1-2), 61-67 (2001)
   PUBMED   11404080
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Visser,J.A., Olaso,R., Verhoef-Post,M., Kramer,P., Themmen,A.P. and
            Ingraham,H.A.
  TITLE     The serine/threonine transmembrane receptor ALK2 mediates Mullerian
            inhibiting substance signaling
  JOURNAL   Mol Endocrinol 15 (6), 936-945 (2001)
   PUBMED   11376112
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Ebisawa,T., Fukuchi,M., Murakami,G., Chiba,T., Tanaka,K.,
            Imamura,T. and Miyazono,K.
  TITLE     Smurf1 interacts with transforming growth factor-beta type I
            receptor through Smad7 and induces receptor degradation
  JOURNAL   J Biol Chem 276 (16), 12477-12480 (2001)
   PUBMED   11278251
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Zavadil,J., Brezinova,J., Svoboda,P., Zemanova,Z. and Michalova,K.
  TITLE     Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost
            and not mutated in the retained allele in human leukemia cell line
            HL60
  JOURNAL   Leukemia 11 (8), 1187-1192 (1997)
   PUBMED   9264367
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB010955.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010955.1, BC161849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1685
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /note="SMAD family member 5"
                     /db_xref="GeneID:59328"
                     /db_xref="RGD:620158"
     exon            1..477
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1472
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /note="SMAD 5; mothers against DPP homolog 5; MAD homolog
                     5; SMAD, mothers against DPP homolog 5"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 5"
                     /protein_id="NP_067724.1"
                     /db_xref="GeneID:59328"
                     /db_xref="RGD:620158"
                     /translation="MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKK
                     KKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHH
                     ELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNL
                     SHNEPHMPQNATFPDSFHQPNSTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLP
                     ADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVY
                     YELNNRVGEAFHASSTSVLVDGFTDPANNKSRFCLGLLSNVNRNSTIENTRRHIGKGV
                     HLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLL
                     AQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV
                     LTQMGSPLNPISSVS"
     exon            478..729
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /inference="alignment:Splign:2.1.0"
     exon            730..849
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1071
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1328
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1685
                     /gene="Smad5"
                     /gene_synonym="Madh5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcttctcc tgtgattctg cttttcgtgt ctactgactt tgattacagg aaaggctctg
       61 acgattcgta tcaaatgacg tcaatggcca gcctgttttc tttcactagt ccagccgtga
      121 agcgattgtt gggctggaaa caaggtgatg aggaagagaa atgggcagaa aaggccgtgg
      181 atgctttagt gaaaaagctg aagaagaaga agggcgccat ggaggagttg gagaaagcct
      241 tgagcagccc aggacagcca agcaagtgtg tcactatccc caggtccttg gacggccgtt
      301 tgcaagtctc tcacaggaaa ggcttgcccc acgttatata ttgccgtgtt tggcgctggc
      361 cagatttgca gagccatcat gagctaaagc ctttggatat ttgtgagttt ccttttggat
      421 cgaagcaaaa agaagtttgt atcaatccat accactataa gagagtggag agtccagtct
      481 tacctccagt gttagtgcct cgtcacaacg aattcaatcc ccagcacagc cttctggttc
      541 agttcaggaa cctgagccac aatgagccgc acatgcccca gaatgccacg tttcctgatt
      601 ccttccacca gcccaacagc actcctttcc ccttatctcc taacagcccc tatcctcctt
      661 cccctgctag cagcacatat cccaactccc ctgcaagctc cggaccagga agtccatttc
      721 aactcccagc tgatacccct ccccctgcct atatgccacc tgacgatcag atgggtcagg
      781 ataactccca gcctatggac acaagcaaca acatgattcc tcagatcatg cccagcatat
      841 ctagcagaga tgttcagcct gttgcctatg aagagcccaa acactggtgt tcgattgtgt
      901 actatgaact gaacaaccgt gtcggggaag ctttccatgc gtcttccacc agtgtgttag
      961 tagacgggtt tacagaccct gccaataaca agagccgctt ctgcttgggg ctgctgtcca
     1021 acgttaatcg caactcaacc atcgagaaca ccaggcggca catcgggaaa ggtgtccatc
     1081 tatactacgt tggtggggag gtgtatgccg agtgtcttag tgacagcagc atctttgttc
     1141 agagtaggaa ctgcaacttt caccatggct tccaccccac caccgtctgt aagattccca
     1201 gcagctgcag cctcaaaatt tttaacaatc aggagtttgc tcagcttctg gctcagtcag
     1261 tcaaccatgg gtttgaggct gtgtatgagc tcaccaagat gtgtaccatt cgaatgagtt
     1321 ttgtcaaggg ctggggagca gagtaccacc gacaggatgt aaccagtact ccatgctgga
     1381 ttgagattca cctccatggg cctctgcagt ggctggataa agtcctgacc cagatgggct
     1441 ctccgctgaa ccccatttct tctgtttcat agtgcagaag tattcttttc aactatattt
     1501 ttagtggact tgttttaatt ttagaggaat ttccagcaca gatactgtga gctgacatgg
     1561 aaaaacagat attatggctt attttttcta cgtaattgtg accaacacat ttgtatttta
     1621 tgatattaca tttgtttgta ttcgtgttca ttgtgattaa ctttcaaaag tattgtaaac
     1681 gacat
//
