LOCUS       NM_013130               2970 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus SMAD family member 1 (Smad1), mRNA.
ACCESSION   NM_013130
VERSION     NM_013130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Zheng,Z., Wang,D., Zhang,W., Yu,H., Zhang,Y., Feng,T. and Zhong,X.
  TITLE     MiR-20 promotes cartilage repair in knee osteoarthritis rats via
            BMP2/Smad1 signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 256-261 (2023)
   PUBMED   38063098
  REMARK    GeneRIF: MiR-20 promotes cartilage repair in knee osteoarthritis
            rats via BMP2/Smad1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Peng,Y., Wu,S., Tang,Q., Li,S. and Peng,C.
  TITLE     KGF-1 accelerates wound contraction through the TGF-beta1/Smad
            signaling pathway in a double-paracrine manner
  JOURNAL   J Biol Chem 294 (21), 8361-8370 (2019)
   PUBMED   30894415
  REMARK    GeneRIF: findings demonstrate that KGF-1 promotes fibroblast
            contraction and accelerates wound contraction via the
            TGF-beta1/Smad signaling pathway in a double-paracrine manner.
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Sirohi,V.K., Gupta,K., Kapoor,R. and Dwivedi,A.
  TITLE     MicroRNA-145 targets Smad1 in endometrial stromal cells and
            regulates decidualization in rat
  JOURNAL   J Mol Med (Berl) 97 (4), 509-522 (2019)
   PUBMED   30729278
  REMARK    GeneRIF: MiR-145 expression is downregulated during decidualization
            in the rat uterus. MiR-145 downregulated Smad1 which suppresses
            Smad1/5/8, Wnt-4, MMP-9, Cox-2, and VEGF.
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Tang,Y., Zheng,L., Zhou,J., Chen,Y., Yang,L., Deng,F. and Hu,Y.
  TITLE     miR-203-3p participates in the suppression of diabetes-associated
            osteogenesis in the jaw bone through targeting Smad1
  JOURNAL   Int J Mol Med 41 (3), 1595-1607 (2018)
   PUBMED   29328402
  REMARK    GeneRIF: miR2033p inhibits osteogenesis in jaw bones of diabetic
            rats by targeting Smad1 to inhibit the BMP/Smad pathway.
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Xu,H., Wu,F., Zhang,H., Yang,C., Li,K., Wang,H., Yang,H., Liu,Y.,
            Ding,B., Tan,Y., Yuan,M., Li,Y. and Dai,Z.
  TITLE     Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in
            preosteoblast under simulated microgravity
  JOURNAL   Biochimie 138, 184-193 (2017)
   PUBMED   28457943
  REMARK    GeneRIF: Actin cytoskeleton depolymerization inhibites BMP2
            signaling via blocking of Smad by dephosphorylated CNN1 in
            osteoblast cells under simulated microgravity.
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Liu,F., Pouponnot,C. and Massague,J.
  TITLE     Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible
            transcriptional complexes
  JOURNAL   Genes Dev 11 (23), 3157-3167 (1997)
   PUBMED   9389648
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Wu,R.Y., Zhang,Y., Feng,X.H. and Derynck,R.
  TITLE     Heteromeric and homomeric interactions correlate with signaling
            activity and functional cooperativity of Smad3 and Smad4/DPC4
  JOURNAL   Mol Cell Biol 17 (5), 2521-2528 (1997)
   PUBMED   9111321
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Chen,Y., Lebrun,J.J. and Vale,W.
  TITLE     Regulation of transforming growth factor beta- and activin-induced
            transcription by mammalian Mad proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12992-12997 (1996)
   PUBMED   8917532
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Hoodless,P.A., Haerry,T., Abdollah,S., Stapleton,M., O'Connor,M.B.,
            Attisano,L. and Wrana,J.L.
  TITLE     MADR1, a MAD-related protein that functions in BMP2 signaling
            pathways
  JOURNAL   Cell 85 (4), 489-500 (1996)
   PUBMED   8653785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013130.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061757.1, SRR26643293.79443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000019.1  45417542-45417698
            158-734             JAXUCZ010000019.1  45443818-45444394
            735-992             JAXUCZ010000019.1  45458851-45459108
            993-1118            JAXUCZ010000019.1  45461731-45461856
            1119-1340           JAXUCZ010000019.1  45465359-45465580
            1341-1597           JAXUCZ010000019.1  45470374-45470630
            1598-2970           JAXUCZ010000019.1  45476577-45477949
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2970
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /note="SMAD family member 1"
                     /db_xref="GeneID:25671"
                     /db_xref="RGD:3030"
     exon            1..157
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..734
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1741
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /note="MAD (mothers against decapentaplegic, Drosophila)
                     homolog 1; MAD homolog1 (mothers against decapentaplegic,
                     Drosophila); SMAD 1; mothers against DPP homolog 1; MAD
                     homolog 1; SMAD, mothers against DPP homolog 1"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 1"
                     /protein_id="NP_037262.3"
                     /db_xref="GeneID:25671"
                     /db_xref="RGD:3030"
                     /translation="MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKK
                     KGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHE
                     LKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG
                     QNEPHMPLNATFPDSFQQPHSHPFPQSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM
                     PADTPPPAYLPPEDPMAQDGSQPMDTNMTNMTAPTLPAEINRGDVQAVAYEEPKHWCS
                     IVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIG
                     KGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFA
                     QLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWL
                     DKVLTQMGSPHNPISSVS"
     exon            735..992
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1118
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1340
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1597
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2970
                     /gene="Smad1"
                     /gene_synonym="Madh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgagcgg gcgcaccaag gcgaggccag ggccgaggcg cggggacggc ggccgagagc
       61 taagcgaagc gctgggacgg tgactgggaa cggatcggag cgcgggaccc ggcgccgggt
      121 ctcgtgcgtc cccgccgatg ggcgcgccgc cgagccggtg ctaactgggt cttccctgaa
      181 gcagaaggaa cagtatttcc tacctttccg aaccgaagac caagaagcta gagaatctat
      241 gtaaataaac tgaaatctct gttggctttg cacccccagc ccggagccgt cacttttcct
      301 ggtctgagga gcgtgtagac ctcggccagc cgctatgaat gtgaccagct tgttttcatt
      361 cacaagccca gctgtgaaga gactccttgg gtggaaacag ggcgacgaag aagagaaatg
      421 ggcggagaag gctgtggacg ctttggtgaa gaaactgaag aagaagaaag gggccatgga
      481 agagctggag aaggccctga gctgccccgg gcagccgagt aactgtgtca ccattcctcg
      541 ctccctggat ggcaggttgc aggtgtccca ccggaaggga ctgcctcatg tcatttattg
      601 ccgcgtgtgg cgctggcccg acctccagag ccatcatgaa ctaaagcctc tggaatgctg
      661 cgagttccca tttggttcca agcagaagga agtctgcatc aatccctacc actataagcg
      721 agtggagagc cccgttctcc caccggtgct ggttccgagg cacagcgagt acaaccctca
      781 gcacagcctt ctggctcagt tccgaaacct gggacaaaat gagccccaca tgccactgaa
      841 tgccacgttc cccgactcct tccagcagcc acacagccac ccgtttcccc agtcccccaa
      901 cagcagctac cccaactctc ctggcagcag cagcagcacc taccctcact ccccgaccag
      961 ctcagacccg ggcagccctt ttcagatgcc agccgacaca cccccgcctg cttacctgcc
     1021 tcctgaagac cccatggccc aggatggctc tcagcctatg gacacgaaca tgacgaacat
     1081 gacggcaccg acactgcccg cggagatcaa tagaggagat gttcaagcag ttgcttacga
     1141 ggaaccaaaa cactggtgct ctattgtgta ctatgagctc aacaaccgtg tgggcgaagc
     1201 gttccatgcc tcctccacca gcgtgttggt ggatggtttc accgatcctt ccaacaataa
     1261 gaaccgattc tgccttgggc tgctctccaa tgttaaccgg aactccacta ttgaaaatac
     1321 caggcgacac atcgggaaag gagtccacct ttattacgtc ggaggagagg tgtatgcgga
     1381 gtgcctcagt gacagcagca tcttcgtgca gagtcggaac tgcaactacc accatggctt
     1441 tcatcccacc acggtctgca agatccccag cgggtgcagc ttgaaaatct tcaacaacca
     1501 agagttcgct cagctactgg cgcagtctgt gaaccatggg ttcgagacag tgtatgaact
     1561 caccaaaatg tgcactattc gaatgagctt cgtgaagggc tggggagcag agtaccaccg
     1621 gcaggatgtc actagcaccc cctgctggat tgagatacac ctgcatggcc ctctccagtg
     1681 gctggataaa gtccttaccc agatgggttc gccccacaac cctatttcgt cggtgtctta
     1741 aagggccctc ggcttctgtc tcttgcaaac tattgggcct tgcatgtact tgaaggacgg
     1801 agaagtcaga caggatgggg agctgtaaag gagccgtgat acttgacctc tgtgaccaac
     1861 cgttggatgg agaagctgac aggccttggt aacaagctgt tgatatcaag aacccgctta
     1921 gtttacattg tgacattctg ttgtaaaatc aactaaaatg ctgactttta gcaggacttt
     1981 gtgaatagtt agaaaagaga tggccaagcc aggggcaaat tatctattag gaaaaaagca
     2041 aaaaaaaagg ccctaagcaa tccttttgtg tggggtgttg gcagaaggtt ggcgccgatc
     2101 atctttatgg agtgggctct catcaggctc ggagcccacg ctgatcatcc tctcatgggt
     2161 tttcttaata ttttaaaact atttgtttag aaatgaatgg gtttttttgt ttgttttaaa
     2221 gtaaaggtta attgttatgc catgcgtagt aacctttctg aagctgtatg ctgactgtat
     2281 tgctgtcagg atgacgtcag gcatatgccc tttgctaaat atgtatatac agaatacttg
     2341 gaggttatga atagtccaaa tggctagtgg gtctacacag tatctgaggg gcggggtcgg
     2401 ggaggaaaaa cgacagctgc aaatgtagac attgccgtaa agcccagcct gttgccttaa
     2461 acggacaagc tggtgtcgga ctttgctgtg tttcaggttt tttagagttt tacctggctt
     2521 ttcttccttt cttttctgct gtctcatccg ctccacaatg cagttaagca gctggttaat
     2581 tcctctaact gtaagggcaa atgagtaatt ccttctgttc gcaaacggac tggctctgcg
     2641 tcccagttcc cggaacatga aaagcgtgga tttaacgagc agttcttatg gcgtttacaa
     2701 tacagacata ggctttgatt tttcaaataa attgtttgcc aaacctggta actctgttca
     2761 ttattcgcag gtttgaagaa gatctctatc agaatccatt tcaaagtttt ttttttttta
     2821 attttgtttc attttttttg tactatttgg ttttcttctg ttgaagtttt ctattctcct
     2881 tttctcttat acagcgagtt cttttattcc aacactagca gggtttttct ctactggaaa
     2941 tttttaaata aaacctgtca ttattgctta
//
