LOCUS       NM_001009292            2830 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SLX1 homolog B, structure-specific endonuclease
            subunit (Slx1b), mRNA.
ACCESSION   NM_001009292 XM_215073
VERSION     NM_001009292.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Wan,B., Yin,J., Horvath,K., Sarkar,J., Chen,Y., Wu,J., Wan,K.,
            Lu,J., Gu,P., Yu,E.Y., Lue,N.F., Chang,S., Liu,Y. and Lei,M.
  TITLE     SLX4 assembles a telomere maintenance toolkit by bridging multiple
            endonucleases with telomeres
  JOURNAL   Cell Rep 4 (5), 861-869 (2013)
   PUBMED   24012755
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Vannier,J.B., Pavicic-Kaltenbrunner,V., Petalcorin,M.I., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 dismantles T loops and counteracts telomeric G4-DNA to
            maintain telomere integrity
  JOURNAL   Cell 149 (4), 795-806 (2012)
   PUBMED   22579284
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Fekairi,S., Scaglione,S., Chahwan,C., Taylor,E.R., Tissier,A.,
            Coulon,S., Dong,M.Q., Ruse,C., Yates,J.R. 3rd, Russell,P.,
            Fuchs,R.P., McGowan,C.H. and Gaillard,P.H.L.
  TITLE     Human SLX4 is a Holliday junction resolvase subunit that binds
            multiple DNA repair/recombination endonucleases
  JOURNAL   Cell 138 (1), 78-89 (2009)
   PUBMED   19596236
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Svendsen,J.M., Smogorzewska,A., Sowa,M.E., O'Connell,B.C.,
            Gygi,S.P., Elledge,S.J. and Harper,J.W.
  TITLE     Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and
            is required for DNA repair
  JOURNAL   Cell 138 (1), 63-77 (2009)
   PUBMED   19596235
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Andersen,S.L., Bergstralh,D.T., Kohl,K.P., LaRocque,J.R.,
            Moore,C.B. and Sekelsky,J.
  TITLE     Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with
            DNA structure-specific endonucleases in DNA repair and
            recombination
  JOURNAL   Mol Cell 35 (1), 128-135 (2009)
   PUBMED   19595722
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Munoz,I.M., Hain,K., Declais,A.C., Gardiner,M., Toh,G.W.,
            Sanchez-Pulido,L., Heuckmann,J.M., Toth,R., Macartney,T.,
            Eppink,B., Kanaar,R., Ponting,C.P., Lilley,D.M. and Rouse,J.
  TITLE     Coordination of structure-specific nucleases by human SLX4/BTBD12
            is required for DNA repair
  JOURNAL   Mol Cell 35 (1), 116-127 (2009)
   PUBMED   19595721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087090.1.
            
            On Jan 7, 2005 this sequence version replaced XM_215073.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087090.1, SRR8487231.21191.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2830
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /note="SLX1 homolog B, structure-specific endonuclease
                     subunit"
                     /db_xref="GeneID:293489"
                     /db_xref="RGD:1311568"
     exon            1..314
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..951
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /note="GIY-YIG domain containing 2; GIY-YIG
                     domain-containing protein 1"
                     /codon_start=1
                     /product="structure-specific endonuclease subunit SLX1"
                     /protein_id="NP_001009292.1"
                     /db_xref="GeneID:293489"
                     /db_xref="RGD:1311568"
                     /translation="MGHAARPGRFFGVYLLYCQNPRHRGRVYVGFTVNPARRVRQHNA
                     GRKKGGAWRTSGRGPWDMVLILHGFPSAVAALRFEWAWQHPQASRRLTHVGPRLRSEA
                     SFTFHLRVLAHMLRVPPWVRLPLTVRWLRPDFRHELCPAPPPHMPIAFGPPPPQPLVP
                     KRPAASEADSERRLDLGAKASCTLCARMLQDEEGPLCCPHPGCPLRAHIICLAEEFLQ
                     EEPGQLLPLEGHCPSCKKSLLWGNLVGQCHEDTEEEEVDLELEEEHWTDLLET"
     exon            315..366
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /inference="alignment:Splign:2.1.0"
     exon            367..705
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /inference="alignment:Splign:2.1.0"
     exon            706..833
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /inference="alignment:Splign:2.1.0"
     exon            834..921
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /inference="alignment:Splign:2.1.0"
     exon            922..2807
                     /gene="Slx1b"
                     /gene_synonym="Giyd1; Giyd2; LRRGT00058; RGD1311568"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaatttg caggaccatc gttccgtgct ttttcctaaa gcaacgtttt tgcagtcctg
       61 gctacccagc cctttccgag gtccgaggac ccagaaacca cccctaactc tggaccttca
      121 acccagaaag tccggatggg acatgcagca agaccggggc gcttcttcgg agtctacctg
      181 ctctactgtc agaaccctcg gcatcggggc cgtgtttacg tgggattcac tgtcaatcct
      241 gctcgtcggg tccggcaaca caacgcgggt cgcaaaaaag gtggcgcctg gcggaccagc
      301 gggcgaggac cctgggacat ggtgctgatt ctacacgggt tcccgtctgc tgtggccgcc
      361 cttcggtttg aatgggcctg gcagcatcct caagcttcgc gacgtctgac tcacgtgggg
      421 ccgcgcctgc gcagcgaggc ttcctttacc ttccacctgc gcgtgctggc gcacatgctt
      481 cgagttcctc cgtgggtgcg cctccctcta acagtgcggt ggctgcgacc tgatttccgc
      541 catgaactct gtccagctcc accaccacac atgcccattg cctttggacc gccaccaccc
      601 cagcccttgg tcccaaaacg acccgctgca agtgaggctg acagtgagcg acggctggat
      661 ctaggtgcca aggccagctg cactctatgt gcgcgtatgc tgcaggatga agagggcccc
      721 ttgtgttgcc cccatcctgg ttgtccccta agggcccata tcatctgctt ggcagaggag
      781 ttcctgcagg aagagcctgg gcagcttctg cccctagagg gccattgtcc tagctgcaag
      841 aagtcactac tttggggaaa cctggttggg cagtgccacg aggacaccga ggaggaagag
      901 gtggatttgg aattagagga ggaacactgg acagacttgc tggagacttg atcctaagtg
      961 tccccaactt tgacccctgc accttttctg cctctcaagt caattgacag cttaacttgg
     1021 gcacaataaa aaggctgagt taggggtacc ttctgatgtt ttctcagaga ggggccggaa
     1081 ggcaagaagt gaagtggaag ctttggcatg accatgtggc ctccctacct ccctcacctt
     1141 tctcagagat aacagctact gtcttcattc acttcccata gcttataaat attgggacca
     1201 gcaacttggg ggaggaggga gcttgtctca tcttacactt ccaggtaaca gcccttcagt
     1261 gaaggaactt tgggtggaca ctcaaggcag gaaccgggag cagaaaccat gcaggcaggg
     1321 gttgtttatt ggctccatct ctctggctgg tgcgccagtg aacacttaca taacccagaa
     1381 ccacctgcct agaggtggcg ctgtccagtg ggctgggcct tctcacatca atcaacacta
     1441 aagacagtgc ccccagagac acgcccacag gcccgtttgg ccgagacagc ccgggattga
     1501 ggatccctct gataaggctg ggctgtgtaa agttgacaac ggaaactaaa taggagaata
     1561 attaaaggct cagagagtag cacctgtgac ttggagttgg gagcacaaag gtccttgtgt
     1621 tcacacatca gcaccagggg aaaacaggaa tgttaaaaca ggttgtcttt tccaggaaaa
     1681 agatgtataa tctgccggcc tccgagtccg gagcgggcta acagcctaga taacccctgt
     1741 gctatttaca gggctttgaa tccaaaaagc tcccacaacc agggccaggt gacctctgtg
     1801 ccatctgtat gactcagact acactagatc cttccctagg tctttaacac acgtagccta
     1861 cccaccttca cggaggaagt aactcttctg agaagagttc agatgtaatt gtgcctcctt
     1921 gtgcgcacgg gatttggtac aacaggaaac tttcccaaat tgttctgcac ttacatatgt
     1981 gaaccctaaa ataaaccacc tggtctcaga ctccagaagt ttgaaccaca accagctact
     2041 gtgtcctgct gaccggattt cctttgtgcc tcactggtct ttactctgct aaccctggtg
     2101 tttgcacctg ggagcccagg aagccacaga ccagatcctc ttgggtaagc gcctgtgtga
     2161 gggggacttg ccagacagcc ctcgctctgc ccagctcctc actctatcct gctccacatg
     2221 agacttgctc tggttgtgtg ggcaactcct atttgctctc tcccctctgt gctctgtcca
     2281 tgcttcccca tcttagtggg caactccagg taacaggcag agctttgctc atgcccaaac
     2341 aagcacagcg cctccactaa ctgcatttgt cttagtgcca aataaaccca caccctgagt
     2401 ggttgccttt cgtggagagc ctgagctcct ggggacagga gggatggctg taggctgaca
     2461 gctgcagtag gaggtggttg gagagatgaa gctggctgca agctgtgagc acaggcaggt
     2521 cccaggggac ttttctggta cattatggca tctcctggaa agctatcaaa ctttgtgacc
     2581 cccaagagtt catgaatggg ggctagagag ctggcccagt ggttaagtgg ctgttcttgt
     2641 agaggactca ggttcaattc ctaacaccca catggtgtct cacaaccacc tacaactcca
     2701 attccaaggg atccaatggc atcttctgct cttgtgggac taggcagact ggtggtccac
     2761 agagtaggct gcacataaat aaaataataa agttaaattt aaaaaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa
//
