LOCUS       NM_001100550            2256 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SLU7 homolog, splicing factor (Slu7), mRNA.
ACCESSION   NM_001100550 XM_001067382 XM_001067430 XM_220315
VERSION     NM_001100550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2256)
  AUTHORS   Matera,A.G. and Wang,Z.
  TITLE     A day in the life of the spliceosome
  JOURNAL   Nat Rev Mol Cell Biol 15 (2), 108-121 (2014)
   PUBMED   24452469
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2014 Apr;15(4):294]
REFERENCE   2  (bases 1 to 2256)
  AUTHORS   Janowicz,A., Michalak,M. and Krebs,J.
  TITLE     Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7
  JOURNAL   Biochim Biophys Acta 1813 (5), 1045-1049 (2011)
   PUBMED   21122810
REFERENCE   3  (bases 1 to 2256)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2256)
  AUTHORS   Shomron,N., Alberstein,M., Reznik,M. and Ast,G.
  TITLE     Stress alters the subcellular distribution of hSlu7 and thus
            modulates alternative splicing
  JOURNAL   J Cell Sci 118 (Pt 6), 1151-1159 (2005)
   PUBMED   15728250
  REMARK    Erratum:[J Cell Sci. 2005 Mar 15;118(Pt 6):1331]
REFERENCE   5  (bases 1 to 2256)
  AUTHORS   Shomron,N., Reznik,M. and Ast,G.
  TITLE     Splicing factor hSlu7 contains a unique functional domain required
            to retain the protein within the nucleus
  JOURNAL   Mol Biol Cell 15 (8), 3782-3795 (2004)
   PUBMED   15181151
REFERENCE   6  (bases 1 to 2256)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 2256)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     The RNA splicing factor hSlu7 is required for correct 3'
            splice-site choice
  JOURNAL   Nature 402 (6758), 207-210 (1999)
   PUBMED   10647016
REFERENCE   8  (bases 1 to 2256)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     Human step II splicing factor hSlu7 functions in restructuring the
            spliceosome between the catalytic steps of splicing
  JOURNAL   Genes Dev 13 (7), 841-850 (1999)
   PUBMED   10197984
REFERENCE   9  (bases 1 to 2256)
  AUTHORS   Pei,L.
  TITLE     Genomic organization and identification of an enhancer element
            containing binding sites for multiple proteins in rat pituitary
            tumor-transforming gene
  JOURNAL   J Biol Chem 273 (9), 5219-5225 (1998)
   PUBMED   9478977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062243.1 and BC158865.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_001067382.1, XM_001067430.1, XM_220315.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BC062243.1         5-45
            42-519              BC158865.1         8-485
            520-1254            BC062243.1         524-1258
            1255-2073           BC158865.1         1221-2039
            2074-2256           BC158865.1         2050-2232
FEATURES             Location/Qualifiers
     source          1..2256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2256
                     /gene="Slu7"
                     /note="SLU7 homolog, splicing factor"
                     /db_xref="GeneID:303057"
                     /db_xref="RGD:631432"
     exon            1..57
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            58..243
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1834
                     /gene="Slu7"
                     /note="step II splicing factor SLU7; SLU7 splicing factor
                     homolog"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SLU7"
                     /protein_id="NP_001094020.1"
                     /db_xref="GeneID:303057"
                     /db_xref="RGD:631432"
                     /translation="MSAAAVDPVSATPMTGSKEMNLEEPKKMTREDWRKKKELEEQRK
                     LGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWY
                     KRGVKENSITTKYRKGACENCGAMTHKRKDCFERPRRVGAKFTGTNIAPDEHIQPQLM
                     FDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKH
                     QWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLR
                     NLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEA
                     YDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLA
                     QTEDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFF
                     KYSYCTGEAGKESVNSEECIINDATGEEPVKKPQTLMELHQEKLKEEKKKKKKKKKHR
                     KSSSDSDDDEERKQEKLKKALNAEEARLLHVKEIMQVDERKRPYNSIYETREPTEEEM
                     EAYRMKRQRPDDPMASFLGQ"
     exon            244..397
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            398..478
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            479..643
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            644..712
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            713..760
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            761..892
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            893..990
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1058
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1198
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1360
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1465
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1537
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1654
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..2256
                     /gene="Slu7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtcgggt cgcttcgttt ctggcggatg gttttgagtg gtctgtggcg ggactggagg
       61 aagccagttc atcatgtcgg cggcagctgt ggacccagtt agtgccacac ccatgacggg
      121 ctcaaaggaa atgaatttgg aggagccgaa aaagatgacc agagaggact ggaggaaaaa
      181 gaaggagcta gaagaacaga gaaaactggg caatgcccct gcagaagttg atgaagaggg
      241 aaaagatatc aaccctcata ttcctcagta tatttcttca gttccatggt atatcgatcc
      301 atccaagaga cccactttaa agcatcagag accacagcca gagaaacaga agcaattcag
      361 ttcatctggg gaatggtaca agagaggtgt aaaggagaac tctataacta ccaagtaccg
      421 caaaggtgca tgcgagaact gcggagccat gacacacaag aggaaagatt gttttgagag
      481 gccaaggcgg gttggagcta aattcacagg tactaacatc gccccagacg agcacatcca
      541 gcctcagctg atgttcgact atgatgggaa aagagaccgg tggaatggct acaatccaga
      601 agagcacatg aaaattgttg aggaatatgc caaagttgac ctggcaaaac gaacattgaa
      661 agcacagaaa ctgcaagaag agttagcctc tggaaaatta gtggagcaag ctaattctcc
      721 aaaacaccag tggggagaag aggaacccaa ttctcagatg gaaaaggatc ataacagtga
      781 ggatgaggac gaagacaaat acgcggatga cattgacatg ccggggcaga acttcgactc
      841 caagaggcgc atcactgttc ggaatctccg gattcgggaa gatattgcaa aatatttgag
      901 aaatttagat ccaaattctg cctattatga tccaaaaact agagcgatga gagagaaccc
      961 ttacgccaat gcagggaaga atccagacga agtgagctac gctggagata actttgttcg
     1021 atacacaggc gacaccattt caatggctca aacacaactg tttgcgtggg aagcctacga
     1081 caaggggtct gaagtgcatc tccaggcaga tcctaccaaa ctcgagctgc tgtataagtc
     1141 cttcaaagtc aaaaaagaag acttcaaaga gcagcagaag gaaagcatcc tggaaaagta
     1201 tggcggccaa gaacacctgg atgcccctcc ggctgagctg ctcttagcgc agacagaaga
     1261 ctatgtggag tactccaggc atgggactgt cattaaaggc caggagcggg ctgtggcctg
     1321 ttccaagtac gaggaagacg tgaagatcaa taaccacacg catatctggg gatcttactg
     1381 gaaagaaggc cgctggggat acaaatgctg ccactctttt tttaagtatt cctattgtac
     1441 tggagaagct gggaaggaga gtgttaattc agaggaatgt attataaatg atgcgactgg
     1501 agaagagcct gtgaagaaac cgcagaccct catggagctg caccaggaga aactaaaaga
     1561 ggagaagaag aagaaaaaga agaagaagaa acaccgaaag agcagttctg acagtgacga
     1621 cgacgaggaa aggaagcagg agaaactgaa aaaggcgttg aatgcagagg aggctcgcct
     1681 tcttcacgtg aaggagatca tgcaggttga tgagcggaag cggccctaca acagcatata
     1741 tgaaacccga gagcccacag aggaggaaat ggaggcctac aggatgaaac ggcagaggcc
     1801 agatgacccc atggcctctt tcctaggaca gtaactagtc agggtcagac acatacacag
     1861 tgttcttttc agctcctctc ggcctgtaga tagaaagtct tcatctgtcc tgctgtctga
     1921 cattaataaa gttttctgaa gtctccaagt cagtctcaac agtcaaacaa agcaagcaag
     1981 aaagaccata cagttatgat tagggttaaa atcatccttc ctaatcaacg atttggaagg
     2041 agagtttgga tctcttcctc tctagtgtct ggcatgatga ctcatgcttg taatgccagc
     2101 acctgagagt ggtagagcag gggaaccaag agttcaaggt cagccgaggg tggtgcacac
     2161 ctgtaatcct agcactcagc acactgaggc aggagactcc cagcattaac tacatagcaa
     2221 ggttggaacc agcctgcagt gcatgaggct gtccta
//
