LOCUS       NM_053372                653 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus secretory leukocyte peptidase inhibitor (Slpi),
            mRNA.
ACCESSION   NM_053372
VERSION     NM_053372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 653)
  AUTHORS   Lee,S.Y., Moon,J.S., Yang,D.W., Yoo,H.I., Jung,J.Y., Kim,O.S.,
            Kim,M.S., Koh,J.T., Chung,H.J. and Kim,S.H.
  TITLE     SLPI in periodontal Ligament is not sleepy during biophysical
            force-induced tooth movement
  JOURNAL   J Clin Periodontol 48 (4), 528-540 (2021)
   PUBMED   33370451
  REMARK    GeneRIF: SLPI in periodontal Ligament is not sleepy during
            biophysical force-induced tooth movement.
REFERENCE   2  (bases 1 to 653)
  AUTHORS   Fujiwara,M., Miyoshi,M., Sakai,S., Nishiokada,A.,
            Aoyama-Ishikawa,M., Maeshige,N., Usami,Y., Hamada,Y., Takahashi,M.
            and Usami,M.
  TITLE     Lard-based high-fat diet increases secretory leukocyte protease
            inhibitor expression and attenuates the inflammatory response of
            acute lung injury in endotoxemic rats
  JOURNAL   Clin Nutr 34 (5), 997-1009 (2015)
   PUBMED   25466948
REFERENCE   3  (bases 1 to 653)
  AUTHORS   Palaniyappan,A., Uwiera,R.R., Idikio,H., Menon,V., Jugdutt,C. and
            Jugdutt,B.I.
  TITLE     Attenuation of increased secretory leukocyte protease inhibitor,
            matricellular proteins and angiotensin II and left ventricular
            remodeling by candesartan and omapatrilat during healing after
            reperfused myocardial infarction
  JOURNAL   Mol Cell Biochem 376 (1-2), 175-188 (2013)
   PUBMED   23361363
REFERENCE   4  (bases 1 to 653)
  AUTHORS   Hannila,S.S., Siddiq,M.M., Carmel,J.B., Hou,J., Chaudhry,N.,
            Bradley,P.M., Hilaire,M., Richman,E.L., Hart,R.P. and Filbin,M.T.
  TITLE     Secretory leukocyte protease inhibitor reverses inhibition by CNS
            myelin, promotes regeneration in the optic nerve, and suppresses
            expression of the transforming growth factor-beta signaling protein
            Smad2
  JOURNAL   J Neurosci 33 (12), 5138-5151 (2013)
   PUBMED   23516280
  REMARK    GeneRIF: SLPI can overcome inhibition by central nervous system
            myelin and significantly enhance regeneration of transected retinal
            ganglion cell axons in rats.
REFERENCE   5  (bases 1 to 653)
  AUTHORS   Muller,A.M., Jun,E., Conlon,H. and Sadiq,S.A.
  TITLE     Inhibition of SLPI ameliorates disease activity in experimental
            autoimmune encephalomyelitis
  JOURNAL   BMC Neurosci 13, 30 (2012)
   PUBMED   22436018
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 653)
  AUTHORS   Song,Xy., Zeng,L., Jin,W., Thompson,J., Mizel,D.E., Lei,K.,
            Billinghurst,R.C., Poole,A.R. and Wahl,S.M.
  TITLE     Secretory leukocyte protease inhibitor suppresses the inflammation
            and joint damage of bacterial cell wall-induced arthritis
  JOURNAL   J Exp Med 190 (4), 535-542 (1999)
   PUBMED   10449524
REFERENCE   7  (bases 1 to 653)
  AUTHORS   Gipson,T.S., Bless,N.M., Shanley,T.P., Crouch,L.D., Bleavins,M.R.,
            Younkin,E.M., Sarma,V., Gibbs,D.F., Tefera,W., McConnell,P.C.,
            Mueller,W.T., Johnson,K.J. and Ward,P.A.
  TITLE     Regulatory effects of endogenous protease inhibitors in acute lung
            inflammatory injury
  JOURNAL   J Immunol 162 (6), 3653-3662 (1999)
   PUBMED   10092827
REFERENCE   8  (bases 1 to 653)
  AUTHORS   Kinne,R.W., Meyer,P., Grunder,W., Buchner,E., Palombo-Kinne,E.,
            Heinzel-Wieland,R., Becker,W., Wolf,F., Kalden,J.R. and
            Burkhardt,H.
  TITLE     Rat antigen-induced arthritis: cartilage alterations assessed with
            iodine-123-antileukoproteinase
  JOURNAL   J Nucl Med 39 (9), 1638-1645 (1998)
   PUBMED   9744360
REFERENCE   9  (bases 1 to 653)
  AUTHORS   Miller,K.W., Evans,R.J., Eisenberg,S.P. and Thompson,R.C.
  TITLE     Secretory leukocyte protease inhibitor binding to mRNA and DNA as a
            possible cause of toxicity to Escherichia coli
  JOURNAL   J Bacteriol 171 (4), 2166-2172 (1989)
   PUBMED   2467900
REFERENCE   10 (bases 1 to 653)
  AUTHORS   Thompson,R.C. and Ohlsson,K.
  TITLE     Isolation, properties, and complete amino acid sequence of human
            secretory leukocyte protease inhibitor, a potent inhibitor of
            leukocyte elastase
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6692-6696 (1986)
   PUBMED   3462719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_053372.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151982.1, CO563760.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760494,
                                           SAMN09345330 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000003.1  173503726-173503822 c
            98-259              JAXUCZ010000003.1  173502990-173503151 c
            260-409             JAXUCZ010000003.1  173502366-173502515 c
            410-653             JAXUCZ010000003.1  173501573-173501816 c
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..653
                     /gene="Slpi"
                     /note="secretory leukocyte peptidase inhibitor"
                     /db_xref="GeneID:84386"
                     /db_xref="RGD:621768"
     exon            1..97
                     /gene="Slpi"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..408
                     /gene="Slpi"
                     /note="secretory leukocyte protease inhibitor"
                     /codon_start=1
                     /product="secretory leukocyte peptidase inhibitor
                     precursor"
                     /protein_id="NP_445824.2"
                     /db_xref="GeneID:84386"
                     /db_xref="RGD:621768"
                     /translation="MKSSGLFPLMVLLALGVLAPWSVEGGKNDAIKIGACPARKPAQC
                     LKREKPECGTDWECPGKQRCCQDTCGFKCLNPVPIRGPVKKKPGRCLKFQGKCLMLNP
                     PNKCQNDGQCDGKYKCCEGMCGKVCLPPV"
     exon            98..259
                     /gene="Slpi"
                     /inference="alignment:Splign:2.1.0"
     exon            260..409
                     /gene="Slpi"
                     /inference="alignment:Splign:2.1.0"
     exon            410..653
                     /gene="Slpi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgccttca ccatgaagtc cagcggcctg ttccctctca tggtgctcct tgctctgggt
       61 gtcctggcac cctggagtgt ggaaggaggc aaaaatgatg ctatcaaaat tggagcctgc
      121 cctgctagaa agcctgccca gtgccttaaa cgtgagaaac cagagtgcgg tactgactgg
      181 gaatgcccag gaaagcagag atgctgccaa gatacctgtg gtttcaagtg cctgaatcct
      241 gttcccattc gtggaccagt gaagaagaag cctgggaggt gcctcaaatt tcaaggaaaa
      301 tgtctgatgc ttaaccctcc caataagtgc cagaatgacg gccagtgtga tggcaaatac
      361 aaatgttgtg agggcatgtg tgggaaagtc tgccttcccc cagtgtaagt ctgattcctg
      421 acatttggaa atggctctgg acccgtgctc tatatgttct ggaaactact tccctgcttt
      481 caggtttccc ggttccgggt tccggtgctc tggggtgccc aggcttggac atttgaataa
      541 tgtttatttc tgccgccaac atctcttttt ttgtcccatg tcagcattca tcaagcccta
      601 aggaaatgct gttggagagc aaataaataa aggcaatcat ttctctaagc aca
//
